Neurotrophins and their role in pathogenesis of alopecia areata

Journal of Investigative Dermatology Symposium Proceedings

Volumn 8, Issue 2, 2003, Pages 195-198

  Botchkarev, Vladimir A ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Autoimmune disorder; Nerve growth factor

Indexed keywords

CD8 ANTIGEN; NERVE GROWTH FACTOR; NEUROTROPHIN; NEUROTROPHIN RECEPTOR;

ALOPECIA AREATA; APOPTOSIS; AUTOIMMUNE DISEASE; BRAIN DEVELOPMENT; CELL DEATH; CELL FUNCTION; CELL SURVIVAL; CONFERENCE PAPER; CYCLIZATION; HAIR FOLLICLE; HAIR GROWTH; HOMEOSTASIS; IMMUNOCOMPETENT CELL; INFLAMMATORY INFILTRATE; MOLECULAR DYNAMICS; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; REGULATORY MECHANISM;

EID: 0141707004     PISSN: 10870024     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1087-0024.2003.00808.x     Document Type: Conference Paper

References (53)

1. Aloe L, Bracci-Laudiero L, Bonini S, Manni L: The expanding role of nerve growth factor: from neurotrophic activity to immunologic diseases. Allergy 52:883-894, 1997
2. Aloe L, Tuveri MA: Nerve growth factor and autoimmune rheumatic diseases. Clin Exp Rheumatol 15:433-438, 1997
3. Aloe L, Tuveri MA, Carcassi U, Levi Montalcini R: Nerve growth factor in the synovial fluid of patients with chronic arthritis. Arthritis Rheum 35:351-355, 1992
4. Aloyz RS, Bamji SX, Pozniak CD, Toma JG, Atwal J, Kaplan DR, Miller FD: p53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors. J Cell Biol 143:1691-1703, 1998
5. Ansel JC, Armstrong CA, Song I, Quinlan KL, Olerud JE, Caughman SW, Bunnett NW: Interactions of the skin and nervous system. Symp Proc The 2:23-26, 1997
6. Arredondo L, Deng C, Ratts RB, Lovett-Racke AE, Holtzman DM, Racke MK: Role of nerve growth factor in experimental autoimmune encephalomyelitis. Eur J Immunol 31:625-633, 2001
7. van Baar HM, Perret CM, van Vlijmen IM, van de Kerkhof PC, Happle R, Schalkwijk J: Abnormal expression of Ki-67 antigen in hair follicle of alopecia areata. Acta Derm Venereol 72:161-164, 1992
8. Bamji S, Majdan M, Pozniak CD, et al: The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occuring sympathetic neuron death. J Cell Biol 140:911-923, 1998
9. Bibel M, Barde Y-A: Neurotrophins. Key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev 14:2919-2937, 2000
10. Botchkarev VA, Botchkareva NV, Albers KM, Chen L-H, Welker P, Paus R: A role for p75 neurotrophin receptor in the control of apoptosis-driven hair follicle regression. FASEB J 14:1931-42, 2000a
11. Botchkarev VA, Freyschmidt-Paul P, Bajoghli A, Botchkareva NV, Hoffmann R, Sundberg JP, Gilchrest BA: Evidence that neurotrophins and their receptors are involved in hair loss in the C3H/HeJ mouse model for alopecia areata. J Invest Dermatol 114:800, 2000b
12. Botchkarev VA, Botchkareva NV, Welker P, et al: A new role for neurotrophins involvement of brain-derived neurotrophic factor and neurotrophin-4 in hair cycle control. FASEB J 13:395-410,1999a
13. Botchkarev VA, Metz M, Botchkareva NV, Welker P, Lommatzsch M, Renz H, Paus R: Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 act as 'epitheliotrophins' in murine skin. Lab Invest 79:557-572, 1999b
14. Botchkarev VA, Welker P, Albers KM, et al: A new role for neurotrophin-3 involvement in the control of hair follicle regresssion (catagen). Am J Pathol 153:785-799, 1998
15. Botchkarev VA, Yaar M, Gilchrest BA, Paus R: p75 neurotrophin receptor antagonist retards apoptosis-driven hair follicle involution (catagen). J Invest Dermatol 120:168-169, 2003
16. Bothwell M: Neurotrophin function in skin. J Invest Dermatol Symp Proc The 2:27-30, 1997
17. Bothwell M: Functional, interactions, of, neurotrophins, and, neurotrophin receptors. Annu Rev Neurosci 18:223-253, 1995
18. Bracci-Laudiero L, Aloe L, Levi-Montalcini R, Galeazzi M, Schilter D, Scully JL, Otten U: Increased levels of NGF in sera of systemic lupus erythematosus patients. Neuroreport 4:563-565, 1993
19. Bracci-Laudiero L, Aloe L, Levi-Montalcini R, Buttinelli C, Schilter D, Gillessen S: Multiple sclerosis patients express increased levels of β3-nerve growth factor in cerebrospinal fluid. Neurosci Lett 147:9-12, 1992
20. Braun A, Appel E, Baruch R, et al: Role of nerve growth factor in a mouse model of allergic airway inflammation and asthma. Eur J Immunol 28:3240-3251, 1998
21. Chao M, Casaccia-Bonnefil P, Carter B, Chittka A, Kong H, Yoon SO: Neurotrophin receptors. Med Life Death 26:295-301, 1998
22. Dmitrieva N, Shelton D, Rice AS, McMahon SB: The role of nerve growth factor in a model of visceral inflammation. Neuroscience 78:449-459, 1997
23. Donovan MJ, Miranda RC, Kraemer R, et al: Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury. Am J Pathol 147:309-324, 1995
24. Gilhar A, Ullmann Y, Berkutzki T, Assy B, Kalish RS: Autoimmune hair loss (alopecia arcata) transferred by T lymphocytes to human scalp explants on SCID mice. J Clin Invest 101:62-67, 1998
25. Hoffmann R: The potential role of cytokines and T cells in alopecia areata. J Invest Dermatol Symp Proc The 4:235-238, 1999
26. Hordinsky MK, Ericson ME: Relationship between follicular nerve supply and alopecia. Dermatol Clinics 14:651-660, 1996
27. Hordinsky M, Ericson M, Snow D, Boeck C, Lee W-S: Peribulbar innervation and substance P expression following non-permanent injury to the human scalp hair follicle. J Invest Dermatol Symp Proc The 4:316-319, 1999
28. Kerschensteiner M, Gallmeier E, Behrens L, et al: Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J Exp Med 189:865-870, 1999
29. Konig A, Happle R, Hoffmann R: 1FN-gamma-induced HLA-DR but not ICAM-1 expression on cultured dermal papilla cells is downregulated by TNF-alpha. Arch Dermatol Res 289:466-470, 1997
30. Lambiase A, Bracci Laudiero L, Bonini S, et al: Human CD4+ Tcell clones produce and release nerve growth factor and express high-affinity nerve growth factor receptors. J Allergy Clin Immunol 100:408-414, 1997
31. Lewin GR, Barde YA: Physiology of the neurotrophins. Annu Rev Neurosci 19:289-317, 1996
32. McDonagh AJ, Messenger AG: The pathogenesis of alopecia areata. Dermatol Clin 14:661-670, 1996
33. McElwee KJ, Hoffmann R, Freyschmidt-Paul P, Wenzel E, Kissling S, Sundberg JP, Zoller M: Resistance to alopecia areata in C3H/HeJ mice is associated with increased expression of regulatory cytokines and a failure to recruit CD4+ and CD8+ cells. J Invest Dermatol 119:1426-1433, 2002
34. Messenger AG, Bleehen SS: Expression of HLA-DR: By anagen hair follicles in alopecia areata. J Invest Dermatol 85:569-572, 1985
35. Micera A, Propezzi F, Triaca V, Aloe L: Nerve growth factor antibody exacerbates neuropathological signs of experimental autoimmune encephalomyelitis in adult Lewis rats. J Neuroimmunol 104:116-123, 2000
36. Miller FD, Kaplan DR: Neurotrophin signaling pathways regulating neuronal apoptosis. Cell Mol Life Sci 58:1045-1053, 2001
37. Nickoloff BJ, Griffiths CE: Aberrant intercellular adhesion molecule-1 (ICAM-1) expression by hair-follicle epithelial cells and endothelial leukocyte adhesion molecule-1 (ELAM-1) by vascular cells are important adhesion-molecule alterations in alopecia areata. J Invest Dermatol 96:91S-92S, 1991
38. Norris DA, Duke R, Whang K, Middleton M: Immunologic cytotoxicity in alopecia areata, apoptosis of dermal papilla cells inn alopecia areata. J Invest Dermatol 104 (Suppl.):8S-9S, 1995
39. Palkina TN, Sharov AA, et al: Brain-derived neurotrophic factor signaling through p75 kDa neurotrphin receptor stimulates CD8 cell apoptosis in autoimmune alopecia. J Invest Dermatol 119:315, 2002
40. Paus R, Peters EM, Eichmuller S, Botchkarev VA: Neural mechanisms of hair growth control. J Invest Dermatol Symp Proc The 2:61-68,1997
41. Pincelli C, Haake AR, Benassi L, et al: Autocrine nerve growth factor protects human keratinocytes from apoptosis through its high affinity receptor (Trk): a role for Bcl-2. J Invest Dermatol 109:757-764, 1997
42. Pincelli C, Yaar M: Nerve growth factor: its significance in cutaneous biology. J Invest Dermatol Symp Proc The 2:31-36, 1997
43. Price VH: Alopecia areata: Clinical aspects. J Invest Dermatol 96:685, 1991
44. Ransohoff RM, Trebst C: Surprising pleotropy of nerve growth factor in the treatment of experimental autoimmune encephalomyelitis. J Exp Med 191:1625-1629, 2000
45. Scholzen T, Armstrong CA, Bunnett NW, Luger TA, Olerud JE, Ansel JC: Neuropeptides in the skin interactions between the neuroendocrine and the skin immune systems. Exp Dermatol 7:81-96, 1998
46. Shapiro J, Price VH: Hair regrowth. Therapeutic agents. Dermatol Clin 16:341-356, 1998
47. Thies W: Über die Morphologie des vegetativen Nervensystems in der menschlichen Haut nebst Untersuchung über neuropathologische Veränderungen bei verschiedenen Hautkrankheiten. VI. Mitteilung Alopecia areata. Z Haut Geschlechtskr 28:47-52, 1960
48. Tobin SJ: Morphological analysis of hair follicles in alopecia areata. Microsc Res Tech 38:443-451, 1997
49. Tobin DJ, Fenton DA, Kendall MD: Cell degeneration in alopecia areata. An ultrastructural study. Am J Dermatopathol 13:248-256, 1991
50. Tuveri MA, Passiu G, Mathieu A, Aloe L: Nerve growth factor and mast cell distribution in the skin of patients with systemic sclerosis. Clin Exp Rheumatol 11:319-322, 1993
51. Villoslada P, Hauser SL, Bartke I, et al: Human nerve growth factor protects common marmosets against autoimmune encephalomyclitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous system. J Exp Med 191:1799-1806, 2000
52. Wakabayashi Y, Maeda T, Kwok YN: Increase of p75 immunoreactivity in rat urinary bladder following inflammation. Neuroreport 7:1141-1144, 1996
53. Welker P, Peters EMJ, Botchkarev VA, Petho-Schramm A, Eichmuller S, Paus R: Nerve growth factor and the murine hair cycle. J Invest Dermatol 106:910, 1996