Chymase: Its pathophysiological roles and inhibitors

Current Pharmaceutical Design

Volumn 4, Issue 6, 1998, Pages 439-453

  Fukami, H ^a   Okunishi, H ^a   Miyazaki, M ^a  

^a SUNTORY LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; CHYMASE; PROTEINASE INHIBITOR;

ARTICLE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; EXTRACELLULAR MATRIX; HUMAN; INFLAMMATION; MAST CELL; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANGIOTENSIN I; ANGIOTENSIN II; ANIMALS; CARDIOVASCULAR DISEASES; CHYMASES; CYTOKINES; HUMANS; INFLAMMATION; PEPTIDYL-DIPEPTIDASE A; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031731007     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (85)

1. Yurt, R. W , Austen, K F. J. Exp. Med., 1979, 146, 1405-1419. Banno, Y.; Morris, H. P.; Katunuma, N. Eur J. Biochem., 1979, 97, 11-21. Kido, H.; Fukusen, N ; Katunuma, N. Anal. Biochem., 1984, 137, 449-453. Woodbury, R. G.; Everitt, M.; Sanada, Y.; Katunuma, N.; Lagunoff, E.; Neurath, H. Proc. Natl Acad. Sci. USA, 1987, 75, 5311-5313.
2. Yurt, R. W , Austen, K F. J. Exp. Med., 1979, 146, 1405-1419. Banno, Y.; Morris, H. P.; Katunuma, N. Eur J. Biochem., 1979, 97, 11-21. Kido, H.; Fukusen, N ; Katunuma, N. Anal. Biochem., 1984, 137, 449-453. Woodbury, R. G.; Everitt, M.; Sanada, Y.; Katunuma, N.; Lagunoff, E.; Neurath, H. Proc. Natl Acad. Sci. USA, 1987, 75, 5311-5313.
3. Yurt, R. W , Austen, K F. J. Exp. Med., 1979, 146, 1405-1419. Banno, Y.; Morris, H. P.; Katunuma, N. Eur J. Biochem., 1979, 97, 11-21. Kido, H.; Fukusen, N ; Katunuma, N. Anal. Biochem., 1984, 137, 449-453. Woodbury, R. G.; Everitt, M.; Sanada, Y.; Katunuma, N.; Lagunoff, E.; Neurath, H. Proc. Natl Acad. Sci. USA, 1987, 75, 5311-5313.
4. Yurt, R. W , Austen, K F. J. Exp. Med., 1979, 146, 1405-1419. Banno, Y.; Morris, H. P.; Katunuma, N. Eur J. Biochem., 1979, 97, 11-21. Kido, H.; Fukusen, N ; Katunuma, N. Anal. Biochem., 1984, 137, 449-453. Woodbury, R. G.; Everitt, M.; Sanada, Y.; Katunuma, N.; Lagunoff, E.; Neurath, H. Proc. Natl Acad. Sci. USA, 1987, 75, 5311-5313.
5. Katunuma, N.; Kominami, E , Kobayashi, K.; Banno, Y.; Suzuki, K ; Chichibu, K ; Hamaguchi, Y., Katsunuma, T. Eur. J. Biochem., 1975, 52, 37-50 Lagunoff, D.; Pritzl, P. Arch. Biochem. Biophys., 1976, 173, 554-563
6. Katunuma, N.; Kominami, E , Kobayashi, K.; Banno, Y.; Suzuki, K ; Chichibu, K ; Hamaguchi, Y., Katsunuma, T. Eur. J. Biochem., 1975, 52, 37-50 Lagunoff, D.; Pritzl, P. Arch. Biochem. Biophys., 1976, 173, 554-563
7. Irani, A A.; Schechter, N. M ; Craig, S S.; Deblois, G.; Schwartz, L. B. Proc. Natl. Acad. Sci. USA, 1986, 83, 4464-4468. Schwartz, L B ; Irani, A -M. A.; Roller, K.; Castells, M C.; Schechter, N M. J Immunol., 1987, 138, 2611-2615.
8. Irani, A A.; Schechter, N. M ; Craig, S S.; Deblois, G.; Schwartz, L. B. Proc. Natl. Acad. Sci. USA, 1986, 83, 4464-4468. Schwartz, L B ; Irani, A -M. A.; Roller, K.; Castells, M C.; Schechter, N M. J Immunol., 1987, 138, 2611-2615.
9. Stevens, R. L., Friend, D. S.; McNeil, H. P.; Schiller, V.; Ghildyal, N., Austen, K F. Proc. Natl Acad. Sci USA, 1994, 91, 128-132
10. Lutzelschwab, C., Pejler, G ; Aveskogh, M.; Hellman, L J. Exp. Med, 1997, 185, 13-29
11. Takai, S.; Shiota, N., Yamamoto, D ; Okunishi, H ; Miyazaki, M. Life Sciences, 1996, 58, 591-597
12. Caughey, G. H., Blount, J. L ; Koerber, K. L ; Kitamura, M ; Fang, K C. J. Immunology, 1997, 159, 4367-4375.
13. Takai, S ; Shiota, N.; Kobayashi, S , Matsumura, E.; Miyazaki, M. FEBS Lett , 1997, 412, 86-90
14. Urata, H.; Boehm, K D ; Philip, A.; Kinoshita, A ; Gabrovsek, J , Bumpus, F. M ; Husain, A. J. Clin Invest., 1993, 91, 1269-1281
15. Chandrasekharan, U. M.; Sanker, S.; Glynias, M. J , Karnik, S. S.; Husain, A. Science, 1996, 271, 502-505.
16. Urata, H.; Kinoshita, A.; Misono, K. S.; Bumpus, F. M.; Husain, A. J. Biol. Chem , 1990, 265, 22348-22357.
17. Urata, H ; Kinoshita, A , Perez, D M ; Misono, K. S ; Bumpus, F. M.; Graham, R. M.; Husain, A J. Biol. Chem., 1991, 266, 17173-17179.
18. Caughey, G. H , Zerweck, E. H ; Vanderslice, P J. Biol. Chem., 1991, 260, 12956-12963.
19. Okunishi, H.; Miyazaki, M.; Toda, N. J. Hypertens., 1984, 2, 277-284 Okunishi, H.; Miyazaki, M.; Okamura, T.; Toda, N. Biochem. Biophys. Res. Commun., 1987, 149, 1186-1192 .
20. Okunishi, H.; Miyazaki, M.; Toda, N. J. Hypertens., 1984, 2, 277-284 Okunishi, H.; Miyazaki, M.; Okamura, T.; Toda, N. Biochem. Biophys. Res. Commun., 1987, 149, 1186-1192 .
21. Sanker, S.; Chandrasekharan, U. M.; Wilk, D., Glynias, M. J.; Karnik, S. S ; Husain, A. J. Biol. Chem., 1997, 272, 2963-2968.
22. Yamamoto, D.; Shiota, N., Takai, S.; Ishida, T.; Okunishi, H., Miyazaki, M. Biochem. Biophys. Res. Commun., 1998, 242, 158-163.
23. McGrath, M E., Mirzadegan, T., Schmidt, B. F. Biochemistry, 1997, 36, 14318-14324.
24. Taipale, J.; Lohi, J.; Saarinen, J.; Kovanen, P. T.; Keski-Oja, J. J. Biol. Chem , 1995, 270, 4689-4696.
25. References in reference 16.
26. Kofford, M. W., Schwartz, L. B.; Schechter, N. M., Yager, D. R., Diegelmann, R. F.; Graham, M. F. J. Biol. Chem., 1997, 272, 7127-7131
27. J.; Saarinen, J ; Kalkkinen, N ; Welgus, H. G ; Kovanen, P. T. J. Biol. Chem., 1994, 269, 18134-18140.
28. Mizutani, H.; Schechter, N.; Lazarus, G.; Black, R. A ; Kupper, T S. J Exp Med., 1991, 174, 821-825.
29. Longley, B J.; Tyrrell, L.; Ma, Y ; Williams, D. A.; Halaban, R ; Langley, K.; Lu, H S.; Schechter, N. M. Proc. Natl. Acad Sci USA, 1997, 94, 9017-9021
30. Le Trong, H.; Neurath, H.; Woodbury, R. G. Proc. Natl. Acad. Sci. USA, 1987, 84, 364-367.
31. Kovanen, P. T. Eur. Heart J , 1993, 14 (Supplement K), 105-117 Kokkonen, J. O ; Lindstedt, K. A., Kovanen, P. T. In M C Proteases in Immunology and Biology; Caughey, G H , Ed.; Marcel Dekker, Inc : New York, 1995, pp. 257-287.
32. Kovanen, P. T. Eur. Heart J , 1993, 14 (Supplement K), 105-117 Kokkonen, J. O ; Lindstedt, K. A., Kovanen, P. T. In M C Proteases in Immunology and Biology; Caughey, G H , Ed.; Marcel Dekker, Inc : New York, 1995, pp. 257-287.
33. Kido, H ; Katunuma, N. In MC Proteases in Immunology and Biology; Caughey, G. H., Ed ; Marcel Dekker, Inc.: New York, 1995, pp. 231-255.
34. Li, Y ; Stechschulte, A. C.; Smith, D. D.; Lindsley, H. B.; Stechschulte, D. J.; Dileepan, K. N. J. Leukoc. Biol., 1997, 62, 210-216
35. Banovac, K , Banovac, F , Yang, J.; Koren, E. Proc. Soc Exp. Bio. Med., 1993, 203, 221-235.
36. Forrester, J. S ; Fishbein, M.; Helfant, R ; Fagin, J. J. Am Coll. Cardiol , 1991, 17, 758-769
37. Rakugi, H ; Krieger, J.; Wang, D S.; Dzau, V. J.; Pratt, R E Circulation, 1991, 84, II-113 (abstract).
38. Powell, J. S , Clozel, J -P ; Müller, R. K M.; Kuhn, H., Hefti, F.; Hosang, M., Baumgartner, H. R. Science, 1991, 245, 186-188 Osterrieder, W.; Muller, R K. M , Powell, J S.; Clozel, J.-P.; Hefti, F ; Baumgartner, H R. Hypertension, 1991, 18 (Suppl. II), II-60-II-64.
39. Powell, J. S , Clozel, J -P ; Müller, R. K M.; Kuhn, H., Hefti, F.; Hosang, M., Baumgartner, H. R. Science, 1991, 245, 186-188 Osterrieder, W.; Muller, R K. M , Powell, J S.; Clozel, J.-P.; Hefti, F ; Baumgartner, H R. Hypertension, 1991, 18 (Suppl. II), II-60-II-64.
40. MERCATOR Study Group. Circulation, 1992, 86, 100-110. Hanson, S. R.; Powell, J S ; Dodson, T.; Lumsden, A.; Kelly, A. B.; Anderson, J. S ; Clowes, A. W.; Harker, L A. Hypertension, 1991, 18 (Suppl. II), II-70-II-76. Lam, J. Y. T.; Lacoste, L.; Bourass, M. G Circulation, 1992, 85, 1542-1547.
41. MERCATOR Study Group. Circulation, 1992, 86, 100-110. Hanson, S. R.; Powell, J S ; Dodson, T.; Lumsden, A.; Kelly, A. B.; Anderson, J. S ; Clowes, A. W.; Harker, L A. Hypertension, 1991, 18 (Suppl. II), II-70-II-76. Lam, J. Y. T.; Lacoste, L.; Bourass, M. G Circulation, 1992, 85, 1542-1547.
42. MERCATOR Study Group. Circulation, 1992, 86, 100-110. Hanson, S. R.; Powell, J S ; Dodson, T.; Lumsden, A.; Kelly, A. B.; Anderson, J. S ; Clowes, A. W.; Harker, L A. Hypertension, 1991, 18 (Suppl. II), II-70-II-76. Lam, J. Y. T.; Lacoste, L.; Bourass, M. G Circulation, 1992, 85, 1542-1547.
43. Shiota, N ; Okunishi, H.; Fukamizu, A ; Sakonjo, H.; Kikumori, M , Nishimura, T.; Nakagawa, T.; Murakami, K ; Miyazaki, M. FEBS Lett., 1993, 323, 239-242
44. Okunishi, H.; Shiota, N ; Fukamizu, A ; Takai, S ; Murakami, K.; Miyazaki, M. J. Hypertens, 1994, 12 (Suppl. 3), S132.
45. Stunder, R ; Reinecke, H.; Müllar, B.; Holtz, J.; Just, H.; Drexler, H J Clin. Invest., 1994, 94, 301-310.
46. Urata, H ; Healy, B ; Stewart, R. W.; Bumpus, F. M ; Husain, A. Circ. Res., 1990, 66, 883-890
47. Shiota, N.; Fukamizu, A.; Takai, S.; Okunishi, H.; Murakami, K , Miyazaki, M J Hypertens., 1997, 15, 431-440.
48. Shiota, N.; Jin, D.; Takai, S.; Kawamura, T.; Koyama, M., Nakamura, N , Miyazaki, M. FEBS Lett., 1997, 406, 301-304.
49. Buja, L. M.; Willerson, J. T. Circulation, 1994, 89, 503-505.
50. Ross, R. Nature, 1993, 362, 801-809.
51. Kaartinen, M.; Penttila, A., Kovanen, P T. Circulation, 1994, 90, 1669-1678.
52. Kovanen, P T.; Kaartinen, M.; Paavonen, T. Circulation, 1995, 92, 1084-1088.
53. Chobanian, A. V. Clin. Cardiol., 1990, 13, (Suppl 7), 43-48. Fennessy, P. A.; Campbell, J. H ; Campbell, G. R. Clin. Sci. Colch , 1994, 87, 685-691.
54. Chobanian, A. V. Clin. Cardiol., 1990, 13, (Suppl 7), 43-48. Fennessy, P. A.; Campbell, J. H ; Campbell, G. R. Clin. Sci. Colch , 1994, 87, 685-691.
55. Miyazaki, M.; Sakonjo, H.; Takai, S ; Shiota, N. J. Hypertens., 1996, 14 (Suppl. 1), S138.
56. Gotis-Graham, I., McNeil, H. P. Arthritis Rheum , 1997, 40, 479-489.
57. DeMora, F.; García, G.; Puigdemont, A Arboix, M.; Ferrer, L Inflamm. Res., 1996, 45, 424-427
58. Mao, X. Q.; Shirakawa, T.; Yoshikawa, T.; Yoshikawa, K ; Kawai, M.; Sasaki, S.; Enomoto, T.; Hashimioto, T.; Furuyama, J. Lancet, 1996, 348, 581-583.
59. Barrett, A. J In Proteinase Inhibitors, Barrett, A. J.; Salvesen, G , Eds; Elsevier Science B. V : Amsterdam, 1986, pp. 3-9.
60. Burchardi, H ; Stokke, T.; Hensel, I.; Koestering, H ; Rahlf, G.; Schlag, G ; Heine, H.; Horl, W. H. Adv Exp. Med Biol , 1984, 167, 319-333.
61. Powers, J. C.; Harper, J. W. In Proteinase Inhibitors; Barrett, A. J., Salvesen, G., Eds; Elsevier Science B V : Amsterdam, 1986, pp. 55-152.
62. Oleksyszyn, J., Powers, J. C. In Methods in Enzymology; Barrett, A. J., Ed.; Academic Press.:, 1994, Vol. 244, pp. 423-441.
63. Tapparelli, C ; Metternich, R ; Ehrhardt, C.; Cook, N S Trend in Pharm Science, 1993, 14, 366-376.
64. Nagahara, T ; Yokoyama, Y ; Inamura, K., Katakura, S , Komiyama, S ; Yamaguchi, H.; Hara, T ; Iwamoto, M. J Med Chem , 1994, 37, 1200-1207.
65. Umezawa, H ; Aoyagi, T., Morishima, H., Kunimoto, S ; Matsuzaki, M.; Hamada, M ; Takeuchi, T. J. Antibiot., 1970, 25, 267-270.
66. Powers, J. C., Tanaka, T ; Harper, J. W ; Minematsu, Y.; Barker, L ; Lincoln, D., Crumley, K. V ; Fraki, J E., Schechter, N. M ; Lazarus, G. G.; Nakajima, K., Nakashino, K., Neurath, H ; Woodbury, R. G. Biochemistry, 1985, 24, 2048-2058.
67. Kato, Y., Kido, H., Fukusen, N.; Katunuma, N. J Biochem , 1988, 103, 820-822 .
68. Oleksyszyn, J.; Powers, J C Biochemistry, 1991, 30, 485-493
69. Hof, P.; Mayr, I.; Huber, R ; Korzus, E.; Potempa, J., Travis, J.; Powers, J. C ; Bode, W. EMBO J., 1996, 15, 5481-5491.
70. Hoover, D. J. WO 93/25574, 1993.
71. Bastos, M., Maeji, N. J.; Abeles, R. H. Proc. Natl. Acad Sci. USA, 1995, 92, 6738-6742.
72. Eda, M.; Ashimori, A ; Akahoshi, F ; Yoshimura, T.; Inoue, Y ; Fukaya, C ; Nakajima, M.; Fukuyama, H.; Imada, T., Nakamura, N. Bioorg. Med. Chem. Lett., 1998, 8, 913-918. Eda, M.; Ashimori, A ; Akahoshi, F.; Yoshimura, T ; Inoue, Y., Fukaya, C ; Nakajima, M.; Fukuyama, H , Imada, T.; Nakamura, N Bioorg Med Chem Lett , 1998, 8, 919-924.
73. Eda, M.; Ashimori, A ; Akahoshi, F ; Yoshimura, T.; Inoue, Y ; Fukaya, C ; Nakajima, M.; Fukuyama, H.; Imada, T., Nakamura, N. Bioorg. Med. Chem. Lett., 1998, 8, 913-918. Eda, M.; Ashimori, A ; Akahoshi, F.; Yoshimura, T ; Inoue, Y., Fukaya, C ; Nakajima, M.; Fukuyama, H , Imada, T.; Nakamura, N Bioorg Med Chem Lett , 1998, 8, 919-924.
74. Akahoshi, F., Yoshimura, T ; Eda, M.; Ashimori, A ; Fukuyama, H.; Nakajima, M., Imada, M.; Okunishi, H ; Miyazaki, M. WO 96/33974, 1996
75. Andisik, D ; Bernstein, P.; Brown, F.; Bryant, C.; Ceccarelli, C.; Damewood, J.; Edwards, P.; Feeney, S.; Gomes, B.; Green, R.; Kosmider, B., Shaw, A , Steelman, G., Thomas, R ; Tuthill, P.; Vacek, E.; Veale, C , Warner, P., Williams, J., Wolanin, D.; Woolson, S. In Proceedings, XIVth International Symposium on Medicinal Chemistry, Awouters, F , Ed., Elsevier Science B. V.: Amsterdam, 1997, pp. 499-508.
76. Akahoshi, F., Takeuchi, M.; Yoshimura, T.; Eda, M.; Ashimori, A ; Fukuyama, H., Nakajima, M ; Imada, M ; Okunishi, H.; Miyazaki, M Japan Patent 98-7661, 1998
77. Akabane, A.; Takenaka, K ; Itani, H., Sato, A.; Nakanishi, I. Japan Patent 98-53579, 1998.
78. Zimmerman, M ; Morman, H.; Mulvey, D.; Jones, H.; Frankshun, R.; Ashe. B M J Biol. Chem., 1980, 255, 9848-9851.
79. Harper, J. D ; Powers, J. C. Biochemistry, 1985, 24, 7200-7213.
80. Kouno, K.; Akiba, K ; Toyohuku, H., Agata, M.; Ohmura, T.; Maeda, W Japan Patent 96-208654, 1996
81. Nishitani, Y.; Nakajima, M.; Uenaka, M.; Ku, M. Japan Patent 98-87493, 1998.
82. Ito, K ; Igarashi, K ; Muramatsu, M.; Harada, T ; Hayashi, Y.; Katada, J ; Uno. I Biochem. Biophys Res. Comm., 1997, 240, 850-855.
83. Niwata, S , Fukami, H ; Sumida, M ; Ito, A.; Kakutani, S.; Saitoh, M ; Suzuki, K ; Imoto, M.; Shibata, H ; Imajo, S.; Kiso, Y.; Tanaka, T.; Nakazato, H.; Ishihara, T ; Takai, S.; Yamamoto, D.; Shiota, N., Miyazaki, M.; Okunishi, H.; Kinoshita, A.; Urata, H ; Arakawa, K. J. Med. Chem., 1997, 40, 2156-2163.
84. Groutas, W. C ; Houser-Archield, N ; Choug, L. S.; Venkataraman, R.; Epp, J. B.; Huang, H , McClenahan, J. J. J. Med. Chem , 1993, 36, 3178-3181.
85. Fukami, H ; Ho, A ; Niwata, S.; Kakutani, S ; Sumida, M.; Kiso, Y. EP 0795548, 1997