Rate of change of blood concentrations is a major determinant of the pharmacodynamics of midazolam in rats

British Journal of Pharmacology

Volumn 127, Issue 1, 1999, Pages 227-235

  Cleton, A ^a   Mazee, D ^a   Voskuyl, R A ^b   Danhof, M ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b Instituut voor E   (Netherlands)

Author keywords

Computer controlled infusion; Electroencephalogram; Functional adaptation; Pharmacokinetics

Indexed keywords

MIDAZOLAM;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; ELECTROENCEPHALOGRAM; INTRAVENOUS DRUG ADMINISTRATION; MALE; MATHEMATICAL MODEL; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT;

ALGORITHMS; ANIMALS; ANTI-ANXIETY AGENTS; ELECTROENCEPHALOGRAPHY; HYPNOTICS AND SEDATIVES; INFUSIONS, INTRAVENOUS; MALE; MIDAZOLAM; MODELS, BIOLOGICAL; RATS; RATS, WISTAR; REGRESSION ANALYSIS;

EID: 0032903031     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702499     Document Type: Article

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