Synaptotagmin-syntaxin interaction: The C2 domain as a Ca2+-dependent electrostatic switch

Neuron

Volumn 18, Issue 1, 1997, Pages 133-142

  Shao, Xuguang ^a   Li, Cai ^a,b   Fernandez, Imma ^a   Zhang, Xiangyang ^a   Südhof, Thomas C ^a   Rizo, Josep ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SYNAPTOTAGMIN; SYNTAXIN;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; NEUROTRANSMITTER RELEASE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; SYNAPSE VESICLE;

EID: 0031019191     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(01)80052-0     Document Type: Article

References (42)

1. Augustine, G.J., and Charlton, M.P. (1986). Calcium dependence of presynaptic calcium current and post-synaptic response at the squid giant synapse. J. Physiol. 381, 619-640.
2. Bajjalieh, S.M., and Scheller, R.H. (1995). The biochemistry of neurotransmitter secretion. J. Biol. Chem. 270, 1971-1974.
3. Bennett, M., Calakos, N., and Scheller, R.H. (1992). Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones. Science 257, 255-259.
4. Blasi, J., Chapman, E.R., Yamasaki, S., Binz, T., Niemann, H., and Jahn, R. (1993). Botulinium neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin. EMBO J. 12, 4821-4828.
5. Bodenhausen, G., and Ruben, D.J. (1980). Natural abundance nitrogen-15 NMR by enhanced heteronuclear spectroscopy. Chem. Phys. Lett. 69, 185-199.
6. 2-domain peptides implicates synaptotagmin in exocytosis. Nature 363, 163-165.
7. Brose, N., Petrenko, A.G., Südhof, T.C., and Jahn, R. (1992). Synaptotagmin: a calcium sensor on the synaptic vesicle surface. Science 256, 1021-1025.
8. 2+-dependent translocation domain with homology to PKC and GAP. Cell 65, 1043-1051.
9. 2+/phospholipid binding. J. Biol. Chem. 268, 26386-26390.
10. DiAntonio, A., and Schwarz, T.L. (1994). The effect on synaptic physiology of synaptotagmin mutations in Drosophila. Neuron 12, 909-920.
11. Elferink, LA., Peterson, M.R., and Scheller, R.H. (1993). A role for synaptotagmin (p65) in regulated exocytosis. Cell 72, 153-159.
12. 2+ sensor for transmitter release at a central synapse. Cell 79, 717-727.
13. c fragment. J. Mol. Biol. 233, 331-335.
14. Hata, Y., Davletov, B., Petrenko, A.G., Jahn, R., and Südhof, T.C. (1993). Interaction of synaptotagmin with the cytoplasmic domains of neurexins. Neuron 10, 307-315.
15. Hayashi, T., McMahon, H., Yamasaki, S., Binz, T., Hata, Y., Südhof, T.C., and Niemann, H. (1994). Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly. EMBO J. 13, 5051-5061.
16. Heidelberger, R., Heinemann, C., Neher, E., and Mathews, G. (1994). Calcium dependence of the rate of exocytosis in a synaptic terminal. Nature 377, 513-515.
17. Inoue, A., Obata, K., and Akagawa, K. (1992). Cloning and sequence analysis of cDNA for a neuronal cell membrane antigen, HPC-1. J. Biol. Chem. 267, 10613-10619.
18. Kee, Y., and Scheller, R.H. (1996). Localization of synaptotagmin-binding domains on syntaxin. J. Neurosci. 16, 1975-1981.
19. Kelly, R.B. (1993). Storage and release of neurotransmitters. Cell 72/Neuron 10 (Suppl.), 43-53.
20. LeMaster, D.M., and Richards, F.M. (1988). NMR sequential assignment of Eschericia coli thioredoxin utilizing random fractional deuteration. Biochemistry 27, 142-150.
21. 2+-dependent and -independent activities of neural and non-neural synaptotagmins. Nature 375, 594-599.
22. 2+-activated neurotransmitter release. Cell 74, 1125-1134.
23. Marion, D. Ikura, M., and Bax, A. (1989). Improved solvent suppression in one-and two-dimensional NMR spectra by convolution of time-domain data. J. Magn. Reson. 84, 425-430.
24. McMahon, H.T., and Südhof, T.C. (1995). Synaptic core complex of synaptobrevin, syntaxin and SNAP-25 forms high affinity α-SNAP binding site. J. Biol. Chem. 270, 2213-2217.
25. Messerle, B.A., Wider, G., Otting, G., Weber, C., and Wüthrich, K. (1989). J. Magn. Reson. 85, 608-613.
26. Newton, A.C. (1993). Interaction of proteins with lipid headgroups: lessons from protein kinase C. Annu. Rev. Biophys. Biomol. Struct. 22, 1-25.
27. Nicholls, A., Sharp, K.A., and Honig, B. (1991). Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins 11, 281-296.
28. Nonet, M.L., Grundahl, K., Meyer, B.J., and Rand, J.B. (1993). Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin. Cell 73, 1291-1305.
29. Perin, M.S., Fried, V.A., Mignery, G.A., Jahn, R., and Südhof, T.C. (1990). Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C. Nature 345, 260-263.
30. Perin, M.S., Johnston, P.A., Özcelik, T., Jahn, R., Francke, U., and Südhof, T.C. (1991a). Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans. J. Biol. Chem. 266, 615-622.
31. Perin, M.S., Brose, N., Jahn, R., and Südhof, T.C. (1991b). Domain structure of synaptotagmin (p65). J. Biol. Chem. 266, 623-629.
32. Petrenko, A.G., Perin, M.S., Davletov, B.A., Ushkaryov, Y.A., Geppert, M., and Südhof, T.C. (1991). Binding of synaptotagmin to the α-latrotoxin receptor implicates both in synaptic vesicle exocytosis. Nature 353, 65-68.
33. 2-domains of synaptotagmin and protein kinase C. Science 273, 248-251.
34. Smith, D.B., and Johnson, K.S. (1988). Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67, 31-40.
35. Söllner, T., Whiteheart, S.W., Brunner, M., Erdjument-Bromage, H., Geromanos, S., Tempst, P., and Rothman, J.E. (1993). SNAP receptors implicated in vesicle targeting and fusion. Nature 362, 318-324.
36. Südhof, T.C. (1995). The synaptic vesicle cycle: a cascade of protein-protein interactions. Nature 375, 645-653.
37. 2-domain proteins that regulate membrane traffic. Neuron 17, 379-388.
38. 2-domains of synaptotagmin I. J. Biol. Chem. 271, 1262-1265.
39. 2+/phospholipid-binding fold. Cell 80, 929-938.
40. 2+-binding domains. J. Biol. Chem. 268, 27164-27170.
41. Yoshida, A., Chikara, O., Omori, A., Kuwahara, R., Ito, T., and Takahashi, M. (1992). HPC-1 is associated with synaptotagmin and ω-conotoxin receptor. J. Biol. Chem. 267, 24925-24928.
42. 15N resonance assignments of N-terminal SH3 domain of drk in folded and unfolded states using enhanced-sensitivity pulsed field gradient NMR techniques. J. Biomol. NMR 4, 845-858.