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Volumn 3, Issue 5, 2003, Pages 347-352

The genetics of CD14 in allergic disease

Author keywords

Atopy; CD14; Endotoxin; Genetics; Toll like receptor 4

Indexed keywords

CD14 ANTIGEN; ENDOTOXIN;

EID: 0141988979     PISSN: 15284050     EISSN: None     Source Type: Journal    
DOI: 10.1097/00130832-200310000-00005     Document Type: Review
Times cited : (20)

References (44)
  • 1
    • 0032865289 scopus 로고    scopus 로고
    • Role of microbial burden in aetiology of allergy and asthma
    • Martinez FD, Holt PG. Role of microbial burden in aetiology of allergy and asthma. Lancet 1999; 354 (Suppl. II):S12-S15.
    • (1999) Lancet , vol.354 , Issue.SUPPL. II
    • Martinez, F.D.1    Holt, P.G.2
  • 2
    • 0035804276 scopus 로고    scopus 로고
    • Review articles: Advances in immunology: Allergy and allergic diseases (first of two parts)
    • Kay AB. Review articles: Advances in immunology: allergy and allergic diseases (First of two parts). N Engl J Med 2001; 344:30-37.
    • (2001) N Engl J Med , vol.344 , pp. 30-37
    • Kay, A.B.1
  • 3
    • 0035843316 scopus 로고    scopus 로고
    • Review articles: Advances in immunology: Allergy and allergic diseases (second of two parts)
    • Kay AB. Review articles: Advances in immunology: allergy and allergic diseases (Second of two parts). N Engl J Med 2001; 344:109-113.
    • (2001) N Engl J Med , vol.344 , pp. 109-113
    • Kay, A.B.1
  • 4
    • 0001872241 scopus 로고    scopus 로고
    • Genetics of asthma
    • Clark TJH, Godfrey S, Lee TH, Thomson NC, editors. London: Arnold
    • Koppelman GH, Meijer GG, Bleecker ER, Postma DS. Genetics of asthma. In: Clark TJH, Godfrey S, Lee TH, Thomson NC, editors. Asthma. London: Arnold; 2000. pp. 146-174.
    • (2000) Asthma , pp. 146-174
    • Koppelman, G.H.1    Meijer, G.G.2    Bleecker, E.R.3    Postma, D.S.4
  • 5
    • 0034241683 scopus 로고    scopus 로고
    • Family size, infection and atopy: The first decade of the 'hygiene hypothesis'
    • Strachan DP. Family size, infection and atopy: the first decade of the 'hygiene hypothesis'. Thorax 2000; 55 (Suppl. 1):S2-S10.
    • (2000) Thorax , vol.55 , Issue.SUPPL. 1
    • Strachan, D.P.1
  • 6
    • 0343619375 scopus 로고    scopus 로고
    • CD14, new aspects of ligand and signal diversity
    • Landmann R, Muller B, Zimmerli W. CD14, new aspects of ligand and signal diversity. Microbes Infect 2000; 2:295-304.
    • (2000) Microbes Infect , vol.2 , pp. 295-304
    • Landmann, R.1    Muller, B.2    Zimmerli, W.3
  • 7
    • 0035889904 scopus 로고    scopus 로고
    • A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity
    • LeVan TD, Bloom JW, Bailey TJ, et al. A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity. J Immunol 2001; 167:5838-5844.
    • (2001) J Immunol , vol.167 , pp. 5838-5844
    • LeVan, T.D.1    Bloom, J.W.2    Bailey, T.J.3
  • 8
    • 0035987294 scopus 로고    scopus 로고
    • Toll-like receptors: Their role in allergy and non-allergic inflammatory disease
    • Sabroe I, Parker LC, Wilson AG, et al. Toll-like receptors: their role in allergy and non-allergic inflammatory disease. Clin Exp Allergy 2002; 32:984-989. This paper reviews the possible role of the Toll-like receptor family in allergic disease and discusses interesting opportunities for the prevention of allergy.
    • (2002) Clin Exp Allergy , vol.32 , pp. 984-989
    • Sabroe, I.1    Parker, L.C.2    Wilson, A.G.3
  • 9
    • 0037312509 scopus 로고    scopus 로고
    • NALPs: A novel protein family involved in inflammation
    • Tschopp J, Martinon F, Burns K. NALPs: a novel protein family involved in inflammation. Nat Rev Mol Cell Biol 2003; 4:95-104. A state of the art review on signal transduction pathways of the CD 14 and Toll-like receptor 4 complex, including an excellent overview of the CATERPILLAR signal transduction family.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 95-104
    • Tschopp, J.1    Martinon, F.2    Burns, K.3
  • 10
    • 0036067659 scopus 로고    scopus 로고
    • Toll receptors, CD14, and macrophage activation and deactivation by LPS
    • Dobrovolskaia MA, Vogel SN. Toll receptors, CD14, and macrophage activation and deactivation by LPS. Microbes Infect 2002; 4:903-914.
    • (2002) Microbes Infect , vol.4 , pp. 903-914
    • Dobrovolskaia, M.A.1    Vogel, S.N.2
  • 11
    • 0036196817 scopus 로고    scopus 로고
    • CD14: An example of gene by environment interaction in allergic disease
    • Baldini M, Vercelli D, Martinez FD. CD14: an example of gene by environment interaction in allergic disease. Allergy 2002; 57:188-192. A proposal for the mechanism of CD14 by endotoxin interactions in allergic disease by authors who first identified a role of the CD14 - 159 variant in atopy.
    • (2002) Allergy , vol.57 , pp. 188-192
    • Baldini, M.1    Vercelli, D.2    Martinez, F.D.3
  • 12
    • 0033129061 scopus 로고    scopus 로고
    • A polymorphism in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E
    • Baldini M, Lohman IC, Halonen M, et al. A polymorphism in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Respir Cell Mol Biol 1999; 20:976-983.
    • (1999) Am J Respir Cell Mol Biol , vol.20 , pp. 976-983
    • Baldini, M.1    Lohman, I.C.2    Halonen, M.3
  • 13
    • 0034985509 scopus 로고    scopus 로고
    • CD14: A bridge between innate immunity and adaptive IgE responses
    • Vercelli D, Baldini M, Stern D, et al. CD14: a bridge between innate immunity and adaptive IgE responses. J Endotox Res 2001; 7:45-48.
    • (2001) J Endotox Res , vol.7 , pp. 45-48
    • Vercelli, D.1    Baldini, M.2    Stern, D.3
  • 14
    • 0036950351 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in innate immunity genes: Abundant variation and potential role in complex human disease
    • Lazarus R, Vercelli D, Palmer LJ, et al. Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human disease. Immunological Reviews 2002; 190:9-25. A complete review of genetic variants in innate immunity genes, including a discussion of different approaches to study these variants in complex genetic disease.
    • (2002) Immunological Reviews , vol.190 , pp. 9-25
    • Lazarus, R.1    Vercelli, D.2    Palmer, L.J.3
  • 15
    • 0035206253 scopus 로고    scopus 로고
    • Lack of association between the 260 C → T promoter polymorphism of the endotoxin receptor CD14 gene and the CD14 density of unstimulated human monocytes and soluble CD14 plasma levels
    • Heesen M, Blomeke B, Schluter B, et al. Lack of association between the 260 C → T promoter polymorphism of the endotoxin receptor CD14 gene and the CD14 density of unstimulated human monocytes and soluble CD14 plasma levels. Intens Care Med 2001; 27: 1770-1775.
    • (2001) Intens Care Med , vol.27 , pp. 1770-1775
    • Heesen, M.1    Blomeke, B.2    Schluter, B.3
  • 16
  • 17
    • 0032847362 scopus 로고    scopus 로고
    • Serum total IgE levels and CD14 on chromosome 5q31
    • Gao PS, Mao XQ, Baldini M, et al. Serum total IgE levels and CD14 on chromosome 5q31. Clin Genet 1999; 56:164-165.
    • (1999) Clin Genet , vol.56 , pp. 164-165
    • Gao, P.S.1    Mao, X.Q.2    Baldini, M.3
  • 18
    • 0033759713 scopus 로고    scopus 로고
    • A second-generation genomewide screen for asthma-susceptibility alleles in a founder population
    • Ober C, Tsalenko A, Parry R, Cox NJ. A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. Am J Hum Genet 2000; 67:1154-1162.
    • (2000) Am J Hum Genet , vol.67 , pp. 1154-1162
    • Ober, C.1    Tsalenko, A.2    Parry, R.3    Cox, N.J.4
  • 19
    • 0037326378 scopus 로고    scopus 로고
    • Evaluation of the CD14 C159 T polymorphism in the German Multicenter Allergy Study cohort
    • Sengler C, Haider A, Sommerfeld C, et al. Evaluation of the CD14 C159 T polymorphism in the German Multicenter Allergy Study cohort. Clin Exp Allergy 2003; 33:166-169. The most recent association study on CD14 and atopy in children, with measurements of atopic phenotypes at different timepoints. However, no associations of the CD14 genotype and atopy were identified.
    • (2003) Clin Exp Allergy , vol.33 , pp. 166-169
    • Sengler, C.1    Haider, A.2    Sommerfeld, C.3
  • 20
    • 0035665615 scopus 로고    scopus 로고
    • Allelic frequencies and patterns of single-nucleotide polymorphisms in candidate genes for asthma and atopy in Iceland
    • Hakonarson H, Bjornsdottir US, Ostermann E, et al. Allelic frequencies and patterns of single-nucleotide polymorphisms in candidate genes for asthma and atopy in Iceland. Am J Respir Crit Care Med 2001; 164:2036-2044.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 2036-2044
    • Hakonarson, H.1    Bjornsdottir, U.S.2    Ostermann, E.3
  • 21
    • 0031954852 scopus 로고    scopus 로고
    • The genetics of asthma. Mapping genes for complex traits in founder populations
    • Ober C, Cox NJ. The genetics of asthma. Mapping genes for complex traits in founder populations. Clin Exp Allergy 1998; 28 (Suppl. 1):101-105.
    • (1998) Clin Exp Allergy , vol.28 , Issue.SUPPL. 1 , pp. 101-105
    • Ober, C.1    Cox, N.J.2
  • 22
    • 0034084438 scopus 로고    scopus 로고
    • TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
    • Arbour NC, Lorenz E, Schutte BC, et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 2000; 25:187-191.
    • (2000) Nat Genet , vol.25 , pp. 187-191
    • Arbour, N.C.1    Lorenz, E.2    Schutte, B.C.3
  • 23
    • 0036893595 scopus 로고    scopus 로고
    • Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes
    • Raby BA, Klimecki WT, Laprise C, et al. Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes. Am J Respir Crit Care Med 2002; 166:1449-1456. The first study of genetic variants in Toll-like receptor 4 and atopy.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 1449-1456
    • Raby, B.A.1    Klimecki, W.T.2    Laprise, C.3
  • 24
    • 0036138963 scopus 로고    scopus 로고
    • Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma
    • Howard TD, Koppelman GH, Xu J, et al. Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma. Am J Hum Genet 2002; 70:230-236. The first study showing a proof of concept of gene-gene interaction in asthma.
    • (2002) Am J Hum Genet , vol.70 , pp. 230-236
    • Howard, T.D.1    Koppelman, G.H.2    Xu, J.3
  • 25
    • 0029874553 scopus 로고    scopus 로고
    • Human monocyte CD14 is upregulated by lipopolysaccharide
    • Landmann R, Knopf HP, Link S, et al. Human monocyte CD14 is upregulated by lipopolysaccharide. Infect Immun 1996; 64:1762-1769.
    • (1996) Infect Immun , vol.64 , pp. 1762-1769
    • Landmann, R.1    Knopf, H.P.2    Link, S.3
  • 27
    • 0033962806 scopus 로고    scopus 로고
    • Austrian children living on a farm have less hay fever, asthma and allergic sensitization
    • Riedler J, Eder W, Oberfeld G, Schreuer M. Austrian children living on a farm have less hay fever, asthma and allergic sensitization. Clin Exp Allergy 2000; 30:194-200.
    • (2000) Clin Exp Allergy , vol.30 , pp. 194-200
    • Riedler, J.1    Eder, W.2    Oberfeld, G.3    Schreuer, M.4
  • 28
    • 0035818268 scopus 로고    scopus 로고
    • Exposure to farming in early life and development of asthma and allergy: A cross-sectional survey
    • Riedler J, Braun-Fahrlander C, Eder W, et al. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 2001; 358:1129-1133.
    • (2001) Lancet , vol.358 , pp. 1129-1133
    • Riedler, J.1    Braun-Fahrlander, C.2    Eder, W.3
  • 29
    • 0033856713 scopus 로고    scopus 로고
    • Exposure to endotoxin or other bacterial components might protect against the development of atopy
    • von Mutius E, Braun-Fahrlander C, Schierl R, et al. Exposure to endotoxin or other bacterial components might protect against the development of atopy. Clin Exp Allergy 2000; 30:1230-1234.
    • (2000) Clin Exp Allergy , vol.30 , pp. 1230-1234
    • Von Mutius, E.1    Braun-Fahrlander, C.2    Schierl, R.3
  • 30
    • 0037055631 scopus 로고    scopus 로고
    • Expression of CD14 and Toll-like receptor 2 in farmers' and non-farmers' children
    • Lauener RP, Birchler T, Adamski J, et al. Expression of CD14 and Toll-like receptor 2 in farmers' and non-farmers' children. Lancet 2002; 360:465-466. An interesting extension of earlier findings on high endotoxin levels in a farming environment, and the first indication of how this might affect CD14 function.
    • (2002) Lancet , vol.360 , pp. 465-466
    • Lauener, R.P.1    Birchler, T.2    Adamski, J.3
  • 31
    • 0037317763 scopus 로고    scopus 로고
    • Innate immune sensing and its roots: The story of endotoxin
    • Beutler B, Rietschel ET. Innate immune sensing and its roots: the story of endotoxin. Nat Rev Immunol 2003; 3:169-177. A comprehensive review, together with an interesting historical background, on all aspects of endotoxin.
    • (2003) Nat Rev Immunol , vol.3 , pp. 169-177
    • Beutler, B.1    Rietschel, E.T.2
  • 32
    • 0037136585 scopus 로고    scopus 로고
    • Environmental exposure to endotoxin and its relation to asthma in school-age children
    • Braun-Fahrlander C, Riedler J, Herz U, et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002; 347:869-877. A well-designed epidemiological study showing strong protective effects of endotoxin on allergy in farming and non-farming children. These associations are further supported by data on the effects of endotoxin on cytokine production. The consistency of the dose-response curves is convincing.
    • (2002) N Engl J Med , vol.347 , pp. 869-877
    • Braun-Fahrlander, C.1    Riedler, J.2    Herz, U.3
  • 33
    • 0036800204 scopus 로고    scopus 로고
    • House dust endotoxin and allergic sensitization in children
    • Gehring U, Bischof W, Fahlbusch B, et al. House dust endotoxin and allergic sensitization in children. Am J Respir Crit Care Med 2002; 166:939-944.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 939-944
    • Gehring, U.1    Bischof, W.2    Fahlbusch, B.3
  • 34
    • 0034643729 scopus 로고    scopus 로고
    • Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma
    • Gereda JE, Leung DY, Thatayatikom A, et al. Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma. Lancet 2000; 355:1680-1683.
    • (2000) Lancet , vol.355 , pp. 1680-1683
    • Gereda, J.E.1    Leung, D.Y.2    Thatayatikom, A.3
  • 35
    • 17644428280 scopus 로고    scopus 로고
    • Endotoxin levels in Estonian and Swedish house dust and atopy in infancy
    • Bottcher MF, Bjorksten B, Gustafson S, et al. Endotoxin levels in Estonian and Swedish house dust and atopy in infancy. Clin Exp Allergy 2003; 33:295-300.
    • (2003) Clin Exp Allergy , vol.33 , pp. 295-300
    • Bottcher, M.F.1    Bjorksten, B.2    Gustafson, S.3
  • 36
    • 0037121946 scopus 로고    scopus 로고
    • Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen
    • Eisenbarth SC, Piggott DA, Huleatt JW, et al. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med 2002; 196:1645-1651.
    • (2002) J Exp Med , vol.196 , pp. 1645-1651
    • Eisenbarth, S.C.1    Piggott, D.A.2    Huleatt, J.W.3
  • 37
    • 0037329595 scopus 로고    scopus 로고
    • Learning from discrepancies: CD14 polymorphisms, atopy and the endotoxin switch
    • Vercelli D. Learning from discrepancies: CD14 polymorphisms, atopy and the endotoxin switch. Clin Exp Allergy 2003; 33:153-155. An editorial proposing a mechanism of interaction of the CD14 genotype and environmental endotoxin levels. It raises important questions for future research.
    • (2003) Clin Exp Allergy , vol.33 , pp. 153-155
    • Vercelli, D.1
  • 38
    • 0034069884 scopus 로고    scopus 로고
    • Modification of the inflammatory response to allergen challenge after exposure to bacterial lipopolysaccharide
    • Tulic MK, Wale JL, Holt PG, Sly PD. Modification of the inflammatory response to allergen challenge after exposure to bacterial lipopolysaccharide. Am J Respir Cell Mol Biol 2000; 22:604-612.
    • (2000) Am J Respir Cell Mol Biol , vol.22 , pp. 604-612
    • Tulic, M.K.1    Wale, J.L.2    Holt, P.G.3    Sly, P.D.4
  • 39
    • 0025838030 scopus 로고
    • Domestic endotoxin exposure and clinical severity of asthma
    • Michel O, Ginanni R, Duchateau J, et al. Domestic endotoxin exposure and clinical severity of asthma. Clin Exp Allergy 1991; 21:441-448.
    • (1991) Clin Exp Allergy , vol.21 , pp. 441-448
    • Michel, O.1    Ginanni, R.2    Duchateau, J.3
  • 40
    • 0024542885 scopus 로고
    • Effect of inhaled endotoxin on bronchial reactivity in asthmatic and normal subjects
    • Michel O, Duchateau J, Sergysels R. Effect of inhaled endotoxin on bronchial reactivity in asthmatic and normal subjects. J Appl Physiol 1989; 66:1059-1064.
    • (1989) J Appl Physiol , vol.66 , pp. 1059-1064
    • Michel, O.1    Duchateau, J.2    Sergysels, R.3
  • 41
    • 0030451097 scopus 로고    scopus 로고
    • Severity of asthma is related to endotoxin in house dust
    • Michel O, Kips J, Duchateau J, et al. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med 1996; 154:1641-1646.
    • (1996) Am J Respir Crit Care Med , vol.154 , pp. 1641-1646
    • Michel, O.1    Kips, J.2    Duchateau, J.3
  • 42
    • 0036251123 scopus 로고    scopus 로고
    • Reduced soluble CD14 levels in amniotic fluid and breast milk are associated with the subsequent development of atopy, eczema, or both
    • Jones CA, Holloway JA, Popplewell EJ, et al. Reduced soluble CD14 levels in amniotic fluid and breast milk are associated with the subsequent development of atopy, eczema, or both. J Allergy Clin Immunol 2002; 109:858-866. This study comprises five different studies on antenatal and postnatal sCD14 levels. It points attention to the gut as place for endotoxin-CD14-Toll-like receptor interactions.
    • (2002) J Allergy Clin Immunol , vol.109 , pp. 858-866
    • Jones, C.A.1    Holloway, J.A.2    Popplewell, E.J.3
  • 43
    • 0036892895 scopus 로고    scopus 로고
    • Innate immune responses of human neonatal cells to bacteria from the normal gastrointestinal flora
    • Karlsson H, Hessle C, Rudin A. Innate immune responses of human neonatal cells to bacteria from the normal gastrointestinal flora. Infect Immun 2002; 70:6688-6696. This study clearly shows that cord mononuclear cells can respond to bacterial wall components with Th1-type responses, similar to adult mononuclear cell responses.
    • (2002) Infect Immun , vol.70 , pp. 6688-6696
    • Karlsson, H.1    Hessle, C.2    Rudin, A.3
  • 44
    • 0037393553 scopus 로고    scopus 로고
    • Association between polymorphisms in caspase recruitment domain containing protein 15 and allergy in two German populations
    • Kabesch M, Peters W, Carr D, et al. Association between polymorphisms in caspase recruitment domain containing protein 15 and allergy in two German populations. J Allergy Clin Immunol 2003; 111:813-817. The first published study of the gene encoding the intracellular endotoxin receptor CARD15, also known as NOD2. Previously, CARD15 was shown to be associated with Crohn's disease.
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 813-817
    • Kabesch, M.1    Peters, W.2    Carr, D.3


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