DNA targeted platinum complexes: Synthesis, cytotoxicity and DNA interactions of cis-dichloroplatinum(II) complexes tethered to phenazine-1- carboxamides

Journal of Inorganic Biochemistry

Volumn 81, Issue 1-2, 2000, Pages 111-117

  Perrin, Leah C ^a   Prenzler, Paul D ^b   Cullinane, Carleen ^c   Phillips, Don R ^c   Denny, William A ^d   McFadyen, W David ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b CHARLES STURT UNIVERSITY   (Australia)

^c LA TROBE UNIVERSITY   (Australia)

^d UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Cis Dichloroplatinum (II); Cytotoxicity; DNA; Phenazine 1 carboxamides; Unwinding

Indexed keywords

AMIDE; ANTINEOPLASTIC AGENT; DIAMINE; LIGAND; PHENAZINE DERIVATIVE; PLATINUM COMPLEX; PLATINUM DICHLORO N [3 [(2 AMINOETHYL)AMINO]PROPYL] PHENAZINE 1 CARBOXAMIDE; PLATINUM DICHLORO N [4 [(2 AMINOETHYL)AMINO]BUTYL] PHENAZINE 1 CARBOXAMIDE; PLATINUM DICHLORO N [5 [(2 AMINOETHYL)AMINO]PENTYL] PHENAZINE 1 CARBOXAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DNA BINDING; DRUG SYNTHESIS; GENE TARGETING; MOUSE; NONHUMAN; PLASMID; REACTION ANALYSIS;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; CISPLATIN; ESCHERICHIA COLI; INDICATORS AND REAGENTS; INTERCALATING AGENTS; LEUKEMIA P388; MICE; MOLECULAR STRUCTURE; ORGANOPLATINUM COMPOUNDS; PHENAZINES; PLASMIDS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

ANIMALIA; MURINAE;

EID: 0034661015     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0162-0134(00)00092-1     Document Type: Article

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