Mutagenesis by retroviral transgene insertion: Risk assessment and potential alternatives

Current Opinion in Molecular Therapeutics

Volumn 5, Issue 5, 2003, Pages 458-462

  Baum, Christopher ^a,b   Fehse, Boris ^c  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Gene therapy; Hematopoiesis; Integrase; Mutagenesis; Recombinase; Retrovirus

Indexed keywords

ADENOSINE DEAMINASE; CELL DNA; DOUBLE STRANDED DNA; PLASMID DNA; RETROVIRUS VECTOR;

ANIMAL MODEL; CANCER RISK; CARCINOGENICITY; CELL CULTURE; GENE DOSAGE; GENE INSERTION; GENE TARGETING; HEMATOPOIETIC CELL; MUTAGENESIS; MUTATIONAL ANALYSIS; NONHUMAN; RETROSPECTIVE STUDY; REVIEW; RISK ASSESSMENT; RISK FACTOR; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VIRUS DNA CELL DNA INTERACTION;

BASE SEQUENCE; GENE DOSAGE; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; MUTAGENESIS; NEOPLASMS; RECOMBINATION, GENETIC; RETROVIRIDAE; RISK ASSESSMENT; TRANSGENES;

ANIMALIA; INSERTION SEQUENCES; UNIDENTIFIED RETROVIRUS;

EID: 0142185323     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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