Identification of a novel Reg family gene, Reg IIIδ, and mapping of all three types of Reg family gene in a 75 kilobase mouse genomic region

Gene

Volumn 246, Issue 1-2, 2000, Pages 111-122

  Abe, Michiaki ^a   Nata, Koji ^a   Akiyama, Takako ^a   Shervani, Nausheen J ^a   Kobayashi, Seiichi ^a   Tomioka Kumagai, Tomoko ^a   Ito, Sadayoshi ^a   Takasawa, Shin ^a   Okamoto, Hiroshi ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Bacterial artificial chromosome; Cloning; Gene cluster; Multigene family; Nucleotide sequence; Pancreas

Indexed keywords

COMPLEMENTARY DNA;

ARTICLE; COLON; CONTROLLED STUDY; DNA LIBRARY; EXON; GENE CLUSTER; GENE EXPRESSION; GENE ISOLATION; GENE MAPPING; GENOME; INTESTINE; MOLECULAR CLONING; MOUSE; MULTIGENE FAMILY; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN STRUCTURE; SOUTHERN BLOTTING;

ANIMALS; BLOTTING, NORTHERN; CALCIUM-BINDING PROTEINS; CHROMOSOME MAPPING; CRICETINAE; DNA; DNA, COMPLEMENTARY; EVOLUTION, MOLECULAR; EXONS; GENE EXPRESSION; GENES; HUMANS; INTRONS; LITHOSTATHINE; MALE; MESOCRICETUS; MICE; MICE, INBRED C57BL; MULTIGENE FAMILY; NERVE TISSUE PROTEINS; PHYLOGENY; PROTEINS; RATS; RNA; SEQUENCE ANALYSIS, DNA; TISSUE DISTRIBUTION; TRANSCRIPTION, GENETIC;

BACTERIA (MICROORGANISMS); MAMMALIA; RODENTIA;

EID: 0034603809     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(00)00059-7     Document Type: Article

References (28)

1. Dusetti N.J., Frigerio J.M., Szpirer C., Dagorn J.C., Iovanna J.L. Cloning, expression and chromosomal localization of the rat pancreatitis-associated protein III gene. Biochem. J. 307:1995;9-16.
2. Dusetti N.J., Ortiz E.M., Mallo G.V., Dagorn J.C., Iovanna J.L. Pancreatitis-associated protein I (PAP I), an acute phase protein induced by cytokines. Identification of two functional interleukin-6 response elements in the rat PAP I promoter region. J. Biol. Chem. 270:1995;22 417-22 421.
3. Frigerio J.M., Dusetti N.J., Garrido P., Dagorn J.C., Iovanna J.L. The pancreatitis associated protein III (PAP III), a new member of the PAP gene family. Biochim. Biophys. Acta. 1216:1993;329-331.
4. Frigerio J.M., Dusetti N.J., Keim V., Dagorn J.C., Iovanna J.L. Identification of a second rat pancreatitis-associated protein. Messenger RNA cloning, gene structure and expression during acute pancreatitis. Biochemistry. 32:1993;9236-9241.
5. Gross D.J., Weiss L., Reibstein I., van DenBrand J., Okamoto H., Clark A., Slavin S. Amelioration of diabetes in nonobese diabetic mice with advanced disease by linomide-induced immunoregulation combined with Reg protein treatment. Endocrinology. 139:1998;2369-2374.
6. Ingraham H.A., Chen R., Mangalam H.J., Elsholtz H.P., Flynn S.E., Lin C.R., Simmons D.M., Swanson L., Rosenfeld M.G. A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype. Cell. 55:1988;519-529.
7. Iovanna J., Orelle B., Keim V., Dagorn J.C. Messenger RNA sequence and expression of rat pancreatitis-associated protein, a lectin-related protein overexpressed during acute experimental pancreatitis. J. Biol. Chem. 266:1991;24 664-24 669.
8. Katsumata N., Chakrabory C., Myal Y., Schroedter I.C., Murphy L.J., Shiu R.P.C., Friesen H.G. Molecular cloning and expression of peptide 23, a growth hormone-releasing hormone-inducible pituitary protein. Endocrinology. 136:1995;1332-1339.
9. Lasserre C., Christa L., Simon M.T., Vernier P., Bréchot C. A novel gene (HIP) activated in human primary liver cancer. Cancer Res. 52:1992;5089-5095.
10. Meister A., Weinrich S.L., Nelson C., Rutter W.J. The Chymotrypsin enhancer core, specific factor binding and biological activity. J. Biol. Chem. 264:1989;20 744-20 751.
11. Miyashita H., Yonekura H., Unno M., Suzuki Y., Watanabe T., Moriizumi S., Takasawa S., Okamoto H. Characterization of the 5′-regulatory region of rat Reg I gene. Biochim. Biophys. Acta. 1219:1994;241-243.
12. Miyashita H., Nakagawara K., Mori M., Narushima Y., Noguchi N., Moriizumi S., Takasawa S., Yonekura H., Takeuchi T., Okamoto H. Human REG family genes are tandemly ordered in a 95-kilobase region of chromosome 2p12. FEBS Lett. 377:1995;429-433.
13. Moriizumi S., Watanabe T., Unno M., Nakagawara K., Suzuki Y., Miyashita H., Yonekura H., Okamoto H. Isolation, structural determination and expression of a novel reg gene, human reg Iβ Biochim. Biophys. Acta. 1217:1994;199-202.
14. Nata K., Takamura T., Karasawa T., Kumagai T., Hashioka W., Tohgo A., Yonekura H., Takasawa S., Nakamura S., Okamoto H. Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing. Gene. 186:1997;285-292.
15. Narushima Y., Unno M., Nakagawara K., Mori M., Miyashita H., Suzuki Y., Noguchi N., Takasawa S., Kumagai T., Yonekura H., Okamoto H. Structure, chromosomal localization and expression of mouse genes encoding type III Reg, Reg IIIα, Reg IIIβ, Reg IIIγ Gene. 185:1997;159-168.
16. Orelle B., Keim V., Masciotra L., Dagorn J.C., Iovanna J.L. Human pancreatitis-associated protein, messenger RNA cloning and expression in pancreatic diseases. J. Clin. Invest. 90:1992;2284-2291.
17. Rafaeloff R., Pittenger G.L., Barlow S.W., Qin X.Q., Yan B., Rosenberg L., Duguid W.P., Vinik A.I. Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters. J. Clin. Invest. 99:1997;2100-2109.
18. Suzuki Y., Yonekura H., Watanabe T., Unno M., Moriizumi S., Miyashita H., Okamoto H. Structure and expression of a novel rat Reg III gene. Gene. 144:1994;315-316.
19. Terazono K., Yamamoto H., Takasawa S., Shiga K., Yonemura Y., Tochino Y., Okamoto H. A novel gene activated in regenerating islets. J. Biol. Chem. 263:1988;2111-2114.
20. Terazono K., Watanabe T., Yonekura Y. A novel gene reg expressed in regenerating islets, Okamoto H. Molecular Biology of the Islets of Langerhans. 1990;301-313 Cambridge University Press, Cambridge.
21. Terazono K., Uchiyama Y., Ide M., Watanabe T., Yonekura H., Yamamoto H., Okamoto H. Expression of reg protein in rat regenerating islets and its co-localization with insulin in the beta cell secretory granules. Diabetlogia. 33:1990;250-252.
22. Unno M., Yonekura H., Nakagawara K., Watanabe T., Miyashita H., Moriizumi S., Okamoto H., Itoh T., Teraoka H. Structure, chromosomal localization and expression of mouse reg genes, reg I and reg II. A novel type of reg gene, reg II, exists in the mouse genome. J. Biol. Chem. 268:1993;15 974-15 982.
23. Vasseur S., Frigerio J.M., Dusetti N.J., Keim V., Dagorn J.C., Iovanna J.L. Two transcripts are generated from the pancreatitis associated protein II gene by alternative splicing in the 5′ untranslated region. Biochim. Biophys. Acta. 1261:1995;272-274.
24. Watanabe T., Yonekura H., Terazono K., Yamamoto H., Okamoto H. Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. J. Biol. Chem. 265:1990;7432-7439.
25. Watanabe T., Yonemura Y., Yonekura H., Suzuki Y., Miyashita H., Sugiyama K., Moriizumi S., Unno M., Tanaka O., Kondo H., Bone A.J., Takasawa S., Okamoto H. Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein. Proc. Natl. Acad. Sci. U. S. A. 91:1994;3589-3592.
26. Yonekura H., Unno M., Watanabe T., Moriizumi S., Suzuki Y., Miyashita H., Yonemura Y., Sugiyama K., Okamoto H. Structure and expression of reg gene family in pancreatic islets. Flatt P.R., Lenzan S. Frontiers of Insulin Secretion and Pancreatic B-Cell Research. 1994;581-588 Smith-Gordon, London.
27. Yonemura Y., Takashima T., Miwa K., Miyazaki I., Yamamoto H., Okamoto H. Amelioration of diabetes mellitus in partially depancreatized rats by poly (ADP-ribose) synthetase inhibitors. Evidence of islet B-cell regeneration. Diabetes. 33:1984;401-404.
28. Zenilman M.E., Magnuson T.H., Swinson K., Egan J., Perfetti R., Shuldiner A.R. Pancreatic thread protein is mitogenic to pancreatic-derived cells in culture. Gastroenterology. 110:1996;1208-1214.