Phenylimidazolidin-2-one derivatives as selective 5-HT3 receptor antagonists and refinement of the pharmacophore model for 5-HT3 receptor binding

Journal of Medicinal Chemistry

Volumn 40, Issue 21, 1997, Pages 3369-3380

  Heidempergher, Franco ^a   Pillan, Antonio ^a   Pinciroli, Vittorio ^a   Vaghi, Fabrizio ^a   Arrigoni, Claudio ^a   Bolis, Giorgio ^a   Caccia, Carla ^a   Dho, Luciano ^a   McArthur, Robert ^a   Varasi, Mario ^a  

^a CNS Research   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3,5 DICHLOROPHENYL) 3 [(5 METHYL 1H IMIDAZOL 4 YL)METHYL]IMIDAZOLIDIN 2 ONE; GRANISETRON; ONDANSETRON; PHENYLIMIDAZOLIDIN 2 ONE DERIVATIVE; RICASETRON; SEROTONIN; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR; TROPISETRON; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GUINEA PIG; ILEUM; INTRAVENOUS DRUG ADMINISTRATION; MOLECULAR MODEL; NONHUMAN; RAT; REFLEX; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; BRAIN; GUINEA PIGS; HEART RATE; ILEUM; IMIDAZOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUSCLES; RATS; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN ANTAGONISTS;

EID: 9844255572     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970060o     Document Type: Article

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