Regulated-stereoselective construction of thirteen stereogenic centers necessary for the frame of (+)-discodermolide, based on iterative Lewis acid-promoted aldol reactions

Journal of Organic Chemistry

Volumn 68, Issue 21, 2003, Pages 7967-7978

  Kiyooka, Syun Ichi ^a,b   Shahid, Kazi Abdus ^a,c   Goto, Fumitaka ^d   Okazaki, Momotoshi ^c   Shuto, Yoshihiro ^c  

^a KOCHI UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c EHIME UNIVERSITY   (Japan)

^d OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BROMINE; MAGNESIUM COMPOUNDS; SYNTHESIS (CHEMICAL);

KINETIC CONTROL;

ALDEHYDES;

2 BROMOPROPIONIC ACID ETHYL ESTER; 2 METHYL 1,3 PROPANEDIOL DIOCTANOATE; ACETAL DERIVATIVE; ALDEHYDE; DISCODERMOLIDE; LEWIS ACID; N 4 TOLUENESULFONYLVALINE; OXAZABOROLIDINE DERIVATIVE; PROPANEDIOL DERIVATIVE; PROPIONIC ACID DERIVATIVE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ALDOL REACTION; ARTICLE; CHIRALITY; DEBROMINATION; DIASTEREOISOMER; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

ALDEHYDES; ALKANES; ANTINEOPLASTIC AGENTS; CARBAMATES; LACTONES; MOLECULAR STRUCTURE; PROPIONATES; PYRONES; STEREOISOMERISM;

EID: 0142121846     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo034901c     Document Type: Article

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