Effect of GH/IGF-I deficiency on long-term renal changes and urinary albumin excretion in diabetic dwarf rats

American Journal of Physiology - Endocrinology and Metabolism

Volumn 272, Issue 5 35-5, 1997, Pages

  Grønbæk, Henning ^a,b   Volmers, Pernille ^a   Bjørn, Signe F ^a   Østerby, Ruth ^a   Ørskov, Hans ^a   Flyvbjerg, Allan ^a  

^a University Institute of Pathology Arhus   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

basement membrane thickening; growth hormone deficiency; insulin like growth factor I; kidney disease; kidney morphology; renal hypertrophy

Indexed keywords

ALBUMIN; GROWTH HORMONE; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DWARFISM; FEMALE; GLOMERULOPATHY; GLOMERULUS BASEMENT MEMBRANE; GROWTH HORMONE DEFICIENCY; HORMONE DEFICIENCY; KIDNEY DISEASE; KIDNEY HYPERTROPHY; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; URINARY EXCRETION;

EID: 0030924916     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1997.272.5.e918     Document Type: Article

References (30)

1. Bidani, A. K., K. D. Mitchell, M. M. Schwartz, G. Navar, and E. J. Lewis. Absence of glomerular injury or nephron loss in a normotensive rat remnant kidney model. Kidney Int. 38: 28-38, 1990.
2. Brekke, I. B., H. J. G. Gundersen, and R. Østerby. Thickening of glomerular basement membrane in rats with severe diabetes without kidney hypertrophy. Diabetic Nephrop. 4: 19-22, 1985.
3. Charlton, H. M., R. G. Clark, I. C. A. F. Robinson, A. E. Goff, B. S. Cox, C. Bugnon, and B. A. Bloch. Growth hormone-deficient dwarfism in the rat: a new mutation. J. Endocrinol. 119: 51-58, 1988.
4. Doi, T., L. J. Striker, C. C. Gibson, L. Y. Agodoa, R. L. Brinster, and G. E. Striker. Glomerular lesions in mice transgenic for growth hormone and insulinlike growth factor-I. I. Relationship between increased glomerular size and mesangial sclerosis. Am. J. Pathol. 137: 541-552, 1990.
5. Doi, T., L. J. Striker, C. Quaife, F. G. Conti, R. Palmiter, R. Behringer, R. Brinster, and G. E. Striker. Progressive glomerulosclerosis develops in transgenic mice chronically expressing growth hormone and growth hormone releasing factor but not in those expressing insulinlike growth factor-1. Am. J. Pathol. 131: 398-403, 1988.
6. Ellis, E. N., T. B. Wiegmann, and V. J. Savin. Diminished glomerular capillary hydraulic conductivity precedes morphologic changes in experimental diabetes mellitus in the rat. Diabetes 41: 1106-1112, 1992.
7. El Nahas, A. M., A. H. Basset, G. H. Cope, and J. E. Le Carpentier. Role of growth hormone in the development of experimental renal scarring. Kidney Int. 40: 29-34, 1991.
8. Flyvbjerg, A., J. Frystyk, R. Østerby, and H. Ørskov. Kidney IGF-I and renal hypertrophy in GH-deficient diabetic dwarf rats. Am. J. Physiol. 262 (Endocrinol. Metab. 25): E956-E962, 1992.
9. Flyvbjerg, A., J. Frystyk, O. Thorlacius-Ussing, and H. Ørskov. Somatostatin analogue administration prevents increase in kidney somatomedin C and initial renal growth in diabetic and uninephrectomized rats. Diabetologia 32: 261-265, 1989.
10. Flyvbjerg, A., S. M. Marshall, J. Frystyk, K. W. Hansen, A. G. Harris, and H. Ørskov. Octreotide administration in diabetic rats: effects on renal hypertrophy and urinary albumin excretion. Kidney Int. 41: 805-812, 1992.
11. Flyvbjerg, A., O. Thorlacius-Ussing, R. Naeraa, J. Ingerslev, and H. Ørskov. Kidney tissue somatomedin C and initial renal growth in diabetic and uninephrectomized rats. Diabetologia 31: 310-314, 1988.
12. Grønbæk, H., J. Frystyk, H. φrskov, and A. Flyvbjerg. Effect of sodium selenite on growth, insulin-like growth factor binding proteins, and insulin-like growth factor I in rats. J. Endocrinol. 145: 105-112, 1995.
13. Grønbæk, H., B. Nielsen, R. Østerby, A. G. Harris, H. Ørskov, and A. Flyvbjerg. Effect of octreotide and insulin on manifest renal and glomerular hypertrophy and urinary albumin excretion in long-term experimental diabetes in rats. Diabetologia 38: 135-144, 1995.
14. Hostetter, T. H., J. L. Troy, and B. M. Brenner. Glomerular hemodynamics in experimental diabetes. Kidney Int. 19: 410-415, 1981.
15. Lundbæk, K., N. J. Christensen, and V. A. Jensen. Diabetes, diabetic angiopathy and growth hormone (hypothesis). Lancet ii: 131-133, 1970.
16. Mackay, K, L. J. Striker, J. W. Stauffer, L. Y. Agodoa, and G. E. Striker. Relationship of glomerular hypertrophy and sclerosis: studies in SV40 transgenic mice. Kidney Int. 37: 741-748, 1990.
17. Makino, H., Y. Yamasaki, K. Hironaka, and Z. Ota. Glomerular extracellular matrices in rat diabetic glomerulopathy by scanning electron microscopy. Virchows Arch. B. Cell Pathol. Ind. Mol. Pathol. 62: 19-24, 1992.
18. Mogensen, C. E., and M. J. F. Andersen. Increased kidney size and glomerular filtration rate in early juvenile diabetes. Diabetes 22: 706-712, 1973.
19. Mogensen, C. E., and C. K. Christensen. Predicting diabetic nephropathy in insulin dependent patients. N. Engl. J. Med. 311: 89-93, 1984.
20. Mogensen, C. E., E. Vestbo, P. L. Poulsen, C. Christiansen, E. Damsgaard, H. Eiskjær, A. Fryland, K. W. Hansen, S. Nielsen, and M. M. Pedersen. Microalbuminuria and potential confounders. Diabetes Care 18: 1-10, 1995.
21. Muchaneta-Kubara, E. C., N. Sayed-Ahmed, N. Besbas, G. Zhang, G. H. Cope, and A. M. El Nahas. Experimental diabetic renal growth: role of growth hormone and insulin-like growth factor-I. Nephrol. Dial. Transplant. 9: 1395-1401, 1994.
22. Ørskov, H. Growth hormone hyperproduction inducing some of the vicious circles in diabetes mellitus. Acta Med. Scand. 217: 343-346, 1985.
23. Østerby, R., and H. J. G. Gundersen. Glomerular size and structure in diabetes mellitus. I. Early abnormalities. Diabetologia 11: 225-229, 1975.
24. Østerby, R., and H. J. G. Gundersen. Glomerular basement membrane thickening in streptozotocin diabetic rats despite treatment with an aldose reductase inhibitor. J. Diabetic Complications 3: 149-153, 1989.
25. Østerby, R., K. Lundbæk, T. S. Olsen, and H. Ørskov. Kidney lesions in rats with severe long term alloxan diabetes. Lab. Invest. 17: 675-692, 1967.
26. Rasch, R., and C. E. Mogensen. Urinary excretion of albumin and total protein in normal and streptozotocin diabetic rats Acta Endocrinol. 95: 376-381, 1980.
27. Seyer-Hansen, K. Renal hypertrophy in streptozotocin diabetic rats. Clin. Sci. Mol. Med. 51: 551-555, 1976.
28. Seyer-Hansen, K., J. Hansen, and H. J. G. Gundersen. Renal hypertrophy in experimental diabetes: a morphometric study. Diabetologia 18: 501-505, 1980.
29. Shirato, I., T. Sakai, M. Fukui, Y. Tomino, and H. Koide. Widening of capillary neck and alteration of extracellular matrix ultrastructure in diabetic rat glomerulus as revealed by computer morphometry and improved tissue processing. Virchows Arch. A. Pathol. Anat. Histopathol. 423: 121-129, 1993.
30. Steffes, M. W., D. M. Brown, J. M. Basgen, A. J. Matas, and S. M. Mauer. Glomerular basement membrane thickness following islet transplantation in the diabetic rat. Lab Invest 41: 116-120, 1979.