The interaction of DNA-targeted platinum phenanthridinium complexes with DNA in human cells

Anti-Cancer Drug Design

Volumn 16, Issue 2-3, 2001, Pages 81-89

  Whittaker, Joanne ^a   McFadyen, W David ^a   Baguley, Bruce C ^a   Murray, Vincent ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Anti tumour drug; Cytotoxicity; DNA damage; DNA intercalation; Taq DNA polymerase

Indexed keywords

CISPLATIN; DNA; DNA POLYMERASE; PHENANTHRIDINE DERIVATIVE; PLATINUM DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA SEQUENCE; DRUG DNA INTERACTION; DRUG STRUCTURE; GENE TARGETING; HUMAN; INTERCALATION COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; CISPLATIN; DENSITOMETRY; DNA; DNA DAMAGE; HELA CELLS; HUMANS; LEUKEMIA P388; OLIGONUCLEOTIDES; ORGANOPLATINUM COMPOUNDS; PHENANTHRIDINES; TANDEM REPEAT SEQUENCES;

ANIMALIA;

EID: 0035727277     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Divergent activity of derivatives of amsacrine (m-AMSA) towards Lewis lung carcinoma and P388 leukaemia in mice
2. Biological processing of DNA modified by platinum compounds
3. Platinum antitumour agents
4. DNA-intercalating agents as antitumour drugs: Prospects for future design
5. Comparison of the in vitro activity of cytotoxic drugs towards human carcinoma and leukemia cell lines
6. Initiatives with platinum- and quinazoline-based antitumor molecules
7. Chromosome-specific subfamilies within human alphoid repetitive DNA
8. Drugs five years later, cisplatin
9. Improved double-stranded DNA sequencing using the linear polymerase chain reaction
10. A survey of the sequence specific interaction of damaging agents with DNA: Emphasis on anti-tumour agents
11. Comparison of the sequence specificity of bleomycin cleavage in two slightly different DNA sequences
12. The sequence specificity of bleomycin-induced DNA damage in intact cells
13. An investigation of the sequence-specific interaction of cis-diamminedichloroplatinum(II) and four analogues, including two acridine-tethered complexes, with DNA inside human cells
14. The use of Taq DNA polymerase to determine the sequence specificity of DNA damage caused by cis-diamminedichloroplatinum(II), acridine-tethered platinum(II) diammine complexes or two analogues
15. The influence of linker chain length on the sequence specificity of DNA damage by n-bromoalkylphenanthridinium bromides in plasmid DNA and in intact human cells
16. Interaction of eleven cisplatin analogues with DNA: Characteristic pattern of damage with monofunctional analogues
17. DNA sequence selectivity of cisplatin analogues in intact human cells
18. DNA-directed alkylating agents. 2. Synthesis and biological activity of platinum complexes linked to 9-anilinoacridine
19. Measurement of the sequence specificity of covalent DNA modification by antineoplastic agents using Taq DNA polymerase
20. An efficient method for large-scale isolation of plasmid DNAs by heat-alkali co-denaturation
21. The interaction of cisplatin and DNA-targeted 9-aminoacridine platinum complexes with DNA
22. The interaction of DNA-targeted platinum phenanthridinium complexes With DNA
23. Sequence definition and organization of a human repeated DNA