-
3
-
-
0032823876
-
-
(b) Tan, X.; Chu, C. K.; Boudinot, F. D. Adv. Drug Deliv. Rev. 1999, 39, 117-151.
-
(1999)
Adv. Drug Deliv. Rev.
, vol.39
, pp. 117-151
-
-
Tan, X.1
Chu, C.K.2
Boudinot, F.D.3
-
8
-
-
0141848867
-
-
(d) Kolesar, J. M.; Morris, A. K.; Kuhn, J. G. J. Oncol. Pharm. Pract. 1996, 2, 211-224.
-
(1996)
J. Oncol. Pharm. Pract.
, vol.2
, pp. 211-224
-
-
Kolesar, J.M.1
Morris, A.K.2
Kuhn, J.G.3
-
10
-
-
0001222924
-
-
(a) Knapp, S. Chem. Rev. 1995, 95, 1859-1876.
-
(1995)
Chem. Rev.
, vol.95
, pp. 1859-1876
-
-
Knapp, S.1
-
11
-
-
0026387906
-
-
(b) Isono, K. Pharmacol. Ther. 1991, 52, 269-286. Isono, K J. Antibiotics 1988, 41, 1711-1739.
-
(1991)
Pharmacol. Ther.
, vol.52
, pp. 269-286
-
-
Isono, K.1
-
12
-
-
0024209272
-
-
(b) Isono, K. Pharmacol. Ther. 1991, 52, 269-286. Isono, K J. Antibiotics 1988, 41, 1711-1739.
-
(1988)
J. Antibiotics
, vol.41
, pp. 1711-1739
-
-
Isono, K.1
-
14
-
-
0036142817
-
-
(b) Klinger, M.; Freissmuth, M.; Nanoff, C. Cell. Signaling 2002, 14, 99-108.
-
(2002)
Cell. Signaling
, vol.14
, pp. 99-108
-
-
Klinger, M.1
Freissmuth, M.2
Nanoff, C.3
-
20
-
-
0029921939
-
-
(h) Daval, J.-L.; Nicolas, F.; Doriat, J.-F. Pharmacol. Ther. 1996, 71, 325-335.
-
(1996)
Pharmacol. Ther.
, vol.71
, pp. 325-335
-
-
Daval, J.-L.1
Nicolas, F.2
Doriat, J.-F.3
-
27
-
-
0033797393
-
-
(o) de Jong, J. W.; de Jonge, R.; Keijzer, E.; Bradamante, S. Pharmacol. Ther. 2000, 87, 141-149.
-
(2000)
Pharmacol. Ther.
, vol.87
, pp. 141-149
-
-
De Jong, J.W.1
De Jonge, R.2
Keijzer, E.3
Bradamante, S.4
-
31
-
-
0141625509
-
-
Klener, P. Basic Clin. Oncol. 1999, 19, 279-295. Kaul, R. Dtsch. Apoth. Ztg. 1995, 135, 19-31.
-
(1999)
Basic Clin. Oncol.
, vol.19
, pp. 279-295
-
-
Klener, P.1
-
32
-
-
0029077557
-
-
Klener, P. Basic Clin. Oncol. 1999, 19, 279-295. Kaul, R. Dtsch. Apoth. Ztg. 1995, 135, 19-31.
-
(1995)
Dtsch. Apoth. Ztg.
, vol.135
, pp. 19-31
-
-
Kaul, R.1
-
34
-
-
0026520040
-
-
(b) Jacobson, K. A.; van Galen, P. J. M.; Williams, M. J. Med. Chem. 1992, 35, 407-422.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 407-422
-
-
Jacobson, K.A.1
Van Galen, P.J.M.2
Williams, M.3
-
35
-
-
0029146120
-
-
(c) Jacobsen, K. A.; Kim, H. O.; Siddiqi, S. M.; Olah, M. E.; Stiles, G. L.; von Lubitz, D. K. J. E. Drugs Future 1995, 20, 689-699.
-
(1995)
Drugs Future
, vol.20
, pp. 689-699
-
-
Jacobsen, K.A.1
Kim, H.O.2
Siddiqi, S.M.3
Olah, M.E.4
Stiles, G.L.5
Von Lubitz, D.K.J.E.6
-
37
-
-
0032461854
-
-
(e) Cristalli, G.; Camaioni, E.; Costanzi, S.; Vittori, S.; Volpini, R.; Klotz, K.-N. Drug Dev. Res. 1998, 45, 176-181.
-
(1998)
Drug Dev. Res.
, vol.45
, pp. 176-181
-
-
Cristalli, G.1
Camaioni, E.2
Costanzi, S.3
Vittori, S.4
Volpini, R.5
Klotz, K.-N.6
-
38
-
-
0032452643
-
-
(f) Knutsen, L. J. S.; Sheardown, M. J.; Roberts, S. M.; Mogensen, J. P. ; Olsen, U. B.; Thomsen, C.; Bowler, A. N. Drug Dev. Res. 1998, 45, 214-221.
-
(1998)
Drug Dev. Res.
, vol.45
, pp. 214-221
-
-
Knutsen, L.J.S.1
Sheardown, M.J.2
Roberts, S.M.3
Mogensen, J.P.4
Olsen, U.B.5
Thomsen, C.6
Bowler, A.N.7
-
40
-
-
0035271592
-
-
(h) Mueller, C. E. Farmaco 2001, 56, 77-80.
-
(2001)
Farmaco
, vol.56
, pp. 77-80
-
-
Mueller, C.E.1
-
42
-
-
0030477258
-
-
(b) Balkenhohl, F.; von dem Bussche-Huennefeld, C.; Lansky, A.; Zechel, C. Angew. Chem., Int. Ed. Engl. 1996, 35, 2288-2337.
-
(1996)
Angew. Chem., Int. Ed. Engl.
, vol.35
, pp. 2288-2337
-
-
Balkenhohl, F.1
Von Dem Bussche-Huennefeld, C.2
Lansky, A.3
Zechel, C.4
-
44
-
-
7444256652
-
-
(d) Nefzi, A.; Ostrech, J. M.; Houghten, R. A. Chem. Rev. 1997, 97, 449-472.
-
(1997)
Chem. Rev.
, vol.97
, pp. 449-472
-
-
Nefzi, A.1
Ostrech, J.M.2
Houghten, R.A.3
-
46
-
-
0034077637
-
-
(a) Ghosh, P. K.; Kumar, P.; Gupta, K. C. J. Ind. Chem. Soc. 2000, 77, 109-132.
-
(2000)
J. Ind. Chem. Soc.
, vol.77
, pp. 109-132
-
-
Ghosh, P.K.1
Kumar, P.2
Gupta, K.C.3
-
47
-
-
0031593026
-
-
(b) Wada, T.; Sato, Y.; Honda, F.; Kawahara, S.; Sekine, M. J. Am. Chem. Soc. 1997, 119, 12710-12721.
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 12710-12721
-
-
Wada, T.1
Sato, Y.2
Honda, F.3
Kawahara, S.4
Sekine, M.5
-
49
-
-
0035930717
-
-
(a) de Champdore, M.; De Napoli, L.; Di Fabio, G.; Messere, A.; Montesarchio, D.; Piccialli, G. Chem. Commun. 2001, 24, 2598-2599.
-
(2001)
Chem. Commun.
, vol.24
, pp. 2598-2599
-
-
De Champdore, M.1
De Napoli, L.2
Di Fabio, G.3
Messere, A.4
Montesarchio, D.5
Piccialli, G.6
-
50
-
-
0034684764
-
-
(b) Bozzoli, A.; Kazmierski, W.; Kennedy, G.; Pasquarello, A.; Pecunioso, A. Bioorg. Med. Chem. Lett. 2000, 10, 2759-2763.
-
(2000)
Bioorg. Med. Chem. Lett.
, vol.10
, pp. 2759-2763
-
-
Bozzoli, A.1
Kazmierski, W.2
Kennedy, G.3
Pasquarello, A.4
Pecunioso, A.5
-
53
-
-
0015233829
-
-
Sano, S.; Tokunaga, R.; Kun, K. A. Biochim. Biophys. Acta 1971, 244, 201-205.
-
(1971)
Biochim. Biophys. Acta
, vol.244
, pp. 201-205
-
-
Sano, S.1
Tokunaga, R.2
Kun, K.A.3
-
55
-
-
0034684764
-
-
(b) Bozzoli, A.; Kazmierski, W.; Kennedy, G.; Pasquarello, A.; Pecunioso, A. Bioorg. Med. Chem. Lett. 2000, 10, 2759-2763.
-
(2000)
Bioorg. Med. Chem. Lett.
, vol.10
, pp. 2759-2763
-
-
Bozzoli, A.1
Kazmierski, W.2
Kennedy, G.3
Pasquarello, A.4
Pecunioso, A.5
-
56
-
-
0034684225
-
-
For information about the IRORI nanokan system, please visit their website at
-
For a recent example, see: Nicolaou, K. C.; Pfefferkorn, J. A.; Mitchell, H. J.; Roecker, A. J.; Barluenga, S.; Cao, G.-Q.; Affleck, R. L.; Lillig, J. E. J. Am. Chem. Soc. 2000, 122, 9954-9967. For information about the IRORI nanokan system, please visit their website at www.discoverypartners.com/Products/index.html.
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 9954-9967
-
-
Nicolaou, K.C.1
Pfefferkorn, J.A.2
Mitchell, H.J.3
Roecker, A.J.4
Barluenga, S.5
Cao, G.-Q.6
Affleck, R.L.7
Lillig, J.E.8
-
57
-
-
33947092534
-
-
Merrifield, R. B.; Mitchell, A. R.; Kent, S. B. H.; Enggelhard, M. J. Org. Chem. 1978, 43, 2845.
-
(1978)
J. Org. Chem.
, vol.43
, pp. 2845
-
-
Merrifield, R.B.1
Mitchell, A.R.2
Kent, S.B.H.3
Enggelhard, M.4
-
58
-
-
0141625508
-
-
Ph.D. Dissertation, UC Berkeley
-
(b) Backes, B. J. Ph.D. Dissertation, UC Berkeley, 1993.
-
(1993)
-
-
Backes, B.J.1
-
60
-
-
0141848866
-
-
3.10
-
Novabiochem Catalog and Peptide Synthesis Handbook 1997/1998, method 16; MilliGen Technical Note 3.10.
-
MilliGen Technical Note
-
-
-
61
-
-
0005367574
-
-
Townsend, L. B., Ed.; Plenum: New York
-
Ueda, T. In Chemistry of Nucleosides and Nucleotides; Townsend, L. B., Ed.; Plenum: New York, 1988; Vol. 1, pp 41-46.
-
(1988)
Chemistry of Nucleosides and Nucleotides
, vol.1
, pp. 41-46
-
-
Ueda, T.1
-
63
-
-
0032568384
-
-
Guibe, F. Tetrahedron 1998, 54, 2967-3041.
-
(1998)
Tetrahedron
, vol.54
, pp. 2967-3041
-
-
Guibe, F.1
-
67
-
-
0001742738
-
-
Maiti, S. N.; Singh, M. P.; Micetich, R. G. Tetrahedron Lett. 1986, 27, 1423-1424.
-
(1986)
Tetrahedron Lett.
, vol.27
, pp. 1423-1424
-
-
Maiti, S.N.1
Singh, M.P.2
Micetich, R.G.3
-
70
-
-
0037169884
-
-
(a) Kilburn, J. P.; Lau, J.; Jones, R. C. F. Tetrahedron 2002, 58, 1739-1743.
-
(2002)
Tetrahedron
, vol.58
, pp. 1739-1743
-
-
Kilburn, J.P.1
Lau, J.2
Jones, R.C.F.3
-
71
-
-
0035937278
-
-
(b) Ghosh, A. K.; Hol, W. G. J.; Fan, E. J. Org. Chem. 2001, 66, 2161-2164.
-
(2001)
J. Org. Chem.
, vol.66
, pp. 2161-2164
-
-
Ghosh, A.K.1
Hol, W.G.J.2
Fan, E.3
-
72
-
-
0034183565
-
-
(c) Chen, J.; Pattarawarapan, M.; Zhang, A. J.; Burgess, K. J. Comb. Chem. 2000, 2, 276-281.
-
(2000)
J. Comb. Chem.
, vol.2
, pp. 276-281
-
-
Chen, J.1
Pattarawarapan, M.2
Zhang, A.J.3
Burgess, K.4
-
74
-
-
0030996006
-
-
(e) Drewry, D. H.; Gerritz, S. W.; Linn, J. A. Tetrahedron Lett. 1997, 38, 3377-3380.
-
(1997)
Tetrahedron Lett.
, vol.38
, pp. 3377-3380
-
-
Drewry, D.H.1
Gerritz, S.W.2
Linn, J.A.3
-
75
-
-
0141848865
-
-
note
-
Hydrolysis of the 5′-phosphinamine on the pyrimidine scaffold under basic conditions did not result in the formation of the free 5′-amine 39 and was inert toward any acylation reagents. Instead, it was suggested that the procedure exclusively yields the product of Michael attack of the free amine on the pyrimidine ring (see ref 13b).
-
-
-
-
77
-
-
0028953105
-
-
Ceulemans, G.; Vandendriessche, F.; Rozenski, J.; Herdewijn, P. Nucleosides Nucleotides 1995, 14, 117-128.
-
(1995)
Nucleosides Nucleotides
, vol.14
, pp. 117-128
-
-
Ceulemans, G.1
Vandendriessche, F.2
Rozenski, J.3
Herdewijn, P.4
-
78
-
-
0034014406
-
-
Robins, M. J.; Doboszewski, B.; Nillson, B. L.; Peterson, M. A. Nucleosides Nucleotides 2000, 19, 69-86.
-
(2000)
Nucleosides Nucleotides
, vol.19
, pp. 69-86
-
-
Robins, M.J.1
Doboszewski, B.2
Nillson, B.L.3
Peterson, M.A.4
-
80
-
-
0004290050
-
-
Academic Press: San Diego
-
Bunin, B. A. The Combinatorial Index; Academic Press: San Diego, 1998; pp 130-133.
-
(1998)
The Combinatorial Index
, pp. 130-133
-
-
Bunin, B.A.1
-
81
-
-
0027104788
-
-
Beebe, X.; Schore, N. E.; Kurth, M. J. J. Am. Chem. Soc. 1992, 114, 10061-10062.
-
(1992)
J. Am. Chem. Soc.
, vol.114
, pp. 10061-10062
-
-
Beebe, X.1
Schore, N.E.2
Kurth, M.J.3
-
82
-
-
0032576190
-
-
Nicolaou, K. C.; Winssinger, N.; Vourloumis, D.; Ohshima, T.; Kim, S.; Pfefferkorn, J.; Xu, J.-Y.; Li, T. J. Am. Chem. Soc. 1998, 120, 10814-10826.
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 10814-10826
-
-
Nicolaou, K.C.1
Winssinger, N.2
Vourloumis, D.3
Ohshima, T.4
Kim, S.5
Pfefferkorn, J.6
Xu, J.-Y.7
Li, T.8
-
84
-
-
0025007622
-
-
Pochet, S.; Kansal, V.; Destouesse, F.; Sarfati, S. R. Tetrahedron Lett. 1990, 31, 6021-6024.
-
(1990)
Tetrahedron Lett.
, vol.31
, pp. 6021-6024
-
-
Pochet, S.1
Kansal, V.2
Destouesse, F.3
Sarfati, S.R.4
-
85
-
-
0141737280
-
-
note
-
Because of the incompatibility of the IRORI cleavap system with our cleavage conditions and the high amount of extractables we observed when using the IRORI cleavap system, we decided to cleave the nucleoside library in-house at GNF. By developing angled plate holders for the Savant centrifuge, we were able to use the advantages of IRORI cleavage plates without using the IRORI cleavap system.
-
-
-
-
86
-
-
0004290050
-
-
Academic Press: San Diego; Section 5 and references therein
-
Bunin, B. A. The Combinatorial Index; Academic Press: San Diego, 1998; Section 5 and references therein.
-
(1998)
The Combinatorial Index
-
-
Bunin, B.A.1
|