Ineffective humoral immunity in the elderly

Microbes and Infection

Volumn 5, Issue 13, 2003, Pages 1279-1284

  McGlauchlen, Kiley S ^a   Vogel, Laura A ^a  

^a ILLINOIS STATE UNIVERSITY   (United States)

Author keywords

Aging; B lymphocytes; Humoral immunity

Indexed keywords

ANTIGEN;

AGE DISTRIBUTION; AGING; ANTIBODY RESPONSE; B LYMPHOCYTE; CELL ACTIVITY; HELPER CELL; HUMAN; HUMORAL IMMUNITY; IMMUNE SYSTEM; MOLECULAR DYNAMICS; PRIORITY JOURNAL; REVIEW;

EID: 0242653842     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.micinf.2003.09.001     Document Type: Short Survey

References (32)

1. Klinman N.R., Kline G.H. The B-cell biology of aging. Immunol. Rev. 160:1997;103-114.
2. Ginaldi L., Loreto M.F., Corsi M.P., Modesti M., De Martinis M. Immunosenescence and infectious diseases. Microbes. Infect. 3:2001;851-857.
3. Wick G., Grubeck-Loebenstein B. Immunity and aging. Dev. Comp. Immunol. J. 21:1997;455-460.
4. LeMaoult J., Manavalan J.S., Dyall R., Szabo P., Nikolic-Zugic J., Weksler M.E. Cellular basis of B cell clonal populations in old mice. J. Immunol. 162:1999;6384-6391.
5. Eun S.-Y., Vogel L.A. T Cell-dependent immune responses: impact of aging on B lymphocytes and antigen-presenting cells. Mod. Asp. Immunobiol. 2:2002;232-235.
6. Herrero C., Sebastian C., Marques L., Comalada M., Xaus J., Valledor A.F., Lloberas J., Celada A. Immunosenescence of macrophages: reduced MHC class II gene expression. Exp. Gerontol. 37:2002;389-394.
7. Hayek M.G., Mura C., Wu D., Beharka A.A., Han S.N., Paulson K.E., Hwang D., Meydani S.N. Enhanced expression of inducible cyclooxygenase with age in murine macrophages. J. Immunol. 159:1997;2445-2451.
8. Sprecher E., Becker Y., Kraal G., Hall E., Harrison D., Shultz L.D. Effect of aging on epidermal dendritic cell populations in C57BL/6J mice. J. Invest. Dermatol. 94:1990;247-253.
9. Manning B.M., Enioutina E.Y., Visic D.M., Knudson A.D., Daynes R.A. CpG DNA functions as an effective adjuvant for the induction of immune responses in aged mice. Exp. Gerontol. 37:2001;107-126.
10. Aydar Y., Balogh P., Tew J.G., Szakal A.K. Age-related depression of FDC accessory functions and CD21 ligand-mediated repair of co-stimulation. Eur. J. Immunol. 32:2002;2817-2826.
11. Johnson K.M., Owen K., Witte P.L. Aging and developmental transitions in the B cell lineage. Int. Immunol. 14:2002;1313-1323.
12. Johnson S.A., Rozzo S.J., Cambier J.C. Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire. J. Immunol. 168:2002;5014-5023.
13. Weksler M.E., Szabo P. The effect of age on the B-cell repertoire. J. Clin. Immunol. 20:2000;240-249.
14. Hu A., Ehleiter D., Ben-Yehuda A., Schwab R., Russo C., Szabo P., Weksler M.E. Effect of age on the expressed B cell repertoire: role of B cell subsets. Int. Immunol. 5:1993;1035-1039.
15. Song H., Price P.W., Cerny J. Age-related changes in antibody repertoire: contribution from T cells. Immunol. Rev. 160:1997;55-62.
16. Yang X., Stedra J., Cerny J. Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice. J. Exp. Med. 183:1996;959-970.
17. Globerson A., Effros R.B. Ageing of lymphocytes and lymphocytes in the aged. Immunol. Today. 21:2000;515-521.
18. Hale T.J., Richardson B.C., Sweet L.I., McElligott D.L., Riggs J.E., Chu E.B., Glynn J.M., LaFrenz D., Ernst D.N., Rochford R., Hobbs M.V. Age-related changes in mature CD4+ T cells: cell cycle analysis. Cell Immunol. 220:2002;51-62.
19. Whisler R.L., Newhouse Y.G., Bagenstose S.E. Age-related reductions in the activation of mitogen-activated protein kinases p44mapk/ERK1 and p42mapk/ERK2 in human T cells stimulated via ligation of the T cell receptor complex. Cell Immunol. 168:1996;201-210.
20. Smith P., Dunne D.W., Fallon P.G. Defective in vivo induction of functional type 2 cytokine responses in aged mice. Eur. J. Immunol. 31:2001;1495-1502.
21. Hagiwara Y., McGhee J.R., Fujihashi K., Kobayashi R., Yoshino N., Kataoka K., Etani Y., Kweon M.N., Tamura S., Kurata T., Takeda Y., Kiyono H. Protective mucosal immunity in aging is associated with functional CD4+ T cells in nasopharyngeal-associated lymphoreticular tissue. J. Immunol. 170:2003;1754-1762.
22. Saurwein-Teissl M., Lung T.L., Marx F., Gschosser C., Asch E., Blasko I., Parson W., Bock G., Schonitzer D., Trannoy E., Grubeck-Loebenstein B. Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines. J. Immunol. 168:2002;5893-5899.
23. Wakikawa A., Utsuyama M., Hirokawa K. Altered expression of various receptors on T cells in young and old mice after mitogenic stimulation: a flow cytometric analysis. Mech. Ageing Dev. 94:1997;113-122.
24. Dennett N.S., Barcia R.N., McLeod J.D. Age associated decline in CD25 and CD28 expression correlate with an increased susceptibility to CD95 mediated apoptosis in T cells. Exp. Gerontol. 37:2002;271-283.
25. Bansal-Pakala P., Croft M. Defective T cell priming associated with aging can be rescued by signaling through 4-1BB (CD137). J. Immunol. 169:2002;5005-5009.
26. Banerjee M., Mehr R., Belelovsky A., Spencer J., Dunn-Walters D.K. Age- and tissue-specific differences in human germinal center B cell selection revealed by analysis of IgVH gene hypermutation and lineage trees. Eur. J. Immunol. 32:2002;1947-1957.
27. Kosco M.H., Burton G.F., Kapasi Z.F., Szakal A.K., Tew J.G. Antibody-forming cell induction during an early phase of germinal centre development and its delay with ageing. Immunology. 68:1989;312-318.
28. Dailey R.W., Eun S.Y., Russell C.E., Vogel L.A. B cells of aged mice show decreased expansion in response to antigen, but are normal in effector function. Cell Immunol. 214:2001;99-109.
29. Han S., Yang K., Ozen Z., Peng W., Marinova E., Kelsoe G., Zheng B. Enhanced differentiation of splenic plasma cells but diminished long-lived high-affinity bone marrow plasma cells in aged mice. J. Immunol. 170:2003;1267-1273.
30. Lu Y.F., Cerny J. Repertoire of antibody response in bone marrow and the memory response are differentially affected in aging mice. J. Immunol. 169:2002;4920-4927.
31. Klinman N.R., Thorbecke G.J. Aging associated changes in the generation and development of B cell memory. Int. Rev. Immunol. 12:1995;5-12.
32. Sanchez M., Lindroth K., Sverremark E., Gonzalez F.A., Fernandez C. The response in old mice: positive and negative immune memory after priming in early age. Int. Immunol. 13:2001;1213-1221.