Dictyostelium discoideum: A new host model system for intracellular pathogens of the genus Legionella

Cellular Microbiology

Volumn 2, Issue 2, 2000, Pages 165-171

  Hägele, Sonja ^a   Köhler, Rolf ^a   Merkert, Hilde ^a   Schleicher, Michael ^b   Hacker, Jörg ^a   Steinert, Michael ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN;

ACANTHAMOEBA CASTELLANII; ARTICLE; DICTYOSTELIUM DISCOIDEUM; GENETIC MANIPULATION; HOST CELL; LEGIONELLA; LYSOSOME; NONHUMAN; PATHOGENESIS; PHAGOSOME; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY;

ACANTHAMOEBA; ANIMALS; DICTYOSTELIUM; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; HUMANS; IN SITU HYBRIDIZATION; LEGIONELLA; LEGIONELLOSIS; MICROSCOPY, CONFOCAL;

ACANTHAMOEBA CASTELLANII; DICTYOSTELIUM DISCOIDEUM; EUKARYOTA; LEGIONELLA;

EID: 0342369378     PISSN: 14625814     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1462-5822.2000.00044.x     Document Type: Article

References (34)

1. Abu Kwaik (1998) Fatal attraction of mammalian cells to Legionella pneumophila. Mol Microbiol 30: 689-695.
2. Abu Kwaik, Y., Fields, B.S., and Engleberg, N.C. (1994) Protein expression by the protozoan Hartmannella vermiformis upon contact with its bacterial parasite, Legionella pneumophila. Infect Immun 62: 1860-1866.
3. Abu Kwaik, Y., Venkataraman, C., Harb, O.S., and Gao, L.Y. (1998a) Signal transduction in the protozoan host Hartmannella vermiformis upon attachment and invasion by Legionella micdadei. Appl Environ Microbiol 64: 3134-3139.
4. Abu Kwaik, Y., Gao, L-Y., Stone, B.J., Venkataraman, C., and Harb, O.S. (1998b) Invasion of protozoa by Legionella pneumophila and its role in bacterial ecology and pathogenesis. Appl Environ Microbiol 64: 3127-3133.
5. Adeleke, A.M.S., Pruckler, J., Benson, R., Rowbotham, M.S.T., Halablab, M., and Fields, B.S. (1996) Legionella-like amoebal pathogens - phylogenetic status and possible role in respiratory Disease. Emerg Infect Dis 3: 225-230.
6. Beckers, M.C., Yoshida, S., Morgan, K., Skamene, E., and Gros, P. (1995) Natural resistance to infection with Legionella pneumophila: chromosomal localization of the Lgn1 susceptibility gene. Mamm Genome 6: 540-545.
7. Berendt, R.F., Young, H.W., Allen, R.G., and Knutsen, G.L. (1980) Dose-response of guinea pigs experimentally infected with aerosols of Legionella pneumophila. J Infect Dis 141: 186-192.
8. Bozue, J.A., and Johnson, W. (1996) Interaction of Legionella pneumophila with Acanthamoeba castellanii: uptake by coiling phagocytosis and of phagosome-lysosome fusion. Infect Immun 64: 279-286.
9. Eichinger, L., Lee, S.S., and Schleicher, M. (1999) Dictyostelium as model system for studies of the actin cytoskeleton by molecular genetics. Microsc Res Techn 47: 124-134.
10. Fields, B. (1996) The molecular ecology of legionellae. Trends Microbiol 7: 286-290.
11. Fields, B., Barbaree, J.M., Sanden, G.N., and Morrill, W.E. (1990) Virulence of a Legionella anisa strain associated with Pontiac fever: an evaluation using protozoan, cell culture, and guinea pig models. Infect Immun 58: 3139-3142.
12. Francis, D., and Eisenberg, R. (1993) Genetic structure of a natural population of Dictyostelium discoideum, a cellular slime mould. Mol Ecol 2: 385-391.
13. Gao, L.Y., Harb, O.S., and Abu Kwaik, Y. (1997) Utilization of similar mechanisms by Legionella pneumophila to parasitize two evolutionary distant hosts, mammalien and protozoan cells. Infect Immun 65: 4738-4746.
14. Gao, L.Y., Harb, O.S., and Abu Kwaik, Y. (1998) Identification of macrophage-specific infectivity loci (mil) of Legionella pneumophila that are not required for infectivity of protozoa. Infect Immun 66: 883-892.
15. Grimm, D., Merkert, H., Ludwig, W., Schleifer, K.-H., Hacker, J., and Brand, B.C. (1998) Specific detection of Legionella pneumophila: construction of a new 16S rRNA-targeted oligonucleotide probe. Appl Environ Microbiol 64: 2686-2690.
16. Hacker, U., Albrecht, R., and Maniak, M. (1997) Fluid-phase uptake by macropinocytosis in Dictyostelium. J Cell Sci 110: 105-112.
17. Hägele, S., Hacker, J., and Brand, B.C. (1998) Legionella pneumophila kills human phagocytes but not protozoan host cells by inducing apoptotic cell death. FEMS Microbial Lett 169: 51-58.
18. Hanahan, D. (1983) Studies on transformation of Escherichia coli plasmids. J Mol Biol 166: 557-580.
19. Haugwitz, M., Noegel, A.A., Rieger, D., Lottspeich, F., and Schleicher, M. (1991) Dictyostelium discoideum contains two profilin isoforms that differ in structure and function. J Cell Sci 100: 481-489.
20. Haugwitz, M., Noegel, A.A., Karakesisoglou, J., and Schleicher, M. (1994) Dictyostelium amoebae that lack G-actin-sequestering profilins show defects in F-actin content, cytokinesis, and development. Cell 79: 303-314.
21. Hickey, E.K., and Cianciotto, N.P. (1997) An iron- and Fur-repressed Legionella pneumophila gene that promotes intracellular infection and encodes a protein that promotes intracellular infection and encodes a protein with similarity to the Escherichia coli aerobactin synthetase. Infect Immun 65: 133-143.
22. Joshi, A.D., and Swanson, M.S. (1999) Comparative analysis of Legionella pneumophila and Legionella micdadei virulence traits. Infect Immun 67: 4134-4142.
23. Karakesioglou, I., Janssen, K.-P., Eichinger, L., Noegel, A.A., and Schleicher, M. (1999) Identification of a suppressor of the Dictyostelium profilin-minus phenotype as a CD36/LIMP-II homologue. J Cell Biol 145: 167-181.
24. Köhler, R., Bubert, A., Goebel, W., Steinert, M., Hacker, J., and Bubert, B. (2000) Expression and use of the green fluorescent protein as a reporter system in Legionella pneumophila. Mol Gen Genet 262: 1060-1069.
25. Noegel, A.A., and Luna, J.E. (1995) The Dictyostelium cytoskeleton. Experientia 51: 1135-1143.
26. Orrison, L.H., Cherry, W.B., Tyndall, R.L., Fliermans, C.B., Gough, S.B., Lambert, M.A., et al. (1983) Legionella oakridgensis: unusual new species isolated from cooling tower water. Appl Environ Microbiol 45: 536-545.
27. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning. A Laboratory Manual. Cold Spring Harbor NY: Cold Spring Harbor Laboratory Press.
28. Saunders, N.A., Doshi, N., and Harrison, T.G. (1992) A second serogroup of Legionella erythra serologically indistinguishable from Legionella rubilucens. J Appl Bacteriol 72: 262-265.
29. Segal, G., Purcell, M., and Shuman, H.A. (1998) Host cell killing and bacterial conjugation require overlapping sets of genes within a 22 kb region of the Legionella pneumophila chromosome. Proc Natl Acad Sci USA 95: 1669-1674.
30. Smith, G.A., and Portnoy, D.A. (1997) How the Listeria monocytogenes ActA protein converts actin polymerization into motile force. Trends Microbiol 5: 272-276.
31. Steele, T.W., and McLennan, A.M. (1996) Infection of Tetrahymena pyriformis by Legionella longbeachae and other Legionella species found in potting mixes. Appl Environ Microbiol 62: 1081-1083.
32. Steinert, M., Emödy, L., Amann, R., and Hacker, J. (1997) Resuscitation of viable but nonculturable Legionella pneumophila Philadelphia JR32 by Acanthamoeba castellanii. Appl Environ Microbiol 63: 2047-2053.
33. Vogel, J.P., Andrews, H.L., Wong, S.K., and Isberg, R.R. (1998) Conjugative transfer by the virulence system of Legionella pneumophila. Science 279: 873-876.
34. Wintermeyer, E., Ludwig, B., Steinert, M., Schmidt, B., Fischer, G., and Hacker, J. (1995) Influence of site specifically altered Mip proteins on intracellular survival of Legionella pneumophila in eukaryotic cells. Infect Immun 63: 4576-4583.