Temporal analysis of goblet cells and mucin gene expression in murine models of allergic asthma

Experimental Lung Research

Volumn 29, Issue 8, 2003, Pages 549-565

  Shahzeidi, Shahriar ^a   Aujla, Pawandeep K ^a   Nickola, Tracey J ^a   Chen, Yajun ^a   Alimam, M Zuhdi ^a   Rose, Mary C ^a,b  

^a GEORGE WASHINGTON UNIVERSITY   (United States)

^b CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

Author keywords

Goblet cells; IL13; Muc2; Mucins; Mucsac; Murine models of asthma

Indexed keywords

INTERLEUKIN 1; MUCIN; OVALBUMIN;

ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; GENE EXPRESSION; GOBLET CELL; HISTOLOGY; MALE; METAPLASIA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM;

EID: 0344010502     PISSN: 01902148     EISSN: None     Source Type: Journal    
DOI: 10.1080/01902140390240159     Document Type: Article

References (42)

1. Osborne ML, Vollmer WM, Buist AS: Diagnostic accuracy of asthma within a health maintenance organization. J Clin Epidemiol. 1992;45:403-411.
2. Holgate ST: The epidemic of allergy and asthma. Nature. 1999;402:B2-B4.
3. Busse W, Elias J, Sheppard D, Banks-Schlegel S: Airway remodeling and repair. Am J Respir Crit Care Med. 1999;160:1035-1042.
4. Elias JA, Zhu Z, Chupp G, Homer RJ: Airway remodeling in asthma. J Clin Invest. 1999;104:1001-1006.
5. Fahy JV, Corry DB, Boushey HA: Airway inflammation and remodeling in asthma. Curr Opin Pulm Med. 2000;6:15-20.
6. Goldstein RA, Paul WE, Metcalfe DD, Busse WW, Reece ER: NIH Conference on Asthma. Ann Intern Med. 1994;121:698.
7. Martinez FD: Definition of pediatric asthma and associated risk factors. Pediatr Pulmonol Suppl. 1997;15:9-12.
8. Holgate ST, Lackie PM, Davies DE, Roche WR, Walls AF: The bronchial epithelium as a key regulator of airway inflammation and remodeling in asthma. Clin Exp Allergy. 1999;29 (Suppl 2):90-95.
9. Nakajima H, Iwamoto I, Tomoe S, Matsumura R, Tomioka H, Takatsu K, Yoshida S. CD4 + T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. Am Rev Respir Dis. 1992;146:374-377.
10. Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, Donaldson DD: Interleukin-13: central mediator of allergic asthma. Science. 1998;282:2258-2261.
11. Grunig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, Corry DB: Requirement for IL-13 independently of IL-4 in experimental asthma. Science, 1998;282:2261-2263.
12. Whittaker L, Niu N, Temann A, Stoddard A, Flavell R, Ray A, Homer R, Cohn L: IL-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and IL-9. Am J Respir Cell Mol Biol. 2002;27:593-602.
13. Basbaum C, Finkbeiner W: Mucus-producing cells of the airways. In: Massaro D, ed. Lung Cell Biology. New York: Marcel Dekker; 1989:37-80.
14. Rose MC: Mucins: structure, function, and role in pulmonary diseases. Am J Physiol 263 (Lung Cell Mol Physiol 7). 1992;263:L413-L429.
15. Aikawa T, Shimura S, Sasaki H, Ebina M, Takishima T: Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthmatic attacks. Chest. 1992;101:916-921.
16. Ordonez CL, Khashayar R, Wong HH, Ferrando R, Wu R, Hyde DM, Hotchkiss JA, Zhang Y, Novikov A, Doglanov G, Fahy JV: Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am J Respir Crit Care Med. 2001;163:517-523.
17. Laitinen A, Laitinen LA: Structural changes and cell findings in airway epithelium in asthmatic patients. Res Clin Forums. 1992;14:59-64.
18. Lozewicz S, Wells C, Gomez E, Ferguson H, Richman P, Devalia J: Morphological integrity of the bronchial epithelium in mild asthma. Thorax. 1990;45:12-15.
19. Pack RJ, Al-Ugaily LH, Morris G: The cells of the tracheobronchial epithelium of the mouse: a quantitative light and electron microscope study. J Anat. 1981;132:71-84.
20. Gavett SH, Chen X, Finkelman FD, Wills-Karp M: Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am J Respir Cell Mol Biol. 1994;10:587-593.
21. Kung TT, Jones H, Adams GK, Umland SP, Kreutner W, Egan RW, Chapman RW, Watnik AS: Characterization of a murine model of allergic pulmonary inflammation. Int Archs Allergy Immunol. 1994;105:83-89.
22. Blyth DI, Pedrick MS, Savage TJ, Hessel EM, Fattah D: Lung inflammation and epithelial changes in a murine model of atopic asthma. Am J Respir Cell Mol Biol. 1996;14:425-438.
23. Alimam MZ, Piazza FM, Selby D, Letwin N, Huang L, Rose MC: Muc-5/5ac mRNA and protein expression is a marker of goblet cell metaplasia in murine airways. Am J Respir Cell Mol Biol. 2000;22:253-260.
24. Zhang Y, Lamm WJE, Albert RK, Chi EY, Henderson WR, Lewis DB: Influence of the route of allergen administration and genetic background on the murine allergic pulmonary response. Am J Respir Crit Care Med. 1997;155:661-669.
25. Ertsey R, Scavo LM: Coverslip mounted-immersion cycled in situ RT-PCR for the localization of mRNA in tissue sections. In: Pardee A, McClelland M, eds. Expression Genetics: Differential Display. Natick, MA: BioTechniques Books; 1999:405-414.
26. Shekels LL, Lyftogt C, Kieliszewski M, Filie JD, Kozak CA, Ho SB: Mouse gastric mucin: cloning and chromosomal localization. Biochem J. 1995;311:775-785.
27. Gum JR, Hicks JW, Gillespie AM, Carlson E, Komuves L, Karnik S, Hong J, Epstein CJ, Kim VS: Goblet cell specific expression mediated by the MUC2 mucin gene promoter in the intestine of transgenic mice. Am J Physiol. 1999;276:G666-G676.
28. Berger JT, Voynow JA, Peters KW, Rose MC: Respiratory carcinoma cell lines: MUC genes and glycoconjugates. Am J Respir Cell Mol Biol. 1999;20:500-510.
29. Blyth DI, Pedrick MS, Savage TJ, Bright H, Sanjar S: Effect of concurrent infection with respiratory syncytial virus (RSV) in a murine model of atopic asthma. Am J Respir Crit Care Med. 1997;155:A742.
30. Wills-Karp M, Ewart SL: The genetics of allergen-induced airway hyperresponsiveness in mice. Am J Respir Crit Care Med. 1997;156:S89-S96.
31. You Y, Richer EJ, Huang T, Brody SL: Growth and differentiation of mouse tracheal epithelial cells: selection of a proliferative population. Am J Physiol Lung Cell Mol Physiol. 2002;283:LI315-LI321.
32. Chen Y, Zhao YH, Wu R: In silico cloning of mouse Muc5b gene and upregulation of its expression in mouse asthma model. Am J Respir Crit Care Med. 2001;164:1059-1066.
33. Rose MC, Aujla P, Shahzeidi S, Flippin J, Borup R: Expression of mucin gene Muc10 is increased in murine trachea 18 hours after IL13 exposure. Am J Respir Crit Care Med. 2002;165:A468.
34. Dorin JR, Innes BA: Submucosal gland distribution in the mouse has a genetic determination localized on chromosome 9. Mammalian Genome. 2001;12:124-128.
35. Brockhausen I: O-linked chain glycosyltransferases. Methods Mol Biol. 2000;125:273-293.
36. Yanagihara K, Seki M, Cheng PW: Lipopolysaccharide induces mucus cell metaplasia in mouse lung. Am J Respir Cell Mol Biol. 2001;24:66-73.
37. Sethi JM, Rochester CL: Smoking and chronic obstructive pulmonary disease. Clin Chest Med. 2000;21:67-86.
38. Tesfaigzi Y: The role of apoptotic regulators in metaplastic mucous cells. Novartis Found Symp. 2002;248:221-230.
39. Rogers DF: Airway goblet cells: responsive and adaptable front-line defenders. Eur Respir J. 1994;7:1690-1706.
40. Rose MC, Nickola TJ, Voynow JA: Airway mucus obstruction: mucin glycoproteins, MUC gene regulation and goblet cell hyperplasia. Am J Respir Cell Mol Biol. 2001;25:533-537.
41. Blyth DI: The homeostatic role of bronchoconstriction. Respiration. 2001;68:217-223.
42. Rogers DF: Airway goblet cell hyperplasia in asthma: hypersecretory and anti-inflammatory? Clin Exp Allergy. 2002;32:1124-1127.