Rapid rewarming causes an increase in the cerebral metabolic rate for oxygen that is temporarily unmatched by cerebral blood flow: A study during cardiopulmonary bypass in rabbits

Anesthesiology

Volumn 84, Issue 6, 1996, Pages 1392-1400

  Enomoto, Sakae ^a   Hindman, Bradley J ^b,c   Dexter, Franklin ^b   Smith, Tom ^b   Cutkomp, Johann ^b  

^a KYOTO UNIVERSITY   (Japan)

^b Department of Anesthesia ^*

^c UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

Brain: cerebral blood flow; rewarming; temperature; Metabolism: flow metabolism coupling; temperature; Surgery, cardiac: cardiopulmonary bypass

Indexed keywords

ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN OXYGEN CONSUMPTION; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; INDUCED HYPOTHERMIA; METABOLIC RATE; NONHUMAN; OPEN HEART SURGERY; PRIORITY JOURNAL; RABBIT; WARMING;

ANIMALS; BODY TEMPERATURE; BRAIN; CARDIOPULMONARY BYPASS; CEREBROVASCULAR CIRCULATION; OXYGEN; RABBITS;

EID: 0029897601     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199606000-00016     Document Type: Article

References (32)

1. McLean RF, Wong BI, Naylor CD, Snow WG, Harrington EM, Gawel M, Fremes SE: Cardiopulmonary bypass, temperature, and central nervous system dysfunction. Circulation 1994; 90[part 2]: II-250-5
2. Croughwell ND, Newman MF, Blumenthal JA, White WD, Lewis JB, Frasco PE, Smith LR, Thyrum EA, Hurwitz BJ, Leone BJ, Schell RM, Reves JG: Jugular bulb saturation and cognitive dysfunction after cardiopulmonary bypass. Ann Thorac Surg 1994; 58:1702-8
3. Shaw PJ, Bates D, Cartlidge NEF, French JM, Heaviside D, Julian DG, Shaw DA: Long-term intellectual dysfunction following coronary artery bypass graft surgery: A six month follow-up study. Q J Med 1987; 62:259-68
4. Townes BD, Bashein G, Hornbein TF, Coppel DB, Goldstein DE, Davis KB, Nessly ML, Bledsoe SW, Veith RC, Ivey TD, Cohen MA: Neurobehavioral outcomes in cardiac operations. A prospective controlled study. J Thorac Cardiovasc Surg 1989; 98:774-82
5. Sotaniemi KA, Mononen H, Hokkanen TE: Long-term cerebral outcome after open-heart surgery. Stroke 1986; 17:410-16
6. Pugsley W, Klinger L, Paschalis C, Treasure T, Harrison M, Newman S: The impact of microemboli during cardiopulmonary bypass on neuropsychological functioning. Stroke 1994; 25:1393-9
7. Blauth CI, Arnold JV, Schulenberg WE, McCartney AC, Taylor KM, Loop FD: Cerebral microembolism during cardiopulmonary bypass. J Thorac Cardiovasc Surg 1988; 95:668-76
8. Clark RE, Brillman J, Davis DA, Lovell MR, Price TRP, Magovern GJ: Microemboli during coronary artery bypass grafting. Genesis and effect on outcome. J Thorac Cardiovasc Surg 1995; 109:249-58
9. Croughwell ND, Frasco P, Blumenthal JA, Leone BJ, White WD, Reves JG: Warming during cardiopulmonary bypass is associated with jugular bulb desaturation. Ann Thorac Surg 1992; 53:827-32
10. Cook DJ, Oliver WC, Orszulak TA, Daly RC: A prospective, randomized comparison of cerebral venous oxygen saturation during normothermic and hypothermic cardiopulmonary bypass. J Thorac Cardiovasc Surg 1994; 107:1020-9
11. Endoh H, Shimoji K: Changes in blood flow velocity in the middle cerebral artery during nonpulsatile hypothermic cardiopulmonary bypass. Stroke 1994; 25:403-7
12. Nakajima T, Kuro M, Hayashi Y, Kitaguchi K, Uchida O, Takaki O: Clinical evaluation of cerebral oxygen balance during cardiopulmonary bypass: On-line continuous monitoring of jugular venous oxyhemoglobin saturation. Anesth Analg 1992; 74:630-5
13. Newman MF, Croughwell ND, Blumenthal JA, White WD, Lewis JB, Smith LR, Frasco P, Towner EA, Schell RM, Hurwitz BJ, Reves JG: Effect of aging on cerebral autoregulation during cardiopulmonary bypass. Association with postoperative cognitive dysfunction. Circulation 1994; 90 [part 2]:II-243-9
14. van der Linden J, Ekroth R, Lincoln C, Pugsley W, Scallan M, Tyden H: Is cerebral blood flow/metabolic mismatch during rewarming a risk factor after profound hypothermic procedures in small children? Eur J Cardiothorac Surg 1989; 3:209-15
15. Dexter F, Hindman BJ: Computer simulation of brain cooling during cardiopulmonary bypass. Ann Thorac Surg 1994; 57:1171-9
16. Scremin OU, Sonnenschein RR, Rubinstein EH: Cerebrovascular anatomy and blood flow measurements in the rabbit. J Cereb Blood Flow Metab 1982; 2:55-66
17. Buckberg GD, Luck JC, Payne DB, Hoffman JIE, Archie JP, Fixler DE: Some sources of error in measuring regional blood flow with radioactive microspheres. J Appl Physiol 1971; 31:598-604
18. Heymann MA, Payne BD, Hoffman JIE, Rudolph AM: Blood flow measurements with radionuclide-labeled particles. Prog Cardiovasc Dis 1977; 20:55-79
19. Marcus ML, Bischof CJ, Heistad DD: Comparison of microsphere and xenon-133 clearance method in measuring skeletal muscle and cerebral blood flow. Circ Res 1981; 48:748-61
20. Wilkinson L: Systat: The System for Statistics. Evanston, Systat, 1990
21. Johnston WE, Vinten-Johansen J, De Witt DS, O'Steen WK, Stump DA, Prough DS: Cerebral perfusion during canine hypothermic cardiopulmonary bypass: Effect of arterial carbon dioxide tension. Ann Thorac Surg 1991; 52:479-89
22. Stone JG, Schwartz AE, Finck AD, Sandhu AA, Adams DC, Wald A, Mongero L, Micheler RE: Brain temperature monitoring during induced hypothermia (abstract). ANESTHESIOLOGY 1995; 83:A173
23. Markand ON, Warren C, Mallik GS, Williams CJ: Temperature-dependent hysteresis in somatosensory and auditory evoked potentials. Electroencephalograph Clin Neurophysiol 1990; 77: 425-35
24. Russ W, Sticher J, Scheid H, Hempelmann G: Effects of hypothermia on somatosensory evoked responses in man. Br J Anaesth 1987; 59:1484-91
25. Munch PA: Flow and thermal responses of aortic baroreceptors. J Neurophysiol 1993; 70:2596-2605
26. Iadecola C: Regulation of the cerebral microcirculation during neural activity: Is nitric oxide the missing link? Trends Neurosci 1993; 16:206-14
27. Lou HC, Edvinsson L, MacKenzie ET: The concept of coupling blood flow to brain function: Revision required? Ann Neurol 1987; 22:289-97
28. Dirnagi U, Niwa K, Lindauer U, Villringer A: Coupling of cerebral blood flow to neuronal activation: role of adenosine and nitric oxide. Am J Physiol 1994; 267:H296-301
29. Ogura K, Takayasu M, Dacey RG: Effects of hypothermia and hyperthermia on the reactivity of rat intracerebral anerioles in vitro. J Neurosurg 1991; 75:433-9
30. Dexter F, Hindman BJ: Theoretical analysis of cerebral venous oxygen saturation as an index of cerebral oxygenation during hypothermic cardiopulmonary bypass: A counter-proposal to the 'luxury perfusion' hypothesis. ANESTHESIOLOGY 1995; 83:405-12
31. Croughwell N, Lyth M, Quill TJ, Newman M, Greeley WJ, Smith LR, Reves JG: Diabetic patients have abnormal cerebral autoregulation during cardiopulmonary bypass. Circulation 1990; 82(suppl IV):IV-407-12
32. Newman MF, Kramer D, Croughwell ND, Sanderson I, Blumenthal JA, White WD, Smith LR, Towner EA, Reves JG: Differential age effects of mean arterial pressure and rewarming on cognitive dysfunction after cardiac surgery. Anesth Analg 1995; 81:236-42