Integrin-linked kinase, a promising cancer therapeutic target: Biochemical and biological properties

Pharmacology and Therapeutics

Volumn 93, Issue 2-3, 2002, Pages 233-242

  Yoganathan, N ^a   Yee, A ^a   Zhang, Z ^a   Leung, D ^a   Yan, J ^a   Fazli, L ^a   Kojic, D L ^a   Costello, P C ^a   Jabali, M ^a   Dedhar, S ^b   Sanghera, J ^a  

^a Kinetek Pharmaceuticals Inc   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cancer; Glycogen synthase kinase 3 (GSK 3 ); Integrin linked kinase (ILK); Protein kinase B (PKB) Akt; Signal transduction; Small molecule inhibitors

Indexed keywords

ANTINEOPLASTIC AGENT; BINDING PROTEIN; INTEGRIN LINKED KINASE; UNCLASSIFIED DRUG; INTEGRIN-LINKED KINASE; PROTEIN SERINE THREONINE KINASE;

BIOCHEMISTRY; BIOLOGY; CANCER; CANCER CHEMOTHERAPY; CELL LINE; CONFERENCE PAPER; ENZYME ANALYSIS; ENZYME STRUCTURE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; CHEMISTRY; DRUG EFFECT; HUMAN; MOUSE; NEOPLASM; NUDE MOUSE; PHOSPHORYLATION; PHYSIOLOGY; REVIEW;

ANIMAL; HUMAN; MICE; MICE, NUDE; NEOPLASMS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; ANIMALS; HUMANS;

EID: 0035990920     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(02)00192-4     Document Type: Conference Paper

References (49)

1. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
2. The integrin-linked kinase (ILK) suppresses anoikis
3. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
4. Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F
5. Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding
6. Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
7. Intact LIM 3 and LIM 4 domains of paxillin are required for the association to a novel polyproline region (Pro 2) of protein-tyrosine phosphatase-PEST
8. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
9. 2+-independent smooth muscle contraction. A novel function for integrin-linked kinase
10. CREB is a regulatory target for the protein kinase Akt/PKB
11. Integrin signaling
12. Integrin-linked kinase expression increases with prostate tumor grade
13. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase
14. Mapping of the gene encoding the integrin-linked kinase, ILK, to human chromosome 11p15. 5-p15. 4
15. A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans
16. Integrin signaling and cell growth control
17. The roles of integrin-linked kinase in the regulation of myogenic differentiation
18. Integrins: Versatility, modulation, and signaling in cell adhesion
19. Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1
20. Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats
21. A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation
22. Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis
23. Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage
24. The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity
25. Integrin-linked kinase (ilk) binding to paxillin ld1 motif regulates ILK localization to focal adhesions
26. Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways
27. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor
28. Wnt signaling in oncogenesis and embryogenesis - A look outside the nucleus
29. Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells
30. Regulation of protein kinase B/Akt-serine-473 phosphorylation by integrin linked kinase (ILK): Critical roles for kinase activity and amino acids arginine-211 and serine-343
31. Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression
32. A new LIM protein containing an autoepitope homologous to "senescent cell antigen"
33. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
34. Quantitative changes in integrin and focal adhesion signaling regulate myoblast cell cycle withdrawal
35. Signal transduction and regulation in smooth muscle
36. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
37. Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells
38. Colocalization and redistribution of dishevelled and actin during Wnt-induced mesenchymal morphogenesis
39. Cell-extracellular matrix interactions stimulate the AP-1 transcription factor in an integrin-linked kinase- and glycogen synthase kinase 3-dependent manner
40. The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9)
41. The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells
42. A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading
43. Frequent inactivation of PTEN in prostate cancer cell lines and xenografts
44. Mutational analysis of the potential phosphorylation sites in the cytoplasmic domain of integrin beta1A. Requirement for threonines 788-789 in receptor activation
45. Regulation of matrix metalloproteinase expression in tumor invasion
46. Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression
47. Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix
48. Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity
49. A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction