The hypervariable region 1 protein of hepatitis C virus broadly reactive with sera of patients with chronic hepatitis C has a similar amino acid sequence with the consensus sequence

Virology

Volumn 264, Issue 1, 1999, Pages 153-158

  Watanabe, Kazuo ^a   Yoshioka, Kentaro ^a   Ito, Hiroshi ^a   Watanabe, Kazumasa ^a   Ishigami, Masatoshi ^a   Takagi, Kenji ^a   Utsunomiya, Setsuo ^a   Kobayashi, Makoto ^a   Kishimoto, Hiroaki ^a   Yano, Motoyoshi ^a   Kakumu, Shinichi ^b  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b AICHI MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS PROTEIN;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; CHRONIC HEPATITIS; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HEPATITIS NON A NON B; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PURIFICATION; RABBIT;

ANIMALIA; HEPATITIS C VIRUS; NON-A, NON-B HEPATITIS VIRUS; ORYCTOLAGUS CUNICULUS; RNA VIRUSES;

EID: 0033544384     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1999.0004     Document Type: Article

References (28)

1. Chen M., Sallberg M., Sonnerborg A., Weiland O., Mattsson L., Jin L., Berkett A., Peterson D., Millich D.R. Limited humoral immunity in hepatitis C virus infection. Gastroenterology. 116:1999;135-143.
2. Choo Q.-L., Kuo G., Weiner A. J., Overby L. R., Bradley D. W., Houghton M. Isolation of a cDNA clone derived from a blood borne non-A, non-B viral hepatitis genome. Science. 244:1989;359-362.
3. da Silva Cardoso M., Siemoneit K., Nemecek V., Epple S., Koerner K., Kubanek B. The serology of hepatitis C virus (HCV) infection: Antibody crossreaction in the hypervariable region 1. Arch. Virol. 140:1995;1705-1713.
4. Esumi M., Ahmed M., Zhou Y.-h., Takahashi H., Shikata T. Murine antibodies against E2 and hypervariable region 1 cross-reactively capture hepatitis C virus. Virology. 251:1998;158-164.
5. Farci P., Shimoda A., Wong D., Cabezon T., De Gioannis D., Strazzera A., Shimizu Y., Shapiro M., Alter H. J., Purcell R. H. Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein. Proc. Natl. Acad. Sci. USA. 93:1996;15394-15399.
6. Hattori M., Yoshioka K., Aiyama T., Iwata K., Terazawa Y., Ishigami M., Yano M., Kakumu S. Broadly reactive antibodies to hypervariable region 1 in hepatitis C virus-infected patients sera; relation to viral loads and response to interferon. Hepatology. 27:1998;1703-1710.
7. Higashi Y., Kakumu S., Yoshioka K., Wakita T., Mizokami M., Ohba K., Ito Y., Ishikawa T., Takayanagi M., Nagai Y. Dynamics of genome change in the E2/NS1 region of hepatitis C virus in vivo. Virology. 197:1992;659-668.
8. Hijikata M., Kato N., Ootsuyama Y., Nakagawa M., Ohkoshi S, Shimotohno K. Hypervariable regions in the putative glycoprotein of hepatitis C virus. Biochem. Biophys. Res. Commun. 175:1991;220-228.
9. Kato N., Sekiya H., Ootsuyama Y., Nakazawa T., Hijikata M., Ohkoshi S., Shimotohno K. Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitis C virus. J. Virol. 67:1993;3923-3930.
10. Kiyosawa K., Sodeyama T., Tanaka E., Gibo Y., Yoshizawa K., Nakano Y., Furuta A., Akahane Y., Nishioka K., Alter H. J. Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: Analysis by detection of antibody to hepatitis C virus. Hepatology. 12:1990;671-675.
11. Kuo G., Choo Q.-L., Alter H. J., Gitnick G. I., Redeker A. G., Purcell R. H., Miyamura T., Dienstag J. L., Alter M. J., Stevens C. E., Tegtmeier G. E., Bonino F., Colombo M., Lee W. S., Kuo C., Berger K., Shuster J. R., Overby L. R., Bradley D. W., Houghton M. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science. 244:1989;362-364.
12. Laemmli A. Cleavage of structural proteins during the assembly of the head of the bacteriophage T4. Nature. 227:1970;680-685.
13. Martell M., Esteban J. I., Quer J., Genesca J., Weiner A., Esteban R., Guardia J., Gomez J. Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: Quasispecies nature of HCV genome distribution. J. Virol. 66:1992;3225-3229.
14. McAllister J., Casino C., Davidson F., Power J., Lawlor E., Yap P. E., Simmonds P., Smith D. B. Long-term evolution of the hypervariable region of hepatitis C virus in a common-source-infected cohort. J. Virol. 72:1998;4893-4905.
15. Nakamoto Y., Kaneko S., Ohno H. Honda, M. Unoura M., Murakami S., Kobayashi K. B-cell epitopes in hypervariable region 1 of hepatitis C virus obtained from patients with chronic persisitent hepatitis. J. Med. Virol. 50:1996;35-41.
16. Ogata N., Alter H. J., Miller R. H., Purcell R. H. Nucleotide sequence and mutation rate of H strain of hepatitis C virus. Proc. Natl. Acad. Sci. USA. 88:1991;3392-3396.
17. Okamoto H., Sugiyama Y., Okada S., Kurai K., Akahane Y., Sugai Y., Tanaka T., Sato K., Tsuda F., Miyakawa Y., Mayumi M. Typing hepatitis C virus by polymerase chain reaction with type-specific primers: Application to clinical surveys and tracing infectious sources. J. Gen. Virol. 73:1992;673-679.
18. Puntoriero G., Lahm A., Zucchelli S., Ercole B. B., Tafi R., Penzzanera M., Mondelli M. U., Cortese R., Tramontano A., Galfre' G., Nicosia A. Towards a solution for hepatitis C virus hypervariablility: Mimotopes of hypervariable region 1 can induce antibodies cross-reacting with a large number of viral variants. EMBO J. 17:1998;3521-3533.
19. Rosa D., Campagnoli S., Moretto C., Guenzi E., Cousens L., Chin M., Dong C., Weiner A. J., Lau J. Y. N., Choo Q.-L., Chien D., Pileri P., Houghton M., Abrignani S. A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: Cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells. Proc. Natl. Acad. Sci. USA. 93:1996;1759-1763.
20. Scarselli E., Cerino A., Esposito G., Silini E., Mondelli M. U., Traboni C. Occurrence of antibodies reactive with more than one variant of the putative envelope glycoprotein (gp 70) hypervariable region 1 in viremic hepatitis C virus-infected patients. J. Virol. 69:1995;4407-4412.
21. Sekiya H., Kato N., Oootsuyama Y., Nakazawa T., Yamaguchi K., Shimotohno K. Genetic alterations of the putative envelope proteins encoding region of the hepatitis C virus in the progression to relapsed phase from acute hepatitis: Humoral immune response to hypervariable region 1. Int. J. Cancer. 57:1994;664-670.
22. Shimizu Y., Igarashi H., Kiyohara T., Cabezon T., Farci P., Purcell R. H., Yoshikura H. A hyperimmune serum against a synthetic peptide corresponding to the hypervariable region 1 of hepatitis C virus can prevent viral infection in cell cultures. Virology. 223:1996;409-412.
23. Simmonds P., McOmish F., Yap P. L., Chan S. W., Lin C. K., Dusheiko G., Saeed A. A., Holmes E. C. Sequence variability in the 5′ non-coding region of hepatitis C virus: Identification of a new virus type and restrictions on sequence diversity. J. Gen. Virol. 74:1993;661-668.
24. Taniguchi S., Okamoto H., Sakamoto M., Kojima M., Tsuda F., Tanaka T., Munekata E., Muchmore E. E., Peterson D. A., Mishiro S. A structurally flexible and antigenetically variable N-terminal domain of the hepatitis C virus E2/NS1 protein: Implication for an escape from antibody. Virology. 1993;297-301.
25. Weiner A. J., Brauer M. J., Rosenblatt J., Richman K. H., Tung J., Crawford K., Bonino F., Saracco G., Choo Q.-L., Houghton M., Han J. H. Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins. Virology. 180:1991;842-848.
26. Weiner A. J., Geysen H. M., Christopherson C., Hall J. E., Mason T. J., Saracco G., Bonino F., Crawford K., Marion C. D., Crawford K. A., Brunetto M., Barr P. J., Miyamura T., McHutchinson J., Houghton M. Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: Potential role in chronic HCV infections. Proc. Natl. Acad. Sci. USA. 89:1992;3468-3472.
27. Yoshioka K., Aiyama T., Okumura A., Takayanagi M., Iwata K., Ishikawa T., Nagai Y., Kakumu S. Humoral immune response to the hypervariable region of hepatitis C virus differs between genotype 1b and 2a. J. Infect. Dis. 175:1997;505-510.
28. Zibert A., Schreier E., Roggendorf M. Antibodies in human sera specific to hypervariable region 1 of hepatitis C virus can block viral attachment. Virology. 208:1995;653-661.