Neuroprotection in cardiac surgery

Anesthesiology Clinics of North America

Volumn 21, Issue 3, 2003, Pages 487-509

  Grocott, Hilary P ^a   Nussmeier, Nancy A ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b ST LUKE S EPISCOPAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; APROTININ; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CLOMETHIAZOLE; COMPLEMENT INHIBITOR; DEXTROMETHORPHAN; GANGLIOSIDE GM1; LEXIPAFANT; LIDOCAINE; NEUROPROTECTIVE AGENT; NIMODIPINE; PERGORGOTEIN; PEXELIZUMAB; PROPOFOL; REMACEMIDE; THIOPENTAL; UNCLASSIFIED DRUG;

EMBOLISM; HEART SURGERY; HUMAN; HYPOTHERMIA; NEUROPROTECTION; NUCLEAR MAGNETIC RESONANCE IMAGING; REVIEW; STROKE; TEMPERATURE;

EID: 0141676739     PISSN: 08898537     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-8537(03)00045-2     Document Type: Review

References (141)

1. Nussmeier N, Arlund A, Slogoff S. Neuropsychiatric complications after cardiopulmonary bypass: cerebral protection by a barbiturate. Anesthesiology 1986;64:165-70.
2. Michenfelder J, Theye R. Cerebral protection by thiopental during hypoxia. Anesthesiology 1973;39:510-7.
3. Zaidan J, Klochany A, Martin W. Effect of thiopental on neurologic outcome following coronary artery bypass grafting. Anesthesiology 1991;74:406-11.
4. Pascoe E, Hudson R, Anderson B, Kassum D, Shanks A, Rosenbloom M, et al. High-dose thiopentone for open-chamber cardiac surgery: a retrospective review. Can J Anaesth 1996; 43:575-9.
5. Warner D, Takaoka S, Wu B, Ludwig P, Pearlstein R, Brinkhous A, et al. Electroencephalographic burst suppression is not required to elicit maximal neuroprotection from pentobarbital in a rat model of focal cerebral ischemia. Anesthesiology 1996;84:1475-84.
6. Pittman JE, Sheng HX, Pearlstein R, Brinkhous A, Dexter F, Warner DS. Comparison of the effects of propofol and pentobarbital on neurologic outcome and cerebral infarct size after temporary focal ischemia in the rat. Anesthesiology 1997;87:1139-44.
7. Roach GW, Newman MF, Murkin JM, Martzke J, Ruskin A, Li J, et al. Ineffectiveness of burst suppression therapy in mitigating perioperative cerebrovascular dysfunction. Multicenter Study of Perioperative Ischemia (McSPI) Research Group [comment]. Anesthesiology 1999;90: 1255-64.
8. Mangano D. Effects of acadesine on the incidence of myocardial infarction and adverse cardiac outcomes after coronary artery bypass graft surgery. Anesthesiology 1995;83:658-73.
9. Levy J, Pifarre R, Schaff H, et al. A multicenter, double-blind, placebo-controlled trial of aprotinin for reducing blood loss and the requirement for donor-blood transfusion in patients undergoing repeat coronary artery bypass grafting. Circulation 1995;92:2236-44.
10. Levy J, Ramsay J, Murkin J. Aprotinin reduces the incidence of strokes following cardiac surgery. Circulation 1996;94:I535.
11. Grocott HP, Sheng H, Miura Y, Sarraf-Yazdi S, Mackensen GB, Pearlstein RD, et al. The effects of aprotinin on outcome from cerebral ischemia in the rat. Anesth Analg 1999;88:1-7.
12. Brooker RF, Brown WR, Moody DM, Hammon Jr JW, Reboussin DM, Deal DD, et al. Cardiotomy suction: a major source of brain lipid emboli during cardiopulmonary bypass. Ann Thorac Surg 1998;65:1651-5.
13. Legault C, Furberg C, Wagenknecht L, Rogers A, Stump D, Coker L, et al. Nimodipine neuroprotection in cardiac valve replacement. Report of an early terminated trial. Stroke 1996; 27:593-8.
14. Gelmers H, Gorter K, de Weerdt C, Wiezer H. A controlled trial of nimodipine in acute ischemic stroke. N Engl J Med 1988;318:203-7.
15. Forsman M, Tubylewicz Olsnes B, Semb G, Steen P. Effects of nimodipine on cerebral blood flow and neuropsychological outcome after cardiac surgery. Brit J Anesthesia 1990;65:514-20.
16. Grieco G, d'Hollosy M, Culliford A, Jonas S. Evaluating neuroprotective agents for clinical anti-ischemic benefit using neurological changes after cardiac surgery under cardiopulmonary bypass. Stroke 1996;27:858-74.
17. Schmitt B, Bauersfeld U, Fanconi S, Wohlrab G, Huisman TA, Bandtlow C, et al. The effect of the N-methyl-D-aspartate receptor antagonist dextromethorphan on perioperative brain injury in children undergoing cardiac surgery with cardiopulmonary bypass: results of a pilot study. Neuropediatrics 1997;28:191-7.
18. Arrowsmith J, Harrison M, Newman S, Stygall J, Timberlake N, Pugsley W. Neuroprotection of the brain during cardiopulmonary bypass. A randomized trial of remacemide during coronary artery bypass in 171 patients. Stroke 1998;29:2357-62.
19. Mitchell SJ, Pellett O, Gorman DF. Cerebral protection by lidocaine during cardiac operations. Ann Thorac Surg 1999;67:1117-24.
20. Amory DW, Grigore A, Amory JK, Gerhardt MA, White WD, Smith PK, et al. Neuroprotection is associated with beta-adrenergic receptor antagonists during cardiac surgery: evidence from 2,575 patients. J Cardiothorac Vasc Anesth 2002;16:270-7.
21. Savitz SI, Erhardt JA, Anthony JV, Gupta G, Li X, Barone FC, et al. The novel beta-blocker, carvedilol, provides neuroprotection in transient focal stroke. J Cereb Blood Flow Metab 2000; 20:1197-204.
22. Butterworth J, Legault C, Stump DA, Coker L, Hammon Jr JW, Troost BT, et al. A randomized, blinded trial of the antioxidant pegorgotein: no reduction in neuropsychological deficits, inotropic drug support, or myocardial ischemia after coronary artery bypass surgery. J Cardiothorac Vasc Anesth 1999;13:690-4.
23. Fitch JC, Rollins S, Matis L, Alford B, Aranki S, Collard CD, et al. Pharmacology and biological efficacy of a recombinant, humanized, single-chain antibody C5 complement inhibitor in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass. Circulation 1999;100:2499-506.
24. Mathew J, Sheman S, White W, Fitch J, Nussmeier N, Bell L, et al. Sustained complement suppression with pexelizumab and reduction in the accelerated neurocognitive decline following CABG surgery. Anesth Analg 2002;93:SCA24.
25. Hofer RE, Christopherson TJ, Scheithauer BW, Milde JH, Lanier WL. The effect of a platelet activating factor antagonist (BN 52021) on neurologic outcome and histopathology in a canine model of complete cerebral ischemia. Anesthesiology 1993;79:347-53.
26. Panetta T, Marcheselli VL, Braquet P, Spinnewyn B, Bazan NG. Effects of a platelet activating factor antagonist (BN 52021) on free fatty acids, diacylglycerols, polyphosphoinositides and blood flow in the gerbil brain: inhibition of ischemia-reperfusion induced cerebral injury. Biochem Biophys Res Commun 1987;149:580-7.
27. Taggart D, et al. Neuroprotection during cardiac surgery: a randomized trial of a platelet activating factor antagonist. Fifth International Brain and Cardiac Surgery Conference. London, UK, September 7-9, 2000.
28. Kong R, Butterworth J, Aveling W, Stump D, Harrison M, Hammon JW, et al. Clinical trial of the neuroprotectant clomethiazole in coronary artery bypass graft surgery. Anesthesiology 2002;97:585-91.
29. Hindman B, Moore S, Cutkomp J, Smith T. Cardiopulmonary bypass (CPB) increases brain inducible cyclooxygenase (COX2) mRNA expression in rats [abstract]. Anesthesiology 2000; 93:A695.
30. Sato Y, Laskowitz DT, Bennett ER, Newman MF, Warner DS, Grocott HP. Differential cerebral gene expression during cardiopulmonary bypass in the rat: evidence for apoptosis? Anesth Analg 2002;94:1389-94.
31. Grocott H, Mackensen G, Newman M, Warner D. Neurological injury during cardiopulmonary bypass in the rat. Perfusion 2001;16:75-81.
32. Ma D, Yang H, Lynch J, Franks N, Maze M, Grocott H. Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat. Anesthesiology 2003; 98:690-8.
33. Busto R, Dietrich W, Globus M, Valdés I, Scheinberg P, Ginsberg M. Small differences in intraischemic brain temperature critically determine the extent of neuronal injury. J Cereb Blood Flow Metab 1987;7:729-38.
34. Busto R, Dietrich W, Globus M-T, Ginsberg M. The importance of brain temperature in cerebral ischemic injury. Stroke 1989;20:1113-4.
35. Busto R, Globus M, Dietrich W, Martinez E, Valdes I, Ginsberg M. Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. Stroke 1989; 20:904-10.
36. Dietrich WD, Busto R, Valdes I, Loor Y. Effects of normothermic versus mild hyperthermic forebrain ischemia in rats. Stroke 1990;21:1318-25.
37. Welsh FA, Sims RE, Harris VA. Mild hypothermia prevents ischemic injury in gerbil hippocampus. J Cereb Blood Flow Metab 1990;10:557-63.
38. Morikawa E, Ginsberg MD, Dietrich WD, Duncan RC, Kraydieh S, Globus MY, et al. The significance of brain temperature in focal cerebral ischemia: histopathological consequences of middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 1992;12:380-9.
39. Ridenour TR, Warner DS, Todd MM, McAllister AC. Mild hypothermia reduces infarct size resulting from temporary but not permanent focal ischemia in rats. Stroke 1992;23:733-8.
40. Goto Y, Kassell NF, Hiramatsu K, Soleau SW, Lee KS. Effects ofintraischemic hypothermia on cerebral damage in a model of reversible focal ischemia. Neurosurgery 1993;32:980-5.
41. Zhang R-L, Chopp M, Chen H, Garcia JH, Zhang ZG. Postischemic (1 hour) hypothermia significantly reduces ischemic cell damage in rats subjected to 2 hours of idle cerebral artery occlusion. Stroke 1993;24:1235-40.
42. Kawai N, Okauchi M, Morisaki K, Nagao S. Effects of delayed intraischemic and postischemic hypothermia on a focal model of transient cerebral ischemia in rats. Stroke 2000;31: 1982-9.
43. Corbett D, Hamilton M, Colbourne F. Persistent neuroprotection with prolonged postischemic hypothermia in adult rats subjected to transient middle cerebral artery occlusion. Exp Neurol 2000;163:200-6.
44. Nakashima K, Todd MM. Effects of hypothermia on the rate of excitatory amino acid release after ischemic depolarization. Stroke 1996;27:913-8.
45. Mitani A, Kataoka K. Critical levels of extracellular glutamate mediating gerbil hippocampal delayed neuronal death during hypothermia: brain microdialysis study. Neuroscience 1991;42: 661-70.
46. Insler SR, O'Connor MS, Leventhal MJ, Nelson DR, Starr NJ. Association between postoperative hypothermia and adverse outcome after coronary artery bypass surgery. Ann Thorac Surg 2000;70:175-81.
47. Frank SM, Fleisher LA, Breslow MJ, Higgins MS, Olson KF, Kelly S, et al. Perioperative maintenance of normothermia reduces the incidence of morbid cardiac events: a randomized clinical trial. JAMA 1997;277:1127-34.
48. Bush Jr HL, Hydo LJ, Fischer E, Fantini GA, Silane MF, Barie PS. Hypothermia during elective abdominal aortic aneurysm repair: the high price of avoidable morbidity. J Vasc Surg 1995;21:392-402.
49. Shum-Tim D, Nagashima M, Shinoka T, Bucerius J, Nollert G, Lidov HG, et al. Postischemic hyperthermia exacerbates neurologic injury after deep hypothermic circulatory arrest. J Thorac Cardiovasc Surg 1998;116:780-92.
50. Dietrich WD. The importance of brain temperature in cerebral injury. J Neurotrauma 1992; 9(Suppl 2):S475-84.
51. Minamisawa H, Smith ML, Siesjo BK. The effect of mild hyperthermia and hypothermia on brain damage following 5, 10, and 15 minutes of forebrain ischemia. Ann Neurol 1990;28:26-33.
52. Ginsberg MD, Stemau LL, Globus MY, Dietrich WD, Busto R. Therapeutic modulation of brain temperature: relevance to ischemic brain injury. Cerebrovasc Brain Metab Rev 1992;4: 189-225.
53. Sternau LL, Globus MYT, Dietrich WD, Martinez E, Busto R, Ginsberg MD. Ischemia-induced neurotransmitter release: effects of mild intraischemic hyperthermia. In: Globus M, Dietrich WD, editors. The role of neurotransmitters in brain injury. New York: Plenum Press; 1992. p. 33-8.
54. Castillo J, Davalos A, Noya M. Aggravation of acute ischemic stroke by hyperthermia is related to an excitotoxic mechanism. Cerebrovasc Dis 1999;9:22-7.
55. Globus MY, Busto R, Lin B, Schnippering H, Ginsberg MD. Detection of free radical activity during transient global ischemia and recirculation: effects of intraischemic brain temperature modulation. J Neurochem 1995;65:1250-6.
56. Chopp M, Welch KMA, Tidwell CD, Knight R, Helpern JA. Effect of mild hyperthermia on recovery of metabolic function after global cerebral ischemia in cats. Stroke 1988;19: 1521-5.
57. Dietrich WD, Busto R, Halley M, Valdes I. The importance of brain temperature in alterations of the blood-brain barrier following cerebral ischemia. J Neuropathol Exp Neurol 1990;49: 486-97.
58. Busto R, Globus MY, Neary JT, Ginsberg MD. Regional alterations of protein kinase C activity following transient cerebral ischemia: effects of intraischemic brain temperature modulation. J Neurochem 1994;63:1095-103.
59. Morimoto T, Ginsberg MD, Dietrich WD, Zhao W. Hyperthermia enhances spectrin breakdown in transient focal cerebral ischemia. Brain Res 1997;746:43-51.
60. Kammersgaard LP, Jorgensen HS, Rungby JA, Reith J, Nakayama H, Weber UJ, et al. Admission body temperature predicts long-term mortality after acute stroke: the Copenhagen Stroke Study. Stroke 2002;33:1759-62.
61. Ginsberg MD, Busto R. Combating hyperthermia in acute stroke: a significant clinical concern. Stroke 1998;29:529-34.
62. Reith J, Jorgensen HS, Pedersen PM, Nakayama H, Raaschou HO, Jeppesen LL, et al. Body temperature in acute stroke: relation to stroke severity, infarct size, mortality, and outcome. Lancet 1996;347:422-5.
63. Azzimondi G, Bassein L, Nonino F, Fiorani L, Vignatelli L, Re G, et al. Fever in acute stroke worsens prognosis: a prospective study. Stroke 1995;26:2040-3.
64. Mora C, Henson M, Weintraub W, Murjin J, Martin T. The effect of temperature management during cardiopulmonary bypass on neurologic and neuropsychologic outcomes in patients undergoing coronary revascularization. J Thorac Cardiovasc Surg 1996;112:514-22.
65. Gaudino M, Martinelli L, Di Lella G, Glieca F, Marano P, Schiavello R, et al. Superior extension of intraoperative brain damage in case of normothermic systemic perfusion during coronary artery bypass operations. J Thorac Cardiovasc Surg 1999;118:432-7.
66. Martin TD, Craver J, Gott J, Weintraub W, Ramsay J, Mora C, et al. Prospective, randomized trial of retrograde warm blood cardioplegia: myocardial benefit and neurologic threat. Ann Thorac Surg 1994;57:298-304.
67. Cheng WP, Marino MR, Romagnoli A, Walding D, Nussmeier NA. Temperature measurement during cardiopulmonary bypass. Anesthesiology 2000;93(3A):A384.
68. Bissonnette B, Holtby HM, Davis AJ, Pua H, Gilder FJ, Black M. Cerebral hyperthermia in children after cardiopulmonary bypass. Anesthesiology 2000;93:611-8.
69. Grocott HP, Newman MF, Croughwell ND, White WD, Lowry E, Reves JG. Continuous jugular venous versus nasopharyngeal temperature monitoring during hypothermic cardiopulmonary bypass for cardiac surgery. J Clin Anesth 1997;9:312-6.
70. Cook DJ. Changing temperature management for cardiopulmonary bypass. Anesth Analg 1999; 88:1254-71.
71. Sandstrom K, Nilsson K, Andreasson S, Larsson LE. Jugular bulb temperature compared with non-invasive temperatures and cerebral arteriovenous oxygen saturation differences during open heart surgery. Paediatr Anaesth 1999;9:123-8.
72. Cook DJ, Orszulak TA, Daly RC, Buda DA. Cerebral hyperthermia during cardiopulmonary bypass in adults. J Thorac Cardiovasc Surg 1996;111:268-9.
73. Stone JG, Young WL, Smith CR, Solomon RA, Wald A, Ostapkovich N, et al. Do standard monitoring sites reflect true brain temperature when profound hypothermia is rapidly induced and reversed? Anesthesiology 1995;82:344-51.
74. Grigore AM, Grocott HP, Mathew JP, Phillips-Bute B, Stanley TO, Butler A, et al. The rewarming rate and increased peak temperature alter neurocognitive outcome after cardiac surgery. Anesth Analg 2002;94:4-10.
75. Rumana CS, Gopinath SP, Uzura M, Valadka AB, Robertson CS. Brain temperature exceeds systemic temperature in head-injured patients. Crit Care Med 1998;26:562-7.
76. Nussmeier NA, Li S, Strickler AG, Dragan E, Korki RK, Cooper JR. Temperature measurements during cardiopulmonary bypass. Anesth Analg 2002;94:SCA35.
77. Regragui I, Birdi I, Izzat MB, Black AM, Lopatatzidis A, Day CJ, et al. The effects of cardiopulmonary bypass temperature on neuropsychologic outcome after coronary artery operations: a prospective randomized trial. J Thorac Cardiovasc Surg 1996;112:1036-45.
78. Lichtenstein SV, Ashe KA, el Dalati H, Cusimano RJ, Panos A, Slutsky AS. Warm heart surgery. J Thorac Cardiovasc Surg 1991;101:269-74.
79. McLean RF, Wong BI, Naylor CD, Snow WG, Harrington EM, Gawel M, et al. Cardiopulmonary bypass, temperature, and central nervous system dysfunction. Circulation 1994;90:11250-5.
80. Singh AK, Bert AA, Feng WC, Rotenberg FA. Stroke during coronary artery bypass grafting using hypothermic versus normothermic perfusion. Ann Thorac Surg 1995;59:84-9.
81. Engelman RM, Pleet AB, Rousou JA, Flack 3rd JE, Deaton DW, Pekow PS, et al. Influence of cardiopulmonary bypass perfusion temperature on neurologic and hematologic function after coronary artery bypass grafting. Ann Thorac Surg 1999;67:1547-56.
82. Engelman RM, Pleet AB, Hicks R, Rousou JA, Flack 3rd JE, Deaton DW, et al. Is there a relationship between systemic perfusion temperature during coronary artery bypass grafting and extent of intraoperative ischemic central nervous system injury? J Thorac Cardiovasc Surg 2000;119:230-2.
83. Grigore AM, Mathew J, Grocott HP, Reves JG, Blumenthal JA, White WD, et al. Prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cognitive function after coronary artery bypass graft surgery. Anesthesiology 2001;95:1110-9.
84. Newman MF, Kramer D, Croughwell ND, Sanderson I, Blumenthal JA, White WD, et al. Differential age effects of mean arterial pressure and rewarming on cognitive dysfunction after cardiac surgery. Anesth Analg 1995;81:236-42.
85. Enomoto S, Hindman BJ, Dexter F, Smith T, Cutkomp J. Rapid rewarming causes an increase in the cerebral metabolic rate for oxygen that is temporarily unmatched by cerebral blood flow. A study during cardiopulmonary bypass in rabbits. Anesthesiology 1996;84:1392-400.
86. Newman MF, Reves JG. Feeling the heat. J Cardiothorac Vasc Anesth 1997;11:687-8.
87. Lam A, Winn H, Cullen B, Sundling N. Hyperglycemia and neurological outcome in patients with head injury. J Neurosurg 1991;75:545-51.
88. Li P-A, Shamloo M, Smith M-L, Katsura K-I, Siesjö BK. The influence of plasma glucose concentrations on ischemic brain damage is a threshold function. Neurosci Lett 1994;177:63-5.
89. Nathan HJ. The potential benefits of perioperative hypothermia. Ann Thorac Surg 1999; 68:1452-3.
90. Nathan HJ, Wells GA, Munson JL, Wozny D. Neuroprotective effect of mild hypothermia in patients undergoing coronary artery surgery with cardiopulmonary bypass: a randomized trial. Circulation 2001;105:185-91.
91. Thong WY, Strickler AG, Li S, Stewart EE, Collier CL, Vaughn WK, et al. Hyperthermia in the forty-eight hours after cardiopulmonary bypass. Anesth Analg 2002;95:1489-95.
92. Grocott HP, Mackensen GB, Grigore AM, Mathew J, Reves JG, Phillips-Bute B, et al. Postoperative hyperthermia is associated with cognitive dysfunction after coronary artery bypass graft surgery. Stroke 2002;33:537-41.
93. Hogue Jr CW, Murphy SF, Schechtman KB, Davila-Roman VG. Risk factors for early or delayed stroke after cardiac surgery. Circulation 1999;100:642-7.
94. Salazar JD, Wityk RJ, Grega MA, Borowicz LM, Doty JR, Petrofski JA, et al. Stroke after cardiac surgery: short- and long-term outcomes. Ann Thorac Surg 2001;72:1195-202.
95. Pugsley W, Klinger L, Paschalis C, Treasure T, Harrison M, Newman S. The impact of microemboli during cardiopulmonary bypass on neuropsychological functioning. Stroke 1994;25: 1393-9.
96. Stump D, Rogers A, Hammon J, Newman S, Phil D. Cerebral emboli and cognitive outcome after cardiac surgery. J Cardiothora Vasc Anesthes 1996;10:113-9.
97. Lapietra A, Grossi EA, Pua BB, Esposito RA, Galloway AC, Derivaux CC, et al. Assisted venous drainage presents the risk of undetected air microembolism. J Thorac Cardiovasc Surg 2000;120:856-62.
98. Borger MA, Peniston CM, Weisel RD, Vasiliou M, Green RE, Feindel CM. Neuropsychologic impairment after coronary bypass surgery: effect of gaseous microemboli during perfusionist interventions. J Thorac Cardiovasc Surg 2001;121:743-9.
99. Webb WR, Harrison Jr LH, Helmcke FR, Camino-Lopez A, Munfakh NA, Heck Jr HA, et al. Carbon dioxide field flooding minimizes residual intracardiac air after open heart operations. Ann Thorac Surg 1997;64:1489-91.
100. Cook DJ, Zehr KJ, Orszulak TA, Slater JM. Profound reduction in brain embolization using an endoaortic baffle during bypass in swine. Ann Thorac Surg 2002;73:198-202.
101. Slater JM, Orszulak TA, Zehr KJ, Cook DJ. Use of the Cobra catheter for targeted temperature management during cardiopulmonary bypass in swine. J Thorac Cardiovasc Surg 2002;123: 936-42.
102. Boston US, Sungurtekin H, McGregor CG, Macoviak JA, Cook DJ. Differential perfusion: a new technique for isolated brain cooling during cardiopulmonary bypass. Ann Thorac Surg 2000;69:1346-50.
103. Cook DJ, Orszulak TA, Zehr KJ, Nussmeier NA, Livesay JJ, Hammon JW, et al. Effectiveness of the Cobra aortic catheter for dual-temperature management during adult cardiac surgery. J Thorac Cardiovasc Surg 2003;125:378-84.
104. Reichenspumer H, Navia JA, Berry G, Robbins RC, Barbut D, Gold JP, et al. Particulate emboli capture by an intra-aortic filter device during cardiac surgery. J Thorac Cardiovasc Surg 2000; 119:233-41.
105. Wimmer-Greinecker G. Reduction of neurologic complications by intra-aortic filtration in patients undergoing combined intracardiac and CABG procedures. Eur J Cardiothorac Surg 2003;23:159-64.
106. Borger MA, Taylor RL, Weisel RD, Kulkami G, Benaroia M, Rao V, et al. Decreased cerebral emboli during distal aortic arch cannulation: a randomized clinical trial. J Thorac Cardiovasc Surg 1999;118:740-5.
107. Amarenco P, Duyckaerts C, Tzourio C, Henin D, Bousser M-G, Hauw J-J. The prevalence of ulcerated plaques in the aortic arch in patients with stroke. N Engl J Med 1992;326:221-5.
108. Amarenco P, Cohen A, Hommel M, Moulin T, Leys D, Bousser M-G. Atherosclerotic disease of the aortic arch as a risk factor for recurrent ischemic stroke. N Engl J Med 1996;334: 1216-21.
109. Amarenco P, Cohen A, Tzourio C, Bertrand B, Hommel M, Besson G, et al. Atherosclerotic disease of the aortic arch and the risk of ischemic stroke. N Engl J Med 1994;331:1474-9.
110. Davila-Romain V, Barzilai B, Wareing T, Murphy S, Schechtman K, Kouchoukos N. Atherosclerosis of the ascending aorta. Prevalence and role as an independent predictor of cerebrovascular events in cardiac patients. Stroke 1994;25:2010-6.
111. Bar-Yosef S, Anders M, Mackensen G, Ti L, Mathew J, Phillips-Bute B, et al. The relationship between aortic atheroma burden and post-coronary artery bypass neurocognitive dysfunction [Abstract]. Anesth Analg 2002;93:SCA25.
112. Grigore AM, Grocott HP. Pro: epiaortic scanning is routinely necessary for cardiac surgery. J Cardiothorac Vasc Anesth 2000;14:87-90.
113. Royse AG, Royse CF, Ajani AE, Symes E, Maruff P, Karagiannis S, et al. Reduced neuropsychological dysfunction using epiaortic echocardiography and the exclusive Y graft. Ann Thorac Surg 2000;69:1431-8.
114. Maisano F, Franze V, De Bonis M, Alfieri O. Off-pump coronary artery surgery with the use of anastomotic devices: an additional tool for the challenging patient. Heart Surg Forum 2002;5: 25-7.
115. Van Dijk D, Jansen EW, Hijman R, Nierich AP, Diephuis JC, Moons KG, et al. Cognitive outcome after off-pump and on-pump coronary artery bypass graft surgery: a randomized trial. JAMA 2002;287:1405-12.
116. Schulze C, Conrad N, Schutz A, Egi K, Reichenspumer H, Reichart B, et al. Reduced expression of systemic proinflammatory cytokines after off-pump versus conventional coronary artery bypass grafting. Thorac Cardiovasc Surg 2000;48:364-9.
117. Mark DB, Newman MF. Protecting the brain in coronary artery bypass graft surgery. JAMA 2002;287:1448-50.
118. Oesterle SN, Reifart N, Hauptmann E, Hayase M, Yeung AC. Percutaneous in situ coronary venous arterialization: report of the first human catheter-based coronary artery bypass. Circulation 2001;103:2539-43.
119. Liistro F, Stankovic G, Di Mario C, Takagi T, Chieffo A, Moshiri S, et al. First clinical experience with a paclitaxel derivate-eluting polymer stent system implantation for in-stent restenosis: immediate and long-term clinical and angiographic outcome. Circulation 2002; 105:1883-6.
120. Kutryk MJ, Foley DP, van den Brand M, Hamburger JN, van der Giessen WJ, deFeyter PJ, et al. Local intracoronary administration of antisense oligonucleotide against c-myc for the prevention of in-stent restenosis: results of the randomized Investigation by the Thoraxcenter of Antisense DNA Using Local Delivery and IVUS After Coronary Stenting (ITALICS) trial. J Am Coll Cardiol 2002;39:281-7.
121. Coussement PK, Stella P, Vanbilloen H, Verbruggen A, van Rijk P, Hoekstra A, et al. Intracoronary beta-radiation of de novo coronary lesions using a (186)Re liquid-filled balloon system: six-month results from a clinical feasibility study. Catheter Cardiovasc Interv 2002;55: 28-36.
122. Gonzalez-Scarano F, Hurtig HI. Neurologic complications of coronary artery bypass grafting: case-control study. Neurology 1981;31:1032-5.
123. Libman RB, Wirkowski E, Neystat M, Barr W, Gelb S, Graver M. Stroke associated with cardiac surgery. Determinants, timing, and stroke subtypes. Arch Neurol 1997;54:83-7.
124. Ricotta JJ, Faggioli GL, Castilone A, Hassett JM. Risk factors for stroke after cardiac surgery: Buffalo Cardiac-Cerebral Study Group. J Vasc Surg 1995;21:359-63; discussion 364.
125. Gerraty RP, Gates PC, Doyle JC. Carotid stenosis and perioperative stroke risk in symptomatic and asymptomatic patients undergoing vascular or coronary surgery. Stroke 1993;24:1115-8.
126. Moazami N, Smedira NG, McCarthy PM, Katzan I, Sila CA, Lytle BW, et al. Safety and efficacy of intraarterial thrombolysis for perioperative stroke after cardiac operation. Ann Thorac Surg 2001;72:1933-7; discussion 1937-9.
127. Wityk RJ. Cardiac surgery and magnetic resonance imaging of the brain. Arch Neurol 2002; 59:1074-6.
128. Vik A, Brubakk AO, Rinck PA, Sande E, Levang OW, Sellevoid O. MRI: A method to detect minor brain damage following coronary bypass surgery? Neuroradiology 1991;33:396-8.
129. Sellman M, Hindmarsh T, Ivert T, Semb BKH. Magnetic resonance imaging of the brain before and after open heart operations. Ann Thorac Surg 1992;53:807-12.
130. Schmidt R, Fazekas F, Offenbacher H, et al. Brain magnetic resonance imaging in coronary artery bypass grafts: a pre- and postoperative assessment. Neurology 1993;43:775-8.
131. Simonson TM, Yuh WTC, Hindman BJ, Embrey RP, Halloran JI, Behrendt DM. Contrast MR of the brain after high-perfusion cardiopulmonary bypass. Am J Neuroradiol 1994;15:3-7.
132. Toner I, Pdene CJ, Hamid SK, Newman S, Taylor KM, Smith PLC. Magnetic resonance imaging and neuropsychological changes after coronary artery bypass graft surgery: preliminary findings. J Neurosurg Anesthesiol 1994;6:163-9.
133. Vanninen R, Aikia M, Kononen M, et al. Subclinical cerebral complications after coronary artery bypass grafting: prospective analysis with magnetic resonance imaging, quantitative electroencephalography, and neuropsychological assessment. Arch Neurol 1998;55:618-27.
134. Anderson RE, Li TQ, Hindmarsh T, Settergren G, Vaage J. Increased extracellular brain water after coronary artery bypass grafting is avoided by off-pump surgery. J Cardiothorac Vasc Anesth 1999;13:698-702.
135. Wityk RJ, Goldsborough MA, Hillis A, et al. Diffusion- and perfusion-weighted brain magnetic resonance imaging in patients with neurologic complications after cardiac surgery. Arch Neurol 2001;58:571-6.
136. Harris DN, Bailey SM, Smith PL, Taylor KM, Oatridge A, Bydder GM. Brain swelling in the first hour after coronary artery bypass surgery. Lancet 1993;342:586-7.
137. Harris DNF, Oatridge A, Dob D, Smith PLC, Taylor KM, Bydder GM. Cerebral swelling after normothermic cardiopulmonary bypass. Anesthesiology 1998;88:340-5.
138. Bendszus M, Reents W, Franke D, Mûllges W, Babin-Ebell J, Koltzenburg M, et al. Brain damage after coronary artery bypass grafting. Arch Neurol 2002;59:1090-5.
139. Kohn A. Magnetic resonance imaging registration and quantitation of the brain before and after coronary artery bypass graft surgery. Ann Thorac Surg 2002;73:S363-5.
140. Selnes OA, McKhann G. Late cognitive decline after CABG. Inevitable or preventable? Neurology 2002;59:660-1.
141. Warach S, Pettigrew LC, Dashe JF, et al, for the Citicoline 010 Investigators. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Ann Neurol 2000;48:713-22.