Protective effects of probucol treatment on pancreatic β-cell function of SZ-induced diabetic APA hamsters

Experimental Animals

Volumn 52, Issue 4, 2003, Pages 317-327

  Takatori, Atsushi ^a   Ohta, Etsuko ^a   Inenaga, Toshiaki ^a   Horiuchi, Keiko ^a   Ishii, Yoshiyuki ^a   Itagaki, Shin Ichi ^a   Kyuwa, Shigeru ^a   Yoshikawa, Yasuhiro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

APA hamsters; Diabetes mellitus; Oxidative stress; Pancreatic islets; Probucol

Indexed keywords

4 HYDROXYNONENAL; ANTILIPEMIC AGENT; ANTIOXIDANT; CYCLINE; GLUCOSE; INSULIN; PROBUCOL; PROTEIN; 4-HYDROXY-2-NONENAL; ALDEHYDE; BIOLOGICAL MARKER; HYPOCHOLESTEROLEMIC AGENT; STREPTOZOCIN;

ACUTE DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL PROTECTION; CHRONIC DISEASE; CONTROLLED STUDY; DATA ANALYSIS; DIABETES MELLITUS; DIET; DRUG MECHANISM; GENE EXPRESSION; GLUCOSE TOLERANCE TEST; HAMSTER; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PANCREAS ISLET DISEASE; PATHOGENESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOZOCIN DIABETES; ANIMAL; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; PANCREAS ISLET; PATHOPHYSIOLOGY; SYRIAN HAMSTER;

ANIMALIA; CRICETINAE;

ALDEHYDES; ANIMALS; ANTICHOLESTEREMIC AGENTS; ANTIOXIDANTS; BIOLOGICAL MARKERS; CRICETINAE; DIABETES MELLITUS, EXPERIMENTAL; ISLETS OF LANGERHANS; MALE; MESOCRICETUS; OXIDATIVE STRESS; PROBUCOL; PROLIFERATING CELL NUCLEAR ANTIGEN; STREPTOZOCIN;

EID: 0242303195     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.52.317     Document Type: Article

References (51)

1. Abe, M., Nata, K., Akiyama, T., Shervani, N.J., Kobayashi, S., Tomioka-Kumagai, T., Ito, S., Takasawa, S., and Okamoto, H. 2000. Identification of a novel Reg family gene, Reg IIIdelta, and mapping of all three types of Reg family gene in a 75 kilobase mouse genomic region. Gene 246: 111-122.
2. Anastasi, E., Ponte, E., Gradini, R., Bulotta, A., Sale, P., Tiberti, C., Okamoto, H., Dotta, F., and Mario, U.D. 1999. Expression of Reg and cytokeratin 20 during ductal cell differentiation and proliferation in a mouse model of autoimmune diabetes. Eur. J. Endocrinol. 141: 644-652.
3. Arbeeny, C.M., Meyers, D.S., Bergquist, K.E., and Gregg, R.E. 1992. Inhibition of fatty acid synthesis decreases very low density lipoprotein secretion in the hamster. J. Lipid Res. 33: 843-851.
4. Arison, R.N., Ciaccio, E.I., Glitzer, M.S., Cassaro, J.A., and Pruss, M.P. 1967. Light and electron microscopy of lesions in rats rendered diabetic with streptozotocin. Diabetes 16: 51-56.
5. Baetens, D., Stefan, Y., Ravazzola, M., Malaisse-Lagae, F., Coleman, D.L., and Orci, L. 1978. Alteration of islet cell populations in spontaneously diabetic mice. Diabetes 27: 1-7.
6. Baynes, J.W. 1991. Role of oxidative stress in development of complications in diabetes. Diabetes 40: 405-412.
7. Bone, A.J., Banister, S.H., and Zhang, S. 1994. Islet cell defence and repair mechanisms in insulin-dependent diabetes: a role for the pancreatic regenerating (Reg) gene? Biochem. Soc. Trans. 22: 37-41.
8. Bonner-Weir, S., Baxter, L.A., Schuppin, G.T., and Smith, F.E. 1993. A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes 42: 1715-1720.
9. Brosky, G. and Logothetopoulos, J. 1969. Streptozotocin diabetes in the mouse and guinea pig. Diabetes 18: 606-611.
10. Fukuda, M., Ikegami, H., Kawaguchi, Y., Sano, T., and Ogihara, T. 1995. Antioxidant, probucol, can inhibit the generation of hydrogen peroxide in islet cells induced by macrophages and prevent islet cell destruction in NOD mice. Biochem. Biophys. Res. Commun. 209: 953-958.
11. Gorogawa, S., Kajimoto, Y., Umayahara, Y., Kaneto, H., Watada, H., Kuroda, A., Kawamori, D., Yasuda, T., Matsuhisa, M., Yamasaki, Y., and Hori, M. 2002. Probucol preserves pancreatic beta-cell function through reduction of oxidative stress in type 2 diabetes. Diabetes Res. Clin. Pract. 57: 1-10.
12. Gurr, W., Yavari, R., Wen, L., Shaw, M., Mora, C., Christa, L., and Sherwin, R.S. 2002. A Reg family protein is overexpressed in islets from a patient with new-onset type 1 diabetes and acts as T-cell autoantigen in NOD mice. Diabetes 51: 339-346.
13. Han, J.-S., Norimatsu, M., Sugawara, Y., Doi, K., Shimura, K., Akai, H., Aikawa, T., and Tamura, K. 1990. Acute toxicity of streptozotocin in Syrian hamsters of the APA strain. J. Toxicol. Pathol. 3: 189-199.
14. Horiuchi, K., Takatori, A., Inenaga, T., Ohta, E., Yamanouchi, J., Kawamura, S., Ishii, Y., Kyuwa, S., and Yoshikawa, Y. 2002. The effect of probucol on atherosclerosis in streptozotocin-induced diabetic-hyperlipidemic APA hamsters in different stages of atherosclerosis. Exp. Anim. 51: 457-464.
15. Ihara, Y., Toyokuni, S., Uchida, K., Odaka, H., Tanaka, T., Ikeda, H., Hiai, H., Seino, Y., and Yamada, Y. 1999. Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes. Diabetes 48: 927-932.
16. Inenaga, T., Nishida, E., Kawamura, S., and Yoshikawa, Y. 2002. Renal function tests on diabetes-induced and non-induced APA hamsters. Exp. Anim. 51: 437-445.
17. Kaneto, H., Kajimoto, Y., Miyagawa, J., Matsuoka, T., Fujitani, Y., Umayahara, Y., Hanafusa, T., Matsuzawa, Y., Yamasaki, Y., and Hori, M. 1999. Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity. Diabetes 48: 2398-2406.
18. Karasu, C. 1998. Acute probucol treatment partially restores vasomotor activity and abnormal lipid metabolism whereas morphological changes are not affected in aorta from long-term STZ-diabetic rats. Exp. Clin. Endocrinol. Diabetes 106: 189-196.
19. Kaul, N., Siveski-Iliskovic, N., Thomas, T.P., Hill, M., Khaper, N., and Singal, P.K. 1995. Probucol improves antioxidant activity and modulates development of diabetic cardiomyopathy. Nutrition 11: 551-554.
20. Lenzen, S., Drinkgern, J., and Tiedge, M. 1996. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic. Biol. Med. 20: 463-466.
21. Ma, P.T.S., Gil, G., Sudhof, T.C., Bilheimer, D.W., Goldstein, J.L., and Brown, M.S. 1986. Mevinolin, an inhibitor of cholesteryl synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits. Proc. Natl. Acad. Sci. USA 83: 8370-8374.
22. Narushima, Y., Unno, M., Nakagawara, K., Mori, M., Miyashita, H., Suzuki, Y., Noguchi, N., Takasawa, S., Kumagai, T., Yonekura, H., and Okamoto, H. 1997. Structure, chromosomal localization and expression of mouse genes encoding type III Reg, RegIII alpha, RegIII beta, RegIII gamma, Gene 185: 159-168.
23. Nishida, E., Yamanouchi, J., Ogata, S., Doi, K., and Itagaki, S. 1997. Modification of spontaneous renal lesion of APA hamsters by streptozotocin-induced diabetes. Int. J. Exp. Pathol. 78: 169-176.
24. Ohno, T., Ishii, C., Kato, N., Ito, Y., Shimizu, M., Tomono, S., Murata, K., and Kawazu, S. 1995. Increased expression of a regenerating (reg) gene protein in neonatal rat pancreas treated with streptozotocin. Endocr. J. 42: 649-653.
25. Parthasarathy, S., Young, S.G., Witztum, J.L., Pittman, R.C., and Steinberg, D. 1986. Probucol inhibits oxidative modification of low density lipoprotein. J. Clin. Invest. 77: 641-644.
26. Phares, C.K. 1980. Streptozotocin-induced diabetes in Syrian hamsters: new model of diabetes mellitus. Experientia 36: 681-682.
27. Pitkin, R.M. and Reynolds, W.A. 1970. Diabetogenic effects of streptozotocin in rhesus monkeys. Diabetes 19: 85-90.
28. Quig, D.W., Arbeeny, C.M., and Zilversmit, D.B. 1991. Effects of hyperlipidemias in hamsters on lipid transfer protein activity and unidirectional cholesteryl ester transfer in plasma. Biochim. Biophys. Acta 1083: 257-264.
29. Rafaeloff, R., Barlow, S.W., Rosenberg, L., and Vinik, A.I. 1995. Expression of Reg gene in the Syrian golden hamster pancreatic islet regeneration model. Diabetologia 38: 906-913.
30. Rafaeloff, R., Pittenger, G.L., Barlow, S.W., Qin, X.F., Yan, B., Rosenberg, L., Duguid, W.P., and Vinik, A.I. 1997. Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters. J. Clin. Invest. 99: 2100-2109.
31. Rakieten, N., Gordon, B.S., Beaty, A., Cooney, D.A., Schein, P.S., and Dixon, R.L. 1976. Modification of renal tumorigenic effect of streptozotocin by nicotinamide: spontaneous reversibility of streptozotocin diabetes. Proc. Soc. Exp. Biol. Med. 151: 356-361.
32. Roche, E., Farfari, S., Witters, L.A., Assimacopoulos-Jeannet, F., Thumelin, S., Brun, T., Corkey, B.E., Saha, A.K., and Prentki, M. 1998. Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis. lipogenesis, and lipogenic gene expression. Diabetes 47: 1086-1094.
33. Rosenberg, L., Duguid, W.P., Brown, R.A., and Vinik, A.I. 1988. Induction of nesidioblastosis will reverse diabetes in Syrian golden hamster. Diabetes 37: 334-341.
34. Rosenberg, L., Rafaeloff, R., Clas, D., Kakugawa, Y., Pittenger, G., Vinik, A.I., and Duguid, W.P. 1996. Induction of islet cell differentiation and new islet formation in the hamster further support for a ductular origin. Pancreas 13: 38-46.
35. Sakuraba, H., Mizukami, H., Yagihashi, N., Wada, R., Hanyu, C., and Yagihashi, S. 2002. Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients. Diabetologia 45: 85-96.
36. Shimizu, H. Uehara, Y., Shimomura, Y., Tanaka, Y., and Kobayashi, I. 1991. Probucol attenuated hyperglycemia in multiple low-dose streptozotocin-induced diabetic mice. Life Sci. 49: 1331-1338.
37. Takatori, A., Nishida, E., Inenaga, T., Horiuchi, K., Kawamura, S., Itagaki, S., and Yoshikawa, Y. 2002. Functional and histochemical analysis on pancreatic islets of APA hamsters with SZ-induced hyperglycemia and hyperlipidemia. Exp. Anim. 51: 9-17.
38. Tanaka, Y., Gleason, C.E., Tran, P.O., Harmon, J.S., and Robertson, R.P. 1999. Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants. Proc. Natl. Acad. Sci. USA 96: 10857-10862.
39. Terazono, K., Yamamoto, H., Takasawa, S., Shiga, K., Yonemura, Y., Tochino, Y., and Okamoto, H. 1988. A novel gene activated in regenerating islets. J. Biol. Chem. 263: 2111-2114.
40. Tiedge, M., Lortz, S., Drinkgern, J., and Lenzen, S. 1997. Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes 46: 1733-1742.
41. Uehara, Y., Shimizu, H., Sato, N., Shimomura, Y., Mori, M., and Kobayashi, I. 1991. Probucol partially prevents development of diabetes in NOD mice. Diabetes Res. 17: 131-134.
42. Unger, R.H. and Grundy, S. 1985. Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes. Diabetologia 28: 119-121.
43. Unno, M., Yonekura, H., Nakagawara, K., Watanabe, T., Miyashita, H., Moriizumi, S., Okamoto, H., Itoh, T., and Teraoka, H. 1993. Structure, chromosomal localization, and expression of mouse reg genes, reg I and reg II. A novel type of reg gene, reg II, exists in the mouse genome. J. Biol. Chem. 268: 15974-15982.
44. Veleminsky, J., Burr, I.M., and Stauffacher, W. 1970. Comparative study of early metabolic events resulting from the administration of the two diabetogenic agents alloxan and streptozotocin. Eur. J. Clin. Invest. 1: 104-108.
45. Wilander, E. and Boquist, L. 1972. Streptozotocin-diabetes in the Chinese hamster. Blood glucose and structural changes during the first 24 h. Horm. Metab. Res. 4: 426-433.
46. Yamanouchi, J., Sugawara, Y., Itagaki, S., and Doi, K. 1997. Ultrastructure of atheromatous lesions experimentally induced in Syrian hamsters of the APA strain. Histol. Histopathol. 12: 433-438.
47. Yamanouchi, J., Nishida, E., Itagaki, S., Kawamura, S., Doi, K., and Yoshikawa, Y. 2000. Aortic atheromatous lesions developed in APA hamsters with streptozotocin induced diabetes: a new animal model for diabetic atherosclerosis. 1. Histopathological studies. Exp. Anim. 49: 259-266.
48. Yamanouchi, J., Takatori, A., Itagaki, S., Kawamura, S., and Yoshikawa, Y. 2000. APA hamster model for diabetic atherosclerosis. 2. Analysis of lipids and lipoproteins. Exp. Anim. 49: 267-274.
49. Yoshino, G., Matsushita, M., Maeda, E., Nagata, K., Morita, M., Matsuba, K., Tani, T., Horinuki, R., Kimura, Y., and Kazumi, T. 1991. Effect of probucol on triglyceride turnover in streptozotocin-diabetic rats. Atherosclerosis 88: 69-75.
50. Yoshino, G., Matsushita, M., Maeda, E., Morita, M., Nagata, K., Matsuba, K., Tani, T., Horinuki, R., Kimura, Y., and Kazumi, T, 1992. Effect of probucol on recovery from streptozotocin diabetes in rats. Horm. Metab. Res. 24: 306-309.
51. Zenilman, M.E., Perfetti, R., Swinson, K., Magnuson, T., and Shuldiner, A.R. 1996. Pancreatic regeneration (reg) gene expression in a rat model of islet hyperplasia. Surgery 119: 576-584.