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Volumn 42, Issue 5, 2003, Pages 662-670

Age Increases Expression and Receptor-Mediated Activation of Gα i in Human Atria

Author keywords

adrenergic; Adenylyl cyclase; Cardiac; Glucagons; Muscarinic

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; ADENOSINE TRIPHOSPHATE; ADENYLATE CYCLASE; ALPRENOLOL; ATROPINE; AZIDOANILIDOGUANOSINE TRIPHOSPHATE P 32; BETA 2 ADRENERGIC RECEPTOR; CARBACHOL; CYANOPINDOLOL I 125; CYCLIC AMP; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; GI2 ALPHA PROTEIN; GI2-ALPHA PROTEIN; GLUCAGON; GUANOSINE TRIPHOSPHATE; GUANOSINE TRIPHOSPHATE DERIVATIVE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE; ONCOPROTEIN; PERTUSSIS TOXIN; UNCLASSIFIED DRUG;

EID: 0142200898     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200311000-00013     Document Type: Article
Times cited : (7)

References (57)
  • 1
    • 0026689278 scopus 로고
    • Receptor systems in the non-failing human heart
    • Brodde OE, Broede A, Daul A, et al. Receptor systems in the non-failing human heart. Basic Res Cardiol. 1992;87:1-14.
    • (1992) Basic Res Cardiol , vol.87 , pp. 1-14
    • Brodde, O.E.1    Broede, A.2    Daul, A.3
  • 2
    • 0021360736 scopus 로고
    • Adrenoceptor function and ageing
    • Kelly J, O'Malley K. Adrenoceptor function and ageing. Clin Sci. 1984;66:509-515.
    • (1984) Clin Sci , vol.66 , pp. 509-515
    • Kelly, J.1    O'Malley, K.2
  • 3
    • 0028980533 scopus 로고
    • Age-dependent changes in the β-adrenoceptor-G-protein(s)-adenylyl cyclase system in human right atrium
    • Brodde OE, Zerkowski HR, Schranz D, et al. Age-dependent changes in the β-adrenoceptor-G-protein(s)-adenylyl cyclase system in human right atrium. J Cardiovasc Pharmacol. 1995;26:20-26.
    • (1995) J Cardiovasc Pharmacol , vol.26 , pp. 20-26
    • Brodde, O.E.1    Zerkowski, H.R.2    Schranz, D.3
  • 4
    • 0028070637 scopus 로고
    • Age-related changes in β-adrenergic neuroeffector systems in the human heart
    • White M, Roden R, Minobe W, et al. Age-related changes in β-adrenergic neuroeffector systems in the human heart. Circulation. 1994;90:1225-1238.
    • (1994) Circulation , vol.90 , pp. 1225-1238
    • White, M.1    Roden, R.2    Minobe, W.3
  • 5
    • 0025775895 scopus 로고
    • Age-related alterations in adenylyl cyclase system of rat hearts
    • Urasawa K, Murakami T, Yasuda H. Age-related alterations in adenylyl cyclase system of rat hearts. Jpn Circ J. 1991;55:676-684.
    • (1991) Jpn Circ J , vol.55 , pp. 676-684
    • Urasawa, K.1    Murakami, T.2    Yasuda, H.3
  • 7
    • 0031080127 scopus 로고    scopus 로고
    • The role of Gi-proteins and β-adrenoceptors in the age-related decline of contraction in guinea-pig ventricular myocytes
    • Ferrara N, Böhm M, Zolk O, et al. The role of Gi-proteins and β-adrenoceptors in the age-related decline of contraction in guinea-pig ventricular myocytes. J Mol Cell Cardiol. 1997;29:439-448.
    • (1997) J Mol Cell Cardiol , vol.29 , pp. 439-448
    • Ferrara, N.1    Böhm, M.2    Zolk, O.3
  • 8
    • 0031933301 scopus 로고    scopus 로고
    • Alterations in myocardial signal transduction due to aging and chronic dynamic exercise
    • Roth DA, White CD, Podolin DA, et al. Alterations in myocardial signal transduction due to aging and chronic dynamic exercise. J Appl Physiol. 1998;84:177-184.
    • (1998) J Appl Physiol , vol.84 , pp. 177-184
    • Roth, D.A.1    White, C.D.2    Podolin, D.A.3
  • 9
    • 0026719320 scopus 로고
    • Differences in cardiovascular responses to isoproterenol in relation to age and exercise training in healthy men
    • Stratton JR, Cerqueira MD, Schwartz RS, et al. Differences in cardiovascular responses to isoproterenol in relation to age and exercise training in healthy men. Circulation. 1992;86:504-512.
    • (1992) Circulation , vol.86 , pp. 504-512
    • Stratton, J.R.1    Cerqueira, M.D.2    Schwartz, R.S.3
  • 10
    • 0034495702 scopus 로고    scopus 로고
    • Research agenda for cardiovascular aging: Humans to molecules
    • Lakatta EG. Research agenda for cardiovascular aging: humans to molecules. Am J Geriatr Cardiol. 2000;9:251-262.
    • (2000) Am J Geriatr Cardiol , vol.9 , pp. 251-262
    • Lakatta, E.G.1
  • 11
    • 0033607665 scopus 로고    scopus 로고
    • The molecular basis for distinct β-adrenergic receptor subtype actions in cardiomyocytes
    • Steinberg SF. The molecular basis for distinct β-adrenergic receptor subtype actions in cardiomyocytes. Circ Res. 1999;85:1101-1111.
    • (1999) Circ Res , vol.85 , pp. 1101-1111
    • Steinberg, S.F.1
  • 13
    • 0023733494 scopus 로고
    • Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart
    • Feldman AM, Cates AE, Veazey WB, et al. Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart. J Clin Invest. 1988;82:189-197.
    • (1988) J Clin Invest , vol.82 , pp. 189-197
    • Feldman, A.M.1    Cates, A.E.2    Veazey, W.B.3
  • 14
    • 0028866483 scopus 로고
    • Signal transduction mechanisms controlling cardiac contractility and their alterations in chronic heart failure
    • Brodde OE, Michel MC, Zerkowski HR. Signal transduction mechanisms controlling cardiac contractility and their alterations in chronic heart failure. Cardiovasc Res. 1995;30:570-584.
    • (1995) Cardiovasc Res , vol.30 , pp. 570-584
    • Brodde, O.E.1    Michel, M.C.2    Zerkowski, H.R.3
  • 15
    • 0028910874 scopus 로고
    • Expression of G protein α subunits in the aging cardiovascular system
    • Johnson MD, Zhou Y, Friedman E, et al. Expression of G protein α subunits in the aging cardiovascular system. J Gerontol A Biol Sci Med Sci 1995;50A:B14-B19.
    • (1995) J Gerontol A Biol Sci Med Sci , vol.50 A
    • Johnson, M.D.1    Zhou, Y.2    Friedman, E.3
  • 16
    • 0028107303 scopus 로고
    • Forskolin binding sites and G-protein immunoreactivity in rat hearts during aging
    • Shu Y, Scarpace PJ. Forskolin binding sites and G-protein immunoreactivity in rat hearts during aging. J Cardiovasc Pharmacol. 1994;23:188-193.
    • (1994) J Cardiovasc Pharmacol , vol.23 , pp. 188-193
    • Shu, Y.1    Scarpace, P.J.2
  • 19
    • 0032521152 scopus 로고    scopus 로고
    • 2-adrenergic responses without changes in inhibitory G proteins or receptor kinases
    • 2-adrenergic responses without changes in inhibitory G proteins or receptor kinases. J Clin Invest. 1998;101:1273-1282.
    • (1998) J Clin Invest , vol.101 , pp. 1273-1282
    • Xiao, R.P.1    Tomhave, E.D.2    Wang, D.J.3
  • 20
    • 0028772915 scopus 로고
    • sα protein mRNA in rat ventricular myocardium with aging
    • sα protein mRNA in rat ventricular myocardium with aging. Eur J Pharmacol. 1994;266:147-154.
    • (1994) Eur J Pharmacol , vol.266 , pp. 147-154
    • Miyamoto, A.1    Kawana, S.2    Kimura, H.3
  • 21
    • 0037163118 scopus 로고    scopus 로고
    • i2 expression, resulting in enhanced coupling to G protein-coupled receptors
    • i2 expression, resulting in enhanced coupling to G protein-coupled receptors. J Biol Chem. 2002;277:31257-31262.
    • (2002) J Biol Chem , vol.277 , pp. 31257-31262
    • Kilts, J.D.1    Akazawa, T.2    Richardson, M.D.3
  • 22
    • 0029731081 scopus 로고    scopus 로고
    • 2-adrenoceptor activation by zinterol causes protein phosphorylation, contractile effects and relaxant effects through a cAMP pathway in human atrium
    • 2-adrenoceptor activation by zinterol causes protein phosphorylation, contractile effects and relaxant effects through a cAMP pathway in human atrium. Mol Cell Biochem. 1996;163/164:113-123.
    • (1996) Mol Cell Biochem , vol.163-164 , pp. 113-123
    • Kaumann, A.J.1    Sanders, L.2    Lynham, J.A.3
  • 23
    • 0033547702 scopus 로고    scopus 로고
    • 2-adrenergic receptors hastens relaxation and mediates phosphorylation of phospholamban, troponin I, and C-protein in ventricular myocardium from patients with terminal heart failure
    • 2-adrenergic receptors hastens relaxation and mediates phosphorylation of phospholamban, troponin I, and C-protein in ventricular myocardium from patients with terminal heart failure. Circulation. 1999;99:65-72.
    • (1999) Circulation , vol.99 , pp. 65-72
    • Kaumann, A.1    Bartel, S.2    Molenaar, P.3
  • 25
    • 0027250720 scopus 로고
    • 2+ current in single rat ventricular cells
    • 2+ current in single rat ventricular cells. Circ Res. 1993;73:286-300.
    • (1993) Circ Res , vol.73 , pp. 286-300
    • Xiao, R.P.1    Lakatta, E.G.2
  • 26
    • 0028175901 scopus 로고
    • 2+ dynamics, contractility, or phospholamban phosphorylation
    • 2+ dynamics, contractility, or phospholamban phosphorylation. J Biol Chem. 1994;269:19151-19156.
    • (1994) J Biol Chem , vol.269 , pp. 19151-19156
    • Xiao, R.P.1    Hohl, C.2    Altschuld, R.3
  • 27
    • 0028987214 scopus 로고
    • 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes
    • 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes. Mol Pharmacol. 1995;47:322-329.
    • (1995) Mol Pharmacol , vol.47 , pp. 322-329
    • Xiao, R.P.1    Ji, X.2    Lakatta, E.G.3
  • 28
    • 0030842696 scopus 로고    scopus 로고
    • --dependent intracellular alkalinization
    • --dependent intracellular alkalinization. Am J Physiol. 1997;273:H1044-H1047.
    • (1997) Am J Physiol , vol.273
    • Jiang, T.1    Steinberg, S.F.2
  • 29
    • 0025769796 scopus 로고
    • 2-adrenoceptor-mediated positive inotropic effect possibly unrelated to cyclic AMP
    • 2-adrenoceptor-mediated positive inotropic effect possibly unrelated to cyclic AMP. Naunyn Schmiedebergs Arch Pharmacol. 1991;344:56-69.
    • (1991) Naunyn Schmiedebergs Arch Pharmacol , vol.344 , pp. 56-69
    • Lemoine, H.1    Kaumann, A.J.2
  • 33
    • 0027423351 scopus 로고
    • The epidemiology of heart failure: The Framingham study
    • Ho KKL, Pinsky JL, Kannel WB, et al. The epidemiology of heart failure: The Framingham study. J Am Coll Cardiol. 1993;22(suppl A):6A-13A.
    • (1993) J Am Coll Cardiol , vol.22 , Issue.SUPPL. A
    • Ho, K.K.L.1    Pinsky, J.L.2    Kannel, W.B.3
  • 34
  • 36
    • 0029969875 scopus 로고    scopus 로고
    • Opioid receptor agonists activate pertussis toxin-sensitive G proteins and inhibit adenylyl cyclase in canine cardiac sarcolemma
    • Niroomand F, Mura RA, Piacentini L, et al. Opioid receptor agonists activate pertussis toxin-sensitive G proteins and inhibit adenylyl cyclase in canine cardiac sarcolemma. Naunyn Schmiedebergs Arch Pharmacol. 1996;354:643-649.
    • (1996) Naunyn Schmiedebergs Arch Pharmacol , vol.354 , pp. 643-649
    • Niroomand, F.1    Mura, R.A.2    Piacentini, L.3
  • 37
    • 0016374975 scopus 로고
    • A highly sensitive adenylate cyclase assay
    • Salomon Y, Londos C, Rodbell M. A highly sensitive adenylate cyclase assay. Anal Biochem. 1974;58:541-548.
    • (1974) Anal Biochem , vol.58 , pp. 541-548
    • Salomon, Y.1    Londos, C.2    Rodbell, M.3
  • 38
    • 0028989428 scopus 로고
    • 1-adrenoceptor-blocked and non-β-adrenoceptor-blocked human atrium
    • 1-adrenoceptor-blocked and non-β-adrenoceptor-blocked human atrium. Clin Sci. 1995;88:571-580.
    • (1995) Clin Sci , vol.88 , pp. 571-580
    • Jia, H.1    Monteith, S.2    Brown, M.J.3
  • 39
    • 0024327222 scopus 로고
    • Altered expression of α-subunits of G proteins in failing human hearts
    • Feldman AM, Cates AE, Bristow MR, et al. Altered expression of α-subunits of G proteins in failing human hearts. J Mol Cell Cardiol. 1989;21:359-365.
    • (1989) J Mol Cell Cardiol , vol.21 , pp. 359-365
    • Feldman, A.M.1    Cates, A.E.2    Bristow, M.R.3
  • 42
    • 0021733711 scopus 로고
    • Pertussis toxin-catalyzed ADP-ribosylation: Effects on the coupling of inhibitory receptors to the adenylate cyclase system
    • Moss J, Bruni P, Hsia JA, et al. Pertussis toxin-catalyzed ADP-ribosylation: effects on the coupling of inhibitory receptors to the adenylate cyclase system. J Recept Res. 1984;4:459-474.
    • (1984) J Recept Res , vol.4 , pp. 459-474
    • Moss, J.1    Bruni, P.2    Hsia, J.A.3
  • 43
    • 0024360671 scopus 로고
    • Phospholamban phosphorylation in intact ventricles. Phosphorylation of serine 16 and threonine 17 in response to β-adrenergic stimulation
    • Wegener AD, Simmerman HKB, Lindemann JP, et al. Phospholamban phosphorylation in intact ventricles. Phosphorylation of serine 16 and threonine 17 in response to β-adrenergic stimulation. J Biol Chem. 1989;264:11468-11474.
    • (1989) J Biol Chem , vol.264 , pp. 11468-11474
    • Wegener, A.D.1    Simmerman, H.K.B.2    Lindemann, J.P.3
  • 44
    • 0029830352 scopus 로고    scopus 로고
    • Phospholamban: A prominent regulator of myocardial contractility
    • Koss KL, Kranias EG. Phospholamban: a prominent regulator of myocardial contractility. Circ Res. 1996;79:1059-1063.
    • (1996) Circ Res , vol.79 , pp. 1059-1063
    • Koss, K.L.1    Kranias, E.G.2
  • 45
    • 0023513117 scopus 로고
    • Dissociation between contraction and relaxation: The possible role of phospholamban phosphorylation
    • Mundiña de Weilenmann C, Vittone L, de Cingolani G, et al. Dissociation between contraction and relaxation: The possible role of phospholamban phosphorylation. Basic Res Cardiol. 1987;82:507-516.
    • (1987) Basic Res Cardiol , vol.82 , pp. 507-516
    • Mundiña de Weilenmann, C.1    Vittone, L.2    De Cingolani, G.3
  • 46
    • 0032909057 scopus 로고    scopus 로고
    • Cardiovascular aging research: The next horizons
    • Lakatta EG. Cardiovascular aging research: the next horizons. J Am Geriatr Soc. 1999;47:613-625.
    • (1999) J Am Geriatr Soc , vol.47 , pp. 613-625
    • Lakatta, E.G.1
  • 47
    • 0033847565 scopus 로고    scopus 로고
    • Alterations in G-proteins and β-adrenergic responsive adenylyl cyclase in rat urinary bladder during aging
    • Derweesh IH, Wheeler MA, Weiss RM. Alterations in G-proteins and β-adrenergic responsive adenylyl cyclase in rat urinary bladder during aging. J Pharmacol Exp Ther. 2000;294:969-974.
    • (2000) J Pharmacol Exp Ther , vol.294 , pp. 969-974
    • Derweesh, I.H.1    Wheeler, M.A.2    Weiss, R.M.3
  • 49
    • 0025571457 scopus 로고
    • iα in human hearts with dilated but not ischemic cardiomyopathy
    • iα in human hearts with dilated but not ischemic cardiomyopathy. Circulation. 1990;82:1249-1265.
    • (1990) Circulation , vol.82 , pp. 1249-1265
    • Böhm, M.1    Gierschik, P.2    Jakobs, K.H.3
  • 51
    • 0034712586 scopus 로고    scopus 로고
    • i-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy
    • i-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy. Proc Natl Acad Sci U S A. 2000;97:4826-4831.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 4826-4831
    • Redfern, C.H.1    Degtyarev, M.Y.2    Kwa, A.T.3
  • 54
    • 0035497751 scopus 로고    scopus 로고
    • i3 proteins by basic secretagogues induces exocytosis through phospholipase Cβ and arachidonate release through phospholipase Cβ in mast cells
    • i3 proteins by basic secretagogues induces exocytosis through phospholipase Cβ and arachidonate release through phospholipase Cβ in mast cells. J Immunol. 2001;167:4805-4813.
    • (2001) J Immunol , vol.167 , pp. 4805-4813
    • Ferry, X.1    Eichwald, V.2    Daeffler, L.3
  • 55
    • 0030462327 scopus 로고    scopus 로고
    • Identification and characterization of G protein-regulated phospholipase C in human myocardium
    • Schnabel P, Gäs H, Nohr T, et al. Identification and characterization of G protein-regulated phospholipase C in human myocardium. J Mol Cell Cardiol. 1996;28:2419-2427.
    • (1996) J Mol Cell Cardiol , vol.28 , pp. 2419-2427
    • Schnabel, P.1    Gäs, H.2    Nohr, T.3


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