The uncertain glory of APRIL

Cell Death and Differentiation

Volumn 10, Issue 10, 2003, Pages 1121-1125

  Medema, J P ^a   Planelles Carazo, L ^b   Hardenberg, G ^a   Hahne, M ^b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

APRIL; Immune regulation; TNF superfamily

Indexed keywords

APRIL PROTEIN; B LYMPHOCYTE ANTIGEN; CYCLOPHILIN; MEMBRANE PROTEIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

B LYMPHOCYTE ACTIVATION; CANCER GROWTH; CARCINOGENESIS; CELL PROLIFERATION; HEMATOPOIETIC CELL; HUMAN; IMMUNOREGULATION; IN VITRO STUDY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; REVIEW; T LYMPHOCYTE ACTIVATION; TUMOR CELL;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; B-CELL ACTIVATING FACTOR; B-CELL MATURATION ANTIGEN; B-LYMPHOCYTES; CARRIER PROTEINS; HUMANS; MEMBRANE PROTEINS; RECEPTORS, TUMOR NECROSIS FACTOR; T-LYMPHOCYTES; TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13; TUMOR NECROSIS FACTOR-ALPHA; TUMOR NECROSIS FACTORS;

EID: 0141927968     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401291     Document Type: Review

References (49)

1. Moore PA et al. (1999) BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 285: 260-263
2. Khare SD et al. (2000) Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice. Proc. Natl. Acad. Sci. USA 97: 3370-3375
3. Gross JA et al. (2000) TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature 404: 995-999
4. Mackay F et al. (1999) Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J. Exp. Med. 190: 1697-1710
5. Gross JA et al. (2001) TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. Impaired B cell maturation in mice lacking BLyS. Immunity 15: 289-302
6. Schiemann B et al. (2001) An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 293: 2111-2114
7. von Bulow GU, van Deursen JM and Bram RJ (2001) Regulation of the T-independent humoral response by TACI. Immunity 14: 573-582
8. Yan M et al. (2001) Activation and accumulation of B cells in TACI-deficient mice. Nat. Immunol. 2: 638-643
9. Xu S and Lam KP (2001) B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses. Mol. Cell. Biol. 21: 4067-4074
10. Thompson JS et al. (2001) Baff-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 293: 2108-2111
11. Yan M et al. (2001) Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency. Curr. Biol. 11: 1547-1552
12. Marsters SA et al. (2000) Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. Curr. Biol. 10: 785-788
13. Rennert P et al. (2000) A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth. J. Exp. Med. 192: 1677-1684
14. Thompson JS et al. (2000) BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population. J. Exp. Med. 192: 129-135
15. Wu Y et al. (2000) Tumor necrosis factor receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS. J. Biol. Chem. 275: 35478-35485
16. Yu G et al. (2000) APRIL and TALL-1 and receptors BCMA and TACI: system for regulation humoral activity. Nat. Immunol. 1: 252-256
17. Hahne M et al. (1998) APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. J. Exp. Med. 188: 1185-1190
18. Mackay F et al. (2002) BAFF and APRIL: A Tutorial on B Cell Survival. Annu. Rev. Immunol. 7: 7
19. Hatzoglou A et al. (2000) TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase. J. Immunol. 165: 1322-1330
20. von Bulow GU and Bram RJ (1997) NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily. Science 278: 138-141
21. Kelly K et al. (2000) APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death. Cancer Res. 60: 1021-1027
22. Novak AJ et al. (2002) Aberrant expression of B-lymphocyte stimulator by B chronic lymphocytic leukemia cells: a mechanism for survival. Blood 100: 2973-2979
23. Roth W et al . (2001) APRIL, a new member of the tumor necrosis factor family, modulates death ligand-induced apoptosis. Cell Death Differ. 8: 403-410
24. Pradet-Balade B et al. (2002) An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein. EMBO J. 21: 5711-5720
25. Lopez-Fraga M et al. (2001) Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase. EMBO Rep. 2: 945-951
26. Molloy SS et al. (1999) Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis. Trends Cell. Biol. 9: 28-35
27. Chicheportiche Y et al. (1997) TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J. Biol. Chem. 272: 32401-32410
28. Schneider P et al. (1999) BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J. Exp. Med 189: 1747-1756
29. Nakayama M et al . (2000) Involvement of TWEAK in interferon gamma-stimulated monocyte cytotoxicity. J. Exp. Med. 192: 1373-1380
30. Nardelli B et al. (2001) Synthesis and release of B-lymphocyte stimulator from myeloid cells. Blood 97: 198-204
31. Roschke V et al. (2002) BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases. J. Immunol. 169: 4314-4321
32. Stein JV et al. (2002) APRIL modulates B and T cell immunity. J. Clin. Invest. 109: 1587-1598
33. Siegel RM and Lenardo MJ (2001) To B or not to B: TNF family signaling in lymphocytes. Nat. Immunol. 2: 577-578
34. Strasser A, Harris AW and Cory S (1991) bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 67: 889-899
35. Lantz O et al. (2000) Gamma chain required for naive CD4+ T cell survival but not for antigen proliferation. Nat. Immunol. 1: 54-58
36. Schneider P et al. (2001) Maturation of marginal zone and follicular B cells requires BAFF and is independent of BCMA. J. Exp. Med. 194: 1691-1697
37. Miller DJ et al. (1992) A single autosomal gene defect severely limits IgG but not IgM responses in B lymphocyte-deficient A/WySnJ mice. Eur. J. Immunol. 22: 373-379
38. Seshasayee D et al. (2003) Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor. Immunity 18: 279-288
39. Cyster JG (2000) B cells on the front line. Nat. Immunol. 1: 9-10
40. Fagarasan S and Honjo T (2000) T-Independent immune response: new aspects of B cell biology. Science 290: 89-92
41. Shu HB, Hu WH and Johnson H (1999) TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J. Leukoc. Biol. 65: 680-683
42. Balazs M et al. (2002) Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses. Immunity 17: 341-352
43. Litinskiy MB et al. (2002) DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat. Immunol. 3: 822-829
44. Craxton A et al. (2003) Macrophage- and dendritic cell-dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF. Blood 101: 4464-4471
45. Lynch CN et al. (1999) TWEAK induces angiogenesis and proliferation of endothelial cells. J. Biol. Chem. 274: 8455-8459
46. Grell M et al. (1995) The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell 83: 793-802
47. Alexopoulou L, Pasparakis M and Kollias G (1997) A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling. Eur. J. Immunol. 27: 2588-2592
48. Kusters S et al . (1997) In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis. Eur. J. Immunol. 27: 2870-2875
49. Ruuls SR et al. (2001) Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation. Immunity 15: 533-543