The role of Toll-like receptors and MyD88 in innate immune responses

Journal of Endotoxin Research

Volumn 6, Issue 5, 2000, Pages 383-387

  Akira, S ^a   Hoshino, K ^a   Kaisho, T ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; BACTERIAL DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; PEPTIDOGLYCAN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; GENETIC CONSERVATION; GRAM POSITIVE BACTERIUM; IMMUNE RESPONSE; MOUSE; NONHUMAN; PHYLOGENY; PROTEIN DEFICIENCY; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, DIFFERENTIATION; BASE SEQUENCE; CELL DIFFERENTIATION; DENDRITIC CELLS; DROSOPHILA PROTEINS; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MYELOID DIFFERENTIATION FACTOR 88; OLIGODEOXYRIBONUCLEOTIDES; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS;

ANIMALIA; BACTERIA (MICROORGANISMS); POSIBACTERIA;

EID: 0034460947     PISSN: 09680519     EISSN: None     Source Type: Journal    
DOI: 10.1179/096805100101532315     Document Type: Article

References (12)

1. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
2. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
3. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
4. Unresponsiveness of MyD88-deficient mice to endotoxin
5. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
6. Cutting edge: Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway
7. Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades
8. The role of CpG motifs in innate immunity
9. Bacterial DNA as immune cell activator
10. How BCG led to the discovery of immunostimulatory DNA
11. Immune cell activation by bacterial CpG-DNA through MyD88 and TRAF6
12. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor