Radiation-induced apoptosis and cell cycle alterations in human carcinoma cell lines with different radiosensitivities

Neoplasma

Volumn 47, Issue 1, 2000, Pages 25-31

  Hunakova L' ^a   Chorvath M ^b   Duraj, J ^a   Bartosova Z ^a   Sevcikova L' ^b   Sulikova M ^a   Chovancova J ^a   Sedlak J ^a   Chorvath B ^a   Bolesikova E ^b  

^a INSTITUTE OF CHEMISTRY   (Slovakia)

^b St Elisabeth Cancer Institute   (Slovakia)

Author keywords

Apoptosis; Cell cycle alterations; Cell lines; Flow cytometry; Human breast and ovarian carcinoma; Ionizing irradiation; MTT assay; PARP cleavage; Radiosensitivity

Indexed keywords

APOPTOSIS; ARTICLE; BREAST CARCINOMA; CARCINOMA CELL; CELL CYCLE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; OVARY CARCINOMA; RADIATION; RADIATION DOSE; RADIOSENSITIVITY;

EID: 0342545497     PISSN: 00282685     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. ALGAN, O., STOBBE, C.C., HELT, A.M., HANKS, G.E., CHAPMAN, J.D.: Radiation inactivation of human prostate cancer cells: The role of apoptosis. Radiat. Res., 146, 1996, 267-275.
2. BANASIAK, D., BARNETSON, A.R., ODELL, R.A., MAMEGHAN, H., RUSSELL, P.J.:Comparison between the clonogenic, MTT, and SRB assays for determining radiosensitivity in a panel of human bladder cancer cell lines and a ureteral cell line. Radiat. Oncol. Investig., 7, 1999, 77-85.
3. BERRY, S.E., GARCES, C., HWANG, H.S., KUNUGI, K., MEYERS, M., DAVIS, T.W., BOOTHMAN, D.A., KINSELLA, T.J.: The mismatch repair protein, hMLH1, mediates 5-substituted halogenated thymidine analogue cytotoxicity, DNA incorporation, and radiosensitization in human colon cancer cells. Cancer Res., 59, 1999, 1840-1845.
4. BOYER, J.C., UMAR, A., RISINGER, J.I., LIPFORD, J.R., KANE, M., YIN, S., BARRETT, J.C., KOLODNER, R.D., KUNKEL, T.A.: Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines. Cancer Res., 55, 1995, 6063-6070.
5. BROWNE, S.J., MACFARLANE, M., COHEN, G.M., PARASKEVA, C.: The adenomatous polyposis coli protein and Rb protein are cleaved early in apoptosis and are potential substrates for caspases. Cell Death Different., 5, 1998, 206-213.
6. BUNZ, F., DUTRIAUX, A., LENGAUER, C., WALDMAN, T., ZHOU, S., BROWN, J.P., SEDIVY, J.M., KINZLER, K.W., VOGELSTEIN, B.: Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science, 282, 1998, 1497-1501.
7. COHEN, M.: Caspases: The executioners of apoptosis. Biochem. J., 326, 1994, 1-16.
8. DAVIS, T.W., WILSON-VAN PATTEN, C., MEYERS, M., KUNUGI, K.A., CUTHILL, S., REZNTKOFF, C., GARCES, C., BOLAND, C.R., KINSELLA, T.J., FISHEL, R., BOOTHMAN, D.A.: Defective expression of the DNA mismatch repair protein, MLH1, alters G2-M cell cycle checkpoint arrest following ionizing radiation. Cancer Res., 58, 1998, 767-778.
9. DEWEESE, T.L., SHIPMANN, J.M., LARRIER, L.A., BUCKLEY, M.N., KIDD, L.R., GROOFMAN, J.D., CUTLER, R.G., DE RIELE, H., NELSON, W.G.: Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation. Proc. Natl. Acad. Sci. USA, 93, 1998, 11915-11 920.
10. FAN, S., Twu, N.F., WANG, J.A., YUAN, R.Q., ANDRES, J., GOLDBERG, I.D., ROSEN, E.M.: Down-regulation of BRCA1 and BRCA2 in human ovarian cancer cells exposed to adriamycin and UV radiation. Int. J. Cancer, 77, 1998, 600-609.
11. FILIPPOVITCH, I.V., SOROKINA, N.I., ROBILLARD, N., LISBONA, A., CHATAL, J.F.: Radiation-induced apoptosis in human tumor cell lines: Adaptive response and split-dose effect. Int. J. Cancer, 77, 1998, 76-81.
12. FRITZELL, J.A., NARAYANAN, L., BAKER, S.M., BRONNER, C.E., ANDREW, S.E., PROLLA, T.A., BRADLEY, A., JIRIK, F.R., LISKAY, R.M., GLAZER, P.M.: Role of DNA mismatch repair in the cytotoxicity of ionizing radiation. Cancer Res., 57, 1997, 5143-5147.
13. HE, A.W., CORY, J.G.: Effect of ionizing radiation on wild-type and mutant mouse leukemia L1210 cells. Oncol. Res., 10(9), 1998, 455-464.
14. JONGMANS, W., HALL, J.: Cellular responses to radiation and risk of breast cancer. Eur. J. Cancer, 35, 1999, 540-548.
15. LAURENT, D., PRADIER, O., SCHMIDBERGER, H., RAVE-FRANK, M., FRANKENBERG, D., HESS, C.F: Radiation rendered more cytotoxic by fludarabine monophosphate in a human oropharynx carcinoma cell-line than in fetal lung fibroblasts. J. Cancer Res. Clin. Oncol., 124, 1998, 485-492.
16. NING, S., KNOX, S.J.: G2/M-phase arrest and death by apoptosis of HL60 cells irradiated with exponentially decreasing low-dose-rate gamma radiation. Radiat. Res., 151, 1999, 659-669.
17. MAITY, A., KAO, G.D., MUSCHELL, R.J., MCKENNA, W.G.: Potential molecular targets for manipulating the radiation response. Int. J. Radiat. Oncol. Biol. Phys., 37, 1997, 639-653.
18. MORELAND, N.J., ILLAND, M., KIM, Y.T., PAUL, J., BROWN, R.: Modulation of drug resistance mediated by loss of mismatch repair by the DNA polymerase inhibitor aphidicolin. Cancer Res., 59, 1999, 2002-2016.
19. O'CONNELL, A.C., LILLIBRIDGE, C.D., ZHENG, C., BAUM, B.J., O'CONNELL, B.C., AMBUDKAR, I.S.: Gamma-irradiation-induced cell cycle arrest and cell death in a human submandibular gland cell line: Effect of E2F1 expression. J. Cell Physiol., 177, 1998, 264-273.
20. OLIVER, F.J., DE LA RUBIA, G., ROLLI, V., Ruiz-Ruiz, M. C., DE MURCIA, G., MENISSIER-DE MURCIA, G.: Importance of poly (ADP-ribose) polymerase and its cleavage in apoptosis. J. Biol. Chem., 273, 1998, 33 533-33 539.
21. PATEL, T., GORES, G.J., KAUFMANN, S.H.: The role of proteases during apoptosis. FASEB J., 10, 1996, 587-597.
22. PESTELL, K.E., MA, C.J., TA, J.C., KELLAND, R.J., WALTON, M.J.: Characterization of the p53 status, bcl-2 expression and radiation and platinum drug sensitivity of a panel of human ovarian cancer cell lines. Int. J. Cancer, 77, 1998, 913-918.
23. PETRU, E., SEVIN, B.U., GOTTLIEB, C.H.: Radiosensitivity patterns of four human ovarian cancer cell line in vitro. Gynecol. Oncol., 64, 1977, 490-492.
24. RADFORD, I.R., ALDRIDGE, D.R.: Importance of DNA damage in the induction of apoptosis by ionizing radiation: Effect of the seid mutation and DNA ploidy on the radiosensitivity of murine lymphoid cell lines. Int. J. Radiat. Biol., 75, 1999, 143-153.
25. RIGBERG, D.A., BLINMAN, T.A., KIM, F.S., COLE, M.A., MCFADDEN, D.W.: Antisense blockade of p21/WAF1 decreases radiation-induced G2 arrest in esophageal squamous cell carcinoma. J. Surg. Res., 81, 1999, 6-10.
26. ROSENZWEIG, K.E., YOUMELL, M.B., PALAYOOR, S.T., PRICE, B.D.: Radiosensitization of human tumor cells by the phosphatidylinosito13-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay. Clinic Cancer Res., 3, 1997, 1149-1156.
27. SEDLÁK, J., HUNÁKOVÁ, L., DURAJ, J., CHORVÁTU, B., NOVOTNẎ, L.: Effects of protein kinase C inhibitor, staurosporine derivative CGP 41 251 on cell cycle, DNA synthesis and drug uptake in neoplastic cell lines. Anti-Cancer Drugs, 6, 1995, 70-76.
28. SEDLÁK, J., SEDLÁKOVÁ, O., HLAVČÁK, P., HUNÁKOVÁ, L., BİZIK, J, GROFOVÁ, M., CHORVÁTH, B.: Cell surface phenotype and increased penetration of human multidrug-resistant ovarian carcinoma cells into in vitro collagen-fibroblast matrix. Neoplasma, 43, 1996, 389-395.
29. SIDDIK, Z.H., MIMS, B., LOZANO, G., THAI, G.: Independent pathways of p53 induction by cisplatin and X-rays in a cisplatin-resistant ovarian tumor cell line. Cancer Res., 58, 1998, 698-703.
30. SILES, E., VILLALOBOS, M., JONES, L., GUERRERO, R., EADY, J.J., VALENZUELA, M.T., NUNEZ, M.I., MAMA, T.J., RUIZ DE ALMODOVAR, J.M.: Apoptosis after gamma irradiation. Is it an important cell death modality? Br. J. Cancer, 78, 1998, 1594-1599.
31. SIRZÉN, F., ZHIVOTOVSKY, B., NILSSON, A., BERGH, J., LEWENSOHN, R.: Spontaneous and radiation-induced apoptosis in lung carcinoma cells with different radiosensitivities. Anticancer Res., 18, 1998, 695-700.
32. SYLJUASEN, R.G., JI-HONG, H., MCBRIDE, W.: Apoptosis and delayed expression of c-jun and c-fos after gamma irradiation of Jurkat T cells. Radiation Res., 146, 1996, 276-282.
33. TAMAMOTO, T., OHNISHI, K., TAKAHASHI, A., WANG, X., YOSIMURA, H., OHISHI, H., UCHIDA, H., OHNISHI, T.: Correlation between gamma-ray-induced G2 arrest and radioresistance in two human cancer cells. Int. J. Radiat. Oncol. Biol. Phys., 44, 1999, 905-909.
34. TEYSSIER, F., BAY, J.-O., DIONET, C., VERELLE, P.: Régulation du cycle cellulaire des cellules exposées aux radiations ionisantes. Bull. Cancer, 86, 1999, 345-352.
35. VAISMAN, A., VARCHENKO, M., UMAR, A., KUNKEL, T.A., RISINGER, J.L., BARRET, J.C., HAMILTON, T.C., CHANCY, S.G.: The role of hMLH1, hMSH3 and hMSH6 in cisplatin and oxaliplatin resistance: Correlation with replication bypass of platinum-DNA adducts. Cancer Res., 58, 1998, 35 679-35 685.
36. WILKINS, D.E., NG, C.E., RAAPHORST, G.P.: Cell cycle perturbations in cisplatin-sensitive and resistant human ovarian carcinoma cells following treatment with cisplatin and low dose rate irradiation. Cancer Chemother. Pharmacol., 40, 1997, 159-166.
37. ZHIVOTOVSKY, B., JOSEPH, B., ORRENIUS, S.: Tumor radiosensitivity and apoptosis. Exp. Cell Res., 248, 1999, 10-17.