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Volumn 44, Issue 1, 1999, Pages 39-44

Phase I study of the cytotoxic agent N-[2-(dimethylamino) ethyl]acridine-4-carboxamide

Author keywords

DACA; Phase I; Topoisomerase

Indexed keywords

CYTOTOXIC AGENT; DNA TOPOISOMERASE; N (2 DIMETHYLAMINOETHYL) 4 ACRIDINECARBOXAMIDE;

EID: 0032991591     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050942     Document Type: Article
Times cited : (43)

References (13)
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  • 3
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    • Comparison of the blood-brain barrier and liver penetration of acridine antitumor drugs
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    • Cornford, E.M.1    Young, D.2    Paxton, J.W.3
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    • Pharmacokinetically guided dose escalation in phase I clinical trials. Commentary and proposed guidelines
    • EORTC Pharmacokinetics and Metabolism Group (1987) Pharmacokinetically guided dose escalation in phase I clinical trials. Commentary and proposed guidelines. Eur J Cancer Clin Oncol 23: 1083-1087
    • (1987) Eur J Cancer Clin Oncol , vol.23 , pp. 1083-1087
  • 5
    • 0028158726 scopus 로고
    • Plasma protein binding of the experimental antitumour agent acridine-4-carboxamide in man, dog, rat and rabbit
    • Evans SMH, Robertson IGC, Paxton JW (1994) Plasma protein binding of the experimental antitumour agent acridine-4-carboxamide in man, dog, rat and rabbit. J Pharm Pharmacol 46: 63-67
    • (1994) J Pharm Pharmacol , vol.46 , pp. 63-67
    • Evans, S.M.H.1    Robertson, I.G.C.2    Paxton, J.W.3
  • 6
    • 0026457782 scopus 로고
    • Intraperitoneal administration of the antitumour agent N-[(2-(dimethylamino)ethyl)]acridine-4-carboxamide in the mouse: Bioavailability, pharmacokinetics and toxicity after a single dose
    • Evans SMH, Young D, Robertson IGC, Paxton JW (1992) Intraperitoneal administration of the antitumour agent N-[(2-(dimethylamino)ethyl)]acridine-4-carboxamide in the mouse: bioavailability, pharmacokinetics and toxicity after a single dose. Cancer Chemother Pharmacol 31: 32-36
    • (1992) Cancer Chemother Pharmacol , vol.31 , pp. 32-36
    • Evans, S.M.H.1    Young, D.2    Robertson, I.G.C.3    Paxton, J.W.4
  • 7
    • 0027447244 scopus 로고
    • In vitro assessment of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide, a DNA-intercalating antitumour drug with reduced sensitivity to multidrug resistance
    • Finlay GJ, Marshall ES, Matthews JHL, Paull KD, Baguley BC (1993) In vitro assessment of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide, a DNA-intercalating antitumour drug with reduced sensitivity to multidrug resistance. Cancer Chemother Pharmacol 31: 401-406
    • (1993) Cancer Chemother Pharmacol , vol.31 , pp. 401-406
    • Finlay, G.J.1    Marshall, E.S.2    Matthews, J.H.L.3    Paull, K.D.4    Baguley, B.C.5
  • 8
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    • From amsacrine to DACA (N-[2-(dimethylamino)ethyl]acridine 4-carboxamide): Selectivity for topoisomerases I and II among acridine derivatives
    • Finlay GJ, Riou J-F, Baguley BC (1996) From amsacrine to DACA (N-[2-(dimethylamino)ethyl]acridine 4-carboxamide): selectivity for topoisomerases I and II among acridine derivatives. Eur J Cancer 32 A: 708-714
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    • Pharmacokinetics and toxicity of the antitumour agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide after i.v. administration in the mouse
    • Paxton JW, Young D, Evans SM, Kestell P, Robertson IG, Cornford EM (1992) Pharmacokinetics and toxicity of the antitumour agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide after i.v. administration in the mouse. Cancer Chemother Pharmacol 29: 379-384
    • (1992) Cancer Chemother Pharmacol , vol.29 , pp. 379-384
    • Paxton, J.W.1    Young, D.2    Evans, S.M.3    Kestell, P.4    Robertson, I.G.5    Cornford, E.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.