Extrathymic T cell differentiation in the human intestine early in life

Journal of Immunology

Volumn 161, Issue 11, 1998, Pages 5862-5872

  Howie, Duncan ^a   Spencer, Jo ^b   DeLord, Denise ^c   Pitzalis, Costantino ^c   Wathen, Neville C ^a   Dogan, Ahmet ^d   Akbar, Arne ^e   MacDonald, Thomas T ^a,f  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b Medical and Dental School ^*  (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^f ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD7 ANTIGEN; HLA DR ANTIGEN; KI 67 ANTIGEN; L SELECTIN; MESSENGER RNA; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CELL MATURATION; CHILD; FETUS; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INFANT; INTESTINE; LAMINA PROPRIA; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE;

AGING; ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CELL DIVISION; CHILD; CHILD, PRESCHOOL; EMBRYONIC AND FETAL DEVELOPMENT; FETAL BLOOD; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; GENES, T-CELL RECEPTOR BETA; HUMANS; IMMUNOPHENOTYPING; INFANT; INTESTINAL MUCOSA; JEJUNUM; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MICE; MICE, INBRED BALB C; MICE, SCID; MOLECULAR SEQUENCE DATA; T-LYMPHOCYTE SUBSETS; THYMUS GLAND; TRANSCRIPTION, GENETIC;

EID: 0032403527     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Fichtelius, K. E. 1967. The gut epithelium: a first level lymphoid organ? Exp. Cell. Res. 49:87.
2. Lefrancois, L., and L. Puddington. 1995. Extrathymic intestinal T-cell development: virtual reality? Immunol. Today 16:16.
3. Bandeira, A., S. Itohara, M. Bonneville, O. Burlen-De Franoux, T. MotoSantos, A. Coutinko, and S. Tonegawa. 1990. Extrathymic origin of intestinal intraepithelial lymphocytes bearing T cell antigen receptor γδ. Proc. Natl. Acad. Sci. USA 88:43.
4. De Geus, B., M. Van den Enden, C. Coolen, L. Nagelkerken, P. Van der Heijden, and J. Rozing. 1990. Phenotype of intraepithelial lymphocytes in euthymic and athymic mice: implications for differentiation of cells bearing a CD3-associated γδ T cell receptor. Eur. J. Immunol. 20:291.
5. + lymphocytes reveals a major extrathymic pathway of T cell differentiation. J. Exp. Med. 173:483.
6. Poussier, P., P. Edouard, C. Lee, M. Binnie, and M. Julius. 1992. Thymus-independent development and negative selection of T cells expressing T cell receptor α/β in the intestinal epithelium: evidence for distinct circulation patterns of gut and thymus derived T lymphocytes. J. Exp. Med. 176:187.
7. Lefrancois, L., and S. Olson. 1994. A novel pathway of thymus directed T lymphocyte maturation. J. Immunol. 153:987.
8. Rocha, B., P. Vassalli, and D. Guy-Grand. 1994. Thymic and extrathymic origin of gut intraepithelial lymphocyte populations in mice. J. Exp. Med. 180:681.
9. Lynch, S., D. Kelleher, R. McManus, and C. O'Farrelly. 1995. RAG1 and RAG2 expression in human intestinal epithelium: evidence of extrathymic T cell differentiation. Eur. J. Immunol. 25:1143.
10. Taplin, M. E., M. E. Frantz, C. Canning, J. Ritz, R. S. Blumberg, and S. P. Balk. 1996. Evidence against T-cell development in the adult human intestinal mucosa based upon lack of terminal deoxynucleotidyltransferase expression. Immunology 87:402.
11. Blumberg, R. S., C. E. Yockey, G. C. Gross, E. C. Ebert, and S. P. Balk. 1993. Human intestinal intraepithelial lymphocytes are derived from a limited number of T cell clones that utilise multiple Vβ T cell receptor genes. J. Immunol 150:5144.
12. Van Kerckhove, C., G. J. Russel, K. Deusch, K. Reich, A. K. Bhan, H. Dersimonian, and M. Brenner. 1992. Oligoclonality of human intestinal intraepithelial T cells. J. Exp. Med. 175:57.
13. Spencer, J., T. T. MacDonald, T. Finn, and P. G. Isaacson. 1986. The development of gut associated lymphoid tissue in the terminal ileum of fetal human intestine. Clin. Exp. Immunol. 64:536.
14. Maloy, K. J., A. M. Mowat, R. Zamoyska, and I. N. Crispe. 1991. Phenotypic heterogeneity of intraepithelial T lymphocytes from mouse small intestine. Immunology 72:555.
15. Spencer, J., P. G. Isaacson, T. C. Diss, and T. T. MacDonald. 1989. Expression of disulphide linked and non-disulphide linked forms of the T cell receptor γ/δ heterodimer in human intestinal intraepithelial lymphocytes. Eur. J. Immunol. 19:1335.
16. Brenner, M. B., J. McLean, D. P. Dialynas, J. L. Strominger, J. A. Smith, F. L. Owen, J. G. Seidman, S. Ip, F. Rosen, and M. S. Krangel. 1986. Identification of a putative second T cell receptor. Nature 322:145.
17. Faure, F., S. Jitsukawa, F. Triebe, and T. Hercend. 1988. Characterisation of human peripheral lymphocytes expressing the γ/δ complex with monoclonal antibodies. J. Immunol. 141:335.
18. Spencer, J., P. G. Isaacson, T. T. MacDonald, A. J. Thomas, and J. A. Walker-Smith. 1991. γ/δ cells and the diagnosis of coeliac disease. Clin. Exp. Immunol. 85:109.
19. Koningsberger, J. C., A. Chott, T. Logtenberg, L. J. J. M. Wiegman, R. S. Blumberg, G. P. van Berge Henegouwen, and S. P. Balk. 1997. TCR expression in human fetal intestine and identification of an early T cell receptor β-chain transcript. J. Immunol. 159:1775.
20. Bosma, G. C., M. T. Davisson, N. R. Reutsch., H. O. Sweet, L. D. Shultz, and M. J. Bosma. 1989. The mouse mutation severe combined immune deficiency (scid) is on chromosome 16. Immunogenetics 29:54.
21. Geiler, T., J. Kreigsmann, G. M. Keyszer, R. E. Gay, and S. A. Gay. 1994. A new model for rheumatoid arthritis generated by engraftment of rheumatoid synovial tissue and normal human cartilage into SCID mice. Arthritis Rheum. 37:1664.
22. Spencer, J., T. T. MacDonald, T. C. Diss, J. A. Walker-Smith, P. J. Ciclitira, and P. G. Isaacson. 1989. Changes in intraepithelial lymphocyte subpopulations in coeliac disease and enteropathy associated T cell lymphoma (malignant histiocytosis of the intestine). Gut 30:339.
23. Spencer, J., P. G. Isaacson, J. A. Walker-Smith, and T. T. MacDonald. 1989. Heterogeneity in intraepithelial lymphocyte subpopulations in fetal and postnatal human small intestine. J. Pediatr. Gastroenterol. Nutr. 9:173.
24. Fell, J. M., J. A. Walker-Smith, J. Spencer, and T. T. MacDonald. 1996. The distribution of dividing T cells throughout the intestinal wall in inflammatory bowel disease (IBD). Clin. Exp. Immunol. 104:280.
25. Thomas, R., G. Schurmann, P. Lionetti, S. L. F. Pender, and T. T. MacDonald. 1996. T cell receptor Vβ expression in human intestine: regional variation in postnatal intestine and biased usage in fetal gut. Gut 38:190.
26. +) thymocytes in normal and genetically modified mice. J. Immunol. 154:5103.
27. Scammon, R. E., and J. A. Kittleson. 1926. The growth of the gastrointestinal tract of the human fetus. Proc. Soc. Exp. Biol. Med. 24:303.
28. Du Pasquier, L. 1993. In Fundamental Immunology, W. E. Paul, ed. Raven Press, New York, p. 199.
29. + lympho-hemopoietic progenitors develop. J. Exp. Med. 184:1449.
30. Saito, H, Y. Kanamori, T. Takemori, H. Nariuchi, E. Kubota, H. Takahashi-Iwanaga, T. Iwanaga, and H. Ishikawa. 1998. Generation of intestinal T cells from progenitors residing in gut cryptopatches. Science 280:275.
31. Latthe, M., L. Terry, and T. T. MacDonald. 1994. High frequency of CD8αα homodimer-bearing T cells in human fetal intestine. Eur. J. Immunol. 24:1703.
32. Collins, C., S. Norris, G. McEntee, O. Traynor, L. Bruno, H. von Boehmer, J. Hegarty, and C. O'Farrelly. 1996. RAG1, RAG2 and pre-T cell receptor α chain expression by adult human hepatic cells: evidence for extrathymic T cell maturation. Eur. J. Immunol. 26:3114.
33. Geister, C., G. Pallessen, P. Platz, N. Odum, E. Dickmeiss, L. P. Ryder, A. Svejgaard, T. Plesner, J. K. Larsen, and C. Koch. 1989. Novel primary thymic defect with T lymphocytes expressing the γ/δ T cell receptor. J. Clin. Pathol. 42:705.
34. Haynes, B. F., S. M. Denning, P. T. Le, and K. H. Singer. 1990. Human intrathymic T cell differentiation. Semin. Immunol. 2:67.
35. Haynes, B. F., S. M. Denning, K. H. Singer, and J. Kurtzberg. 1989. Ontogeny of T-cell precursors: a model for the initial stages of human T cell development. Immunol. Today 10:87.
36. Van Houten, N., P. F. Mixter, J. Wolfe, and R. C. Budd. 1993. CD2 expression on murine intestinal intraepithelial lymphocytes is bimodal and defines proliferative capacity. Int. Immunol. 5:665.
37. Zuniga-Pflücker, J. C., H. L. Schwartz, and M. J. Lenardo. 1993. Gene transcription in differentiating immature T cell receptor (neg) thymocytes resembles antigen activated mature T cells. J. Exp. Med. 178:1139.
38. Pilarski, L. M., and J. P. Deans. 1993. CD45 isoform transition on multinegative human thymocytes differentiating in vitro mimic patterns predicted for selective events in vivo. Immunol. Cell Biol. 71:289.
39. Saint-ruf, C., K. Ungewiss, M. Groettrup, L. Bruno, H. J. Fehling, and H. von Boehmer. 1994. Analysis and expression of a cloned pre-T cell receptor gene. Science 266:1208.
40. Del Porto, P., L. Bruno, M. G. Mattei, H. von Boehmer, and C. Saint-Ruf. 1995. Cloning and comparative analysis of the human pre-T-cell receptor α-chain gene. Proc. Natl. Acad. Sci. USA 92:12105.
41. Bruno, L., B. Rocha, A. Rolink, H. von Boehmer, and H. R. Rodewald. 1995. Intra and extra-thymic expression of the pre-T cell receptor α gene. Eur. J. Immunol. 25:1877.
42. Kaneshima, H., R. Namikawa, and J. M. McCune. 1994. Human hematolymphoid cells in seid mice. Curr. Opin. Immunol. 6:327.
43. Zuniga-Pflucker, J. C., and M. L. Lenardo. 1996. Regulation of thymocyte development from immature progenitors. Curr. Opin. Immunol. 8:215.
44. Von Freeden-Jeffry, U., P. Vieira, L. A. Lucian, T. McNeil, S. E. Burdach, and R. Murray. 1995. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 181:1519.
45. Peschon, J. J., P. J. Morrissey, K. H. Grabstein, F. J. Ramsdell, E. Maraskovsky, B. C. Gliniak. L. S. Park, S. F. Zieglar, D. E. Williams, C. B. Ware, J. D. Meyer, and B. L. Davison. 1994. Early lymphocyte expansion is severely impaired in interleukin 7 receptor deficient mice. J. Exp. Med. 180:1955.
46. WHO-IUIS Nomenclature Sub-Committee on TCR Designation. 1995. Nomenclature for T-cell receptor (TCR) gene segments of the immune system. Immunogenetics 42:451.
47. Arden, B., S. P. Clarke, D. Kabelitz, and T. W. Mak. 1995. Human T-cell receptor variable gene segment families. Immunogenetics 42:455.
48. Kimura, N., B. Toyonaga, Y. Yoshikai, F. Triebel, P. Debre, M. D. Minden, and T. W. Mak. 1986. Sequences and diversity of human T-cell receptor β-chain variable region genes. J. Exp. Med. 164:73.