Broadly Cross-Reactive Mimotope of Hypervariable Region 1 of Hepatitis C Virus Derived From DNA Shuffling and Screened by Phage Display Library

Journal of Medical Virology

Volumn 71, Issue 4, 2003, Pages 511-517

  Zhang, Xin Xin ^a,b   Deng, Qiang ^a   Zhang, Shen Ying ^b   Liu, Jing ^a   Cai, Qian ^b   Lu, Zhi Meng ^b   Wang, Yuan ^a,b  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

DNA shuffling; Hepatitis C virus; Hypervariable region 1; Mimotope; Phage display

Indexed keywords

ANTIGEN; COMPLEMENTARY DNA; DEOXYRIBONUCLEASE I; DNA POLYMERASE; EPITOPE; NEUTRALIZING ANTIBODY; POLYCLONAL ANTIBODY; VIRUS DNA; VIRUS VACCINE;

AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; ARTICLE; BACTERIOPHAGE; CROSS REACTION; DNA DETERMINATION; DNA SEQUENCE; GENE INSERTION; HEPATITIS C VIRUS; HYPERVARIABLE REGION 1; MOLECULAR RECOGNITION; NONHUMAN; PHAGE DISPLAY; SEQUENCE ANALYSIS; VIRUS ISOLATION;

AMINO ACID SEQUENCE; BASE SEQUENCE; CROSS REACTIONS; DNA, VIRAL; HEPACIVIRUS; HEPATITIS C; HEPATITIS C ANTIBODIES; HUMANS; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; PEPTIDE FRAGMENTS; PEPTIDE LIBRARY; VIRAL PROTEINS;

ANIMALIA; BACTERIOPHAGE 13; HEPATITIS C VIRUS;

EID: 0142151267     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmv.10521     Document Type: Article

References (38)

1. Alberti A, Chemello L, Benvegnu L. 1999. Natural history of hepatitis C. J Hepatol 31(Suppl 1):17-24.
2. Allain JP, Zhai L, Shang D, Timmers E, Alexander GJM. 1999. Hypervariable region diversity of hepatitis C virus and humoral response: Comparison between patients with or without cirrhosis. J Med Virol 59:25-31.
3. Barban V, fraysse-Corgier S, Paranhos-Baccala G, Petit M, Manin C, Berard Y, Prince AM, Mandrand B, Meulien P. 2000. Identification of a human epitope in hepatitis C virus (HCV) core protein using a molecularly cloned antibody repertoire from a non-symptomatic, anti-HCV-positive patient. J Gen Virol 81:461-469.
4. Burritt JB, Bond CW, Doss KW, Jesaitis AJ. 1996. Filamentous phage display of oligopeptide libraries. Anal Biochem 238:1-13.
5. Cai Q, Zhang XX, Tian LF, Yuan M, Jin GD, Lu ZM. 2002. Variant analysis and immunogenicity prediction of envelope gene of HCV strains from China. J Med Virol 67:490-500.
6. Cerino A, Meola A, Segagni L, Furione M, Marciano S, Triyatni M, Liang TJ, Nicosia A, Mondelli MU. 2001. Monoclonal antibodies with broad specificity for hepatitis C virus hypervariable region 1 variants can recognize viral particles. J Immunol 167:3878-3886.
7. Chan SW, Bye JM, Jackson P, Allain JP. 1996. Human recombinant antibodies specific for hepatitis C virus core and envelope E2 peptides from an immune phage display library. J Gen Virol 77:2531-2539.
8. Chang CCJ, Chen TT, Cox BW, Dawes GN, Stemmer WPC, Punnonen J, Patten PA. 1999. Evolution of a cytokine using DNA family shuffling. Nat Biotechnol 17:793-797.
9. Crameri A, Raillard SA, Bermudez E, Stemme RWP. 1998. DNA shuffling of a family of genes from divers species accelerates directed evolution. Nature 15:288-291.
10. Dente L, Cesareni G, Micheli G, Felici F, Folgori A, Luzzago A, Monaci P, Nicosia A, Delmastro P. 1994. Monoclonal antibodies that recognise filamentous phage: Tools for phage display technology. Gene 148:7-13.
11. Esumi M, Rikihisa T, Nishimura S, Goto J, Mizuno K, Zhou YH, Shikata T. 1999. Experimental vaccine activities of recombinant E1 and E2 glycoproteins and hypervariable region 1 peptides of hepatitis C virus in chimpanzees. Arch Virol 144:973-980.
12. Farci P, Shimoda A, Wong D, Cabezon T, De Gioannis D, Strazzera A, Shimizu Y, Shapiro M, Alter HJ, Purcell HJ. 1996. Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope E2 protein. Proc Natl Acad Sci USA 96:15394-15399.
13. Hattori M, Yoshioka K, Aiyama T, Iwata K, Terazawa Y, Ishigami M, Yano M, Kakumu S. 1998. Broadly reactive antibodies to hypervariable region 1 in hepatitis C virus-infected patient sera: Relation to viral loads and response to interferon. Hepatology 27:1703-1710.
14. Isaguliants MG, Widell A, Zhang SM, Sidorchuk A, Levi M, Smirnov VD, Santantonio T, Diepolder HM, Pape GR, Nordenfelt E. 2002. Antibody responses against B-cell epitopes of the hypervariable region 1 of hepatitis C virus in self-limiting and chronic human hepatitis C followed-up using consensus peptides. J Med Virol 66:204-217.
15. Jackson P, Petrik J, Alexander GJM, Pearson G, Allain JP. 1997. Reactivity of synthetic peptides representing selected sections of hepatitis C virus core and envelope proteins with a panel of hepatitis C virus-seropositive human plasma. J Med Virol 51:67-79.
16. Li C, Candotti D, Allain JP. 2001. Production and characterization of monoclonal antibodies specific for a conserved epitope within hepatitis C virus hypervariable region 1. J Virol 75:12412-12420.
17. Lyra AC, Fan X, Lang DM, Yusim K, Ramrakhiani S, Brunt EM, Korber B, Perelson AS, Di Bisceglie AM. 2002. Evolution of hepatitis C viral quasispecies after liver transplantation. Gastroenterology 123:1485-1493.
18. McHutchison JG, Gordon SC, Schiff ER, Shiffman ML, Lee WM, Rustgi VK, Goodman ZD, Ling MH, Cort S, Albrecht JK. 1998. Interferon alpha-2 alone or in combination with ribavirin as initial treatment for chronic hepatitis C. N Engl J Med 339:1485-1492.
19. Minshull J, Stemmer WPC. 1999. Protein evolution by molecular breeding. Curr Opin Chem Biol 3:284-290.
20. Mondelli MU, Cerino A, Lisa A, Brambilla S, Segagni L, Cividini A, Bissolati M, Missale G, Bellati G, Meola A, Bruniercole B, Nicosia B, Galfre G, Silini E. 1999. Antibody responses to hepatitis C virus hypervariable region 1: Evidence for cross-reactivity and immune-mediate sequence variation. Hepatology 30:537-545.
21. Pereboeva LS, Pereboev AV, Wang LF, Morris GE. 2000. Hepatitis C epitopes from phage-displayed cDNA libraries and improved diagnosis with a chimeric antigen. J Med Virol 60:144-151.
22. Poynard T, Bedossa P, Opolon P. 1997. Natural history of liver fibrosis progression in patients with chronic hepatitis C. Lancet 349:825-832.
23. Puntoriero G, Meola A, Lahm A, Zucchelli S, Ercole BB, Tafi R, Pezzanera M, Mondelli MU, Cortese R, Tramontano A, Galfre G, Nicosia A. 1998. Towards a solution for hepatitis C virus hypervariability: Mimotopes of the hypervariable region 1 can induce antibodies cross-reacting with a large number of viral variants. EMBO J 17:3521-3533.
24. Roccasecca R, Folgori A, Ercole BB, Puntoriero G, Lahm A, Zucchelli S, Tafi R, Pezzanera M, Galfre G, Tramontano A, Mondelli MU, Pessi A, Nicosia A, Cortese R, Meola A. 2001. Induction of cross-reactive humoral immune response by immunization with mimotopes of the hypervariable region 1 of the hepatitis C virus. Int Rev Immunol 20:289-300.
25. Rosa D, Campagnoli S, Morretto C, Guenzi E, Cousens L, Chin M, Dong C, Weiner AJ, Lau JYN, Choo QL, Chien D, Pileri P, Houghton M, Abrignani S. 1996. A quantitative test to estimate neutralizing antibodies to the glycoprotein 2 binding to target cells. Proc Natl Acad Sci USA 93:1759-1763.
26. Shang D, Zhai W, Allain JP. 1999. Broadly cross-reactive, high-affinity antibody to hypervariable region 1 of the hepatitis C virus in rabbits. Virology 258:396-405.
27. Sheiner PA, Boros P, Klion FM, Thung SN, Schluger LK, Lau JY, Mor E, Bodian C, Guy SR, Schwartz ME, Emre S, Bodenheimer HCJ, Miller CM. 1998. The efficacy of prophylactic interferon alpha-2b in preventing recurrent hepatitis C after liver transplantation. Hepatology 28:831-838.
28. Shimizu YK, Hijikata M, Iwamoto A, Alter HJ, Purcell RH, Yoshikura H. 1994. Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses. J Virol 65:1494-1500.
29. Shimizu YK, Igarashi H, Kiyohara T, Cabezon T, Farci P, Purcell RH, Yoshikura H. 1996. A hyperimmune serum against a synthetic peptide corresponding to the hypervariable region 1 of hepatitis C virus can prevent viral infection in cell cultures. Virology 223:409-412.
30. Stemmer WPC. 1994. DNA shuffling by random fragmentation and reassembly: In vitro recombination for molecular evolution. Proc Natl Acad Sci USA 91:10747-10751.
31. Taniguchi S, Okamoto H, Sakamoto M, Kojima M, Tsuda F, Tanaka T, Munekata E, Muchmore EE, Peterson DA, Mishiro S. 1993. A structurally flexible and antigenitically variable N-terminal domain of the hepatitis C virus E2/NS1 protein: Implication for an escape from antibody. Virology 195:297-301.
32. Van Doorn LJV, Capriles I, Maertens G, Deleys R, Murray K, Kos T, Schellekens H, Quint W. 1995. Sequence evolution of the hypervariable region in putative envelope region E2/NS1 of hepatitis C virus is correlated with specific humoral responses. J Virol 69:773-778.
33. Watanabe K, Yoshioka K, Ito H, Watanabe Kazumasa, Ishigami M, Takagi K, Utsunomiya S, Kobayashi M, Kishimoto H, Yano M, Kakumu S. 1999. The hypervariable region 1 protein of hepatitis C virus broadly reactive with sera of patients with chronic hepatitis C has a similar amino acid sequence with the consensus sequence. Virology 264:153-158.
34. Zhai W, Davies J, Shang DZ, Chan SW, Allain JP. 1999. Human recombinant single-chain antibody fragments, specific for the hypervariable region 1 of hepatitis C virus, from immune phage-display libraries. J Viral Hepat 6:115-124.
35. Zhang XX, Zhang SY, Liu J, Lu ZM, Wang Y. 2003. Expression of hepatitis C virus hypervariable region 1 and its clinical significance. World J gastroenterol 9:1003-1007.
36. Zhou YH, Moriyama M, Esumi M. 1999. Multiple sequence-reactive antibodies induced by a single peptide immunization with hypervariable region 1 of hepatitis C virus. Virology 256:360-370.
37. Zibert A, Schreier E, Roggendorf M. 1995. Antibodies in human sera specific to hypervariable region 1 of hepatitis C virus can block viral attachment. Virology 208:653-661.
38. Zucchelli S, Roccasecca R, Meola A, Ercole BB, Tafi R, Dubuisson J, Galfre G, Cortese R, Nicosia A. 2001. Mimotopes of the hepatitis C virus hypervariable region 1, but not the natural sequences, induce cross-reactive antibody response by genetic immunization. Hepatology 33:692-703.