Multivalent neoglycoconjugates by regiospecific cycloaddition of alkynes and azides using organic-soluble copper catalysts

Organic Letters

Volumn 5, Issue 11, 2003, Pages 1951-1954

  Pérez Balderas, Francisco ^a   Ortega Muñoz, Mariano ^a   Morales Sanfrutos, Julia ^a   Hernández Mateo, Fernando ^a   Calvo Flores, Francisco G ^a   Calvo Asín, Jose A ^a   Isac García, Joaquín ^a   Santoyo González, Francisco ^a  

^a UNIVERSITY OF GRANADA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYNE; AZIDE; COPPER COMPLEX;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CONJUGATION; CYCLOADDITION; GLUCONEOGENESIS; MICROWAVE IRRADIATION; REACTION TIME;

EID: 0141629513     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol034534r     Document Type: Article

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39. 3P·CuI] (10-20 mmol %) in toluene (25 mL) was irradiated at 850 W (100% power) in a microwave oven (LG MG-5507D) for periods of 2 min, allowing the solution to cool heating intervals, until TLC or the IR spectra of the reaction mixture showed complete disappearance of the starting material. The reaction mixture was evaporated and the crude purified in a short flash column chromatography to yield the 1,2,3-triazole derivative.