Progress in Xenotransplantation Research Employing Transgenic Pigs

Transplantationsmedizin: Organ der Deutschen Transplantationsgesellschaft

Volumn 15, Issue 1, 2003, Pages 3-14

  Niemann, Heiner ^a   Kues, W A ^a  

^a INSTITUT FÜR TIERZUCHT   (Germany)

Author keywords

Microinjection; Nuclear transfer; Transgenic pigs; Xenotransplantation

Indexed keywords

COMPLEMENT; GALACTOSYLTRANSFERASE; N ACETYLLACTOSAMINIDE ALPHA 1,3 GALACTOSYLTRANSFERASE; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; DNA TRANSFER; DONOR; GENE DELETION; HOMOLOGOUS RECOMBINATION; HYPERACUTE GRAFT REJECTION; MICROINJECTION; NONHUMAN; PROTEIN EXPRESSION; REVIEW; SOMATIC CELL; SWINE; TRANSGENIC ANIMAL; TRANSGENICS; XENOGRAFT; XENOTRANSPLANTATION;

EID: 0142260598     PISSN: 09469648     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (68)

1. Pursel VG, Rexroad CE Jr (1993) Status of research with transgenic farm animals. J Anim Sci 71: 10-19
2. Wall RJ (1996) Transgenic livestock: Progress and prospects for the future. Theriogenology 45: 57-68
3. Seidel GE Jr (1993) Resource requirements for transgenic livestock research. J Anim Sci 71: 26-33
4. Wall RJ, Hawk HW, Nel N (1992) Making transgenic livestock: Genetic engineering on a large scale. J Cell Biochem 49: 113-120
5. Rexroad CE Jr (1992) Transgenic technology in animal agriculture. Anim Biotech 3: 1-13
6. th World Congress 'Genetics Applied to Livestock Production', Guelph (Canada), Vol 21: pp 339-346
7. Murray JD (1999) Genetic modification of animals in the next century. Theriogenology 51: 149-159
8. nd Edition. pp. 337-357). San Diego, USA: Academic Press
9. Niemann H, Kues WA (2000) Transgenic livestock: premises and promises. Anim Reprod Sci 60-61: 277-293
10. Niemann H, Kues WA (2003) Application of transgenesis in livestock for agriculture and biomedicine. Anim. Reprod Sci (in press)
11. Michler RE (1996) Xenotransplantation: Risks and prospects. Xeno 4: 21-26
12. Petit-Zeman S (2001) Regenerative medicine. Nature Biotech 19: 201-206
13. Bach FH (1998) Xenotransplantation: Problems and prospects. Ann Rev Mol 49: 301-310
14. Platt JL, Lin SS (1998) The future promises of xenotransplantation. In: Fishman J, Sachs D, Shaikh R (Eds.) Xenotransplantation - Scientific frontiers and public policy. Annals of the New York Academy of Sciences 862: 5-18
15. Patience C, Takeuchi Y, Weiss RA (1997) Infection of human cells by an endogenous retrovirus of pigs. Nature Med 3: 282-286
16. Paradis K, Langford G, Long Z, Heneine W. Sandstrom P, Switzer WM et al. (1999) Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue. Science 285: 1236-1241
17. Patience C, Patton GS, Takeuchi Y, Weiss RA, McClure MO, Rydberg L (1998) No evidence of pig DNA of retroviral infection in patients with short-term extracorporal connection of pig kidneys. The Lancet 352: 699-701
18. Dinsmore LE, Manhardt C, Rameri R, Jacoby DB, Moore A (2000) No evidence for infection of human cells with porcine endogenous retrovirus (PERV) after exposure to porcine fetal neuronal cells. Transplantation 71: 132-142
19. Switzer WM, Michler RE, Shanmugan V, Matthews A, Hussain AI, Wright A, et al. (2001) Lack of cross-species transmission of porcine endogenous retrovirus infection to nonhuman primate recipients of porcine cells, tissues and organs. Transplantation 71: 959-965
20. Martin U, Tacke SJ, Simon A, Schröder C, Wiebe K, Lapin B et al. (2002) Absence of PERV specific humoral immune response in baboons after transplantation of porcine cells of organs. Transplantation Int 15: 361-368
21. Oldmixon BA, Wood JC, Ericcson TA, Wilson CA, White-Scharf ME, Andersson G et al. (2002) Porcine endogenous retrovirus transmission characteristics of an inbred herd of miniature swine. J Virology 76: 3045-3048
22. White D (1996) Alteration of complement activity: a strategy for xenotransplantation. TIB 14: 3-5
23. Cozzi E, White DJ (1995) The generation of transgenic pigs as potential organ donors for humans. Nature Med 1: 964-966
24. White D (1996) hDAF transgenic pig organs: are they concordant for human transplantation? Xeno 4: 50-54
25. Bach FH, Ferran C, Soares M, Wrighton CJ, Anrather J, Winkler H et al. (1997) Modification of vascular responses in xenotransplantation: Inflammation and apoptosis. Nature Med 3: 944-948
26. Cozzi E, Masroar S, Soni B, Vial C, White DJ (2000) Progress in xenotransplantation. Clin Neprol 53: 13-18
27. Diamond LE, Quinn CM, Martin MJ, Lawson J, Platt JL, Logan JS (2001) A human CD46 transgenic pig model system for the study of discordant xenotransplantation. Transplantation 71: 132-142
28. Fodor WL, Williams BL, Matis LA, Madri JA, Rollins SA, Knight JW et al. (1994) Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection. Proc Natl Acad Sci USA 91: 11153-11157
29. Zaidi A, Schmoeckel M, Bhatti F, Waterworth P, Tolan M, Cozzi E et al. (1998) Life-supporting pig to primated renal xenotransplantation using genetically modified donors. Transplantation 65: 1584-1590
30. Niemann H, Verhoeyen E, Wonigeit K, Lorenz R, Hecker J, Schwinzer R et al. (2001) CMV early promoter induced expression of hCD59 in porcine organs provides protection against hyperacute rejection. Transplantation 72: 1898-1906
31. Lai L, Kolber-Simonds D, Park KW, Cheong HT, Greenstein JL, Im GS et al. (2002) Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 295: 1089-1092
32. Dai Y, Vaught TD, Boone J, Chen SH, Phelps CJ, Ball S et al. (2002) Targeted disruption of the alpha1,3-galactosyltransferase gene in cloned pigs. Nature Biotechnol 20: 251-255
33. Phelps CJ, Koike C, Vaught TD, Boone J, Wells KD, Chen SH et al. (2003) Production of α1,3-Galactosyltransferase-deficient pigs. Science 299: 411-414
34. Greenstein J, Sachs DH (1997) The use of tolerance for transplantation across xenogeneic barriers. Nature Biotechn 15: 235-238
35. Auchincloss H Jr, Sachs DH (1998) Xenogenic transplantation. Ann Rev Immunol 16: 433-470
36. Fändrich F, Lin X, Chai G, Schulze M, Ganten D, Bader M et al. (2002) Preimplantation-stage stem cells induce long-term allogeneic graft acceptance without supplementary host conditioning. Nature Med 8: 171-178
37. Jones I (1996) 2010 - a pig odyssey. Nature Biotechn 14: 698-699
38. Edge ASB, Gosse ME, Dinsmore J (1998) Xenogeneic cell therapy: Current progress and future developments in porcine cell transplantation. Cell Transplantation 7: 525-539
39. Groth CG, Korsgren O, Tibell A, Tollemar J, Möller E, Bolinder J et al. (1994) Transplantation of porcine fetal pancreas to diabetic patients. The Lancet 344: 1402-1404
40. Deacon T, Schumacher J, Dinsmore J, Thomas C, Palmer P, Kott S et al. (1997) Histological evidence of fetal pig neutral cell survival after transplantation into a patient with Parkinson's disease. Nature Med 3: 350-353
41. Fink JS, Schumacher JM, Ellias SL, Palmer EP, Saint-Hilaire M, Shannon K et al. (2000) Porcine xenografts in Parkinson's disease and Huntington's disease patients: preliminary results. Cell Transplant 2: 273-278
42. Björklund A (1991) Neural transplantation - An experimental tool with clinical possibilities. Trends Neurosci 14: 319-322
43. Imaizumi T, Lankford KL, Burton WV, Fodor W, Kocsis JD (2000) Xenotransplantation of transgenic pig olfactory ensheathing cells promotes axonal regeneration in rat spinal cord. Nature Biotechn 18: 949-953
44. Gunsalus JR, Brady DA, Coulter SM, Gray BM, Edge ASB (1997) Reduction of serum cholesterol in Watanabe rabbits by xenogeneic hepatocellular transplantation. Nature Med 3: 49-53
45. Thomas M, Northrup R, Hornsby PJ (1997) Adrenocortical tissue formed by transplantation of normal clones of bovine adrenocortical cells in scid mice replaces the essential functions of the animals' adrenal glands. Nature Med 3: 978-983
46. Zawada WM, Cibelli JB, Chei PK, Clarkson ED, Golueke PJ, Witta SE et al. (1998) Somatic cell cloned transgenic bovine neurons for transplantation in parkinson rats. Nature Med 4: 569-574
47. Baltimore D (2001) Our genome unveiled. Nature 409: 814-816
48. Graveley BR (2001) Alternative splicing: increasing diversity in the proteomic world. Trends in Genetics 17: 100-107
49. Modrek B, Lee C (2001) A genomic view of alternative splicing. Nature Genet 30: 13-19
50. O'Brien SJ, Menotti-Raymond M, Murphy WJ, Nash WG, Wienberg J, Stanyon R et al. (1999) The promise of comparative genomics in mammals. Science 286: 458-481
51. Brambrink T, Wabnitz P, Halter R, Klocke R, Carnwath JW, Kues WA et al. (2002) Application of cDNA arrays to monitor mRNA profiles in single preimplantation mouse embryos. Biotechniques 33: 376-378
52. Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH (1997) Viable offspring derived from fetal and adult mammalian cells. Nature 385: 810-803
53. Cibelli JB, Stice SL, Golueke PL, Kane JJ, Jerry J, Blackwell C et al. (1998) Cloned calves produced from nonquiescent fetal fibroblasts. Science 280: 1256-1258
54. Baguisi A, Behboodi E, Melican D, Pollock JS, Destrempes MM, Cammuso C et al. (1999) Production of goats by somatic cell nuclear transfer. Nature Biotech 17: 456-461
55. Polejaeva IA, Chen SH, Vaught TD, Page RL, Mullins J, Ball S et al. (2000) Cloned pigs produced by nuclear transfer from adult somatic cells. Nature 407: 505-509
56. Betthauser J, Forsberg E, Augenstein M, Childs L, Eilertsen K, Enos J et al. (2000) Production of cloned pigs from in vitro systems. Nature Biotech 18: 1055-1059
57. Wakayama T, Perry ACF, Zuccotti M, Johnson KR, Yanagimachi R (1998) Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei. Nature 394: 369-374
58. Wilmut I, Beaujean N, De Sousa PA, Dinnyes A, King TJ, Paterson LA et al. (2002) Somatic cell nuclear transfer. Nature 419: 583-586
59. Campbell KH, McWhir J, Ritchie WA, Wilmut I (1996) Sheep cloned by nuclear transfer from a cultured cell line. Nature 380: 64-66
60. Boquest AC, Day BN, Prather RS (1999) Flow cytometric cell cycle analysis of cultured porcine fetal fibroblasts cells. Biol Reprod 60: 1013-1019
61. Kues WA, Anger M, Carnwath JW, Paul D, Motlik J, Niemann H (2000) Cell cycle synchronization of porcine fetal fibroblasts: Effects of serum deprivation and reversible cell cycle inhibitors. Biol Reprod 62: 412-419
62. Kues WA, Carnwath JW, Paul D, Niemann H (2002) Cell cycle synchronization of porcine fetal fibroblasts by serum deprivation initiates a nonconventional form of apoptosis. Cloning and Stem Cells 4: 231-243.
63. Anger M, Kues WA, Klima J, Mielenz M, Kubelka M, Motlik J et al. (2003) Cell cycle dependent expression of Plk1 in synchronized porcine fetal fibroblasts. Mol Reprod Dev 65: 245-253
64. Young LE, Sinclair KD, Wilmut I (1998) Large offspring syndrome in cattle and sheep. Rev Reprod 3: 155-163
65. Kato Y, Tani T, Sotomaru Y, Kurokawa K, Kato J, Doguchi H et al. (1998) Eight calves cloned from somatic cells of a single adult. Science 282: 2095-2098
66. Niemann H, Wrenzycki C (2000) Alterations of expression of developmentally important genes in preimplantation bovine embryos by in vitro culture conditions: Implications for subsequent development. Theriogenology 53: 21-34
67. Niemann H, Wrenzycki C, Lucas-Hahn A, Brambrink T, Kues WA, Carnwath JW (2002) Gene expression patterns in bovine in vitro produced and nuclear transfer derived embryos and their implication for early development. Cloning and Stem Cells 4: 29-37
68. Niemann H, Hauser HJ, Wirth D, Wonigeit K, Schwinzer R, Kues WA (2002) Expression von TET-hCD59 und TET-hCD55 Konstrukten in transgene Schweine, Transplantationsmedizin (Suppl. DTG Jahrestagung Hannover, 24.-26.10.2002): 94