Mechanism of cell death of rat cardiac fibroblasts induced by serum depletion

Molecular and Cellular Biochemistry

Volumn 251, Issue 1-2, 2003, Pages 119-126

  Leicht, Monika ^a   Marx, Grit ^a   Karbach, Doris ^b   Gekle, Michael ^b   Köhler, Thomas ^c   Zimmer, Heinz Gerd ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c RGMBmbH   (Germany)

Author keywords

Apoptosis; Caspase; Ischemia; Necrosis; Protein kinase

Indexed keywords

CASPASE 7; DNA; DNA FRAGMENT; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

ANIMAL CELL; ANTIBODY SPECIFICITY; ARTICLE; CELL ACTIVITY; CELL COUNT; CELL DEATH; CELL ISOLATION; CONTROLLED STUDY; COULTER COUNTER; CULTURE MEDIUM; DNA SYNTHESIS; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME SUBSTRATE; FEMALE; FIBROBLAST; FIBROBLAST CULTURE; HEART MUSCLE CELL; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN ANALYSIS; QUANTITATIVE ANALYSIS; RAT; STAINING; TIME; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASES; CELL DIVISION; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; FEMALE; FIBROBLASTS; MAP KINASE KINASE KINASES; MYOCARDIUM; NECROSIS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TIME FACTORS;

ANIMALIA;

EID: 0141616591     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025446302759     Document Type: Article

References (44)

1. Fliss H, Gattinger D: Apoptosis in ischemic and reperfused rat myocardium. Circ Res 79: 949-956, 1996
2. Olivetti G, Quaini F, Sala R, Lagrasta C, Corradi D, Bonacina E, Gambert SR, Cigola E, Anversa P: Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart. J Mol Cell Cardiol 28: 2005-2016, 1996
3. Gottlieb RA, Burleson KO, Kloner RA, Babior BM, Engler RL: Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J Clin Invest 94: 1621-1628, 1994
4. Haunstetter A, Izumo S: Apoptosis: Basic mechanisms and implications for cardiovascular disease. Circ Res 82: 1111-1129, 1998
5. Arends MJ, Wyllie AH: Apoptosis: Mechanisms and roles in pathology. Int Rev Exp Pathol 32: 223-254, 1991
6. Simm A, Hoppe V, Tatje D, Schenzinger A, Hoppe J: PDGF-AA effectively stimulates early events but has no mitogenic activity in AKR-2B mouse fibroblasts. Exp Cell Res 201: 192-199, 1992
7. Williams GT, Smith CA: Molecular regulation of apoptosis: Genetic controls on cell death. Cell 74: 777-779, 1993
8. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME: Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331, 1995
9. Wang Y, Huang S, Sah VP, Ross J Jr, Brown JH, Han J, Chien KR: Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. J Biol Chem 273: 2161-2168, 1998
10. Wang Y, Su B, Sah VP, Brown JH, Han J, Chien KR: Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. J Biol Chem 273: 5423-5426, 1998
11. Matsui T, Li L, del Monte F, Fukui Y, Franke TF, Hajjar RJ, Rosenzweig A: Adenoviral gene transfer of activated phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation 100: 2373-2379, 1999
12. Aikawa R, Nawano M, Gu Y, Katagiri H, Asano T, Zhu W, Nagai R, Komuro I: Insulin prevents cardiomyocytes from oxidative stress-induced apoptosis through activation of PI3 kinase/Akt. Circulation 102: 2873-2879, 2000
13. Fujio Y, Nguyen T, Wencker D, Kitsis RN, Walsh K: Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation 101: 660-667, 2000
14. Steller H: Mechanisms and genes of cellular suicide. Science 267: 1445-1449, 1995
15. Kumar S: ICE-like proteases in apoptosis. Trends Biochem Sci 20: 198-202, 1995
16. Leicht M, Briest W, Holzl A, Zimmer HG: Serum depletion induces cell loss of rat cardiac fibroblasts and increased expression of extra-cellular matrix proteins in surviving cells. Cardiovasc Res 52: 429-437, 2001
17. Leicht M, Greipel N, Zimmer H: Comitogenic effect of catecholamines on rat cardiac fibroblasts in culture. Cardiovasc Res 48: 274-284, 2000
18. Henkel AW, Bieger SC: Quantification of proteins dissolved in an electrophoresis sample buffer. Anal Biochem 223: 329-331 1994
19. Gekle M, Schwerdt G, Freudinger R, Mildenberger S, Wilflingseder D, Pollack V, Dander M, Schramek H: Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. J Pharmacol Exp Ther 293: 837-844, 2000
20. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987
21. Köhler T, Schill C, Deininger MW, Krahl R, Borchert S, Hasenclever D, Leiblein S, Wagner O, Niederwieser D: High Bad and Bax mRNA expression correlate with negative outcome in acute myeloid leukemia (AML). Leukemia 2002 (in press)
22. Taubert H, Köhler T, Meye A, Bartel F, Lautenschläger C, Borchert S, Bache M, Schmidt H, Würl P: mdm2 gene expression level is a prognostic factor in soft tissue sarcoma. Mol Med 6: 50-59, 2000
23. Cohen GM: Caspases: The executioners of apoptosis. Biochem J 326: 1-16, 1997
24. Bialik S, Geenen DL, Sasson IE, Cheng R, Horner JW, Evans SM, Lord EM, Koch CJ, Kitsis RN: Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53. J Clin Invest 15: 1363-1372, 1997
25. Kajstura J, Cheng W, Reiss K, Clark WA, Sonnenblick EH, Krajewski S, Reed JC, Olivetti G, Anversa P: Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab Invest 74: 86-107, 1996
26. Force T, Bonventre JV: Growth factors and mitogen-activated protein kinases. Hypertension 31: 152-161, 1998
27. Sugden PH, Clerk A: 'Stress-responsive' mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium. Circ Res 83: 345-352, 1998
28. Seger R, Krebs EG: The MAPK signaling cascade. FASEB J 9: 726-735, 1995
29. Sheng Z, Knowlton K, Chen J, Hoshijima M, Brown JH, Chien KR: Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy. J Biol Chem 272: 5783-5791, 1997
30. Gu Y, Zou Y, Aikawa R, Hayashi D, Kudoh S, Yamauchi T, Uozumi H, Zhu W, Kadowaki T, Yazaki Y, Komuro I: Growth hormone signalling and apoptosis in neonatal rat cardiomyocytes. Mol Cell Biochem 223: 35-46, 2001
31. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331, 1995
32. Wang Y, Huang S, Sah VP, Ross J Jr, Brown JH, Han J, Chien KR: Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. J Biol Chem 273: 2161-2168, 1998
33. Wang Y, Su B, Sah VP, Brown JH, Han J, Chien KR: Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. J Biol Chem 273: 5423-5426, 1998
34. Zechner D, Craig R, Hanford DS, McDonough PM, Sabbadini RA, Glembotski CC: MKK6 activates myocardial cell NF-kappaB and inhibits apoptosis in a p38 mitogen-activated protein kinase-dependent manner. J Biol Chem 273: 8232-8239, 1998
35. Whitmarsh AJ, Davis RJ. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J Mol Med 74: 589-607, 1996
36. Nishina H, Fischer KD, Radvanyi L, Shahinian A, Hakem R, Rubie EA, Bernstein A, Mak TW, Woodgett JR, Penninger JM: Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature 385: 350-353, 1997
37. Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME: Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275: 661-665, 1997
38. Fujio Y, Guo K, Mano T, Mitsuuchi Y, Testa JR, Walsh K: Cell cycle withdrawal promotes myogenic induction of Akt, a positive modulator of myocyte survival. Mol Cell Biol 19: 5073-5082, 1999
39. Salvesen GS, Dixit VM: Caspase activation: The induced-proximity model. Proc Natl Acad Sci USA 96: 10964-10967, 1999
40. Nemoto S, Xiang J, Huang S, Lin A: Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase. J Biol Chem 273: 16415-16420, 1998
41. Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA et al.: Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376: 37-43, 1995
42. Xiang J, Chao DT, Korsmeyer SJ: BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases. Proc Natl Acad Sci USA 93: 14559-14563, 1996
43. Gross A, Jockel J, Wei MC, Korsmeyer SJ: Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis. EMBO J 17: 3878-3885, 1998
44. Simin A, Bertsch G, Frank H, Zimmermann U, Hoppe J: Cell death of AKR-2B fibroblasts after serum removal: A process between apoptosis and necrosis. J Cell Sci 110: 819-828, 1997