Neural 5-HT4 receptors in the human isolated detrusor muscle: Effects of indole, benzimidazolone and substituted benzamide agonists and antagonists

British Journal of Pharmacology

Volumn 118, Issue 8, 1996, Pages 1965-1970

  Candura, S M ^b   Messori, Eliana ^a   Franceschetti, G P ^c   D'Agostino, G ^a   Vicini, D ^c   Tagliani, Monica ^b   Tonini, M ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b Toxicology Unit   (Italy)

^c Ospedale Civile Novara   (Italy)

Author keywords

5 hydroxytryptamine; DAU 6285; Detrusor strips; GR 125487; Human urinary bladder; Neuromuscular cholinergic transmission; RS 23597

Indexed keywords

2,3 DIHYDRO 2 OXO 1 BENZIMIDAZOLECARBOXYLIC ACID 6 METHOXY 3ALPHA TROPANYL ESTER; 2,3 DIHYDRO 3 ISOPROPYL 2 OXO 1 BENZIMIDAZOLECARBOXYLIC ACID 3ALPHA TROPANYLAMIDE; 4 AMINO 5 CHLORO 2 METHOXYBENZOIC ACID 3 PIPERIDINOPROPYL ESTER; 5 METHOXYTRYPTAMINE; BENZAMIDE DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; BENZOIC ACID DERIVATIVE; CISAPRIDE; INDOLE; METHYSERGIDE; ONDANSETRON; SEROTONIN 4 RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; ZACOPRIDE; BENZIMIDAZOLONE; INDOLE DERIVATIVE; PIPERIDINE DERIVATIVE; SEROTONIN RECEPTOR;

ARTICLE; CHOLINERGIC TRANSMISSION; CONTROLLED STUDY; DETRUSOR MUSCLE; ELECTROSTIMULATION; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION; BLADDER; DOSE RESPONSE; DRUG EFFECT; MUSCLE CONTRACTION;

BENZIMIDAZOLES; CISAPRIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INDOLES; MUSCLE CONTRACTION; PIPERIDINES; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; URINARY BLADDER;

EID: 0029658137     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15631.x     Document Type: Article

References (50)

1. ANDERSON, K.-E. (1993). Pharmacology of lower urinary tract smooth muscles and penile erectile tissues. Pharmacol. Rev., 45, 253-308.
2. ANDRADE, R. & NICOLL, R.A. (1987). Novel anxiolytics discriminate between postsynaptic serotonin receptors mediating different physiological responses on single neurons of the rat hippocampus. Naunyn-Schmiedeberg's Arch. Pharmacol., 336, 5-10.
3. ARUNLAKSHANA, O. & SCHILD, H.O. (1959). Some quantitative uses of drug antagonists. Br. J. Pharmacol. Chemother., 14, 48-58.
4. 4 receptors mediate relaxation of the rat oesophageal tunica muscularis mucosae. Naunyn-Schmiedeberg's Arch. Pharmacol., 343, 439-446.
5. 4 receptor: a place in the sun. Trends Pharmacol. Sci., 13, 141-145.
6. 4) receptors positively coupled to adenylate cyclase in adult guinea pig hippocampal membranes: effects of substituted benzamide derivatives. Mol. Pharmacol., 37, 408-411.
7. BOYD, I.W. & ROHAN, A.P. (1994). Urinary disorders associated with cisapride. Med. J. Aust., 160, 579-580.
8. CHEN, H.I. (1990). Evidence for the presynaptic action of 5-hydroxytryptamine and the involvement of purinergic innervation in the rabbit lower urinary tract. Br. J. Pharmacol., 101, 212-216.
9. CLEAN, A., CORSI, M., FENIUK, W., GAVIRAGHI, G., TOSON, G., TREZISE, D. & TRIST, D. (1989). Potentiating action of 5-hydroxytryptamine on electrically induced contractions in the mouse urinary bladder. Br. J. Pharmacol., 97, 564P.
10. 2 receptors. J. Urol., 143, 1037-1040.
11. CORSI, M., PIETRA, C., TOSON, G., TRIST, D., TUCCITTO, G & ARTIBANI, W. (1991). Pharmacological analysis of 5-hydroxytryptamine effects on electrically stimulated human isolated urinary bladder. Br. J. Pharmacol., 104, 719-725.
12. CRAIG, D.A. & CLARKE, D.E. (1990). Pharmacological characterization of a neural receptor for 5-hydroxytryptamine in guinea-pig ileum with properties similar to 5-hydroxytryptamine4 receptor. J. Pharmacol. Exp. Ther., 252, 1378-1386.
13. DE GROOT, G.H. & DE PAGTER, G.F. (1988). Effects of cisapride on constipation due to a neurological lesion. Paraplegia, 26, 159-161.
14. 4) positively coupled to adenylate cylase in neurons. Naunyn-Schmiedeberg's Arch. Pharmacol., 340, 403-410.
15. DUMUIS. A., SEBBEN, M., MONFERINI, E., NICOLA, M., TURCONI, M., LADINSKY, H. & BOCKAERT, J. (1991). Azabicycloalkyl benzimidazolone derivatives as a novel class of potent agonists at the 5-HT4 receptor positively coupled to adenylate cyclase in brain. Naunyn-Schmiedeberg's Arch. Pharmacol., 343, 245-251.
16. 4 receptor antagonist. Br. J. Pharmacol., 10, 119-126.
17. 4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. Br. J. Pharmacol., 115, 1387-1389.
18. 3 and 'atypical' 5-HT receptors mediating guinea-pig ileal contractions in vitro. Br. J. Pharmacol., 101, 513-520.
19. 4 receptors in guinea-pig ascending colon. Eur. J. Pharmacol., 196, 149-155.
20. ERSPAMER, V. (1952). Enteramina e 5-metossitriptamina. Tossicità. Azione sulla diuresi, sulla pressione del sangue e su alcuni organi a muscolatura liscia. Ricerca Scientiflca, 22, 694-702.
21. ETIENNE, M., VERLINDEN, M. & BRASSINNE, A. (1988). Treatment with cisapride of the gastrointestinal and urological sequelae of spinal cord transection: case report. Paraplegia, 26, 162-164.
22. GADDUM, J.H. (1957). Series of drug antagonism. Pharmacol. Rev., 9, 211-218.
23. 4 receptor antagonist. Br. J. Pharmacol., 113, 120P.
24. 4 receptor antagonist (Abstract). J. Gastrointest. Motil., 5, 192.
25. 4 receptor; molecular cloning and pharmacological characterization of two splice variants. EMBO J., 14, 2806-2815.
26. HANSON, P. & SOLER, J.M. (1989). Effet du cisapride sur les vessies neurologiques. Acta Belg. Med. Phys., 12, 81-88.
27. HINDMARSH, J.R., IDOWU, O.A., YEATES, W.K. & ZAR, M.A. (1977). Pharmacology of electrically evoked contractions of human bladder. Br. J. Pharmacol., 61, 115P.
28. HOLT, S.E., COOPER, M. & WYLLIE, J.H. (1986). On the nature of the receptors mediating the action of 5-hydroxytryptamine in potentiating responses of the mouse urinary bladder strip to electrical stimulation. Naunyn-Schmiedberg's Arch. Pharmacol., 334, 333-340.
29. KENAKIN, T. (1995). Efficacy as the molecular property of ligand. Trends Pharmacol. Sci., 16, 84-85.
30. KENAKIN, T.P. (1987). Drug antagonism. In Pharmacologic Analysis of Drug-Receptor Interaction. pp. 205-244. New York: Raven Press.
31. KLARSKOV, P. & HØRBY-PETERSEN, J. (1986). Influence of serotonin on lower urinary tract muscle in vitro. Br. J. Urol., 58, 507-513.
32. MAGGI, C.A., PATACCHINI, R., SANTICIOLI, P., TURINI, D, BARBANTI, G., BENEFORTI. P., ROVERO, P. & MELI, A. (1989). Further studies on the motor response of the human isolated urinary bladder to tachykinins, capsaicin and electrical field stimulation. Gen. Pharmacol., 20, 663-669.
33. MESSORI, E., RIZZI, C.A., CANDURA, S.M., LUCCHELLI, A., BALESTRA, B. & TONINI, M. (1995). 5-Hydroxytryptamine receptors that facilitate excitatory neuromuscular transmission in the guinea-pig isolated detrusor muscle. Br. J. Pharmacol., 115, 677-683.
34. MUNDY, A.R., STEPHENSON, T.P. & WEIN, A.J. (1994). Urodynamics. Principles, Practice and Application. 2nd ed. Edinburgh: Churchill Livingstone.
35. PILLANS, P.I. & WOOD, M.D. (1994). Cisapride increases micturition frequency. J. Clin. Gastroenterol., 19, 336-346.
36. REEVES, J.J., BUNCE, K.T. & HUMPHREY, P.P.A. (1991). Investigation into the 5-hydroxytryptamine receptor mediating smooth muscle relaxation in the rat oesophagus. Br. J. Pharmacol., 103, 1067-1072.
37. RUGGIERI, M.R., WHITMORE, K.E. & LEVIN, R.M. (1990). Bladder purinergic receptors. J. Urol., 144, 176-181.
38. 2type. J. Auton. Pharmacol., 5, 101-107.
39. 4 receptors. Life Sci., 51, 583-592.
40. SCHUURKES, J.A.J., VAN NUETEN, J.M., VAN DAELE, P.G.H., REYNTJENS, A.J. & JANSSEN, P.A.J. (1985). Motor-stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea-pig. J. Pharmacol. Exp. Ther., 234, 775-783.
41. TALLARIDA, R.J. & MURRAY, R.B. (1986). Manual of Pharmacologic Calculations with Computer Programs. 2nd ed. New York: Springler-Verlag.
42. TODD, J.K. & MACK, A.J. (1969). A study of human bladder detrusor muscle. Br. J. Urol., 41, 448-454.
43. 4 receptor agonists facilitate cholinergic transmission in the circular muscle of guinea pig ileum: antagonism by tropisetron and DAU 6285. Life Sci., 50, PL 173-PL 178.
44. TONINI, M. & DE PONTI, F. (1995). Serotonin modulation of gastrointestinal motility. In Serotonin and Gastrointestinal Function. ed. Gaginella, T.S. & Galligan, J.J. pp. 53-84. Boca Raton: CRC Press.
45. TONINI, M., MESSORI, E., FRANCESCHETTI, G.P., RIZZI, C.A., CASTOLDI, A.F., COCCINI, T. & CANDURA, S.M. (1994). Characterization of the 5-HT receptor potentiating neuromuscular cholinergic transmission in strips of human isolated detrusor muscle. Br. J. Pharmacol., 113, 1-2.
46. 4 receptors and gastrointestinal prokinetic action. Pharmacol. Res., 24, 5-14.
47. 1A receptors occupied by 5-HT or 8-OH-DPAT to adenylyl cyclase. Naunyn-Schmiedeberg's Arch. Pharmacol., 346, 367-374.
48. 4 receptor mediating tachycardia in the pig. Br. J. Pharmacol., 102, 107-112.
49. 4 receptor in urinary bladder of Rhesus and Cynomolgus monkeys. Br. J. Pharmacol., 111, 213-218.
50. 4 receptor-mediated contractions. Br. J. Pharmacol., 110, 1593-1599.