Hypervariable region diversity of hepatitis C virus and humoral response: Comparison between patients with or without cirrhosis

Journal of Medical Virology

Volumn 59, Issue 1, 1999, Pages 25-31

  Allain, Jean Pierre ^a,b   Zhai, Wenwu ^a   Shang, Dazhuang ^a   Timmers, Erik ^a   Alexander, Graeme J M ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b East Anglia Blood Centre   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS PROTEIN;

ADULT; AGED; AMINO ACID SEQUENCE; ARTICLE; CLINICAL ARTICLE; CROSS REACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC VARIABILITY; HEPATITIS C; HUMAN; LIVER CIRRHOSIS; MALE; VIRUS CARRIER; VIRUS INFECTIVITY;

ADULT; AGED; CROSS REACTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FEMALE; HEPACIVIRUS; HEPATITIS C ANTIBODIES; HEPATITIS C, CHRONIC; HUMANS; LIVER CIRRHOSIS; MALE; MIDDLE AGED; PEPTIDES; PHYLOGENY; VARIATION (GENETICS);

EID: 0032781708     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9071(199909)59:1<25::AID-JMV5>3.0.CO;2-J     Document Type: Article

References (25)

1. Choo QL, Richman KH, Han JH, et al. 1991. Genetic organization and diversity of the hepatitis C virus. Proc Natl Acad Sci USA 88: 2451-2455.
2. Enomoto N, Kurosaki M, Tanaka Y, Marumo F. 1994. Fluctuation of hepatitis C virus quasispecies in persistent infection and interferon treatment revealed by single-strand conformation polymorphism analysis. J Gen Virol 75:1361-1369.
3. Farci P, Shimoda A, Wong D, et al. 1996. Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein. Proc Natl Acad Sci USA 93:15394-15399.
4. Higgins DG, Sharp PM. 1988. Clustal: a package for performing multiple sequence alignments on a microcomputer. Gene 73:237-244.
5. Honda M, Kaneko S, Sakai A, Unouba M, Murakami S, Kobayashi K. 1994. Degree of diversity of hepatitis C virus quasispecies and progression of liver disease. Hepatology 20:1144-1151.
6. Jackson P, Petrik J, Alexander GJM, Pearson J, Allain JP. 1997. Reactivity of synthetic peptides representing selected sections of hepatitis C virus core and envelope proteins with a panel of hepatitis C virus-seropositive human plasma. J Med Virol 51:67-79.
7. Kato N, Sekiya H, Ootsuyama Y, et al. 1993. Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp 70) of hepatitis C virus. J Virol 67:3923-3930.
8. Koizumi K, Enomoto N, Kurosami M, et al. 1995. Diversity of quasispecies in various disease stages of chronic hepatitis C virus infection and its significance in interferon treatment. Hepatology 22:30-35.
9. Kurosaki M, Enomoto N, Marumo F, Sato C. 1994. Evolution and selection of hepatitis C virus variants in patients with chronic hepatitis C. Virology 205:161-169.
10. Lawal Z, Petrik J, Wong VS, Alexander GJM, Allain JP. 1997. Hepatitis C virus genomic variability in untreated and immunosuppressed patients. Virology 228:107-111.
11. Moribe T, Hayashi N, Kanazawa Y, et al. 1995. Hepatitis C viral complexity detected by single-strand conformation polymorphism and response to interferon therapy. Gastroenterology 108:789
12. Okamoto H, Kurai S, Okada S, et al. 1992. Full-length sequence of a hepatitis C virus genome having poor homology to reported isolates: comparative study of four distinct genotypes. Virology 188: 331-341.
13. Rosa D, Campagnoli S, Moretto C, et al. 1996. A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorometric assessment of envelope glycoprotein 2 binding to target cells. Proc Natl Acad Sci USA 93:1759-1763.
14. Saitou N, Nei M. 1987. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol 4:406-425.
15. Scarcelli E, Cerino A, Esposito G, Silini E, Mondelli MU, Traboni C. 1995. Occurrence of antibodies reactive with more than one variant of the putative envelope glycoprotein (gp 70) hypervariable region 1 in viremic hepatitis C virus-infected patients. J Virol 60:4407-4412.
16. Sekiya H, Kato N, Ootsuyama Y, Nakazawa T, Yamauchi K, Shimomoto K. 1994. Genetic alterations of the putative envelope proteins encoding region of the hepatitis C virus in the progression to relapsed phase from acute hepatitis humoral immune response to hypervariable region 1. Int J Cancer 57:664-670.
17. Tagariello G, Pontisso P, Davoli PG, Ruvoletto MG, Traldi A, Alberti A. 1995. Hepatitis C virus genotypes and severity of chronic liver disease in haemophiliacs. Br J Haematol 91:708-713.
18. Tanaguchi S, Okamoto H, Sakamoto M, et al. 1993. A structurally flexible and antigenically variable N-terminal domain of the hepatitis C virus E2/NS1 protein: implication for an escape from antibody. Virology 195:297-301.
19. Toyoda H, Fukuda Y, Koyama Y, et al. 1996. Nucleotide sequence diversity of hypervariable region 1 of hepatitis C virus in Japanese hemophiliacs with chronic hepatitis C and patients with chronic posttransfusion hepatitis C. Blood 88:1488-1493.
20. van Doorn LJ, Quint W, Tsiquaye K, et al. 1994. Longitudinal analysis of hepatitis C virus infection and genetic drift of the hypervariable region. J Infect Dis 169:1226-1235.
21. van Doorn LJ, Capriles I, Maertens G, et al. 1995. Sequence evolution of the hypervariable region in the putative envelope region E2/ NS1 of hepatitis C virus is correlated with specific immune responses. J Virol 69:773-778.
22. Wilson JJ, Polyak SJ, Day TD, Gretch DR. 1995. Characterisation of simple and complex hepatitis C virus quasispecies by heteroduplex gel shift analysis: correlation with nucleotide sequencing J Gen Virol 76:1763-1771.
23. Wong V, Wight DGD, Palmer CR, Alexander GJM. 1996. Fibrosis and other histological features in chronic hepatitis C virus infection-a statistical model. J Clin Pathol 49:465-469.
24. Zibert A, Schreier E, Roggendorf M. 1995. Antibodies in human sera specific to hypervariable region 1 of hepatitis C virus can block viral attachment. Virology 208:653-661.
25. Zibert A, Kraas W, Meisel H, Jung G, Roggendorf M. 1997. Epitope mapping of antibodies directed against hypervariable region 1 in acute self-limiting and chronic infections due to hepatitis C virus J Virology 71:4123-4127.