APRIL modulates B and T cell immunity

Journal of Clinical Investigation

Volumn 109, Issue 12, 2002, Pages 1587-1598

  Stein, Jens V ^a   López Fraga, Marta ^a   Elustondo, Fernando A ^a   Carvalho Pinto, Carla E ^a   Rodríguez, Dolores ^a   Gómez Caro, Ruth ^a   De Jong, Joan ^b   Martínez A, Carlos ^a   Medema, Jan Paul ^b   Hahne, Michael ^a,c  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

APRIL PROTEIN; CD4 ANTIGEN; CYTOKINE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MESSENGER RNA; PROTEIN BCL 2; PROTEIN BCMA; PROTEIN BLYS; PROTEIN TACI; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CELL HYPERPLASIA; CELL SURVIVAL; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; HOMEOSTASIS; HUMORAL IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RECEPTOR BINDING; T LYMPHOCYTE; TRANSGENE;

EID: 0036081039     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0215034     Document Type: Article

References (55)

1. The TNF receptor super-family of cellular and viral proteins: Activation, costimulation, and death
2. APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth
3. BLyS: Member of the tumor necrosis factor family and B lymphocyte stimulator
4. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
5. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoprosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase
6. Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice
7. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease
8. Biologically active APRIL is secreted following intracellular processing in Golgi apparatus by furin convertase
9. Synthesis and release of B-lymphocyte stimulator from myeloid cells
10. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens
11. BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population
12. Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity
13. TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation
14. Baff-R, a newly identified TNF receptor that specifically interacts with BAFF
15. Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency
16. The role of TALL-1 and APRIL in immune regulation
17. TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice
18. APRIL and TALL-1 and receptors BCMA and TACI: System for regulation humoral activity
19. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations
20. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
21. TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. Impaired B cell maturation in mice lacking BLyS
22. Regulation of the T-independent humoral response by TACI
23. Activation and accumulation of B cells in TACI-deficient mice
24. B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses
25. Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI
26. Functional dissection of the murine lck distal promoter
27. Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors
28. Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: Differential modulation by T helper type 1 and type 2 cells
29. Nucleotide sequence of a full-length cDNA for mouse cytoskeletal beta-actin mRNA
30. Biology of attenuated modified vaccinia virus Ankara recombinant vector in mice: Virus fate and activation of B- and T-cell immune responses in comparison with the Western Reserve strain and advantages as a vaccine
31. Maturation of marginal zone and follicular B cells requires BAFF and is independent of BCMA
32. Proliferation is a prerequisite for bacterial superantigen-induced T cell apoptosis in vivo
33. Regulation of programmed cell death following T cell activation in vivo
34. bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
35. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
36. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals
37. BAFF mediates survival of peripheral immature B lymphocytes
38. T-independent immune response: New aspects of B cell biology
39. Attenuated modified vaccinia virus Ankara can be used as an immunizing agent under conditions of preexisting immunity to the vector
40. T cell-independent antigens type 2
41. To B or not to B: TNF family signaling in lymphocytes
42. NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor super-family
43. The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed
44. A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRlL, inhibits tumor cell growth
45. Gamma chain required for naive CD4+ T cell survival but not for antigen proliferation
46. Lymphocyte homing and homeostasis
47. Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice
48. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
49. Homeostatic regulation of CD8+ T cells by perforin
50. Constitutive expression of Bcl-xL or Bcl-2 prevents peptide antigen-induced T cell deletion but does not influence T cell homeostasis after a viral infection
51. B cells on the front line
52. Human marginal-zone B cells
53. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens
54. A single autosomal gene defect severely limits IgG but nor IgM responses in B lymphocyte-deficient A/WySnJ mice Eur
55. The buzz about BAFF