An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein

EMBO Journal

Volumn 21, Issue 21, 2002, Pages 5711-5720

  Pradet Balade, B ^a   Medema, J P ^a   Lopez Fraga M ^a   Lozano, J C ^a   Kolfschoten, G M ^a   Picard, A ^a   Martinez A C ^a   Garcia Sanz, J A ^a   Hahne, M ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

APRIL; Cell membrane anchoring; Hybrid mRNA; TNF family; TWEAK

Indexed keywords

APRIL PROTEIN; CELL SURFACE PROTEIN; HYBRID PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN TWEAK; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; B CELL LYMPHOMA; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA LIBRARY; DNA SCREENING; HUMAN; HUMAN CELL; IMMUNOREGULATION; MONOCYTE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIBONUCLEASE PROTECTION ASSAY; T CELL LYMPHOMA; T LYMPHOCYTE;

AMINO ACID SEQUENCE; APOPTOSIS REGULATORY PROTEINS; BASE SEQUENCE; CARRIER PROTEINS; CELL LINE; COCULTURE TECHNIQUES; DNA; HUMANS; MOLECULAR SEQUENCE DATA; MONOCYTES; NEUROPEPTIDES; NUCLEAR PROTEINS; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTORS;

EID: 0036847318     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf565     Document Type: Article

References (35)

1. Alexopoulou, L., Pasparakis, M. and Kollias, G. (1997) A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling. Eur. J. Immunol., 27, 2588-2592.
2. Black, D.L. (1998) Splicing in the inner ear: A familiar tune, but what are the instruments? Neuron, 20, 165-168.
3. Chicheportiche, Y., Bourdon, P.R., Xu, H., Hsu, Y.M., Scott, H., Hession, C., Garcia, I. and Browning, J.L. (1997) TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J. Biol. Chem., 272, 32401-32410.
4. Communi, D., Suarez-Huerta, N., Dussossoy, D., Savi, P. and Boeynaems, J.M. (2001) Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes. J. Biol. Chem., 276, 16561-16566.
5. Espel, E., Garcia-Sanz, J.A., Aubert, V., Menoud, V., Sperisen, P., Fernandez, N. and Spertini, F. (1996) Transcriptional and translational control of TNF-α gene expression in human monocytes by major histocompatibility complex class II ligands. Eur. J. Immunol., 26, 2417-2424.
6. Fears, S., Mathieu, C., Zeleznik-Le, N., Huang, S., Rowley, J.D. and Nucifora, G. (1996) Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family. Proc. Natl. Acad. Sci. USA, 93, 1642-1647.
7. Finta, C. and Zaphiropoulos, P.G. (2000) The human CYP2C locus: A prototype for intergenic and exon repetition splicing events. Genomics, 63, 433-438.
8. Garcia-Sanz, J.A. and Müllner, E.W. (1997) RNase protection and primer extension. In Lefkovits, I.(ed.), Immunology Methods Manual. Vol. 1. Academic Press, London, UK, pp. 425-438.
9. Grell, M. et al. (1995) The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell, 83, 793-802.
10. Hahne, M. et al. (1998) APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. J. Exp. Med., 188, 1185-1190.
11. Kelly, K., Manos, E., Jensen, G., Nadauld, L. and Jones, D.A. (2000) APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death. Cancer Res., 60, 1021-1027.
12. Kusters, S. et al. (1997) In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis. Eur. J. Immunol., 27, 2870-2875.
13. Lopez-Fraga, M., Fernandez, R., Albar, J.P. and Hahne, M. (2001) Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase. EMBO Rep., 2, 945-951.
14. Lynch, C.N., Wang, Y.C., Lund, J.K., Chen, Y.W., Leal, J.A. and Wiley, S.R. (1999) TWEAK induces angiogenesis and proliferation of endothelial cells. J. Biol. Chem., 274, 8455-8459.
15. Magrangeas, F. et al. (1998) Cotranscription and intergenic splicing of human galactose-1-phosphate uridylyltransferase and interleukin-11 receptor α-chain genes generate a fusion mRNA in normal cells. Implication for the production of multidomain proteins during evolution. J. Biol. Chem., 273, 16005-16010.
16. Mijatovic, T., Houzet, L., Defrance, P., Droogmans, L., Huez, G. and Kruys, V. (2000) Tumor necrosis factor-α mRNA remains unstable and hypoadenylated upon stimulation of macrophages by lipopolysaccharides. Eur. J. Biochem., 267, 6004-6012.
17. Mikulits, W., Pradet-Balade, B., Habermann, B., Beug, H., Garcia-Sanz, J.A. and Mullner, E.W. (2000) Isolation of translationally controlled mRNAs by differential screening. FASEB J., 14, 1641-1652.
18. Millar, J.K., Christie, S., Semple, C.A. and Porteous, D.J. (2000) Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia. Genomics, 67, 69-77.
19. Molloy, S.S., Anderson, E.D., Jean, F. and Thomas, G. (1999) Bi-cycling the furin pathway: From TGN localization to pathogen activation and embryogenesis. Trends Cell Biol., 9, 28-35.
20. Moore, R.C. et al. (1999) Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel. J. Mol. Biol., 292, 797-817.
21. Müllner, E.W. and Garcia-Sanz, J.A. (1997a) Analysis of RNA expression by Northern blotting. In Lefkovits, I. (ed.), Immunology Methods Manual. Vol. 1. Academic Press, London, UK, pp. 407-424.
22. Müllner, E.W. and Garcia-Sanz, J.A. (1997b) Polysome gradients. In Lefkovits, I. (ed.), Immunology Methods Manual. Vol. 1. Academic Press, London, UK, pp. 457-462.
23. Müllner, E.W. and Garcia-Sanz, J.A. (1997c) Preparation of RNA. In Lefkovits, I. (ed.), Immunology Methods Manual. Vol. 1. Academic Press, London, UK, pp. 389-406.
24. Nakayama, M., Kayagaki, N., Yamaguchi, N., Okumura, K. and Yagita, H. (2000) Involvement of TWEAK in interferon γ-stimulated monocyte cytotoxicity. J. Exp. Med., 192, 1373-1380.
25. Nardelli, B. et al. (2001) Synthesis and release of B-lymphocyte stimulator from myeloid cells. Blood, 97, 198-204.
26. Pradet-Balade, B., Boulme, F., Beug, H., Mullner, E.W. and Garcia-Sanz, J.A. (2001) Translation control: Bridging the gap between genomics and proteomics? Trends Biochem. Sci., 26, 225-229.
27. Proudfoot, N.J., Furger, A. and Dye, M.J. (2002) Integrating mRNA processing with transcription. Cell, 108, 501-512.
28. Rennert, P. et al. (2000) A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth. J. Exp. Med., 192, 1677-1684.
29. Roth, W., Wagenknecht, B., Klumpp, A., Hahne, M., Tschopp, J. and Weller, M. (2001) Protection from death ligand-induced apoptosis by APRIL, a new ligand of the tumor necrosis factor family. Cell Death Differ., 8, 403-410.
30. Ruuls, S.R. et al. (2001) Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation. Immunity, 15, 533-543.
31. Shu, H.-B., Hu, W.-H. and Johnson, H. (1999) TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J. Leukoc. Biol., 65, 680-683.
32. Smith, C.A., Farrah, T. and Goodwin, R.G. (1994) The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation and death. Cell, 76, 959-962.
33. Smith, C.W. and Valcarcel, J. (2000) Alternative pre-mRNA splicing: The logic of combinatorial control. Trends Biochem. Sci., 25, 381-388.
34. Stein, J.V. et al. (2002) APRIL modulates B and T cell immunity. J. Clin. Invest., 109, 1587-1598.
35. Yu, G. et al. (2000) APRIL and TALL-I and receptors BCMA and TACI: System for regulating humoral immunity. Nat. Immunol., 1, 252-256.