Structure-activity relationship of benzo[b]thiophene-2-sulfonamide derivatives as novel human chymase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 22, 2003, Pages 4085-4088

  Masaki, Hidekazu ^a   Mizuno, Yusuke ^a   Tatui, Akira ^a   Murakami, Akira ^a   Koide, Yuuki ^a   Satoh, Shoji ^a   Takahashi, Atsuo ^a  

^a TOA EIYO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN G; CHYMASE; CHYMASE INHIBITOR; CHYMOTRYPSIN; ENZYME INHIBITOR; MWP 00965; SULFONAMIDE; THIOPHENE DERIVATIVE; TY 51076; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STABILITY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROGEN BOND; IC 50; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

EID: 0242348690     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.08.040     Document Type: Article

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