Osteoclast differentiation by human osteoblastic cell line SaOS-2 primed with bacterial lipid A

FEMS Immunology and Medical Microbiology

Volumn 38, Issue 1, 2003, Pages 71-79

  Asai, Yasuyuki ^a   Hirokawa, Yoshitaka ^a   Niwa, Kin Ichiro ^a   Ogawa, Tomohiko ^a  

^a ASAHI UNIVERSITY   (Japan)

Author keywords

Bacterial synthetic lipid A; Osteoblastic cell; Osteoclastogenesis; Receptor activator of nuclear factor B ligand; Toll like receptor

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CD14 ANTIGEN; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIGAND; LIPID A; MESSENGER RNA; MONOCLONAL ANTIBODY; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN MD 2; SECRETORY PROTEIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ESCHERICHIA COLI; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MONONUCLEAR CELL; NUCLEOTIDE SEQUENCE; OSTEOBLAST; OSTEOCLAST; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0142029137     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-8244(03)00111-1     Document Type: Article

References (56)

1. Jimi E., Nakamura I., Amano H., Taguchi Y., Tsurukai T., Tamura M., Takahashi N., Suda T. Osteoclast function is activated by osteoblastic cells through a mechanism involving cell-to-cell contact. Endocrinology. 137:1996;2187-2190.
2. Matsuzaki K., Udagawa N., Takahashi N., Yamaguchi K., Yasuda H., Shima N., Morinaga T., Toyama Y., Yabe Y., Higashio K., Suda T. Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures. Biochem. Biophys. Res. Commun. 246:1998;199-204.
3. Udagawa N., Takahashi N., Jimi E., Matsuzaki K., Tsurukai T., Itoh K., Nakagawa N., Yasuda H., Goto M., Tsuda E., Higashio K., Gillespie M.T., Martin T.J., Suda T. Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor: receptor activator of NF-kappa B ligand. Bone. 25:1999;517-523.
4. Yasuda H., Shima N., Nakagawa N., Yamaguchi K., Kinosaki M., Goto M., Mochizuki S.I., Tsuda E., Morinaga T., Udagawa N., Takahashi N., Suda T., Higashio K. A novel molecular mechanism modulating osteoclast differentiation and function. Bone. 25:1999;109-113.
5. Kong Y.Y., Yoshida H., Sarosi I., Tan H.L., Timms E., Capparelli C., Morony S., Oliveira-dos-Santos A.J., Van G., Itie A., Khoo W., Wakeham A., Dunstan C.R., Lacey D.L., Mak T.W., Boyle W.J., Penninger J.M. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 397:1999;315-323.
6. Lacey D.L., Timms E., Tan H.L., Kelley M.J., Dunstan C.R., Burgess T., Elliott R., Colombero A., Elliott G., Scully S., Hsu H., Sullivan J., Hawkins N., Davy E., Capparelli C., Eli A., Qian Y.X., Kaufman S., Sarosi I., Shalhoub V., Senaldi G., Guo J., Delaney J., Boyle W.J. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell. 93:1998;165-176.
7. Wong B.R., Rho J., Arron J., Robinson E., Orlinick J., Chao M., Kalachikov S., Cayani E., Bartlett F.S. III, Frankel W.N., Lee S.Y., Choi Y. TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J. Biol. Chem. 272:1997;25190-25194.
8. Wong B.R., Josien R., Lee S.Y., Sauter B., Li H.L., Steinman R.M., Choi Y. TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor. J. Exp. Med. 186:1997;2075-2080.
9. Yasuda H., Shima N., Nakagawa N., Yamaguchi K., Kinosaki M., Mochizuki S., Tomoyasu A., Yano K., Goto M., Murakami A., Tsuda E., Morinaga T., Higashio K., Udagawa N., Takahashi N., Suda T. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc. Natl. Acad. Sci. USA. 95:1998;3597-3602.
10. Yoshida H., Hayashi S., Kunisada T., Ogawa M., Nishikawa S., Okamura H., Sudo T., Shultz L.D., Nishikawa S. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature. 345:1990;442-444.
11. Anderson D.M., Maraskovsky E., Billingsley W.L., Dougall W.C., Tometsko M.E., Roux E.R., Teepe M.C., DuBose R.F., Cosman D., Galibert L. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature. 390:1997;175-179.
12. Hsu H., Lacey D.L., Dunstan C.R., Solovyev I., Colombero A., Timms E., Tan H.L., Elliott G., Kelley M.J., Sarosi I., Wang L., Xia X.Z., Elliott R., Chiu L., Black T., Scully S., Capparelli C., Morony S., Shimamoto G., Bass M.B., Boyle W.J. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc. Natl. Acad. Sci. USA. 96:1999;3540-3545.
13. Simonet, W.S., Lacey, D.L., Dunstan, C.R., Kelley, M., Chang, M.S., Luthy, R., Nguyen, H.Q., Wooden, S., Bennett, L., Boone, T., Shimamoto, G., DeRose, M., Elliott, R., Colombero, A., Tan, H.L., Trail, G., Sullivan, J., Davy, E., Bucay, N., Renshaw-Gegg, L., Hughes, T.M., Hill, D., Pattison, W., Campbell, P., Sander, S., Van, G., Tarpley, J., Derby, P., Lee, R., Amgen EST Program and Boyle, W.J. (1997) Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89, 309-319.
14. Nair S.P., Meghji S., Wilson M., Reddi K., White P., Henderson B. Bacterially induced bone destruction: mechanisms and misconceptions. Infect. Immun. 64:1996;2371-2380.
15. Hausmann E., Raisz L.G., Miller W.A. Endotoxin: stimulation of bone resorption in tissue culture. Science. 168:1970;862-864.
16. Ishihara Y., Nishihara T., Maki E., Noguchi T., Koga T. Role of interleukin-1 and prostaglandin in in vitro bone resorption induced by Actinobacillus actinomycetemcomitans lipopolysaccharide. J. Periodontal Res. 3:1991;155-160.
17. Orcel P., Feuga M., Bielakoff J., De Vernejoul M.C. Local bone injections of LPS and M-CSF increase bone resorption by different pathways in vivo in rats. Am. J. Physiol. 264:1993;E391-E397.
18. Kopp E.B., Medzhitov R. The Toll-receptor family and control of innate immunity. Curr. Opin. Immunol. 11:1999;13-18.
19. Akira S., Hoshino K., Kaisho T. The role of Toll-like receptors and MyD88 in innate immune responses. J. Endotoxin Res. 6:2000;383-387.
20. Medzhitov R. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 1:2001;135-145.
21. Hoshino K., Takeuchi O., Kawai T., Sanjo H., Ogawa T., Takeda Y., Takeda K., Akira S. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162:1999;3749-3752.
22. Ogawa T., Asai Y., Hashimoto M., Takeuchi O., Kurita T., Yoshikai Y., Miyake K., Akira S. Cell activation by Porphyromonas gingivalis lipid A molecule through Toll like receptor 4- and myeloid differentiation factor 88-dependent signaling pathway. Int. Immunol. 14:2002;1-8.
23. Poltorak A., He X., Smirnova I., Liu M.Y., Huffel C.V., Du X., Birdwell D., Alejos E., Silva M., Galanos C., Freudenberg M., Ricciardi-Castagnoli P., Layton B., Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 282:1998;2085-2088.
24. Shimazu R., Akashi S., Ogata H., Nagai Y., Fukudome K., Miyake K., Kimoto M. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189:1999;1777-1782.
25. Ogata H., Su I., Miyake K., Nagai Y., Akashi S., Mecklenbrauker I., Rajewsky K., Kimoto M., Tarakhovsky A. The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. J. Exp. Med. 192:2000;23-29.
26. Miyake K., Ogata H., Nagai Y., Akashi S., Kimoto M. Innate recognition of lipopolysaccharide by Toll-like receptor 4/MD-2 and RP105/MD-1. J. Endotoxin Res. 6:2000;389-391.
27. Takeuchi O., Hoshino K., Kawai T., Sanjo H., Takada H., Ogawa T., Takeda K., Akira S. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity. 11:1999;443-451.
28. Yoshimura A., Lien E., Ingalls R.R., Tuomanen E., Dziarski R., Golenbock D. Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J. Immunol. 63:1991;1-5.
29. Asai Y., Ohyama Y., Gen K., Ogawa T. Bacterial fimbriae and their peptides activate human gingival epithelial cells through Toll-like receptor 2. Infect. Immun. 69:2001;7387-7395.
30. Aliprantis A.O., Yang R.B., Mark M.R., Suggett S., Devaux B., Radolf J.D., Klimpel G.R., Godowski P., Zychlinsky A. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science. 285:1999;736-739.
31. Ogawa T., Asai Y., Hashimoto M., Uchida H. Bacterial fimbriae activate human peripheral blood monocytes utilizing TLR2, CD14 and CD11a/CD18 as cellular receptors. Eur. J. Immunol. 32:2002;2543-2550.
32. Imoto M., Yoshimura N., Kusumoto S., Shiba T. Total synthesis of lipid A, active principle of bacterial endotoxin. Proc. Jpn. Acad. Ser. B. 60:1984;285-288.
33. Ogawa T., Kotani S., Tsujimoto M., Kusumoto S., Shiba T., Kawata S., Yokogawa K. Contractile effects of bacterial cell walls, their enzymatic digests, and muramyl dipeptides on ileal strips from guinea pigs. Infect. Immun. 35:1982;612-619.
34. Ogawa T., Shimauchi H., Hamada S. Mucosal and systemic immune responses in BALB/c mice to Bacteroides gingivalis fimbriae administered orally. Infect. Immun. 57:1989;3466-3471.
35. Anderson H.C., Hsu H.H., Raval P., Hunt T.R., Schwappach J.R., Morris D.C., Schneider D.J. The mechanism of bone induction and bone healing by human osteosarcoma cell extracts. Clin. Orthop. 313:1995;129-134.
36. Hunt T.R., Schwappach J.R., Anderson H.C. Healing of a segmental defect in the rat femur with use of an extract from a cultured human osteosarcoma cell-line (Saos-2). A preliminary report. J. Bone Joint Surg. Am. 78:1996;41-48.
37. Dilworth D., McCarrey J.R. Single-step elimination of contaminating DNA prior to reverse transcriptase PCR. PCR Methods Appl. 1:1992;279-282.
38. Manabe N., Kawaguchi H., Chikuda H., Miyaura C., Inada M., Nagai R., Nabeshima Y., Nakamura K., Sinclair A.M., Scheuermann R.H., Kuro-o M. Connection between B lymphocyte and osteoclast differentiation pathways. J. Immunol. 167:2001;2625-2631.
39. Zhang F.X., Kirschning C.J., Mancinelli R., Xu X.P., Jin Y., Faure E., Mantovani A., Rothe M., Muzio M., Arditi M. Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. J. Biol. Chem. 274:1999;7611-7614.
40. Kinpara K., Mogi M., Kuzushima M., Togari A. Osteoclast differentiation factor in human osteosarcoma cell line. J. Immunoassay. 21:2000;327-340.
41. Tokukoda Y., Takata S., Kaji H., Kitazawa R., Sugimoto T., Chihara K. Interleukin-1beta stimulates transendothelial mobilization of human peripheral blood mononuclear cells with a potential to differentiate into osteoclasts in the presence of osteoblasts. Endocr. J. 48:2001;443-452.
42. Canalis, E. (1993) Regulation of bone remodeling. In: Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 2nd edn. (Favus, M.J., Ed.), pp. 33-37. Raven Press, New York.
43. Takada, H. and Kotani, S. (1985) Immunopharmacological activities of synthetic muramyl-peptides. In: Immunology of the Bacterial Cell Envelope (Stewart-Tull, D.E.S. and Davies, M., Eds.), pp. 119-152. John Wiley and Sons, New York.
44. Yang R.B., Mark M.R., Gray A., Huang A., Xie M.H., Zhang M., Goddard A., Wood W.I., Gurney A.L., Godowski P.J. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature. 395:1998;284-288.
45. Hirschfeld M., Ma Y., Weis J.H., Vogel S.N., Weis J.J. Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2. J. Immunol. 165:2000;618-622.
46. Zarember K.A., Godowski P.J. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J. Immunol. 168:2002;554-561.
47. Fichorova R.N., Cronin A.O., Lien E., Anderson D.J., Ingalls R.R. Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling. J. Immunol. 168:2002;2424-2432.
48. Kikuchi T., Matsuguchi T., Tsuboi N., Mitani A., Tanaka S., Matsuoka M., Yamamoto G., Hishikawa T., Noguchi T., Yoshikai Y. Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors. J. Immunol. 166:2001;3574-3579.
49. Hayashi F., Smith K.D., Ozinsky A., Hawn T.R., Yi E.C., Goodlett D.R., Eng J.K., Akira S., Underhill D.M., Aderem A. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 410:2001;1099-1103.
50. Hemmi H., Takeuchi O., Kawai T., Kaisho T., Sato S., Sanjo H., Matsumoto M., Hoshino K., Wagner H., Takeda K., Akira S. A Toll-like receptor recognizes bacterial DNA. Nature. 408:2000;740-745.
51. Chaudhary L.R., Spelsberg T.C., Riggs B.L. Production of various cytokines by normal human osteoblast-like cells in response to interleukin-1 beta and tumor necrosis factor-alpha: lack of regulation by 17 beta-estradiol. Endocrinology. 130:1992;2528-2534.
52. Fujikawa Y., Quinn J.M., Sabokbar A., McGee J.O., Athanasou N.A. The human osteoclast precursor circulates in the monocyte fraction. Endocrinology. 137:1996;4058-4060.
53. Massey H.M., Flanagan A.M. Human osteoclasts derive from CD14-positive monocytes. Br. J. Haematol. 106:1999;167-170.
54. Quinn J.M., Neale S., Fujikawa Y., McGee J.O., Athanasou N.A. Human osteoclast formation from blood monocytes, peritoneal macrophages, and bone marrow cells. Calcif. Tissue Int. 62:1998;527-531.
55. Kanzaki H., Chiba M., Shimizu Y., Mitani H. Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activator of nuclear factor kappaB ligand up-regulation via prostaglandin E2 synthesis. J. Bone Miner. Res. 17:2002;210-220.
56. Shimauchi H., Ogawa T., Okuda K., Kusumoto Y., Okada H. Autoregulatory effect of interleukin-10 on proinflammatory cytokine production by Porphyromonas gingivalis lipopolysaccharide-tolerant human monocytes. Infect. Immun. 67:1999;2153-2159.