The effect of interleukin 12 desensitization on the antitumor efficacy of recombinant interleukin 12

Cancer Research

Volumn 57, Issue 12, 1997, Pages 2460-2467

  Coughlin, Christina M ^a   Wysocka, Maria ^a   Trinchieri, Giorgio ^a   Lee, William M F ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CRB 663 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12;

ANGIOGENESIS; ANIMAL CELL; ANTIGEN PRESENTATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELLULAR IMMUNITY; DESENSITIZATION; DRUG EFFECT; DRUG EFFICACY; GROWTH INHIBITION; MOUSE; NONHUMAN; OPSONIZATION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TUMOR GROWTH;

ANIMALS; ANTINEOPLASTIC AGENTS; FEMALE; INTERFERON TYPE II; INTERLEUKIN-12; MAMMARY NEOPLASMS, EXPERIMENTAL; MELANOMA; MICE; MICE, INBRED C3H; MICE, INBRED STRAINS; NEOPLASM TRANSPLANTATION; RECOMBINANT PROTEINS; TUMOR CELLS, CULTURED;

EID: 0030976279     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Trinchieri, G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol., 13: 251-276, 1995.
2. Hsieh, C-S., Macatonia, S. E., Tripp, C. S., Wolf, S. F., O'Garra, A., and Murphy, K. M. Development of THI CD4+ T cells through IL-12 produced by Listeria-induccd macrophages. Science (Washington DC), 260: 547-550, 1993.
3. Gracie, J. A., and Bradley, J. A. Interleukin 12 induces interferon-γ-dependent switching of IgG alloantibody subclass. Eur. J. Immunol., 26: 1217-1221, 1996.
4. Morris, S. C., Madden, K. B., Adamovicz, J. J., Cause, W. C., Hubbard, B. R., Gately, M. K., and Finkelman, F. D. Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J. Immunol., 152: 1047-1056, 1994.
5. Chemini, J., Valiante, N. M., D'Andrea, A., Rengaraju, M., Rosado, Z., Kohayashi, M., Perussia, B., Wolf, S., Starr, S. E., and Trinchieri, G. Enhancing effect of natural killer cell stimulatory factor (NKSF/TL-12) on cell-mediated toxicity against tumor-derived and virus-infected cells. Eur. J. Immunol., 23: 1826-1830, 1993.
6. Gately, M. K., Warrier, R. R., Honasoge, S., Carvajal, D. M., Faherty, D. A., Connaughton, S. E., Anderson, T. D., Sarmiento, U., Hubbard, B. R., and Murphy, M. Administration of recombinant IL-12 to normal mice enhances cytolylic lymphocyte activity and induces production of interferon-γ in vivo. Int. Immunol., 6: 157-167, 1994.
7. Schreiber, R. D., and Farrar, M. A. The biology and biochemistry of interferon-γ and its receptor. Annu. Rev. Immunol., 11: 571-611, 1993.
8. Voerst, E. E., Kenyon, B. M., O'Reilly, M. S., Truitt, G., D'Amato, R. J., and Folkman, J. Inhibition of angiogenesis in vivo by IL-12. J. Natl. Cancer Inst. (Bethesda), 87: 581-586, 1995.
9. Lindahl, P., Leary, P., and Gresser, I. Enhancement by intcrferon of the expression of surface antigens on murine leukemia L 1210 cells. Proc. Natl. Acad. Sci. USA, 70: 2785-2789, 1973.
10. Wong, G. H. W., Clark-Lewis, I., Harris, A. W., and Schrader, J. W. Effect of cloned interferon-γ on expression of H-2 and Ia antigens on cell lines of hematopoietic, lymphoid, epithelial, fibroblastic and neuronal origin. Eur. J. Immunol., 14: 52-61, 1984.
11. Brunda, M. J., Luistro, L., Warrier, L. L., Wright, R. B., Hubbard, B. R., Murphy, M., Wolf, S. F., and Gately, M. K. Anti-tumor and anti-metastatic activity of IL-12 against murine tumors. J. Exp. Med., 178: 1223-1230, 1993.
12. Naslala, C. L., Edington, H. D., McKinney, T. G., Tahara, H., Nalesnik, M. A., Brunda, M. J., Gately, M. K., Wolf, S. F., Schreiber, R. D., Storkus, W. J., and Lotze, M. T. Recombinanl IL-12 administration induces tumor regression in association with IFN-γ production. J. Immunol., 153: 1697-1706, 1994.
13. Tahara, H., Zitvogel, L., Storkus, W. J., Zeh, H. J., III, McKinney, T. G., Schreiber, R. D., Gubler, U., Robhins, P. D., and Lotze, M. T. Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector. J. Immunol., 154: 6466-6474, 1995.
14. Zitvogel, L., Tahara, H., Cai, Q., Storkus, W. J., Muller, G., Wolf, S. K., Gately, M., Robbins, P. D., and Lotze, M. T. Construction and characterization of retroviral vectors expressing biologically active human intcrleukin-12. Hum. Gene Ther., 5: 1493-1506, 1996.
15. Maninotti, A., Stoppacciaro, A., Vagliani, M., Melani, C. Spreafico, F., Wysocka, M., Parmiani, G., Trinchieri, G., and Colombo. M. CD4 T cells inhibit in vivo CDS-mediated immune response against a murine colon carcinoma transduced with IL-12 genes. Eur. J. Immunol., 25: 137-146, 1995.
16. Colombo, M. P., Vagliani, M., Spreafico, F., Parenza, M., Chiodoni, C., Melani, C., and Stoppacciaro. A. Amount of interleukin-12 available at the tumor site is critical for tumor regression. Cancer Res., 56: 2531-2534, 1996.
17. Cohen, J. IL-12 deaths: explanation and a puzzle. Science (Washington DC), 270: 908, 1995.
18. Kang, M-K., Song, C. W., and Levitt, S. H. Role of vascular function in response of tumors in vivo to hyperthermia. Cancer Res., 40: 1130-1135, 1980.
19. Chang, S. Y., Song, S. W., and Levitt, S. H. Change in fibrinogen turnover in tumors by hyperthermia. Eur. J. Cancer Clin. Oncol., 21: 1507-1513, 1985.
20. Coughlin, C. M., Wysocka, M., Kurzawa, H. L., Lee, W. M. F., Trinchieri, G., and Eck, S. L. B7-1 and interleukin-12 synergistically induce effective antitumor immunity. Cancer Res., 55: 4980-4987, 1995.
21. Kripke, M. Speculations on the role of ultraviolet radiation in the development of malignant melanoma. J. Natl. Cancer Inst. (Bethesda), 63: 541-545, 1979.
22. Wysocka, M., Kubin, M., Vieira, L. Q., Ozmen, L., Garotta, G., Scott, P., and Trinchieri, G. Interleukin-12 is required for interteron-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol., 25: 672-676, 1995.
23. Townsend, S. E., Su, F. W., Atherton, J. M., and Allison, J. P. Specificity and longevity of antitumor immune responses induced by B7-transfected tumors. Cancer Res., 54: 6477-6483, 1994.
24. Car, B. D., Eng, V. M., Schnyder, B., LeHir, M., Shakov, A. N., Woerly, G., Huang, S., Aguet, M., Anderson, T. D., and Ryffel, B. Role of interferon-γ in interleukin-12-induced pathology in mice. Am. J. Pathol., 147: 1693-1707, 1995.
25. Sarmiento, U. M., Riley, J. H., Knack, P. A., Lipman, J. M., Becker, J. M., Galely, M. K., Chizzonite, R., and Anderson, T. D. Biologic effects of recombinant human interleukin 12 in squirrel monkeys. Lab. Invest., 71: 862-874, 1994.
26. Ozmen, L., Pericin, M., Hakimi, J., Chizzonile, R. A., Wysocka, M., Trinchieri, G., Gately, M., and Garotta, G. Interleukin-12, interferon-γ and tumor necrosis factor α are the key cytokines of the generalized Shwartzman reaction. J. Exp. Med., 180: 907-915, 1994.
27. Noguchi, Y., Richards, E., Chen, Y-T., and Old, L. J. Influence of interleukin-12 on p53 peptide vaccination against established Meth A sarcoma. Proc. Natl. Acad. Sci. USA, 92: 2219-2223, 1995.
28. Biron, C. A., and Orange, J. S. IL-12 in acute viral infectious disease. Forum Immunol., 62: 590-600, 1995.