Structure-based design of β-lactamase inhibitors. 1. Synthesis and evaluation of bridged monobactams

Journal of Medicinal Chemistry

Volumn 41, Issue 21, 1998, Pages 3961-3971

  Heinze Krauss, Ingrid ^a   Angehrn, Peter ^a   Charnas, Robert L ^a   Gubernator, Klaus ^a,b   Gutknecht, Eva Maria ^a   Hubschwerlen, Christian ^a   Kania, Malgosia ^a   Oefner, Christian ^a   Page, Malcolm G P ^a   Sogabe, Satoshi ^a   Specklin, Jean Luc ^a   Winkler, Fritz ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b Formerly CombiChem Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE INHIBITOR; BRIDGED COMPOUND; CLAVULANIC ACID; MONOBACTAM DERIVATIVE; PENAM DERIVATIVE; SULBACTAM; TAZOBACTAM;

ARTICLE; DRUG BINDING; DRUG CONFORMATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR MODEL; REACTION ANALYSIS; X RAY CRYSTALLOGRAPHY;

ACYLATION; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; BINDING SITES; CEFTRIAXONE; CEPHALOSPORINS; CITROBACTER FREUNDII; DRUG DESIGN; DRUG SYNERGISM; ENZYME INHIBITORS; ESCHERICHIA COLI; KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MONOBACTAMS; PSEUDOMONAS AERUGINOSA;

EID: 0344175930     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980023c     Document Type: Article

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