Ghrelin and growth hormone (GH) secretagogues potentiate GH-releasing hormone (GHRH)-induced cyclic adenosine 3′,5′-monophosphate production in cells expressing transfected GHRH and GH secretagogue receptors

Endocrinology

Volumn 143, Issue 12, 2002, Pages 4570-4582

  Cunha, Shane R ^a   Mayo, Kelly E ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 HYDROXYPROPYLAMINO) 3 METHYL N [2,3,4,5 TETRAHYDRO 2 OXO 1 [[2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL] 1H 1 BENZAZEPIN 3 YL]BUTANAMIDE; 3 AMINO 3 METHYL N [2,3,4,5 TETRAHYDRO 2 OXO 1 [[2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL] 1H 1 BENZAZEPIN 3 YL]BUTANAMIDE; CYCLIC AMP; FORSKOLIN; GHRELIN; GROWTH HORMONE RELEASING FACTOR; GROWTH HORMONE SECRETAGOGUE; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; PHOSPHOLIPASE C; PROTEIN KINASE C INHIBITOR; VASOACTIVE INTESTINAL POLYPEPTIDE;

ARTICLE; CELL POPULATION; CONTROLLED STUDY; GENETIC TRANSFECTION; HORMONE RELEASE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INHIBITION KINETICS; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ANIMALS; BENZAZEPINES; CYCLIC AMP; DRUG SYNERGISM; ENZYME INHIBITORS; FLUORESCENT ANTIBODY TECHNIQUE; FORSKOLIN; GENE EXPRESSION; GROWTH HORMONE; GROWTH HORMONE-RELEASING HORMONE; HELA CELLS; HEMAGGLUTININS; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; IMMUNOSORBENT TECHNIQUES; PEPTIDE HORMONES; PHOSPHOLIPASE C; PROTEIN KINASE C; RATS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, GASTROINTESTINAL HORMONE; RECEPTORS, NEUROPEPTIDE; RECEPTORS, PITUITARY HORMONE-REGULATING HORMONE; RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE; RECOMBINANT FUSION PROTEINS; SECRETIN; SIGNAL TRANSDUCTION; TETRAZOLES; TRANSFECTION; VASOACTIVE INTESTINAL PEPTIDE;

EID: 0036892796     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2002-220670     Document Type: Article

References (61)

1. Devesa J, Lima L, Tresguerres AF 1992 Neuroendocrine control of growth hormone secretion in humans. Trends Endocrinol Metab 3:175-182
2. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660
3. Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, Kennedy AR, Roberts GH, Morgan DG, Ghatei MA, Bloom SR 2000 The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141:4325-4328
4. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS 2001 A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50:1714-1719
5. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S 2001 A role for ghrelin in the central regulation of feeding. Nature 409:194-198
6. Bowers CY 1996 Xenobiotic growth hormone secretagogues: Growth hormone releasing peptides. In: Bercu BB, Walker RF, eds. Growth Hormone Secretagogues. New York: Springer-Verlag; 9-28
7. Bowers C, Momany F, Reynolds G, Chang D, Hong A, Chang K 1980 Structure-activity relationships of a synthetic pentapeptide that specifically releases growth hormone in vitro. Endocrinology 106:663-667
8. Bowers CY, Reynolds GA, Durham D, Barrera CM, Pezzoli SS, Thorner MO 1990 Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone. Journal of Clinical Endocrinology, Metabolism 70:975-982
9. Bowers CY, Momany FA, Reynolds GA, Hong A 1984 On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology 114:1537-1545
10. Bowers C, Sartor A, Reynolds G, Badger T 1991 On the actions of the growth hormone-releasing hexapeptide, GHRP. Endocrinology 128:2027-2035
11. Bowers CY 1993 GH releasing peptides: Structure and kinetics. J Pediatr Endocrinol 6:21-31
12. Deghenghi R, Cananzi MM, Torsello A, Battisti C, Muller EE, Locatelli V 1994 GH-releasing activity of hexarelin, a new growth hormone releasing peptide, in infant and adult rats. Life Sci 54:1321-1328
13. Cheng K, Chan WW, Butler B, Wei L, Schoen WR, Wyvratt Jr MJ, Fisher MH, Smith RG 1993 Stimulation of growth hormone release from rat primary pituitary cells by L-692, 429, a novel non-peptidyl GH secretagogue. Endocrinology 132:2729-2731
14. Smith RG, Cheng K, Schoen WR, Pong SS, Hickey G, Jacks T, Butler B, Chan WW, Chaung LY, Judith F 1993 A nonpeptidyl growth hormone secretagogue. Science 260:1640-1643
15. Jacks T, Hickey G, Judith F, Taylor J, Chen H, Krupa D, Feeney W, Schoen W, Ok D, Fisher M 1994 Effects of acute and repeated intravenous administration of L-692,585, a novel non-peptidyl growth hormone secretagogue, on plasma growth hormone, IGF-1 ACTH, cortisol, prolactin, insulin, and thyroxine levels in beagles. J Endocrinol 143:399-406
16. Patchett AA, Nargund RP, Tata JR, Chen MHH, Barakat KJ, Johnston DB, Cheng K, Chan WW, Butler B, Hickey G 1995 Design and biological activities of L-163, 191 (MK-0677): A potent, orally active growth hormone secretagogue. Proc Natl Acad Sci USA 92:7001-7005
17. Tschop M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML 2001 Circulating ghrelin levels are decreased in human obesity. Diabetes 50:707-709
18. Masuda Y, Tanaka T, Inomata N, Ohnuma N, Tanaka S, Itoh Z, Hosoda H, Kojima M, Kangawa K 2000 Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun 276:905-908
19. Date Y, Nakazato M, Murakami N, Kojima M, Kangawa K, Matsukura S 2001 Ghrelin acts in the central nervous system to stimulate gastric acid secretion. Biochem Biophys Res Commun 280:904-907
20. Lee HM, Wang G, Englander EW, Kojima M, Greeley Jr GH 2002 Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: Enteric distribution, ontogeny, influence of endocrine, and dietary manipulations. Endocrinology 143:185-190
21. Bednarek MA 2000 Structure-function studies on the new growth hormone-releasing peptide, ghrelin: Minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. J Med Chem 43:4370-4376
22. Howard A, Feighner S, Cully D, Arena J, Liberator P, Rosenblum C, Hamelin M, Hreniuk D, Palyha O, Anderson J, Paress P, Diaz C, Chou M, Liu K, McKee K, Pong S, Chaung L, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji D, Dean D, Melillo D, Van der Ploeg L 1996 A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273:974-977
23. Day R, Dong W, Panetta R, Kraicer J, Greenwood MT, Patel YC 1995 Expression of mRNA for somatostatin receptor (sstr) types 2 and 5 in individual rat pituitary cells. A double labeling in situ hybridization analysis. Endocrinology 136:5232-5235
24. Kumar U, Laird D, Srikant CB, Escher E, Patel YC 1997 Expression of the five somatostatin receptor (SSTR1-5) subtypes in rat pituitary somatotrophes: Quantitative analysis by double-layer immunofluorescence confocal microscopy. Endocrinology 138:4473-4476
25. Mezey E, Hunyady B, Mitra S, Hayes E, Liu Q, Schaeffer J, Schonbrunn A 1998 Cell specific expression of the sst2A and sst5 somatostatin receptors in the rat anterior pituitary. Endocrinology 139:414-419
26. Hataya Y, Akamizu T, Takaya K, Kanamoto N, Ariyasu H, Saijo M, Moriyama K, Shimatsu A, Kojima M, Kangawa K, Nakao K 2001 A low dose of ghrelin stimulates growth hormone (GH) release synergistically with GH-releasing hormone in humans. J Clin Endocrinol Metab 86:45-52
27. Penalva A, Carballo A, Pombo M, Casanueva F, Dieguez C 1993 Effect of growth hormone (GH)-releasing hormone (GHRH), atropine, pyridostigmine, or hypoglycemia on GHRP-6-induced GH secretion in man. J Clin Endocrinol Metab 76:168-171
28. Guillaume V, Magnan E, Cataldi M, Dutour A, Sauze N, Renard M, Razafindraibe H, Conte-Devolx B, Deghenghi R, Lenaerts V 1994 Growth hormone (GH)-releasing hormone secretion is stimulated by a new GH-releasing hexapeptide in sheep. Endocrinology 135:1073-1076
29. 2 on growth hormone (GH)-releasing factor-stimulated GH release and intracellular adenosine 3′, 5′-monophosphate accumulation in rat primary pituitary cell culture. Endocrinology 124:2791-2798
30. 2-induced growth hormone release from rat primary pituitary cells. Endocrinology 129:3337-3342
31. Ishihara T, Shigemoto R, Mori K, Takahashi K, Nagata S 1992 Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide. Neuron 8:811-819
32. Ishihara T, Nakamura S, Kaziro Y, Takahashi T, Takahashi K, Nagata S 1991 Molecular cloning and expression of a cDNA encoding the secretin receptor. EMBO J 10:1635-1641
33. DeAlmeida VI, Mayo KE 1998 Identification of binding domains of the growth hormone-releasing hormone receptor by analysis of mutant and chimeric receptor proteins. Mol Endocrinol 12:750-765
34. Miller TL, Godfrey PA, Dealmeida VI, Mayo KE 1999 The rat growth hormone-releasing hormone receptor gene: Structure, regulation, and generation of receptor isoforms with different signaling properties. Endocrinology 140:4152-4165
35. Fuerst TR, Earl PL, Moss B 1987 Use of a hybrid vaccinia virus-T7 RNA polymerase system for expression of target genes. Mol Cell Biol 7:2538-2544
36. Bodart V, Bouchard JF, McNicoll N, Escher E, Carriere P, Ghigo E, Sejlitz T, Sirois MG, Lamontagne D, Ong H 1999 Identification and characterization of a new growth hormone-releasing peptide receptor in the heart. Circ Res 85:796-802
37. Ong H, McNicoll N, Escher E, Collu R, Deghenghi R, Locatelli V, Ghigo E, Muccioli G, Boghen M, Nilsson M 1998 Identification of a pituitary growth hormone-releasing peptide (GHRP) receptor subtype by photoaffinity labeling. Endocrinology 139:432-435
38. A-subunit gene and regulation in an ovarian granulosa cell line. Endocrinology 139:3271-3279
39. Tang WJ, Gilman AG 1991 Type-specific regulation of adenylyl cyclase by G protein βγ subunits. Science 254:1500-1503
40. Yoshimura M, Ikeda H, Tabakoff B 1996 mu-Opioid receptors inhibit dopamine-stimulated activity of type V adenylyl cyclase but enhance dopamine-stimulated activity of type VII adenylyl cyclase. Mol Pharmacol 50:43-51
41. Koch WJ, Hawes BE, Inglese J, Luttrell LM, Lefkowitz, RJ 1994 Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates Gβγ-mediated signaling. J Biol Chem 269:6193-6197
42. s-cAMP-mediated inhibition. J Biol Chem 270:25259-25265
43. Segre G, Goldring S 1993 Receptors for secretin, calcitonin, parathyroid hormone (PTH)/PTH-related peptide, vasoactive intestinal peptide, glucagonlike peptide 1, growth hormone-releasing hormone and glucagon belong to a newly discovered G-protein-linked receptor family. Trends Endocrinol Metab 4:309 -314
44. Seamon KB, Daly JW 1986 Forskolin: Its biological and chemical properties. Ado Cyclic Nucleotide Protein Phosphorylation Res 20:1-150
45. Smith R, Van der Ploeg L, Howard A, Feighner S, Cheng K, Hickey G, Wyvratt MJ, Fisher M, Nargund R, Patchett A 1997 Peptidomimetic regulation of growth hormone secretion. Endocr Rev 18:621-645
46. 14-ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor. J Biol Chem 275:21995-22000
47. Adams EF, Lei T, Buchfelder M, Bowers CY, Fahlbusch R 1996 Protein kinase C-dependent growth hormone releasing peptides stimulate cyclic adenosine 3′,5′-monophosphate production by human pituitary somatotropinomas expressing gsp oncogenes: Evidence for crosstalk between transducfion pathways. Mol Endocrinol 10:432-438
48. Choi EJ, Wong ST, Dittman AH, Storm DR 1993 Phorbol ester stimulation of the type I and type III adenylyl cyclases in whole cells. Biochemistry 32:1891-1894
49. 2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain. J Biol Chem 269:12190-12195
50. Wayman GA, Wei J, Wong S, Storm DR 1996 Regulation of type I adenylyl cyclase by calmodulin kinase IV in vivo. Mol Cell Biol 16:6075-6082
51. Yao L, Arolfo MP, Dohrman DP, Jiang Z, Fan P, Fuchs S, Janak PH, Gordon AS, Diamond I 2002 βγ dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption. Cell 109:733-743
52. Jiang H, Smith R, The synergistic effect of the growth hormone secretagogue receptor on the dopamine D1 receptor signal transduction pathway. Program of the 84th Annual Meeting of the Endocrine Society, San Francisco, CA, 2002, p 541 (Abstract P3-20)
53. Wu D, Chen C, Katoh K, Zhang J, Clarke IJ 1994 The effect of GH-releasing peptide-2 (GHRP-2 or KP 102) on GH secretion from primary cultured ovine pituitary cells can be abolished by a specific GH-releasing factor (GRF) receptor antagonist. J Endocrinol 140:R9-13
54. Pandya N, DeMott-Friberg R, Bowers CY, Barkan AL, Jaffe CA 1998 Growth hormone (GH)-releasing peptide-6 requires endogenous hypothalamic GH-releasing hormone for maximal GH stimulation. J Clin Endocrinol Metab 83:1186-1189
55. Jansson J-O, Downs T, Beamer W, Frohman L, The dwarf 'little' (lit/lit) mouse is resistant to growth hormone (GH)-releasing peptide (GH-RP-6) as well as to GH-releasing hormone (GRH). Program of the 68th Annual Meeting of The Endocrine Society, Anaheim, CA, 1986, p 130 (Abstract 397)
56. Maheshwari HG, Silverman BL, Dupuis J, Baumann G 1998 Phenotype and genetic analysis of a syndrome caused by an inactivating mutation in the growth hormone-releasing hormone receptor: Dwarfism of Sindh. J Clin Endocrinol Metab 83:4065-4074
57. Rocheville M, Lange DC, Kumar U, Patel SC, Patel RC, Patel YC 2000 Receptors for dopamine and somatostatin: Formation of hetero-oligomers with enhanced functional activity. Science 288:154-157
58. Jordan BA, Devi LA 1999 G-Protein-coupled receptor heterodimerization modulates receptor function. Nature 399:697-700
59. AbdAlla S, Lother H, Quitterer U 2000 AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration. Nature 407:94-98
60. Motomura T, Hashimoto K, Koga M, Arita N, Hayakawa T, Kishimoto T, Kasayama S 1998 Inhibition of signal transduction by a splice variant of the growth hormone-releasing hormone receptor expressed in human pituitary adenomas. Metab Clin Exp 47:804-808
61. Horikawa R, Fujita K, Tanaka T, Mastromarino A, Gaylinn BD, A growth hormone-releasing hormone (GHRH) receptor mutation that acts as a dominant negative. Program of the 83rd Annual Meeting of the Endocrine Society, Denver, CO, 2001, p 170 (Abstract P1-97)