Hematopoietic stem cells: Generation and manipulation

Trends in Immunology

Volumn 24, Issue 11, 2003, Pages 589-594

  Nakano, Toru ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 3; INTERLEUKIN 6;

ADOPTIVE IMMUNOTHERAPY; BLOOD CELL; CELL LINE; CELL MANIPULATION; CELL MATURATION; CELL RENEWAL; COMPARATIVE STUDY; EMBRYO CELL; HEMATOPOIETIC STEM CELL; IN VITRO STUDY; IN VIVO STUDY; LYMPHOPOIESIS; MOLECULE; NONHUMAN; REVIEW;

EID: 0242365621     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2003.09.003     Document Type: Review

References (73)

1. Metcalf D. Some general aspects of hematopoietic cell development. Zon L.I. Hematopoiesis: A Developmenta Approach. 2001;Oxford University Press.
2. Orkin S.H. Hematopoietic stem cells: molecular diversification and developmental interrelationships. Marshak D.R., et al. Stem Cell Biology. 2001;289-306 Cold Spring Harbor Laboratory Press.
3. Melchers F., Rolink A. Hematopoietic stem cells: Lyphopoiesis and the problem of commitment versus plasticity. Marshak D.R., et al. Stem Cell Biology. 2001;307-327 Cold Spring Harbor Laboratory Press.
4. Palis J., Yoder M.C. Yolk-sac hematopoiesis: the first blood cells of mouse and man. Exp. Hematol. 29:2001;927-936.
5. Dzierzak E., et al. Qualitative and quantitative aspects of haematopoietic cell development in the mammalian embryo. Immunol. Today. 19:1998;228-236.
6. Ema H., et al. In vitro self-renewal division of hematopoietic stem cells. J. Exp. Med. 192:2000;1281-1288.
7. Fraser C.C., et al. Expansion in vitro of retrovirally marked totipotent hematopoietic stem cells. Blood. 76:1990;1071-1076.
8. Fraser C.C., et al. Proliferation of totipotent hematopoietic stem cells in vitro with retention of long-term competitive in vivo reconstituting ability. Proc. Natl. Acad. Sci. U. S. A. 89:1992;1968-1972.
9. Smith A. Embryonic stem cells. Marshak D.R., et al. Stem Cell Biology. 2001;205-230 Cold Spring Harbor Laboratory Press.
10. Wiles M.V. Embryonic stem cell differentiation in vitro. Methods Enzymol. 225:1993;900-918.
11. Chadwick K., et al. Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells. Blood. 102:2003;906-915.
12. Nakano T., et al. Generation of lymphohematopoietic cells from embryonic stem cells in culture. Science. 265:1994;1098-1101.
13. Nakano T., et al. In vitro development of primitive and definitive erythrocytes from different precursors. Science. 272:1996;722-724.
14. Potocnik A.J., et al. In vitro generation of lymphoid precursors from embryonic stem cells. EMBO J. 13:1994;5274-5283.
15. Cho S.K., et al. Functional characterization of B lymphocytes generated in vitro from embryonic stem cells. Proc. Natl. Acad. Sci. U. S. A. 96:1999;9797-9802.
16. De Pooter R.F., et al. In vitro generation of T lymphocytes from embryonic stem cell-derived pre-hematopoietic progenitors. Blood. 102:2003;1649-1653.
17. Kaufman D.S., et al. Hematopoietic colony-forming cells derived from human embryonic stem cells. Proc. Natl. Acad. Sci. U. S. A. 98:2001;10716-10721.
18. Xu M.J., et al. Stimulation of mouse and human primitive hematopoiesis by murine embryonic aorta-gonad-mesonephros-derived stromal cell lines. Blood. 92:1998;2032-2040.
19. Mukouyama Y., et al. In vitro expansion of murine multipotential hematopoietic progenitors from the embryonic aorta-gonad-mesonephros region. Immunity. 8:1998;105-114.
20. Potocnik A.J., et al. Hemato-lymphoid in vivo reconstitution potential of subpopulations derived from in vitro differentiated embryonic stem cells. Proc. Natl. Acad. Sci. U. S. A. 94:1997;10295-10300.
21. Muller A.M., Dzierzak E.A. ES cells have only a limited lymphopoietic potential after adoptive transfer into mouse recipients. Development. 118:1993;1343-1351.
22. Pinto-do O.P., et al. Expression of the LIM-homeobox gene LH2 generates immortalized steel factor-dependent multipotent hematopoietic precursors. EMBO J. 17:1998;5744-5756.
23. Kitajima K., et al. GATA-2 and GATA-2/ER display opposing activities in the development and differentiation of blood progenitors. EMBO J. 21:2002;3060-3069.
24. Perlingeiro R.C., et al. Clonal analysis of differentiating embryonic stem cells reveals a hematopoietic progenitor with primitive erythroid and adult lymphoid-myeloid potential. Development. 128:2001;4597-4604.
25. Kyba M., et al. HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell. 109:2002;29-37.
26. Sauvageau G., et al. Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev. 9:1995;1753-1765.
27. Thorsteinsdottir U., et al. Enhanced in vivo regenerative potential of HOXB4-transduced hematopoietic stem cells with regulation of their pool size. Blood. 94:1999;2605-2612.
28. Antonchuk J., et al. HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell. 109:2002;39-45.
29. Buske C., et al. Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells. Blood. 100:2002;862-868.
30. Bonifer C., et al. Developmental changes in the differentiation capacity of haematopoietic stem cells. Immunol. Today. 19:1998;236-241.
31. Mikkola H.K., et al. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature. 421:2003;547-551.
32. Raaphorst F.M., et al. Polycomb-group genes as regulators of mammalian lymphopoiesis. Trends Immunol. 22:2001;682-690.
33. Takihara Y., et al. Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects. Development. 124:1997;3673-3682.
34. van der Lugt N.M., et al. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev. 8:1994;757-769.
35. Akasaka T., et al. The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors. Immunity. 7:1997;135-146.
36. Park I.K., et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature. 423:2003;302-305.
37. Lessard J., Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature. 423:2003;255-260.
38. Ohta H., et al. Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells. J. Exp. Med. 195:2002;759-770.
39. Jacobs J.J., et al. Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. Genes Dev. 13:1999;2678-2690.
40. Jacobs J.J., et al. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature. 397:1999;164-168.
41. Cheng T., et al. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science. 287:2000;1804-1808.
42. Daley G.Q. Prospects for stem cell therapeutics: myths and medicines. Curr. Opin. Genet. Dev. 12:2002;607-613.
43. van Lohuizen M., et al. Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging. Cell. 65:1991;737-752.
44. Stier S., et al. Ex vivo targeting of p21Cip1/Waf1 permits relative expansion of human hematopoietic stem cells. Blood. 102:2003;1260-1266.
45. Pawliuk R., et al. Evidence of both ontogeny and transplant dose-regulated expansion of hematopoietic stem cells in vivo. Blood. 88:1996;2852-2858.
46. Sauvageau G., et al. Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation. Immunity. 6:1997;13-22.
47. Daga A., et al. The retroviral transduction of HOXC4 into human CD34(+) cells induces an in vitro expansion of clonogenic and early progenitors. Exp. Hematol. 28:2000;569-574.
48. Bjornsson J.M., et al. Reduced proliferative capacity of hematopoietic stem cells deficient in Hoxb3 and Hoxb4. Mol. Cell. Biol. 23:2003;3872-3883.
49. Krosl J., et al. The competitive nature of HOXB4-transduced HSC is limited by PBX1: the generation of ultra-competitive stem cells retaining full differentiation potential. Immunity. 18:2003;561-571.
50. Kirito, K. et al. Thrombopoietin stimulates HoxB4 expression: an explanation for the favorable effects of TPO on hematopoietic stem cells. Blood (in press).
51. Schiedlmeier B., et al. High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation. Blood. 101:2003;1759-1768.
52. Pinto-do O.P., et al. Hematopoietic progenitor/stem cells immortalized by Lhx2 generate functional hematopoietic cells in vivo. Blood. 99:2002;3939-3946.
53. Porter F.D., et al. Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development. Development. 124:1997;2935-2944.
54. Varnum-Finney B., et al. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nat. Med. 6:2000;1278-1281.
55. Radtke F., et al. The role of Notch signaling during hematopoietic lineage commitment. Immunol. Rev. 187:2002;65-74.
56. Allman D., et al. Notch signaling in hematopoiesis and early lymphocyte development. Immunol. Rev. 187:2002;75-86.
57. Ohishi K., et al. The notch pathway: modulation of cell fate decisions in hematopoiesis. Int. J. Hematol. 75:2002;449-459.
58. Han W., et al. A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells. Blood. 95:2000;1616-1625.
59. Jones P., et al. Stromal expression of Jagged 1 promotes colony formation by fetal hematopoietic progenitor cells. Blood. 92:1998;1505-1511.
60. Karanu F.N., et al. Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells. Blood. 97:2001;1960-1967.
61. Ohishi K., et al. Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells. J. Clin. Invest. 110:2002;1165-1174.
62. Varnum-Finney B., et al. Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability. Blood. 101:2003;1784-1789.
63. Karanu F.N., et al. The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells. J. Exp. Med. 192:2000;1365-1372.
64. Reya T., et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature. 423:2003;409-414.
65. Willert K., et al. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature. 423:2003;448-452.
66. Murdoch B., et al. Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo. Proc. Natl. Acad. Sci. U. S. A. 100:2003;3422-3427.
67. Bhardwaj G., et al. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat. Immunol. 2:2001;172-180.
68. Heike T., Nakahata T. Ex vivo expansion of hematopoietic stem cells by cytokines. Biochim. Biophys. Acta. 1592:2002;313-321.
69. Ueno H., et al. A stromal cell-derived membrane protein that supports hematopoietic stem cells. Nat. Immunol. 4:2003;457-463.
70. Escary J.L., et al. Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation. Nature. 363:1993;361-364.
71. Sui X., et al. gp130 and c-Kit signalings synergize for ex vivo expansion of human primitive hemopoietic progenitor cells. Proc. Natl. Acad. Sci. U. S. A. 92:1995;2859-2863.
72. Audet J., et al. Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells. Proc. Natl. Acad. Sci. U. S. A. 98:2001;1757-1762.
73. Kimura S., et al. Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin. Proc. Natl. Acad. Sci. U. S. A. 95:1998;1195-1200.