Alkylation damage repair protein O6-alkylguanine-DNA alkyltransferase from the hyperthermophiles Aquifex aeolicus and Archaeoglobus fulgidus

Biochemical Journal

Volumn 375, Issue 2, 2003, Pages 449-455

  Kanugula, Sreenivas ^a   Pegg, Anthony E ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Alkylating agent; DNA repair; O6 benzylguanine; O6 alkylguanine DNA alkyltransferase; O6 methylguanine; Thermophile

Indexed keywords

CHEMOTHERAPY; CHROMATOGRAPHIC ANALYSIS; DNA; ENZYME KINETICS; ESCHERICHIA COLI; MUTAGENESIS; PROTEINS; PURIFICATION; TUMORS;

ALKYLATING AGENTS;

BIOCHEMISTRY;

4 O METHYLTHYMINE; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O BENZYLGUANINE; 6 O METHYLGUANINE; ALKYLATING AGENT; AMINO ACID; DNA; METAL; POLYHISTIDINE; UREA;

AFFINITY CHROMATOGRAPHY; ALKYLATION; AMINO TERMINAL SEQUENCE; AQUIFEX AEOLICUS; ARCHAEOGLOBUS FULGIDUS; ARTICLE; CANCER CHEMOTHERAPY; CELL KILLING; CELL PROTECTION; CLONE; DNA DAMAGE; DNA REPAIR; DRUG ACTIVITY; DRUG ISOLATION; DRUG PURIFICATION; ESCHERICHIA COLI; EXPRESSION VECTOR; GENE; GENETIC CODE; HIGH TEMPERATURE PROCEDURES; MOLECULAR WEIGHT; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN FUNCTION; SOLUBILITY; THERMOPHILIC BACTERIUM; THERMOSTABILITY;

ALKYLATING AGENTS; ARCHAEOGLOBUS FULGIDUS; BACTERIA; DNA; DNA DAMAGE; DNA REPAIR; ENZYME STABILITY; GUANINE; HYDROGEN-ION CONCENTRATION; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PROTEIN FOLDING; PROTEIN RENATURATION; TEMPERATURE;

AQUIFEX AEOLICUS; ARCHAEA; ARCHAEOGLOBUS; ARCHAEOGLOBUS FULGIDUS; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; PROKARYOTA; VECTORS;

EID: 0142200464     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030809     Document Type: Article

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