Effect of 7-day exposure to midazolam on electroencephalogram pharmacodynamics in rats: A model to study multiple pharmacokinetic-pharmacodynamic relationships in individual animals

Journal of Pharmacy and Pharmacology

Volumn 54, Issue 1, 2002, Pages 77-86

  Laurijssens, Bart E ^a   Greenblatt, David J ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; DRUG VEHICLE; LIGAND; MIDAZOLAM;

ALBUMIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL USE; ARTICLE; BLOOD SAMPLING; CANNULA; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EXPOSURE; DRUG PROTEIN BINDING; DRUG TOLERANCE; ELECTROCORTICOGRAPHY; ELECTRODE; ELECTROENCEPHALOGRAM; EXPERIMENTAL MODEL; LONG TERM EXPOSURE; MALE; NONHUMAN; PHARMACODYNAMICS; RAT; SEDATION; SERUM;

ANIMALS; ANTI-ANXIETY AGENTS; BODY WEIGHT; ELECTROENCEPHALOGRAPHY; MALE; METABOLIC CLEARANCE RATE; MIDAZOLAM; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SERUM ALBUMIN;

EID: 0036164847     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357021771959     Document Type: Article

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