Preparation, characterization, DNA binding, and in Vitro cytotoxicity of the enantiomers of the platinum(II) complexes N-methyl-, N-ethyl- and N,N- dimethyl-(R)- and -(S)-3-aminohexahydroazepinedichloroplatinum(II)

Journal of Medicinal Chemistry

Volumn 40, Issue 22, 1997, Pages 3508-3515

  Rezler, Evonne M ^a   Fenton, Ronald R ^a   Esdale, Warren J ^b   McKeage, Mark J ^b   Russell, Pamela J ^b   Hambley, Trevor W ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b PRINCE OF WALES HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

3 (N ETHYLAMINO)HEXAHYDROAZEPINEDICHLOROPLATINUM; 3 (N METHYLAMINO)HEXAHYDROAZEPINEDICHLOROPLATINUM; 3 (N,N DIMETHYLAMINO)HEXAHYDROAZEPINEDICHLOROPLATINUM; CISPLATIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CATTLE; CIRCULAR DICHROISM; CYTOPATHOGENIC EFFECT; DRUG CONFORMATION; DRUG DNA BINDING; ENANTIOMER; HUMAN; HUMAN CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; DNA; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; ORGANOPLATINUM COMPOUNDS; STEREOISOMERISM; TUMOR CELLS, CULTURED;

EID: 0030714029     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960854n     Document Type: Article

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