The Proline-Rich Acidic Protein Is Epigenetically Regulated and Inhibits Growth of Cancer Cell Lines

Cancer Research

Volumn 63, Issue 20, 2003, Pages 6658-6665

  Zhang, Jinqiu ^a   Wong, Hangyee ^a   Ramanan, Sriram ^a   Cheong, Denis ^b   Leong, Adrian ^c   Hooi, Shing Chuan ^a,d  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b TAN TOCK SENG HOSPITAL   (Singapore)

^c NATIONAL UNIVERSITY HOSPITAL   (Singapore)

^d Department of Physiology ^*  (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

5' AZA 2' DEOXYCYTIDINE; ACID PROTEIN; BUTYRIC ACID; GENE PRODUCT; HISTONE; PROLINE; PROLINE RICH ACIDIC PROTEIN; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER GROWTH; CARCINOGENESIS; CELL GROWTH; COLON ADENOCARCINOMA; COLONY FORMATION; CONTROLLED STUDY; DEACETYLATION; DOWN REGULATION; EPITHELIUM CELL; GASTROINTESTINAL TRACT; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSFECTION; GROWTH INHIBITION; GROWTH RATE; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY; LIVER; LIVER CELL CARCINOMA; METHYLATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN LOCALIZATION; UTERINE CERVIX; UTERUS;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; CLONING, MOLECULAR; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HELA CELLS; HT29 CELLS; HUMANS; LIVER NEOPLASMS; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN ISOFORMS; RATS; TISSUE DISTRIBUTION; TRANSFECTION;

EID: 0142188731     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Jones, P. A., and Baylin, S. B. The fundamental role of epigenetic events in cancer. Nat. Rev. Genet., 3: 415-428, 2002.
2. Hark, A. T., Schoenherr, C. J., Katz, D. J., Ingram, R. S., Levorse, J. M., and Tilghman, S. M. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature (Lond.), 405: 486-489, 2000.
3. Plass, C., Shibata, H., Kaleheva, I., Mullins, L., Kotelevtscva, N., Mullins, J., Kato, R., Sasaki, H., Hirotsune, S., Okazaki, Y., Held, W. A., Hayashizaki, Y., and Chapman, V. M. Identification of Grf1 on mouse chromosome 9 as an imprinted gene by RLGS-M. Nat. Genet., 14: 106-109, 1996.
4. Gray, S. G., and Ekstrom, T. J. The human histone deacetylase family. Exp. Cell Res., 262: 75-83, 2001.
5. Cress, W. D., and Seto, E. Histone deacetylases, transcriptional control, and cancer. J. Cell Physiol., 184: 1-16, 2000.
6. Wolffe, A. P., and Pruss, D. Targeting chromatin disruption: Transcription regulators that acetylate histones. Cell, 84: 817-819, 1996.
7. Grunstein, M. Histone acetylation in chromatin structure and transcription. Nature (Lond.), 389: 349-352, 1997.
8. Brownell, J. E., and Allis, C. D. Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation. Curr. Opin. Genet. Dev., 6: 176-184, 1996.
9. Nan, X., Ng, H. H., Johnson, C. A., Laherty, C. D., Turner, B. M., Eisenman, R. N., and Bird, A. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature (Lond.), 393: 386-389, 1998.
10. Jones, P. L., Veenstra, G. J., Wade, P. A., Vermaak, D., Kass, S. U., Landsberger, N., Strouboulis, J., and Wolffe, A. P. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat. Genet., 19: 187-191, 1998.
11. Robertson, K. D., Ait-Si-Ali, S., Yokochi, T., Wade, P. A., Jones, P. L., and Wolffe, A. P. DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat. Genet., 25: 338-342, 2000.
12. Tamaru, H., and Selker, E. U. A histone H3 methyltransferase controls DNA methylation in Neurospora erassa. Nature (Lond.), 414: 277-283, 2001.
13. Jenuwein, T. Re-SET-ting heterochromatin by histone methyltransferases. Trends Cell Biol., 11: 266-273, 2001.
14. Marks, P., Rifkind, R. A., Richon, V. M., Breslow, R., Miller, T., and Kelly, W. K. Histone deacetylases and cancer: causes and therapies. Nat. Rev. Cancer, 1: 194-202, 2001.
15. Johnstone, R. W. Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat. Rev. Drug Discov., 1: 287-299, 2002.
16. Marks, P. A., Richon, V. M., and Rifkind, R. A. Histone deacetylase inhibitors: inducers of differentiation of apoptosis of transformed cells. J. Natl. Cancer Inst., 92: 1210-1216, 2000.
17. Mariadason, J. M., Corner, G. A., and Augenlicht, L. H. Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindae, and curcumin and implications for chemoprevention of colon cancer. Cancer Res., 60: 4561-4572, 2000.
18. Yamashita, K., Upadhyay, S., Osada, M., Hoque, M. O., Xiao, Y., Mori, M., Sato, F., Meltzer, S. J., and Sidransky, D. Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma. Cancer Cell, 2: 485-495, 2002.
19. Kasik, J., and Rice, E. A novel complementary deoxyribonucleic acid is abundantly and specifically expressed in the uterus during pregnancy. Am. J. Obstet. Gynecol., 176: 452-456, 1997.
20. Zhang, J., Rajkumar, N., and Hooi, S. C. Characterization and expression of the mouse pregnant specific uterus protein gene and its rat homologue in the intestine and uterus. Biochim. Biophys. Acta., 1492: 526-530, 2000.
21. MacDonald, R. J., Swift, G. H., Przybyla, A. E., and Chirgwin, J. M. Isolation of RNA using guanidinimn salts. Methods Enzymol., 152: 219-227, 1987.
22. Wang, Y., Cheong, D., Chan, S., and Hooi, S. C. Heparin/heparan sulfate interacting protein gene expression is up-regulated in human colorectal carcinoma and correlated with differentiation status and metastasis. Cancer Res., 59: 2989-2994, 1999.
23. Nielsen, H., Engelbrecht, J., Brunak, S., and von Heijne, G. Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Protein Eng., 10: 1-6, 1997.
24. McBain, J. A., Eastman, A., Nobel, C. S., and Mueller, G. C. Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors. Biochem. Pharmacol., 53: 1357-1368, 1997.
25. Heerdt, B. G., Houston, M. A., and Augenlicht, L. H. Short-chain fatty acid-initiated cell cycle arrest and apoptosis of colonie epithelial cells is linked to mitochondrial function. Cell Growth Differ., 8: 523-532, 1997.
26. Hodin, R. A., Meng, S., Areher, S., and Tang, R. Cellular growth state differentially regulates enterocyte gene expression in butyrate-treated HT-29 cells. Cell Growth Differ., 7: 647-653, 1996.
27. Augeron, C., and Laboisse, C. L. Emergence of permanently differentiated cell clones in a human colonie cancer cell line in culture after treatment with sodium butyrate. Cancer Res., 44: 3961-3969, 1984.
28. Yoshida, M., Kijima, M., Akita, M., and Beppu, T. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichoslatin A. J. Biol. Chem., 265: 17174-17179, 1990.
29. Kramer, O. H., Gottlicher, M., and Heinzel, T. Histone deacetylase as a therapeutic target. Trends Endocrinol. Metab., 12: 294-300, 2001.
30. Kosugi, H., Towatari, M., Hatano, S., Kitamura, K., Kiyoi, H., Kinoshita, T., Tanimoto, M., Murate, T., Kawashima, K., Saito, H., and Naoe, T. Histone deacetylase inhibitors are the potent inducer/enhancer of differentiation in acute myeloid leukemia: a new approach to anti-leukemia therapy. Leukemia (Baltimore), 13: 1316-1324, 1999.
31. Santini, V., Kantarjian, H. M., and Issa, J. P. Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications. Ann. Intern. Med., 134: 573-586, 2001.
32. Chen, Z. J., and Pikaard, C. S. Epigenetic silencing of RNA polymerase 1 transcription: a role for DNA methylation and histone modification in nucleolar dominance. Genes Dev., 11: 2124-2136, 1997.
33. Selker, E. U. Trichostatin A causes selective loss of DNA methylation in Neurospora. Proc. Natl. Acad. Sci. USA, 95: 9430-9435, 1998.
34. Cameron, E. E., Bachman, K. E., Myohanen, S., Herman, J. G., and Baylin, S. B. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat. Genet., 21: 103-107, 1999.
35. Suzuki, H., Gabrielson, E., Chen, W., Anbazhagan, R., van Engeland, M., Weijenberg, M. P., Herman, J. G., and Baylin, S. B. A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat. Genet., 31: 141-149, 2002.