Microsomal monooxygenase in apoptosis: Another target for cytochrome c signaling?

Trends in Biochemical Sciences

Volumn 26, Issue 3, 2001, Pages 155-160

  Davydov, Dmitri R ^a  

^a INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENODOXIN; CASPASE 3; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOCHROME B5; CYTOCHROME C; CYTOCHROME P450; CYTOCHROME P450 2E1; CYTOCHROME P450 REDUCTASE; HYDROGEN PEROXIDE; INTERLEUKIN 1BETA CONVERTING ENZYME; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNSPECIFIC MONOOXYGENASE; XENOBIOTIC AGENT;

APOPTOSIS; CATALYSIS; DISSOCIATION; ELECTRON TRANSPORT; ENDOPLASMIC RETICULUM; EUKARYOTE; MITOCHONDRION; OXYGENATION; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; REVIEW;

ANIMALS; APOPTOSIS; CYTOCHROME C GROUP; CYTOCHROMES B5; ENDOPLASMIC RETICULUM; HUMANS; MICROSOMES; MIXED FUNCTION OXYGENASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EUKARYOTA;

EID: 0035281995     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(00)01749-7     Document Type: Review

References (50)

1. Mitochondria and apoptosis
2. Mitochondria as the central control point of apoptosis
3. Cytochrome c and dATP-dependent formation of Apaf1/caspase9 complex initiates an apoptotic cascade
4. Role of mitochondria in oxidative stress and ageing
5. Oxygen radicals and signaling
6. Reactive oxygen species, mitochondria, apoptosis and aging
7. Cytochrome P-450 dependent biotransformation of drugs and other xenobiotics
8. Extrahepatic drug metabolizing enzymes
9. Generation of reactive oxygen intermediates by human liver microsomes in the presence of NADPH or NADH
10. Contribution of hepatic cytochrome P450 systems to the generation of reactive oxygen species
11. Densities of NADPH-ferrihemoprotein reductase and cytochrome P-450 molecules in the endoplasmic reticulum membrane of rat hepatocytes
12. P450s - Structural similarities and functional differences
13. Effect of phenobarbital treatment on characteristics determining susceptibility to oxidants of homogenates, mitochondria and microsomes from rat liver
14. Spectroscopic quantitation of cytochrome P450 in human lung microsomes
15. Stoichiometry of microsomal oxidation reactions. Distribution of redox-equivalents in monooxygenase and oxidase reactions catalyzed by cytochrome P-450
16. 5
17. Uncoupling oxygen transfer and electron transfer in the oxygenation of camphor analogues by cytochrome P450cam - Direct observation of an intermolecular isotope effect for substrate C-H activation
18. 5 rules uncoupling mechanisms
19. Electron pathways in adrenal mitochondrial cytochrome P450 systems: Relative rates of leakage and hydroxylation
20. 5 on the stoichiometry of P450 2E1-catalyzed reactions
21. Ethanol-inducible cytochrome P4502E1: Regulation, enzymology and molecular biology
22. P450BM-3 and other inducible bacterial P450 cytochromes: Biochemistry and regulation
23. The dark side of dioxygen biochemistry
24. Cytotoxicity and apoptosis produced by arachidonic acid in Hep G2 cells overexpressing human cytochrome P4502E1
25. Ethanol-related cytotoxicity catalyzed by CYP2E1-dependent generation of reactive oxygen intermediates in transduced HepG2 cells
26. 5
27. 5 in modulating the partition between productive and abortive mechanisms
28. Phosphorylation of cytochrome P4502E1 (CYP2E1) by calmodulin dependent protein kinase, protein kinase C and cAMP dependent protein kinase
29. 5
30. A possible role of cAMP dependent phosphorylation of hepatic microsomal cytochrome P450: A mechanism to increase lipid peroxidation in response to hormone
31. Effect of glucagon and phorbol myristate acetate on oxidative demethylation and lipid peroxidation in isolated hepatocytes
32. Cytochrome P-450 3A4: Regulation and role in drug metabolism
33. Hormonal regulation of microsomal cytochrome P4502E1 and P450 reductase in rat liver and kidney
34. Insulin effects on CYP2E1, 2B, 3A, and 4A expression in primary cultured rat hepatocytes
35. Regulation of cytochromes P450 during inflammation and infection
36. Hepatic cytochrome P-450 expression in tumor necrosis factor-α receptor (p55/p75) knockout mice after endotoxin administration
37. Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2
38. Withdrawal of life support, altruistic suicide, fratricidal killing and euthanasia by lymphocytes: Different forms of drug-induced hepatic apoptosis
39. Cytochrome P450-generated reactive metabolites cause mitochondrial permeability transition, caspase activation and apoptosis in rat hepatocytes
40. 5
41. 5, its E44A and/or E56A mutants and cytochrome c
42. 5 and cytochrome c
43. Stoichiometry, free energy, and kinetic aspects of cytochrome c: Apaf-1 binding in apoptosis
44. 5 heme propionates in the electrostatic binding to cytochrome c
45. A conformational change in cytochrome c of apoptotic and necrotic cells is detected by monoclonal antibody binding and mimicked by association of the native antigen with synthetic phospholipid vesicles
46. Rates of diffusion-controlled reactions in one, two, and three dimensions
47. +) as a competitive inhibitor of NADPH-dependent reduction of cytochrome P450 LM2: Locating protein-protein interaction sites in microsomal electron carriers
48. Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss