Cloning of the Human Platelet Endothelial Cell Adhesion Molecule-1 Promoter and Its Tissue-Specific Expression: Structural and Functional Characterization

Journal of Immunology

Volumn 157, Issue 12, 1996, Pages 5411-5421

  Almendro, Nuria ^a   Bellón, Teresa ^a   Rius, Carlos ^a   Lastres, Pedro ^a   Langa, Carmen ^a   Corbí, Angel ^b   Bernabéu, Carmelo ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; PROTEIN KINASE C;

ARTICLE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MOLECULAR CLONING; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROMOTER REGION; RESTRICTION MAPPING; TISSUE DISTRIBUTION;

ANTIGENS, CD31; BASE SEQUENCE; CLONING, MOLECULAR; GENE EXPRESSION REGULATION; HUMANS; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); PROTEIN KINASE C; RESTRICTION MAPPING; TISSUE DISTRIBUTION;

EID: 0030589372     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (66)

1. DeLisser, H. M., P. J. Newman, and S. M. Albelda. 1994. Molecular and functional aspects of PECAM-1/CD31. Immunol. Today 15:490.
2. Ohto, H., H. Maeda, Y. Shibata, R.-F. Chen, Y. Qzaki, M. Higashihara, A. Takeuchi, and H. Tohyama. 1985. A novel leukocyte differentiation antigens: two monoclonal antibodies TM2 and TM3 define a 120-kD molecule present on neutrophils, monocytes, platelets, and activated lymphoblasts. Blood 66:873.
3. Goyert, S. M., E. M. Ferrero, S. V. Serementis, R. J. Winchester, J. Silver, and A. C. Mattison. 1986. Biochemistry and expression of myelomonocytic antigens. J. Immunol. 137:3909.
4. Lyons, A. B., S. J. Cooper, S. R. Cole, and K. Ashman. 1988. Human myeloid differentiation antigens identified by monoclonal antibodies to the myelomonocytic leukemia cell line RC-2A. Pathology 20:137.
5. Cabañas, C., F. Sánchez-Madrid, T. Bellón, C. G. Figdor, A. A. Te Velde, J. M. Fernández, A. Acevedo, and C. Bernabéu. 1989. Characterization of a novel myeloid antigen regulated during differentiation of monocytic cells. Eur. J. Immunol. 19:1373.
6. Goldberger, A., K. A. Middleton, and P. J. Newman. 1994. Changes in expression of the cell adhesion molecule PECAM-1 (CD31) during differentiation of human leukemic cell lines. Tissue Antigens 44:285.
7. Lastres, P., N. Almendro, T. Bellón, J. A. López-Guerrero, R. Eritja, and C. Bernabéu. 1994. Functional regulation of platelet/endothelial cell adhesion molecule-1 by TGF-β1 in promonocytic U-937 cells. J. Immunol. 153:4206.
8. Muller, W. A., S. A. Weigl, X. Deng, and D. M. Phillips. 1993. PECAM-1 is required for transendothelial migration of leukocytes. J. Exp. Med. 178:449.
9. Vaporciyan, A. A., H. M. DeLisser, H. Yan, I. I. Mendiguren, S. R. Thom, M. L. Jones, and S. M. Albelda. 1993. Involvement of platelet endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo. Science 262:1580.
10. Albelda, S. M., W. A. Muller, C. A. Buck, and P. J. Newman. 1991. Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule. J. Cell Biol. 114:1059.
11. 3 integrin involved in adhesion of leukocytes to endothelium. J. Cell Biol. 130:451.
12. DeLisser, H. M., C. Y. Yan, P. J. Newman, W. A. Muller, C. A. Buck, and S. M. Albelda. 1993. PECAM-1 (CD31)-mediated cellular aggregation involves cell surface glycosaminoglycans. J. Biol. Chem. 268:16037.
13. Tanaka, Y., S. M. Albelda, K. J. Horgan, G. van Seventer, Y. Shimizu, W. Newman, J. Hallam, P. J. Newman, C. A. Buck, and S. Shaw. 1992. CD31 expressed on distinctive T cell subsets is a preferential amplifier of β1 integrin-mediated adhesion. J. Exp. Med. 176:245.
14. 2 integrins on lymphokine-activated killer cells. Eur. J. Immunol. 23:2464.
15. DeLisser, H. M., J. Chilkotowsky, H.-C. Yan, M. Daise, C. A. Buck, and S. M. Albelda. 1994. Deletions in the cytoplasmic domain of platelet-endothelial cell adhesion molecule-1 (PECAM-1, CD31) result in changes in ligand binding properties. J. Cell Biol. 124:195.
16. Newman, P. J., C. A. Hillery, R. Albrecht, L. V. Parise, M. C. Berndt, A. V. Mazurov, L. C. Dunlop, J. Zhang, and S. E. Rittenhouse. 1992. Activation-dependent changes in human platelet PECAM-1: phosphorylation cytoskeletal association, and surface membrane redistribution. J. Cell Biol. 119:239.
17. Zehnder, J. L., K. Hirai, M. Shatsky, J. L. McGregor, L. J. Levitt, and L. L. K. Leung. 1992. The cell adhesion molecule CD31 is phosphorylated after cell activation: down-regulation of CD31 in activated T lymphocytes, J. Biol. Chem. 267:5243.
18. Baldwin, H. S., H. M. Shen, A. Chung, C. Mickanin, T. Trask, H. Yan, H. M. DeLisser, S. M. Albelda, N. Kirschbaum, P. J. Newman, and C. A. Buck. 1994. Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31): alternatively spliced, functionally distinct isoforms expressed during early mammalian cardiovascular development. Development 120:2539.
19. Goldberger, A., K. A. Middleton, J. A. Oliver, C. Paddock, H. Yan, H. M. DeLisser, S. M. Albelda, and P. J. Newman. 1994. Biosynthesis and processing of the cell adhesion molecule PECAM-1 includes production of a soluble form. J. Biol. Chem. 269:17183.
20. Kirschbaum, N. E., R. J. Gumina, and P. J. Newman. 1994. Organization of the human platelet/endothelial cell adhesion molecule-1 shows alternatively spliced isoforms and a functionally complex cytoplasmic domain. Blood 84:4028.
21. Newman, P. J., M. C. Berndt, J. Gorsky, G. C. White, L. S. Paddock, and W. A. Muller. 1990. PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science, 247:1219.
22. Simmons, D. L., C. Walker, C. Power, and R. Pigott. 1990. Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen. J. Exp. Med. 171:2147.
23. Stockinger, H., S. J. Gadd, R. Eher, O. Majdic, W. Schreiber, W. Kasinrerk, B. Strass, E. Schnabl, and W. Knapp. 1990. Molecular characterization and functional analysis of leucocyte surface protein CD31. J. Immunol. 145:3889.
24. Nordeen, S. K. 1988. Luciferase reporter gene vectors for analysis of promoters and enhancers. Biotechniques 6:454.
25. Von dem Borne A. E. G. Kr., and P. W. Moderman. 1989. Cluster report: CD31. In Leucocyte Typing, Vol. 4. W. Knap, B. Dorken, W. R. Gilks, E. P. Rieber, R. E. Schmidt, H. Stein, and A. E. G. Kr. Von dem Borne, eds. Oxford University Press, New York, p. 995.
26. Sambrook, J. E., Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual, 2nd Ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor
27. Cebrián, M., E. Yagüe, M. Rincón, M. López-Botet, M. O. De Landázuri, and F. Sánchez-Madrid. 1988. Triggering of T cell proliferation through AIM, an activation inducer molecule. J. Exp. Med. 168:1621.
28. Chirgwin, J. M., A. E. Przybyla, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294.
29. Schreiber, E., P. Mathias, M. M. Müller, and W. Schaffer. 1988. Identification of a novel lymphoid specific octamer protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA). EMBO J. 7:4221.
30. López-Rodriguez, C., H. M. Chen, D. G. Tenen, and A. L. Corbí. 1995. Identification of Sp1 binding sites in the CD11c (p150, 95-α) and CD11a (LFA-1-α) integrin subunit promoters and their involvement in the tissue specific expression of CD11c. Eur. J. Immunol. 25:3496.
31. Klemsz, M. J., S. R. McKercher, A. Celada, C. Van-Beveren, and R. A. Maki. 1990. The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell 61:113.
32. Ho, I. C., N. K. Bhat, L. R. Gottschalk, T. Lindsten, C. B. Thompson, T. S. Papas, and M. Leiden. 1990. Sequence-specific binding of human Ets-1 to the T cell receptor alpha gene enhancer. Science 250:814.
33. Orkin, S. H. 1992. GATA-binding transcription factors in hematopoietic cells. Blood 80:575.
34. Nguyen, H. Q., B. Hoffman-Liebermann, and D. A. Liebermann. 1993. The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage. Cell 72:197.
35. de Thé, H., M. M. Vivanco-Ruiz, P. Tiollais, H. Stunnenberg, and A. Dejean. 1990. Identification of a retinoic acid responsive element in the retinoic acid receptor β gene. Nature 343:177.
36. Wasylyk, B. 1993. The ets family of transcription factors. Eur. J. Biochem. 211:7.
37. Cebrián, M., J. M. Redondo, A. López-Rivas, G. Rodríguez-Tarduchy, M. O. De Landázuri, and F. Sánchez-Madrid. 1989. Expression and function of AIM, an activation inducer molecule of human lymphocytes, is dependent on the activation of protein kinase C. Eur. J. Immunol. 19:809.
38. Cao, X., R. Mahendran, G. R. Guy, and Y. H. Tan. 1993. Detection and characterization of cellular EGR-1 binding to its recognition site. J. Biol. Chem. 268:16949.
39. Williams, T., and R. Tijan. Analysis of the DNA-binding and activation properties of the human transcription factor AP-2. Genes Dev. 5:670.
40. Pugh, B. F., and R. Tijan. 1990. Mechanism of transcriptional activation by Sp1: evidence for coactivators. Cell 57:103.
41. Collins, T., M. A. Read, A. S. Neish, M. Whitley, D. Thanos, and T. Maniatis. 1995. Transcriptional regulation of endothelial cell adhesion molecules: NF-κB and cytokine-inducible enhancers. FASEB J. 9:899.
42. Baeuerle, P. A., and T. Henkel. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141.
43. Resnick, N., and M. A. Gimbrone. 1995. Hemodynamic forces are complex regulators of endothelial gene expression. FASEB J. 9:874.
44. Cybulsky, M. I., J. W. U. Fries, A. J. Williams, P. Sultan, R. Eddy, M. Byers, T. Shows, M. A. Gimbrone, and T. Collins. 1991. Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene. Proc. Natl. Acad. Sci. USA 88:7859.
45. Murre, C., G. Bain, M. A. van Dijk, I. Engel, B. A. Furnari, M. E. Massari, J. R. Matthews, M. W. Quong, R. R. Rivera, and M. H. Stuiver. 1994. Structure and function of helix-loop-helix proteins. Biochim. Biophys. Acta 1218:129.
46. Poellinger, L., B. K. Yoza, and R. G. Roeder. 1989. Functional cooperativity between protein molecules bound at two distinct sequence elements of the immunoglobulin heavy-chain promoter. Nature 337:573.
47. Lo, K., N. R. Landau, and S. T. Smale. 1991. LyF-1, a transcriptional regulator that interacts with a novel class of promoters for lymphocyte-specific genes. Mol. Cell. Biol. 11:5229.
48. Bianchi, M. E. 1995. The HMG-box domain. In DNA-Protein Structural Interactions. D. M. J. Lilley, ed. Oxford University Press, Oxford, p. 177.
49. Hattori, M., L. J. Abraham, W. Northermann, and G. H. Fey. 1990. Acute-phase reaction induces a specific complex between hepatic nuclear proteins and the interleukin 6 response element of the rat α2-macroglobulin gene. Proc. Natl. Acad. Sci. USA 87:2364.
50. Mann, E. A., M. L. Croyle, and J. B. Lingrel. 1991. Identification of sequences mediating interleukin-6 induction of a rat kininogen gene. J. Biol. Chem. 266: 16931.
51. Raich, N., C. H. Clegg, J. Grofti, P.-H. Roméo, and G. Stamatoyannopoulos. 1995. GATA1 and YY1 are developmental repressors of the human ∈-globin gene. EMBO J. 14:801.
52. Nueda, A., M. López-Cabrera, A. Vara, and A. L. Corbí. 1993. Characterization of the CD11a (alpha L, LFA-1 alpha) integrin gene promoter. J. Biol. Chem. 268:19305.
53. López-Cabrera, M., A. Nueda, A. Vara, J. García-Aguilar, A. Tugores, and A. L. Corbí. 1993. Characterization of the p150,95 leukocyte integrin α subunit (CD11c) gene promoter. J. Biol. Chem. 268:1187.
54. Shelley, C. S., and M. A. Arnaout. 1991. The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression. Proc. Natl. Acad. Sci. USA 88:10525.
55. Assouline, Z., D. Kerbirou-Nabias, G. Pietu, N. Thomas, B. R. Bahnak, and D. Meyer. 1988. The human gene for von Willebrand factor: identification of repetitive Alu sequences 5′ to the transcription initiation site. Biochem. Biophys. Res. Commun. 153:1159.
56. Wang, X. Y., C. Ohtaka-Maruyama, M. M. Pisano, C. J. Jaworski, and A. B. Chepelinsky. 1995. Isolation and characterization of the 5′-flanking sequence of the human ocular lens MIP gene. Gene 167:321.
57. Bennett, J., D. Sun, and K. Karikó. 1995. Sequence analysis of the 5.34-kb 5′ flanking region of the human rhodopsin-encoding gene. Gene 167:317.
58. Brini, A. T., G. M. Lee, and J. P. Kinet. 1993. Involvement of Alu sequences in the cell-specific regulation of transcription of the γ chain of Fc and T cell receptors. J. Biol. Chem. 268:1355.
59. Nishizuka, Y. 1992. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258:607.
60. Whetton, A. D., C. M. Heyworth, S. E. Nicholls, C. A. Evans, J. M. Lord, T. M. Dexter, and P. J. Owen-Lynch. 1994. Cytokine-mediated protein kinase C activation is a signal for lineage determination in bipotential granulocyte macrophage colony-forming cells. J. Cell Biol. 125:651.
61. Harris, P., and P. Ralph. 1985. Human leukemic models of myelomonocytic development: a review of the HL-60 and U-937 cell lines. J. Leukocyte Biol. 37:407.
62. Ackerman, S. L., A. G. Minden, G. T. Williams, C. Bobonis, and C. Y. Yeung. 1991. Functional significance of an overlapping consensus binding motif for Sp1 and Zif268 in the murine adenosine deaminase gene promoter. Proc. Natl. Acad. Sci. USA 88:7523.
63. Ebert, S. N., and D. L. Wong. 1995. Differential activation of the rat phenylethanolamine N-methyltransferase gene by Sp1 and EGR1. J. Biol. Chem. 270: 17299.
64. Maltzman, J. S., J. A. Carman, and J. G. Monroe. 1996. Transcriptional regulation of the Icam-1 gene in antigen receptor- and phorhol ester-stimulated B lymphocytes: role for transcription factor EGR1. J. Exp. Med. 183:1747.
65. McCoy, C., D. E. Smith, and M. M. Cornwell. 1995. 12-O-tetradecanoylphorbol-13-acetate activation of the MDR1 promoter is mediated by EGR1. Mol. Cell. Biol. 15:6100.
66. Khachigian, L. M., V. Lindner, A. J. Williams, and T. Collins,. 1996. Egr-1-induced endothelial gene expression: a common theme in vascular injury. Science 271:1427.