Redesigning the substrate specificity of human O6-alkylguanine-DNA alkyltransferase. Mutants with enhanced repair of O4-methylthymine

Biochemistry

Volumn 38, Issue 37, 1999, Pages 12097-12103

  Encell, Lance P ^a   Loeb, Lawrence A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 O METHYLTHYMINE; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O BENZYLGUANINE; ALKYLATING AGENT; DNA; GUANINE; THYMINE;

ALKYLATION; ARTICLE; DNA REPAIR; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ESCHERICHIA COLI; MUTANT; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SUBSTITUTION; BINDING, COMPETITIVE; CLONING, MOLECULAR; DNA REPAIR; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; KINETICS; MUTAGENESIS, SITE-DIRECTED; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; OLIGONUCLEOTIDES; PROTEIN ENGINEERING; SUBCELLULAR FRACTIONS; SUBSTRATE SPECIFICITY; THYMINE;

ESCHERICHIA COLI;

EID: 0033554372     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9913606     Document Type: Article

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