Skeletal muscle insulin resistance: Is it important for the pathogenesis of type 2 diabetes after all?

Journal of Endocrinological Investigation

Volumn 26, Issue 7, 2003, Pages 690-692

  Koistinen, H A ^a,b,c   Zierath, Juleen R ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c BIOMEDICUM HELSINKI   (Finland)

Author keywords

Functional genomics; Genetics; Glucose transport; GLUT; Hyperglycemia; Insulin receptor; Insulin signaling; Skeletal muscle

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; PHLORIZIN;

DISEASE COURSE; GENE TRANSLOCATION; GENETIC DISORDER; GENETIC REGULATION; GENOMICS; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; HORMONE ACTION; HUMAN; HYPERGLYCEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; INSULIN RESISTANCE; MOLECULAR DYNAMICS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TRANSGENE;

EID: 0142088903     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03347032     Document Type: Review

References (15)

1. De Fronzo R.A., Gunnarsson R., Bjorkman O., Olsson M., Wahren J. Effects of insulin on peripheral and splanchnic glucose metabolism in non-insulin-dependent (Type II) diabetes mellitus. J. Clin. Invest. 1985, 76: 149-155.
2. Zierath J.R., Krook A., Wallberg-Henriksson H. Insulin action and insulin resistance in human skeletal muscle. Diabetologia 2000, 43: 821-835.
3. Bruning J.C., Michael M.D., Winnay J.N., et al. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol. Cell. 1998, 2: 559-569.
4. Kim J.K., Michael M.D., Previs S.F., et al. Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle. J. Clin. Invest. 2000, 105: 1791-1797.
5. Katz E.B., Stenbit A.E., Hatton K., DePinho R., Charron M.J. Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4. Nature 1995, 377: 151-155.
6. Stenbit A.E., Tsao T.S., Li J., et al. GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes. Nat. Med. 1997, 3: 1096-1101.
7. Rossetti L., Stenbit A.E., Chen W., et al. Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene. J. Clin. Invest. 1997, 100: 1831-1839.
8. Tsao T.S., Stenbit A.E., Li J., et al. Muscle-specific transgenic complementation of GLUT4-deficient mice. Effects of glucose but not lipid metabolism. J. Clin. Invest. 1997, 100: 671-677.
9. Zisman A., Peroni O.D., Abel E.D., et al. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat. Med. 2000, 6: 924-928.
10. Kim J.K., Zisman A., Fillmore J.J., et al. Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4. J. Clin. Invest. 2001, 108: 153-160.
11. Eriksson J., Franssila-Kallunki A., Ekstrand A., et al. Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. N. Engl. J. Med. 1989, 321: 337-343.
12. Henriksen J.E., Alford F., Handberg A., et al. Increased glucose effectiveness in normoglycemic but insulin-resistant relatives of patients with non-insulin-dependent diabetes mellitus. A novel compensatory mechanism. J. Clin. Invest. 1994, 94: 1196-1204.
13. Vaag A., Henriksen J.E., Beck-Nielsen H. Decreased insulin activation of glycogen synthase in skeletal muscles in young non-obese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus. J. Clin. Invest. 1992, 89: 782-788.
14. Henry R.R., Ciaraldi T.P., Abrams-Carter L., Mudaliar S., Park K.S., Nikoulina S.E. Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects. Biochemical and molecular mechanisms. J. Clin. Invest. 1996, 98: 1231-1236.
15. Abel E.D., Peroni O., Kim J.K., et al. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 2001, 409: 729-733.