Hypothermia for Acute Ischemic Stroke: Not Just Another Neuroprotectant

Neurologist

Volumn 9, Issue 6, 2003, Pages 280-289

  Hammer, Maxim D ^a   Krieger, Derk W ^b  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Hypothermia; Neuroprotection; Reperfusion; Stroke; Thrombolysis

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMPA RECEPTOR; CALCIUM ION; EXCITOTOXIN; GLUTAMIC ACID; MATRIX METALLOPROTEINASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OXYGEN RADICAL; TISSUE PLASMINOGEN ACTIVATOR;

ACIDOSIS; ASPIRATION PNEUMONIA; BACTEREMIA; BLOOD BRAIN BARRIER; BLOOD CLOT LYSIS; BLOOD CLOTTING DISORDER; BRADYCARDIA; BRAIN; BRAIN BLOOD FLOW; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN HERNIA; BRAIN INFARCTION; BRAIN INJURY; CALCIUM TRANSPORT; CELL DAMAGE; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; COOLING; CYTOTOXICITY; DIFFUSION WEIGHTED IMAGING; DIURESIS; ELECTROLYTE DISTURBANCE; ENERGY METABOLISM; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART VENTRICLE EXTRASYSTOLE; HEART VENTRICLE FIBRILLATION; HEAT EXCHANGE; HUMAN; HYPERGLYCEMIA; HYPOKALEMIA; HYPOTENSION; HYPOTHERMIA; INTRACRANIAL PRESSURE; LOW TEMPERATURE; METABOLIC ACIDOSIS; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROSURGERY; NONHUMAN; PANCREATITIS; PNEUMONIA; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REACTION TIME; REPERFUSION; REPERFUSION INJURY; REVIEW; TEMPERATURE DEPENDENCE; THORAX SURGERY; THROMBOCYTOPENIA; TREATMENT OUTCOME; URINARY TRACT INFECTION; WARMING;

BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; HUMANS; HYPOTHERMIA, INDUCED;

EID: 0344012204     PISSN: 10747931     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.nrl.0000094628.29312.2b     Document Type: Review

References (89)

1. The National Institutes of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333:1581-1587.
2. Adams HP, Brott TC, Furlan AJ. Guidelines for thrombolytic therapy for acute stroke: a supplement to the guidelines for the management of patients with acute ischemic stroke. Circulation. 1996;94:1167-1174.
3. Quality Subcommittee of the American Academy of Neurology. Practice advisory: thrombolytic therapy for acute ischemic stroke-summary statement. Neurology. 1996;47:835-839.
4. Cummins R. Advanced Cardiac Life Support. New York, NY: American Heart Association, 1997:1-28.
5. delZoppo GJ, Higashida RT, Furlan AJ. PROACT: A phase II randomized trial of recombinant ro-urokinase by direct arterial delivery in acute middle cerebral artery stroke. Stroke. 1998;29:4-11.
6. Furlan AJ, Higashida R, Wechsler L. Intra-arterial prourokinase for acute ischemic stroke-the PROACT II study: a randomized controlled trial. JAMA. 1999;282:2003-2011.
7. Demchuk AM, Burgin S, Christou I, et al. Thrombolysis in Brain Ischemia (TIBI) transcranial doppler flow grades predict clinical severity, early recovery, and mortality in patients treated with intravenous tissue plasminogen activator. Stroke. 2001;32:89-93.
8. Kidwell CS, Saver J L, Mattiello J, et al. Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging. Ann Neurol. 2000;47(4):462-469.
9. Schellinger PD, Jansen O, Fiebach JB, et al. Monitoring intravenous recombinant fissue plasminogen activator thrombolysis for acute ischemic stroke with diffusion and perfusion MRI. Stroke. 2000;31:1318-1328.
10. Parsons MW, Barber A, Chalk J, et al. Diffusion- and perfusion-weighted MRI response to thrombolysis in stroke. Ann Neurol. 2002; 51:28-37.
11. Sharp FR, Swanson RA, Honhaniemi J, et al. Neurochemistry and Molecular Biology. In: Barnett HJM, Stein BM, Mohr JP, Yatsu FM, eds. Stroke: Pathophysiology, Diagnosis, and Management. New York: Churchill Livingstone, 1998:51-83.
12. Symon L, Branston NM, Strong AJ, et al. The concepts of thresholds of ischaemia in relation to brain structure and function. J Clin Pathol. 1977;30:149-154.
13. Ginsberg MA, Pulsinelli W. The ischemic penumbra, injury thresholds and the therapeutic time window for acute stroke. Ann Neurol. 1994;36: 553-554.
14. Hossmann K-A. Viability thresholds and the penumbra of focal ischemia. Ann Neurol. 1994;36:557-565.
15. Xie Y, Mies G, Hossmann K-A. Ischemic threshold of brain protein synthesis after unilateral carotid artery occlusion in gerbils. Stroke. 1989;20:620-626.
16. Rosomoff HL, Holaday DA. Cerebral blood flow and cerebral oxygen consumption during hypothermia. Am J Physiol. 1954;179.
17. Obrenovitch TP, Garofalo O, Harris RJ, et al. Brain tissue concentrations of ATP, phosphocreatine, lactate, and tissue pH in relation to reduced cerebral blood flow following experimental acute middle cerebral artery occlusion. J Cereb Blood Flow Metab. 1988;8:866-874.
18. Castillo J, Dávalos A, Naveiro J, et al. Neuroexcitatory Amino Acids and Their Relation to Infarct Size and Neurological Deficit in Ischemic Stroke. Stroke. 1996;27:1060-1065.
19. Hossmann KA, Schuier FJ. Experimental brain infarcts in cats: pathophysiological observations. Stroke. 1980;11:583-592.
20. Matsuoka Y, Hossman K-A. Brain tissue osmolarity after middle cerebral artery occlusion in cats. Exp Neurol 1982;77:599-611.
21. Ayata C, Ropper AH. Ischemic brain oedema. J Clin Neurosci. 2002; 9:113-124.
22. Buenveniste H, Hedlund LW, Johnson GA. Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy. Stroke. 1992;23:746-754.
23. Back T, Hoehn-Berlage M, Kohno K, et al. Diffusion nuclear magnetic resonance imaging in experimental stroke. Correlation with cerebral metabolites. Stroke. 1994;25.
24. Baird AE, Benfield A, Schlaug G, et al. Enlargement of human cerebral ischemic lesions measured by diffusion-weighted magnetic resonance imaging. Ann Neurol. 1997;41:581-589.
25. Schlaug G, Benfield A, Baird AE, et al. The ischemic penumbra operationally defined by diffusion-perfusion MRI. Neurology. 1999;53: 1528-1537.
26. Jannsen O, Schellinger P, Fieback J, et al. Early recanalization in acute ischemic stroke saves tissue at risk defined by MRI. Lancet. 1999;353: 2036-2037.
27. Kidwell CS, Saver JL, Mattiello J, et al. Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging. Ann Neurol. 2000;47:462-469.
28. Marchal G, Beaudouin V, Rioux P, et al. Prolonged persistence of substantial volumes of potentially viable brain tissue after stroke. Stroke. 1996;27:599-606.
29. Furlan M, Marchal G, Viader F, et al. Spontaneous neurologic recovery after stroke and the fate of the ischemic penumbra. Ann Neurol. 1996; 40:216-226.
30. Jungreis CA, Yonas H, Firlik AD, et al. Advanced CT imaging (functional imaging). Neuroimaging Clin North Am. 1999;9:455-464.
31. Kaufman AM, Firlik AD, Fukui MB, et al. Ischemic core and penumbra in human stroke. Stroke. 1999;30:93-99.
32. 2+ influx underlies potent induction of injury. J Neurosci. 1996;16:5457-5465.
33. Frandsen A, Schousboe A. Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by 2-amino-3(3-hydroxy-5-methylisoxasol-4-yl) propionate and kainate in cultured cerebral cortical neurons. Proc Natl Acad Sci. 1992;89:2590-2594.
34. Katchman AN, Herschkowitz N. Early anoxia-induced vesicular glutamate release results form mobilization of calcium from intracellular strokes. J Neurophysiol. 1993;70:1-7.
35. Pellegrini-Giampietro DE, Cherici G, Alesiani M, et al. Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage. J Neurosci. 1990;10:1035-1041.
36. O'Regan MH, Smith-Barbour M, Perkins LM, et al. A possible role for phsopholipases in the release of neurotransmitter amino acids from ischemic rate cerebral cortex. Neurosci Lett. 1995;185:191-194.
37. Kuroda S, Siesjo BK. Reperfusion damage following focal ischemia: pathophysiology and therapeutic windows. Clin Neurosci. 1997;4:199-212.
38. Jean WC, Spellman SR, Nussbaum ES, et al. Reperfusion injury after focal cerebral ischemia: the role of inflammation and the therapeutic horizon. Neurosurgery. 1998;43:1382-1396.
39. delZoppo GJ, vonKummer R, Hamann GF. Ischaemic damage of brain microvessels: inherent risks for thrombolytic treatment in stroke. J Neurol Neurosurg Psych. 1998;65:1-9.
40. Hamann GF, delZoppo GJ, vonKummer R. Hemorrhagic transformation of cerebral infarction-possible mechanisms. Thromb Haemost. 1999; 82(suppl):92-94.
41. Brown RC, Davis TP. Calcium modulation of adherens and tight junction function: a potential mechanisms for blood-brain barrier disruption after stroke. Stroke. 2002;33:1706-1711.
42. Huber JD, Egleton RD, Davis TP. Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier. Trend Neurosci. 2001;24:719-725.
43. GJ d. Microvascular responses to cerebral ischemia/inflammation. Ann NY Acad Sci. 1997;823:132-147.
44. Yurchenco PD, Schittny JC. Molecular architecture of basement membranes. FASEB J. 1990;4:1577-1590.
45. Risau W. Molecular biology of blood-brain barrier ontogenesis and function. Acta Neurochir. 1994;60:109-112.
46. Erickson AC, Couchman JR. Still more complexity in mammalian basement membranes. J Hixtochem Cytochem. 2000;48:1291-1306.
47. delZoppo GJ, Hallenbeck JM. Advances in the vascular pathophysiology of ischemic stroke. Thromb Res. 2000;98:73-81.
48. Gasche Y, Copin JC, Sugawara T, et al. Matrix metalloproteinase inhibition prevents oxidative stress-associated blood-brain barrier disruption after transient focal cerebral ischemia. J Cereb Blood Flow Metab. 2001;21:1393-1400.
49. Lapchack PA, Chapman DF, Zivin JA. Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke. Stroke. 2000;31:3034-3040.
50. Karibe H, Chen J, Zarow GJ, et al. Delayed induction of mild hypothermia to reduce infarct volume after temporary middle cerebral artery occlusion in rats. J Neurosurg. 1994;80:112-119.
51. Xue D, Huang ZG, Smith KE, et al. Immediate or delayed mild hypothermia prevents focal cerebral infarction. Brain Res. 1992;587:66-72.
52. Busto R, Globus MY, Dietrich WD, et al. Effects of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. Stroke. 1989;20:904-910.
53. Nakashima K, Todd M. Effects of hypothermia on the rate of excitatory amino acid release after ischemic depolarization. Stroke. 1996;27:913-918.
54. Globus MY, Alonso O, Dietrich WD, et al. Glutamate release and free radical production following brain injury: effects of posttraumatic hypothermia. J Neurochem. 1995;65:1250-1256.
55. Globus MY, Busto R, Lin B, et al. Detection of free radical activity during transient global ischemia and recirculation: effects of intraischemic brain temperature modulation. J Neurochem. 1995;65:1250-1256.
56. Smith SL, Hall ED. Mild pre- and posttraumatic hypothermia attenuates blood-brain barrier damage following controlled cortical impact injury in the rat. J Neurotrauma. 1996;13:1-9.
57. Fisher S, Renz D, Wiesnet M, et al. Hypothermia abolishes hypoxiainduced hyperpermeability in brain microvessel endothelial cells. Molec Brain Res. 1999;74:135-144.
58. Ishikawa M, Sekizuka E, Sato S, et al. Effects of moderate hypothermia on leukocyte-endothelium interaction in the rat pial microvasculature after transient middle cerebral artery occlusion. Stroke. 1999;30:1679-1686.
59. Hamann GF, Burggraf D, Martens HK, et al. Mild to moderate hypothermia prevents microvascular basal lamina antigen loss in experimental focal cerebral ischemia. Stroke; (submitted).
60. Maher J, Hachinski V. Hypothermia as a potential treatment for cerebral ischemia. Cereb Brain Metab Rev. 1993;5:277-300.
61. Tisherman SA, Safar P, Radovsky A, et al. Profound hypothermia (<10°C) compared with deep hypothermia (15°C) improves neurologic outcome in dogs after two hours' circulatory arrest induced to enable resuscitative surgery. J Trauma. 1991;31:1051-1062.
62. Green EJ, Dietrich WD, vanDijk F, et al. Protective effects of brain hypothermia on behavior and histopathology following global cerebral ischemia in rats. Brain Res. 1992;580:197-204.
63. Baumgartner WA, Silverberg GD, Ream AK, et al. Reappraisal of cardiopulmonary bypass with deep hypothermia and circulatory arrest for complex neurosurgical operations. Surgery. 1983;94:242-249.
64. Chyatte D, Flefteriades J, Kim B. Profound hypothermia and circulatory arrest for aneurysm surgery. J Neurosurg. 1989;70:489-491.
65. Saccani S, Beghi C, Fragnito C, et al. Carotid endarterectomy under hypothermic extracorporeal circulation: a method of brain protection for special patients. J Cardiovasc Surg. 1992;33:311-314.
66. Spetzler RF, Hadley MN, Rigamonti D, et al. Aneurysms of the basilar artery treated with circulatory arrest, hypothermia, and barbiturate cerebral protection. J Neurosurg. 1988;68:868-879.
67. Busto R, Dietrich WD, Globus MY-T, et al. Small differences in intraischeaemic brain temperature critically determine the extent of ischaemic neuronal injury. J Cereb Blood Flow Metab. 1987;7:729-738.
68. Ikonomidou C, Mosinger JL, Olney JW. Hypothermia enhances protective effect of MK-801 against hypoxic-ischemic brain damage in infant rats. Brain Res. 1989;487:184-187.
69. Leonov Y, Stetz F, Saraf P, et al. Mild cerebral hypothermia during and after cardiac arrest improves neurologic outcome in dogs. J Cereb Blood Flow Metab. 1990;10:57-70.
70. Minimisawa H, Smith M-L, Siesjo BK. The effect of mild hypothermia and hypothermia on brain damage following 5, 10, and 15 minutes of forebrain ischemia. Ann Neurol. 1990;28:26-33.
71. Sterz F, Safar P, Tisherman S, et al. Mild hypothermic cardiopulmonary resuscitation improves outcome after prolonged cardiac arrest in dogs. Crit Care Med. 1991;19:379-389.
72. Busto R, Dietrich WD, Globus MY-T, et al. Postischemic moderate hypothermia inhibits CA1 hippocampal ischemic neuronal injury. Neurosci Lett. 1989;101:299-304.
73. Carroll M, Beck O. Protection against hippocampal CA1 cell loss by post-ischemic hypothermia is dependent on delay of initiation and duration. Metab Brain Dis. 1992;7:45-50.
74. Bernard SA, Jones BM, Home MK. Clinical trial of induced hypothermia in comatose survivors of out-of-hospital cardiac arrest. Ann Emerg Med. 1997;30:146-153.
75. Yanagawa Y, Ishihara S, Norio H, et al. Preliminary clinical outcome study of mild resuscitative hypothermia after out-of-hospital cardiopulomonary arrest. Resuscitation. 1998;39:61-66.
76. Zeiner A, Holzer M, Sterz F, et al. Mild resuscitative hypothermia to improve neurological outcome after cardiac arrest: a clinical feasibility trial. Stroke. 2000;31:86-94.
77. The Hypothermia After Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002;346:549-556.
78. Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002;346:557-563.
79. Rosomoff H. Hypothermia and cerebral vascular lesions: experimental interruption of the middle cerebral artery during hypothermia. J Neurosurg. 1956;13:244-255.
80. Baker CJ, Onesti ST, Solomon RA. Reduction by delayed hypothermia of cerebral infarction following middle cerebral artery occlusion in the rat: a time-course study. J Neurosurg. 1992;77:438-444.
81. Ginsberg MD, Sternau LL, Globus YT, et al. Therapeutic modulation of brain temperature: relevance to ischemic brain injury. Cereb Brain Metab Rev. 1992;4:189-225.
82. Kammersgaard L, Rasmussen B, Jorgensen H, et al. Feasibility and safety of inducint modest hypothermia in awake patients with acute stroke through surface cooling. Stroke. 2000;31:2251-2256.
83. Schwab S, Schwarz S, Spranger M, et al. Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction. Stroke. 1998;29:2461-2466.
84. Krieger DW, DeGeorgia MA, Abou-Chebl A, et al. Cooling for acute ischemic brain damage (COOL AID): an open pilot study of induced hypothermia in acute ischemic stroke. Stroke. 2001;32:1847-1854.
85. Krieger DW, DeGeorgia MA, Abou-Chebl A, et al. Cooling for Acute Ischemic Brain Damage (COOL AID) II. unpublished data from the Cleveland Clinic Foundation.
86. Clifton GL, Miller EM, Choi SC, et al. Lack of effect of induction of hypothermia after acute brain injury. N Engl J Med. 2001;344:556-563.
87. Marion DW, Penrod LE, Kelsery SF, et al. Treatment of traumatic brain injury with moderate hypothermia. N Engl J Med. 1997;336:540-546.
88. Steiner T, Friede T, Aschoff A, et al. Effect and feasibility of controlled rewarming after moderate hypothermia in stroke patients with malignant infarction of the middle cerebral artery. Stroke. 2001;32:2833-2835.
89. Hachimi-Idrissi S, Corne L, Ebinger G, Michotte Y, Huyghens L. Mild hypothermia induced by a helmet device: a clinical feasibility study. Resuscitation. 2001;51:275-281.